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1. 发明申请

WO2007008712A3 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗αVβ6抗体及其用途
公开(公告)号：WO2007008712A3
公开(公告)日：2007-08-02
申请号：PCT/US2006026598
申请日：2006-07-10
申请人： BIOGEN IDEC INC , VIOLETTE SHELIA , KOOPMAN LOUISE A , SIMON KENNETH J , WEINREB PAUL H , VAN VLIJMEN HERMAN , SALDANHA JOSE , LUGOVSKOY ALEXEY A
发明人： VIOLETTE SHELIA , KOOPMAN LOUISE A , SIMON KENNETH J , WEINREB PAUL H , VAN VLIJMEN HERMAN , SALDANHA JOSE , LUGOVSKOY ALEXEY A
IPC分类号： C12P21/08 , A61K39/395 , C07H21/04 , C07K16/00 , C12P21/04 , G01N33/53 , G01N33/574
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
摘要翻译：本发明属于细胞生物学，免疫学和肿瘤学领域。具体而言，本发明涉及识别v6整联蛋白的人源化抗体，其包含非人源可变区和至少一部分人源免疫球蛋白。本发明还涉及其制备方法，包含它们的药物组合物以及通过施用人源化抗v6抗体来治疗各种疾病的方法。本发明还涉及鉴定肿瘤细胞和组织表面上的整联蛋白αvβ6的差异表达，使用这种差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤转移的方法和用于使用配体，特别是与整联蛋白αvβ6结合的抗体消除残留的转移性肿瘤细胞。

2. 发明申请

WO2006125140A9 METHODS FOR TREATING FIBROTIC CONDITIONS 审中-公开
标题翻译：治疗纤维状况的方法
公开(公告)号：WO2006125140A9
公开(公告)日：2007-03-29
申请号：PCT/US2006019404
申请日：2006-05-18
申请人： BIOGEN IDEC INC , NOVOBRANTSEVA TATIANA , VIOLETTE SHELIA , KOTELIANSKY VICTOR , IBRAGHIMOV ALEXANDER
发明人： NOVOBRANTSEVA TATIANA , VIOLETTE SHELIA , KOTELIANSKY VICTOR , IBRAGHIMOV ALEXANDER
IPC分类号： A61K39/395 , A61K39/00 , C07K17/00
CPC分类号： C07K16/2887 , A61K38/10 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/73
摘要： The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens (e.g., antibodies against CD20), and BAFF antagonists.
摘要翻译：本发明涉及治疗肝纤维化病症（例如肝，肾和肺纤维化）以及身体其他组织的纤维化病症的方法。本发明的方法包括向需要这种治疗的患者施用治疗有效量的B细胞拮抗剂。可用于实施本发明方法的示例性B细胞拮抗剂包括针对B细胞表面抗原的抗体（例如针对CD20的抗体）和BAFF拮抗剂。

3. 发明申请

WO2003100033A2 ANTI-αvβ6 ANTIBODIES 审中-公开
标题翻译：抗甲状腺炎抗体
公开(公告)号：WO2003100033A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/008048
申请日：2003-03-13
申请人： BIOGEN, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , VIOLETTE, Shelia, M. , WEINREB, Paul, H. , SIMON, Kenneth, J. , SHEPPARD, Dean , LEONE, Diane, R.
发明人： VIOLETTE, Shelia, M. , WEINREB, Paul, H. , SIMON, Kenneth, J. , SHEPPARD, Dean , LEONE, Diane, R.
IPC分类号： C12N
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose %Qmediated diseases.
摘要翻译：特异性结合M.96的单克隆抗体。还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。

4. 发明申请

WO2008008315A2 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF SMAD4-DEFICIENT CANCERS 审中-公开
标题翻译：抑制SMAD4缺乏癌的生长的组合物和方法
公开(公告)号：WO2008008315A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015692
申请日：2007-07-10
申请人： BIOGEN IDEC MA INC. , VIOLETTE, Shelia, M. , KOOPMAN, Louise, A.
发明人： VIOLETTE, Shelia, M. , KOOPMAN, Louise, A.
IPC分类号： G01N33/574
CPC分类号： G01N33/5011 , A61K38/1793 , A61K39/39558 , A61K2039/505 , C07K16/2839 , C07K2317/73 , G01N33/5091 , G01N33/574 , G01N33/57407 , A61K2300/00
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention relates to the discovery that there is a relationship between the expression levels of the tumor suppressor gene smad4 (also known as dpc4 ) and integrin α v β 6 , and the responsiveness of patient populations to α v β 6 -active compounds and compositions (e.g., antibodies and other ligands that bind α v β 6 ), particularly in cancer cells from such patient populations, more particularly on carcinomas such as pancreatic carcinomas. The invention thus provides methods for determining the responsiveness of tumor cells (particularly those from pancreatic tumors) to such α v β 6 -active compounds and compositions by examining the expression of α v β 6 and smad4 by the tumor cells, as well as methods of diagnosis and treatment/prevention of tumor progression using ligands, including antibodies and small molecule drugs, that bind to integrin α v β 6 on the surfaces of tumor cells and/or that block one or more components of the TGF-β pathway, particularly in 5/≤αrf4-deficient tumor cells.
摘要翻译：本发明涉及细胞生物学，免疫学和肿瘤学领域。本发明涉及在肿瘤抑制基因smad4（也称为dpc4）和整联蛋白的表达水平之间存在关系的发现，以及患者群体对ßß>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> 特别是在来自这些患者群体的癌细胞中，更特别地涉及癌如胰腺癌。因此，本发明提供了通过检查肿瘤细胞（特别是胰腺肿瘤）的表达来确定肿瘤细胞（例如胰腺肿瘤）的反应性的方法，肿瘤细胞中的Smad4和smad4以及使用配体（包括抗体和小分子药物）的诊断和治疗/预防肿瘤进展的方法，所述配体包括抗体和小分子药物，其结合在肿瘤细胞表面上整合整合素和/或阻断TGF-β途径的一种或多种成分，特别是在5 / = arf4缺陷型肿瘤中细胞。

5. 发明申请

WO2007008712A8 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2007008712A8
公开(公告)日：2007-11-01
申请号：PCT/US2006026598
申请日：2006-07-10
申请人： BIOGEN IDEC INC , VIOLETTE SHELIA , KOOPMAN LOUISE A , SIMON KENNETH J , WEINREB PAUL H , VAN VLIJMEN HERMAN , SALDANHA JOSE , LUGOVSKOY ALEXEY A
发明人： VIOLETTE SHELIA , KOOPMAN LOUISE A , SIMON KENNETH J , WEINREB PAUL H , VAN VLIJMEN HERMAN , SALDANHA JOSE , LUGOVSKOY ALEXEY A
IPC分类号： C12P21/08 , A61K39/395 , C07H21/04 , C07K16/00 , C12P21/04 , G01N33/53 , G01N33/574
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.

6. 发明申请

WO2006125140A3 METHODS FOR TREATING FIBROTIC CONDITIONS 审中-公开
标题翻译：处理纤维条件的方法
公开(公告)号：WO2006125140A3
公开(公告)日：2007-01-18
申请号：PCT/US2006019404
申请日：2006-05-18
申请人： BIOGEN IDEC INC , NOVOBRANTSEVA TATIANA , VIOLETTE SHELIA , KOTELIANSKY VICTOR , IBRAGHIMOV ALEXANDER
发明人： NOVOBRANTSEVA TATIANA , VIOLETTE SHELIA , KOTELIANSKY VICTOR , IBRAGHIMOV ALEXANDER
IPC分类号： A61K39/395 , A61K39/00 , C07K17/00
CPC分类号： C07K16/2887 , A61K38/10 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/73
摘要： The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens (e.g., antibodies against CD20), and BAFF antagonists.
摘要翻译：本发明涉及用于治疗纤维化病症如肝，肾和肺纤维化的方法，以及身体其他组织的纤维化病症。本发明的方法包括向需要这种治疗的患者施用治疗有效量的B细胞拮抗剂。可用于实施本发明方法的示例性B细胞拮抗剂包括抗B细胞表面抗原的抗体（例如针对CD20的抗体）和BAFF拮抗剂。

7. 发明申请

WO2003100033A3 ANTI-αvβ6 ANTIBODIES 审中-公开
公开(公告)号：WO2003100033A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/008048
申请日：2003-03-13
申请人： BIOGEN, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , VIOLETTE, Shelia, M. , WEINREB, Paul, H. , SIMON, Kenneth, J. , SHEPPARD, Dean , LEONE, Diane, R.
发明人： VIOLETTE, Shelia, M. , WEINREB, Paul, H. , SIMON, Kenneth, J. , SHEPPARD, Dean , LEONE, Diane, R.
IPC分类号： A61K39/395
摘要： Monoclonal antibodies that specifically bind to α v β 6 . Also included are methods of using these antibodies to treat mammals having or at risk of having α v β 6 -mediated diseases, or to diagnose α v β 6 -mediated diseases.

8. 发明申请

WO2008008315A3 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF SMAD4-DEFICIENT CANCERS 审中-公开
标题翻译：抑制SMAD4缺乏癌的生长的组合物和方法
公开(公告)号：WO2008008315A3
公开(公告)日：2008-12-11
申请号：PCT/US2007015692
申请日：2007-07-10
申请人： BIOGEN IDEC INC , VIOLETTE SHELIA M , KOOPMAN LOUISE A
发明人： VIOLETTE SHELIA M , KOOPMAN LOUISE A
IPC分类号： A61K39/00
CPC分类号： G01N33/5011 , A61K38/1793 , A61K39/39558 , A61K2039/505 , C07K16/2839 , C07K2317/73 , G01N33/5091 , G01N33/574 , G01N33/57407 , A61K2300/00
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention relates to the discovery that there is a relationship between the expression levels of the tumor suppressor gene smad4 (also known as dpc4) and integrin avß6, and the responsiveness of patient populations to avß6-active compounds and compositions (e.g., antibodies and other ligands that bind avß6), particularly in cancer cells from such patient populations, more particularly on carcinomas such as pancreatic carcinomas. The invention thus provides methods for determining the responsiveness of tumor cells (particularly those from pancreatic tumors) to such avß6-active compounds and compositions by examining the expression of avß6 and smad4 by the tumor cells, as well as methods of diagnosis and treatment/prevention of tumor progression using ligands, including antibodies and small molecule drugs, that bind to integrin avß6 on the surfaces of tumor cells and/or that block one or more components of the TGF-ß pathway, particularly in 5/=arf4-deficient tumor cells.
摘要翻译：本发明涉及细胞生物学，免疫学和肿瘤学领域。本发明涉及以下发现：肿瘤抑制基因smad4（也称为dpc4）和整联蛋白avβ6的表达水平与患者群体对avβ6活性化合物和组合物（例如，抗体和其他物质）的反应性之间存在关系结合avß6）的配体，特别是在来自这样的患者群体的癌细胞中，更特别地涉及癌如胰腺癌。因此，本发明提供了通过检查肿瘤细胞的avß6和smad4的表达以及诊断和治疗/预防的方法来确定肿瘤细胞（特别是来自胰腺肿瘤的细胞）对这种avβ6活性化合物和组合物的反应性的方法使用与肿瘤细胞表面上的整联蛋白avβ6结合的配体（包括抗体和小分子药物）和/或阻断TGF-β途径的一个或多个成分，特别是在5 / arf4缺陷型肿瘤细胞中的配体。

9. 发明申请

WO2007008712A2 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗雌激素受体6抗体及其用途
公开(公告)号：WO2007008712A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026598
申请日：2006-06-10
申请人： BIOGEN IDEC MA INC. , VIOLETTE, Shelia , KOOPMAN, Louise, A. , SIMON, Kenneth, J. , WEINREB, Paul, H. , VAN VLIJMEN, Herman , SALDANHA, Jose , LUGOVSKOY, Alexey, A.
发明人： VIOLETTE, Shelia , KOOPMAN, Louise, A. , SIMON, Kenneth, J. , WEINREB, Paul, H. , VAN VLIJMEN, Herman , SALDANHA, Jose , LUGOVSKOY, Alexey, A.
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
摘要翻译：本发明涉及细胞生物学，免疫学和肿瘤学领域。具体地说，本发明涉及识别v6整联蛋白的人源化抗体，其包含非人源的可变区和至少一部分人源免疫球蛋白。本发明还涉及其制备方法，包含它们的药物组合物以及通过施用人源化的抗-V6抗体来治疗各种疾病的方法。本发明还涉及确定肿瘤细胞和组织表面上整合素avβ6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤转移的方法以及用于使用与整联蛋白avβ6结合的配体特别是抗体来消除残余转移性肿瘤细胞。

10. 发明申请

WO2006125140A2 METHODS FOR TREATING FIBROTIC CONDITIONS 审中-公开
标题翻译：处理纤维条件的方法
公开(公告)号：WO2006125140A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/019404
申请日：2006-05-18
申请人： BIOGEN IDEC INC. , NOVOBRANTSEVA, Tatiana , VIOLETTE, Shelia , KOTELIANSKY, Victor , IBRAGHIMOV, Alexander
发明人： NOVOBRANTSEVA, Tatiana , VIOLETTE, Shelia , KOTELIANSKY, Victor , IBRAGHIMOV, Alexander
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K38/10 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/73
摘要： The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens ( e.g ., antibodies against CD20), and BAFF antagonists.
摘要翻译：本发明涉及用于治疗纤维化病症如肝，肾和肺纤维化的方法，以及身体其他组织的纤维化病症。本发明的方法包括向需要这种治疗的患者施用治疗有效量的B细胞拮抗剂。可用于实施本发明方法的示例性B细胞拮抗剂包括抗B细胞表面抗原的抗体（例如针对CD20的抗体）和BAFF拮抗剂。

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