专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1993003725A1 5-HT4 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 5-HT4受体拮抗剂
公开(公告)号：WO1993003725A1
公开(公告)日：1993-03-04
申请号：PCT/GB1992001519
申请日：1992-08-18
申请人： SMITHKLINE BEECHAM PLC , KING, Francis, David , GASTER, Laramie, Mary , JOINER, Graham, Francis , RAHMAN, Shirley, Katherine , SANGER, Gareth, John , WARDLE, Kay, Alison , BAXTER, Gordon, Smith , KENNETT, Guy, Anthony , YOUNG, Rodney, Christopher , VIMAL, Mythily , KAUMANN, Alberto, Julio
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： A61K31/445
CPC分类号： C07D209/42 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/55
摘要： Compounds of formula (I): X-CO-Y-Z wherein the variable groups are as defined in the specification, of use in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
摘要翻译：式（I）化合物：其中可变基团如说明书中所定义的X-CO-Y-Z用于治疗胃肠道疾病，心血管疾病和CNS障碍。

2. 发明申请

WO1994014773A1 TETRAHYDROCARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS 审中-公开
标题翻译：四氢叶酸衍生物作为5-HT1样激动剂
公开(公告)号：WO1994014773A1
公开(公告)日：1994-07-07
申请号：PCT/EP1993003628
申请日：1993-12-16
申请人： SMITHKLINE BEECHAM PLC , PORTER, Roderick, Alan , VIMAL, Mythily
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D209/88
CPC分类号： C07D209/88
摘要： Compounds of formula (I), wherein R represents halogen, C1-4alkyl, C1-4alkoxy, hydroxy, NO2, -NR R , R R NCO(CH2)m-, R R NSO2(CH2)m-, R CONH(CH2)-m or R SO2NH(CH2)m-; R and R each independently hydrogen or C1-4alkyl or NR<>4 represents a 5- to 7-membered heterocyclic ring; R represents hydrogen or C1-4alkyl; R represents C1-4alkyl; m is zero, 1 or 2; n is zero or 1 to 5; R and R each independently represent hydrogen, C1-6alkyl or benzyl or -NR R represents a pyrrolidino, piperidino or hexahydroazepino ring; and A represents a bond, a C1-5alkylene chain or a C3-5alkenyle chain wherein the double bond is not adjacent the nitrogen atom; and salts thereof have affinity for the 5-HT1-like receptor and are useful e.g. in the treatment of migraine.
摘要翻译：式（I）化合物，其中R 1表示卤素，C 1-4烷基，C 1-4烷氧基，羟基，NO 2，-NR 4 R 5，R 4 R 5 NCO（CH 2）m - ，R 4 R 5 NSO 2（CH 2）m - ，R 6 CONH（CH 2）m或R 7 SO 2 NH（CH 2）m - ; R 4和R 5各自独立地为氢或C 1-4烷基或NR <4 表示5-至7-元杂环; R 6表示氢或C 1-4烷基; R 7表示C 1-4烷基; m为零，1或2; n为0或1〜5; R 2和R 3各自独立地表示氢，C 1-6烷基或苄基或-NR 2 R 3表示吡咯烷子基，哌啶子基或六氢氮杂环环。 A表示键，C1-5亚烷基链或C3-5链烯基链，其中双键不与氮原子相邻; 其盐对5-HT1样受体具有亲和力，并且可用于例如在治疗偏头痛。

3. 发明申请

WO1994014772A1 ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS 审中-公开
标题翻译：卡培唑衍生物作为5-HT1样激动剂的成分
公开(公告)号：WO1994014772A1
公开(公告)日：1994-07-07
申请号：PCT/EP1993003627
申请日：1993-12-16
申请人： SMITHKLINE BEECHAM PLC , BORRETT, Gary, Thomas , KITTERINGHAM, John , PORTER, Roderick, Alan , SHIPTON, Mark, Ralph , VIMAL, Mythily , YOUNG, Rodney, Christopher
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D209/88
CPC分类号： C07D209/88 , A61K31/40
摘要： A (+) or (-) enantiomer of a compound of formula (I) wherein R is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT1-like agonists.
摘要翻译：其中R 4为甲基或乙基的式（I）化合物或其盐，溶剂合物或水合物的式（I）化合物的（+）或（ - ）对映异构体，用于制备所述化合物和含有它们的药物组合物的方法。式（+）化合物是5-HT1样激动剂。

4. 发明申请

WO2008138876A1 PYRAZOLE DERIVATIVES AS P2X7 MODULATORS 审中-公开
标题翻译：作为P2X7调节剂的吡唑衍生物
公开(公告)号：WO2008138876A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055724
申请日：2008-05-08
申请人： GLAXO GROUP LIMITED , BESWICK, Paul John , CHAMBERS, Laura Jane , CHESSELL, Iain Patrick , DAVIES, David John , DEMONT, Emmanuel Hubert , GLEAVE, Robert James , LIVERMORE, David George Hubert , THEOBALD, Pamela Joan , VIMAL, Mythily , WALTER, Daryl Simon
发明人： BESWICK, Paul John , CHAMBERS, Laura Jane , CHESSELL, Iain Patrick , DAVIES, David John , DEMONT, Emmanuel Hubert , GLEAVE, Robert James , LIVERMORE, David George Hubert , THEOBALD, Pamela Joan , VIMAL, Mythily , WALTER, Daryl Simon
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/12 , C07D417/04 , C07D417/06 , C07D471/08
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also relates to the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders / diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐：式（I）的吡唑衍生物或其盐调节P2X7受体功能，并且能够拮抗ATP在P2X7受体（P2X7受体）拮抗剂）。本发明还涉及这些化合物或其盐或其药物组合物在治疗或预防P2X7受体介导的疾病/疾病中的用途，例如疼痛，炎症或神经变性疾病。

5. 发明申请

WO2003037847A1 BENZAMIDE DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS 审中-公开
标题翻译：作为OREXIN受体拮抗剂的苯扎林衍生物
公开(公告)号：WO2003037847A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012170
申请日：2002-10-30
申请人： SMITHKLINE BEECHAM P.L.C. , CHAN, Wai, Ngor , JOHNS, Amanda , PORTER, Roderick, Alan , STEAD, Rachel, Elizabeth, Anne , VIMAL, Mythily
发明人： CHAN, Wai, Ngor , JOHNS, Amanda , PORTER, Roderick, Alan , STEAD, Rachel, Elizabeth, Anne , VIMAL, Mythily
IPC分类号： C07C233/73
CPC分类号： C07D271/06 , C07C233/73 , C07C233/77 , C07C233/87 , C07C235/46 , C07C235/84 , C07C255/57 , C07C2603/18 , C07D215/48 , C07D215/50 , C07D217/26 , C07D231/14 , C07D249/06 , C07D277/56 , C07D307/79 , C07D317/68
摘要： This invention relates to certain benzamide derivatives and their use as pharmaceuticals.
摘要翻译：本发明涉及某些苯甲酰胺衍生物及其作为药物的用途。

6. 发明申请

WO1993002677A1 5-HT4 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 5-HT4受体拮抗剂
公开(公告)号：WO1993002677A1
公开(公告)日：1993-02-18
申请号：PCT/GB1992001419
申请日：1992-07-31
申请人： SMITHKLINE BEECHAM P.L.C. , SANGER, Gareth, John , KING, Francis, David , BAXTER, Gordon, Smith , GASTER, Laramie, Mary , KAUMANN, Alberto, Julio , KENNETT, Guy, Anthony , MULHOLLAND, Keith, Raymond , VIMAL, Mythily , WARDLE, Kay, Alison , WYMAN, Paul, Adrian , YOUNG, Rodney, Christopher
发明人： SMITHKLINE BEECHAM P.L.C.
IPC分类号： A61K31/41
CPC分类号： C07D271/06 , A61K31/41 , A61K31/42 , A61K31/435 , A61K31/445 , A61K31/54 , A61K31/55 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D455/02 , C07D471/04
摘要： The use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification, in the manufacture of a medicament for use in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
摘要翻译：使用式（I）化合物或其药学上可接受的盐，其中变量如本说明书中所定义，用于制备用于治疗胃肠道疾病，心血管疾病和CNS疾病的药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式