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1. 发明申请

WO2011133893A3 CYANIDE ANTIDOTES 审中-公开
标题翻译：氰化物抗体
公开(公告)号：WO2011133893A3
公开(公告)日：2012-04-05
申请号：PCT/US2011033619
申请日：2011-04-22
申请人： UNIV MINNESOTA , PATTERSON STEVEN , VINCE ROBERT , NAGASAWA HERBERT
发明人： PATTERSON STEVEN , VINCE ROBERT , NAGASAWA HERBERT
IPC分类号： C07D339/08 , A61K31/385 , A61P25/30 , C07C215/10 , C07C215/12 , G01N33/48
CPC分类号： C07C215/10 , A61K31/385 , C07C215/08 , C07C215/12 , C07C229/12 , C07D339/08
摘要： The invention provides salts of sulfanegen and methods for their use.
摘要翻译：本发明提供了磺胺的盐及其使用方法。

2. 发明申请

WO2011133893A2 CYANIDE ANTIDOTES 审中-公开
标题翻译：氰化物抗体
公开(公告)号：WO2011133893A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033619
申请日：2011-04-22
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , PATTERSON, Steven , VINCE, Robert , NAGASAWA, Herbert
发明人： PATTERSON, Steven , VINCE, Robert , NAGASAWA, Herbert
IPC分类号： C07D339/08 , C07C215/12 , C07C215/10 , A61K31/385 , A61P25/30 , G01N33/48
CPC分类号： C07C215/10 , A61K31/385 , C07C215/08 , C07C215/12 , C07C229/12 , C07D339/08
摘要： The invention provides salts of sulfanegen and methods for their use.
摘要翻译：本发明提供了磺胺的盐及其使用方法。

3. 发明申请

WO2020010021A1 THERAPEUTIC COMPOUNDS AND METHODS 审中-公开
公开(公告)号：WO2020010021A1
公开(公告)日：2020-01-09
申请号：PCT/US2019/040190
申请日：2019-07-01
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , VINCE, Robert , MORE, Swati Sudhakar , RAZA, Abbas
发明人： VINCE, Robert , MORE, Swati Sudhakar , RAZA, Abbas
IPC分类号： A61K38/05 , C07K5/06 , A61P25/16 , A61P25/28
摘要： Disclosed herein are compounds of formula I: (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , and R 3 may any of the values defined herein, as well as compositions comprising such compounds. Also disclosed are methods for treating diseases including neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease.

4. 发明申请

WO2013009647A1 GLUTATHIONE ANALOGS AND USES THEREOF 审中-公开
标题翻译： GLUTATHIONE模拟及其用途
公开(公告)号：WO2013009647A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/045835
申请日：2012-07-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , VINCE, Robert , MORE, Swati Sudhakar
发明人： VINCE, Robert , MORE, Swati Sudhakar
IPC分类号： C07K5/02 , C07K5/06 , A61K38/05 , A61P25/16 , A61P25/28
CPC分类号： C07K5/02 , A61K8/64 , A61K38/00 , A61Q17/04 , A61Q19/08 , C07K5/0215 , C07K7/02
摘要： The invention provides compounds of formula (I): (I) or salts thereof, wherein R1, R2, R3 Z, and X have any of the values defined herein, as well as compositions comprising such compounds. The compounds and compositions are useful for treating neurodegenerative disorders.
摘要翻译：本发明提供式（I）化合物：（I）或其盐，其中R1，R2，R3Z和X具有本文定义的任何值，以及包含这些化合物的组合物。所述化合物和组合物可用于治疗神经变性疾病。

5. 发明申请

WO1996000885A1 THICKENER MUD GAUGE 审中-公开
标题翻译：更厚的泥浆计
公开(公告)号：WO1996000885A1
公开(公告)日：1996-01-11
申请号：PCT/AU1995000377
申请日：1995-06-27
申请人： ALCOA OF AUSTRALIA LIMITED , DOOLEY, Vince, Robert
发明人： ALCOA OF AUSTRALIA LIMITED
IPC分类号： G01F23/22
CPC分类号： G01F23/24 , G01F23/0023 , G01N27/06
摘要： An apparatus for determining the concentration of solids or for measuring the interface between a liquid and settled solids in a settling vessel, comprising: (a) electrical conductivity or resistivity measuring means adapted to monitor electrical conductivity or resistivity within a liquid in a vessel; and (b) monitoring means which is capable of recording electrical conductivity or resistance levels within the vessel and which is capable of determining the concentration of solids from the electrical conductivity or resistivity results. Where the apparatus consists of a conductivity sensor (1) which is in electrical communication with and suspended by a cable (2) from a winch (3). The winch is controlled by the operation of a motor (4) which is controlled by a monitoring means (5). The conductivity sensor signals are transferred from the cable (2) by sliprings (6) to a conductivity meter (7). The conductivity data is then passed from the conductivity meter to the monitoring means (5) which measures positional data from a shaft encoder (8) and controls the position of the conductivity sensor by instructing the winch (3) to raise, lower or hold the sensor in any position inside the settlement vessel. The monitoring means is adapted to continuously examine conductivity data from the sensor.
摘要翻译：一种用于确定固体浓度或用于测量沉降容器中的液体和沉降固体之间的界面的装置，包括：（a）适于监测容器内的液体内的导电性或电阻率的导电性或电阻率测量装置; 和（b）能够在容器内记录电导率或电阻值并且能够根据导电性或电阻率结果确定固体浓度的监测装置。该设备由电导率传感器（1）构成，电导率传感器（1）与绞盘（3）电连通并由电缆（2）悬挂。绞盘由通过监视装置（5）控制的马达（4）的操作来控制。电导率传感器信号通过滑环（6）从电缆（2）传送到电导率计（7）。然后，电导率数据从电导仪传递到测量来自轴编码器（8）的位置数据的监视装置（5），并通过指示绞盘（3）升高，降低或保持电导率传感器的位置来控制电导率传感器的位置传感器在沉降容器内的任何位置。监测装置适于连续检查传感器的电导率数据。

6. 发明申请

WO2012047993A3 N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV 审中-公开
公开(公告)号：WO2012047993A3
公开(公告)日：2012-04-12
申请号：PCT/US2011/054916
申请日：2011-10-05
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , WANG, Zhengqiang , GERAGHTY, Robert J. , VINCE, Robert , TANG, Jinq
发明人： WANG, Zhengqiang , GERAGHTY, Robert J. , VINCE, Robert , TANG, Jinq
IPC分类号： A61K31/105
摘要： The invention provides antiviral compounds that can be used in therapy against human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Compounds of the invention can be dual targeted inhibitors of HIV, inhibiting both the reverse transcriptase and the integrase enzyme systems, thus increasing the barrier to development of viral resistance in patients. Prodrugs of the inventive antiviral compounds are also provided. Compounds of the invention can be used to treat HCV secondary infections in HIV-afflicted patients, reducing the need for administration of drug cocktails containing multiple, potentially conflicting, medicinal compounds. Methods of synthesis of the compounds and methods of treatment using the compounds are also provided.

7. 发明申请

WO2009018344A1 ANTICANCER AGENTS 审中-公开
标题翻译：反对者代理人
公开(公告)号：WO2009018344A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071598
申请日：2008-07-30
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , PANKIEWICZ, Krzysztof , CHEN, Liqiang , VINCE, Robert
发明人： PANKIEWICZ, Krzysztof , CHEN, Liqiang , VINCE, Robert
IPC分类号： A01N43/76 , A61K31/42
CPC分类号： C07D263/32 , C07C275/42
摘要： The invention provides a compound of the invention, which is a compound of formula A-X-L-B, or a salt thereof, as well as compositions comprising a compound of the invention, and therapeutic methods that include the administration of a compound of the invention. The compounds of the invention are useful as therapeutic agents for the treatment of diseases such as cancer.
摘要翻译：本发明提供了本发明的化合物，其为式A-X-L-B化合物或其盐，以及包含本发明化合物的组合物和包括施用本发明化合物的治疗方法。本发明的化合物可用作治疗诸如癌症的疾病的治疗剂。

8. 发明申请

WO2008005806A2 THERAPEUTIC METHODS, COMPOSITIONS, AND COMPOUNDS 审中-公开
标题翻译：治疗方法，组合物和化合物
公开(公告)号：WO2008005806A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072404
申请日：2007-06-28
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , DEPARTMENT OF VETERANS AFFAIRS , NAGASAWA, Herbert T. , GOON, David J.W. , CRANKSHAW, Daune L. , VINCE, Robert
发明人： NAGASAWA, Herbert T. , GOON, David J.W. , CRANKSHAW, Daune L. , VINCE, Robert
IPC分类号： A61K31/19
CPC分类号： C07D339/08 , C07C327/32 , C07C329/06 , C07D277/06 , C07D285/36
摘要： In one embodiment the invention provides a method of combating cyanide poisoning, which comprises administering to a subject a compound capable of releasing 3-mercapto-pyruvate in vivo. In other embodiments the invention also provides pharmaceutical compositions comprising a compound capable of releasing 3-mercaptopyruvate in vivo, as well as novel compounds that are capable of releasing 3-mercaptopyruvate in vivo.
摘要翻译：在一个实施方案中，本发明提供了一种防治氰化物中毒的方法，其包括向受试者施用能体内释放3-巯基丙酮酸的化合物。在其它实施方案中，本发明还提供了包含能够在体内释放3-巯基丙酮酸的化合物的药物组合物，以及能够在体内释放3-巯基丙酮酸的新型化合物。

9. 发明申请

WO1991015490A1 SYNTHESIS OF PURINE SUBSTITUTED CYCLOPENTENE DERIVATIVES 审中-公开
标题翻译：嘌呤取代环己基衍生物的合成
公开(公告)号：WO1991015490A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002355
申请日：1991-04-04
申请人： GLAXO INC. , VINCE, Robert , PETERSON, Mark, Lee , LACKEY, John, William , MOOK, Robert, Anthony, Jr. , PARTRIDGE, John, Joseph
发明人： GLAXO INC.
IPC分类号： C07D473/18
CPC分类号： C07D473/40 , C07C69/96 , C07D473/18
摘要： This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent, and certain intermediates.

10. 发明申请

WO2013086516A1 HYPERSPECTRAL IMAGING FOR EARLY DETECTION OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于早期检测阿尔茨海默病的超检查成像
公开(公告)号：WO2013086516A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068793
申请日：2012-12-10
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , VINCE, Robert , MORE, Swati, Sudhakar
发明人： VINCE, Robert , MORE, Swati, Sudhakar
IPC分类号： A61K49/00 , G01J3/40 , A61B5/00 , A61B6/00 , A61B8/00
CPC分类号： A61B3/12 , A61B3/14 , A61B5/4848 , A61K38/063 , G01N21/31 , G01N33/5038
摘要： Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.
摘要翻译：这里描述的是使用可见近红外（VNIR）高光谱成像系统作为早期检测阿尔茨海默病（AD）的非侵入性诊断工具。本文还描述了在针对AD的潜在治疗剂的高通量筛选中使用VNIR高光谱成像系统。

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