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1. 发明申请

WO0162264A2 HALOTHERAPY METHOD 审中-公开
标题翻译：治疗方法
公开(公告)号：WO0162264A2
公开(公告)日：2001-08-30
申请号：PCT/US0105591
申请日：2001-02-22
申请人： PROCTER & GAMBLE , ZAWADZKI PIOTR , VINOGRADOV VALENTIN ANTONOVICH
发明人： ZAWADZKI PIOTR , VINOGRADOV VALENTIN ANTONOVICH
IPC分类号： A61K9/00 , A61K33/00 , A61K33/14 , A61P11/00
CPC分类号： A61K9/0078 , A61K33/14
摘要： The invention relates to a convenient yet efficacious method of alleviating the severity or reducing the duration of respiratory ailments, especially the common cold or influenza. The method comprises administering to a person, over a period of from 1 to 14 days, by inhalation from a portable dispenser, one or more doses of sodium chloride, wherein the sodium chloride is in the form of an aerosol of 1 to 5 mu m particles and each dose consists essentially of from 50 to 5000 mu m sodium chloride, administered via from 2 to 200 inspirations. Suitable dispensers include self-milling dry powder dispensers and liquid nebulisers. Doses are preferably administered via a pulsed regimen comprising two or more periods of sodium chloride inhalation separated by periods of normal breathing. The invention further relates to the use of sodium chloride in the manufacture of a medicament for such methods.
摘要翻译：本发明涉及一种方便而有效的减轻呼吸道疾病的严重程度或减轻持续时间的方法，特别是感冒或流行性感冒。该方法包括通过从便携式分配器吸入一个或多个剂量的氯化钠，在1至14天的时间内对人施用，其中氯化钠为1至5μm的气溶胶形式颗粒和每个剂量基本上由50至5000微克氯化钠组成，通过2至200次灵感施用。合适的分配器包括自磨干粉分配器和液体雾化器。剂量优选通过脉冲方案施用，该方案包括在正常呼吸期间分离的两个或多个氯化钠吸入期。本发明还涉及氯化钠在制备用于这种方法的药物中的用途。

2. 发明申请

WO2011099881A1 PHARMACEUTICAL COMPOSITIONS CONTAINING ANTIBODIES TO NEUROPEPTIDE HEAD ACTIVATOR AND METHODS THEREOF 审中-公开
标题翻译：含有抗体的神经元激活剂的药物组合物及其方法
公开(公告)号：WO2011099881A1
公开(公告)日：2011-08-18
申请号：PCT/RU2010/000049
申请日：2010-02-09
申请人： POMYTKIN, Igor Anatolievich , VINOGRADOV, Valentin Antonovich , CHERNOPYATKO, Anton Sergeevich , BIOPEPTIDE DEVELOPMENT LIMITED
发明人： POMYTKIN, Igor Anatolievich , VINOGRADOV, Valentin Antonovich , CHERNOPYATKO, Anton Sergeevich
IPC分类号： A61K39/00 , A61P35/00 , A61P9/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/26
摘要： This invention relates to pharmaceutical compositions comprising antibodies that specifically bind to the endogenous neuropeptide head activator (NHA) having the sequence of pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe and neutralize the function of NHA thereby. The invention also provides methods for neutralizing NHA function, and particularly for treating NHA-related disorders (e.g., cancer or cardiovascular diseases) by administering to mammals of the pharmaceutical compositions.
摘要翻译：本发明涉及包含特异性结合具有pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe序列的内源性神经肽头部活化剂（NHA）的抗体的药物组合物，并中和其功能 NHA。本发明还提供了中和NHA功能的方法，特别是通过向哺乳动物施用药物组合物来治疗NHA相关疾病（例如癌症或心血管疾病）。

3. 发明申请

WO2007133104A1 HYDROPEROXYLAPATITE AND COMPOSITIONS THEREOF 审中-公开
标题翻译：羟基磷酸酯及其组合物
公开(公告)号：WO2007133104A1
公开(公告)日：2007-11-22
申请号：PCT/RU2006/000245
申请日：2006-05-17
申请人： POMYTKIN, Igor Anatolievich , VINOGRADOV, Valentin Antonovich
发明人： POMYTKIN, Igor Anatolievich , VINOGRADOV, Valentin Antonovich
IPC分类号： C01B25/32 , A61K8/25 , A61Q11/02
CPC分类号： C01B25/322 , A61K8/24 , A61K33/42 , A61Q11/00 , A61K2300/00
摘要： This invention relates to a compound of general formula Ca 5 (PO4) 3 (OOH) x (OH) 1-X wherein 0
摘要翻译：本发明涉及通式为Ca 5（PO 4）3（OOH）x（OH）1-X（O） / SUB>其中0

4. 发明申请

WO1997024353A1 SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM 审中-公开
标题翻译：取代的6-H-1,3,4-噻二嗪-2-胺，其作为检测用途，心血管和高血糖剂，以及含有它们的药物组合物
公开(公告)号：WO1997024353A1
公开(公告)日：1997-07-10
申请号：PCT/RU1995000286
申请日：1995-12-28
申请人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "e;LIGAND"e; (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU) , CHUPAKHIN, Oleg Nikolaevich , SIDOROVA, Larisa Petrovna , TARAKHTY, Emma Afanasievna , NOVIKOVA, Antonina Petrovna , PEROVA, Natalya Mikhailovna , VINOGRADOV, Valentin Antonovich , VAN GINKEL, Michiel, Franciscus
发明人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "e;LIGAND"e; (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU)
IPC分类号： C07D417/04
CPC分类号： C07D285/16
摘要： The disclosure relates to substituted 6-H-1,3,4-thiadiazine-2-imines of general formula (I), in which (II) represents a morpholine, thiomorpholine, piperidine, pyrrolidine or hexamethylene imine fragment, or to the pharmacologically acceptable salts of said compounds, to their use as anaesthetising, cardiovascular and hypometabolic agents and to pharmaceutical compositions containing them.
摘要翻译：本公开涉及通式（I）的取代的6-H-1,3,4-噻二嗪-2-亚胺，其中（II）表示吗啉，硫代吗啉，哌啶，吡咯烷或六亚甲基亚胺片段，或药理学上所述化合物的可接受的盐，其作为麻醉剂的用途，心血管和代谢药物以及含有它们的药物组合物。

5. 发明申请

WO1997024352A1 SUBSTITUTED 6-H-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS AN AESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM 审中-公开
标题翻译：取代的6-H-1,3,4-噻二嗪-2-胺，其作为美容，心血管和高血糖药物的用途，以及含有它们的药物组合物
公开(公告)号：WO1997024352A1
公开(公告)日：1997-07-10
申请号：PCT/RU1995000284
申请日：1995-12-28
申请人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "LIGAND" (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU) , CHUPAKHIN, Oleg Nikolaevich , SIDOROVA, Larisa Petrovna , TARAKHTY, Emma Afanasievna , NOVIKOVA, Antonina Petrovna , PEROVA, Natalya Mikhailovna , VINOGRADOV, Valentin Antonovich , VAN GINKEL, Michiel, Franciscus
发明人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "LIGAND" (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU)
IPC分类号： C07D417/04
CPC分类号： C07D285/16
摘要： The disclosure relates to substituted 6H-1,3,4-thiadiazine-2-amines of general formula (I), in which Ar stands for phenyl which can be substituted with one or more atoms of chlorine, bromine, C1-C4 alkoxy or C1-C4 alkyl groups; and (a) represents a morpholine, thiomorpholine, piperidine, pyrrolidine or hexamethylene imine fragment; to the pharmacologically acceptable salts of said compounds; to their use as anaesthetising, cardiovascular and hypometabolic agents; and to pharmaceutical compositions containing them.
摘要翻译：本公开涉及通式（I）的取代的6H-1,3,4-噻二嗪-2-胺，其中Ar表示可以被一个或多个氯原子，氯，C 1 -C 4烷氧基或 C1-C4烷基; 和（a）表示吗啉，硫代吗啉，哌啶，吡咯烷或六亚甲基亚胺片段; 所述化合物的药理学上可接受的盐; 用作麻醉药，心血管和代谢药物; 以及含有它们的药物组合物。

6. 发明申请

WO1988010268A1 HEXAPEPTIDE AND PHARMACEUTICAL PREPARATION BASED THEREON FOR CURING EROSIVE-ULCEROUS INJURIES TO THE DIGESTIVE TRACT 审中-公开
标题翻译：用于治疗消化性溃疡对消化性溃疡的下一步和药物制备
公开(公告)号：WO1988010268A1
公开(公告)日：1988-12-29
申请号：PCT/SU1988000115
申请日：1988-05-25
申请人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ... , VINOGRADOV, Valentin Antonovich , TITOV, Mikhail Ivanovich , POLONSKY, Vladimir Markovich , KOROBOV, Nikolai Vasilievich , SOKOLOV, Anatoly Semenovich , YAKUSHEVA, Maria Leonidovna , BESPALOVA, Zhanna Dmitrievna , OVCHINNIKOV, Mikhail Vladimirovich , PEKELIS, Boris Leonidovich
发明人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ...
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00 , C07K14/665
摘要： A new hexapeptide has the following structure: Tyr-D-Ala-Gly-Phe-Leu-Glu. A pharmaceutical preparation for curing erosive-ulcerous injuries to the digestive tract consists of an active substance - said hexapeptide and a pharmaceutical carrier.

7. 发明申请

WO1986000621A1 HEXAPEPTIDE 审中-公开
标题翻译：六肽
公开(公告)号：WO1986000621A1
公开(公告)日：1986-01-30
申请号：PCT/SU1985000031
申请日：1985-04-24
申请人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ... , CHAZOV, Evgeny Ivanovich , SMIRNOV, Vladimir Nikolaevich , VINOGRADOV, Valentin Antonovich , POLONSKY, Vladimir Markovich , TISCHENKO, Valentina Alexeevna , TITOV, Mikhail Ivanovich , BESPALOVA, Zhanna Dmitrievna , PEKELIS, Boris Leonidovich
发明人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ...
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00
摘要： Hexapeptide having a Phe-Ala-Gly-Phe-Gly-Arg structure and possessing hepatoprotective properties.
摘要翻译：具有Phe-Ala-Gly-Phe-Gly-Arg结构并具有肝保护性质的六肽。

8. 发明申请

WO1984002470A1 MEDICINAL PREPARATION FOR THE THERAPEUTIC TREATMENT OF PEPTIC ULCER 审中-公开
标题翻译：药物治疗药物治疗的药物制剂
公开(公告)号：WO1984002470A1
公开(公告)日：1984-07-05
申请号：PCT/SU1983000039
申请日：1983-10-31
申请人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ... , SMIRNOV, Vladimir Nikolaevich , TITOV, Mikhail Ivanovich , BESPALOVA, Zhanna Dmitrievna , AZMUKO, Andrei Andreevich , SAX, Tatyana Rafailovna , MEDVEDEV, Oleg Stefanovich , ROZHANSKAYA, Nadezhda Ivanovna , SMAGIN, Vsevolod Grigorievich , VINOGRADOV, Valentin Antonovich , POLONSKY, Vladimir Markovich , BULGAKOV, Sergei Alexandrovich , IVANOV, Vladimir Nikolaevich
发明人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ...
IPC分类号： A61K37/02
CPC分类号： C07K14/665 , A61K38/00
摘要： The medicinal preparation for the therapeutic treatment of peptic ulcer consists of an active susbtance, i.e., peptide having the following structure: Tyr-D-Ala-Gly-Phe-Leu-Arg, and a pharmaceutical diluent.
摘要翻译：用于治疗消化性溃疡的药物制剂由活性成分组成，即具有以下结构的肽：Tyr-D-Ala-Gly-Phe-Leu-Arg和药物稀释剂。

9. 发明申请

WO1997024354A1 SUBSTITUTED 6-R-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM 审中-公开
标题翻译：取代的6-R-1,3,4-thiadiazine-2-AMINES，其作为检测用途，心血管和高血糖剂，以及含有它们的药物组合物
公开(公告)号：WO1997024354A1
公开(公告)日：1997-07-10
申请号：PCT/RU1995000285
申请日：1995-12-28
申请人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "e;LIGAND"e; (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU) , CHUPAKHIN, Oleg Nikolaevich , SIDOROVA, Larisa Petrovna , TARAKHTY, Emma Afanasievna , NOVIKOVA, Antonina Petrovna , PEROVA, Natalya Mikhailovna , VINOGRADOV, Valentin Antonovich , VAN GINKEL, Michiel, Franciscus
发明人： THE PROCTER & GAMBLE COMPANY , NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE "e;LIGAND"e; (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU)
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The disclosure relates to substituted 6-R-1,3,4-thiadiazine-2-amines of general formula (I), in which Ar stands for phenyl which may be substituted with one or more atoms of chlorine, bromine, C1-C4 alkoxy or C1-C4 alkyl groups; R and R each independently of one another represent a hydrogen atom or a C1-C4 alkyl residue; and R and R are independently selected from C1-C4 alkyl groups. Also disclosed are the pharmacologically acceptable salts of these compounds, their use as anaesthetising, cardiovascular and hypometabolic agents and a pharmaceutical composition containing them.
摘要翻译：本公开涉及通式（I）的取代的6-R-1,3,4-噻二嗪-2-胺，其中Ar表示可被一个或多个氯，溴，C 1 -C 4的原子取代的苯基烷氧基或C 1 -C 4烷基; R 1和R 2各自独立地表示氢原子或C 1 -C 4烷基残基; R 3和R 4独立地选自C 1 -C 4烷基。还公开了这些化合物的药理学上可接受的盐，它们作为麻醉剂的用途，心血管和代谢药物以及含有它们的药物组合物。

10. 发明申请

WO1989002745A1 PHARMACEUTICAL PREPARATION FOR CURING MULTIPLE SCLEROSIS AND LATERAL AMYOTROPHIC SCLEROSIS 审中-公开
标题翻译：用于治疗多发性硬化性心脏病和左心耳痛性肉芽肿的药物制剂
公开(公告)号：WO1989002745A1
公开(公告)日：1989-04-06
申请号：PCT/SU1988000162
申请日：1988-08-19
申请人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ... , GUSEV, Evgeny Ivanovich , ZAVALISHIN, Igor Alexeevich , DEMINA, Tatyana Leonidovna , NEVSKAYA, Olga Mikhailovna , TITOV, Mikhail Ivanovich , BESPALOVA, Zhanna Dmitrievna , VINOGRADOV, Valentin Antonovich , POLONSKY, Vladimir Markovich
发明人： VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR ...
IPC分类号： A61K37/02
CPC分类号： C07K7/06 , A61K38/08
摘要： A pharmaceutical preparation for curing multiple sclerosis and lateral amyotrophic sclerosis contains a peptide active substance of the following structure: Tyr-D-Ala-Gly-Phe-Leu-Arg and a pharmaceutical diluent.

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