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1. 发明申请

WO2008000453A3 PROCESS FOR PREPARING A SOLID DOSAGE FORM 审中-公开
公开(公告)号：WO2008000453A3
公开(公告)日：2008-01-03
申请号：PCT/EP2007/005673
申请日：2007-06-27
申请人： UNIVERSITEIT GENT , REMON, Jean Paul , VERVAET, Chris , GONNISSEN, Yves
发明人： REMON, Jean Paul , VERVAET, Chris , GONNISSEN, Yves
IPC分类号： A61K9/16 , A61K9/20
摘要： This invention provides a process for preparing a solid dosage form, comprising: preparing an aqueous slurry, solution or suspension of (a) a powder material, and (b) a mixture of one or more polyols and one or more maltodextrins, and spray drying the resultant aqueous slurry, solution or suspension, thereby obtaining particles which are directly compressible into a solid dosage form being able to disintegrate in an aqueous medium within no more than 15 minutes.

2. 发明申请

WO2010048389A3 VAGINAL PELLETS COMPRISING DEBRANCHED STARCH 审中-公开
标题翻译：包括DEBANCHED STARCH的VAGINAL PELLETS
公开(公告)号：WO2010048389A3
公开(公告)日：2010-10-07
申请号：PCT/US2009061662
申请日：2009-10-22
申请人： HENKEL CORP , REMON JEAN PAUL , VERVAET CHRIS , FOREMAN PAUL
发明人： REMON JEAN PAUL , VERVAET CHRIS , FOREMAN PAUL
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K9/0034 , A61K9/1652
摘要： Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.
摘要翻译：阴道用组合物包含由脱支淀粉制备的颗粒。可以通过挤出/滚圆法方便地制备颗粒。

3. 发明申请

WO2012025553A1 PARTICULATE BIOLOGIC DRUG DELIVERY SYSTEM WITH A CONTROLLED DUAL RELEASE 审中-公开
标题翻译：具有控制双重释放的颗粒生物药物递送系统
公开(公告)号：WO2012025553A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064511
申请日：2011-08-24
申请人： UNIVERSITEIT GENT , REMON, Jean Paul , DE GEEST, Bruno , DE KOKER, Stefaan , GROOTEN, Johan , VERVAET, Chris
发明人： REMON, Jean Paul , DE GEEST, Bruno , DE KOKER, Stefaan , GROOTEN, Johan , VERVAET, Chris
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/1694 , A61K9/1641 , A61K9/1652 , A61K9/5031 , A61K9/5036
摘要： The present invention discloses a composition comprising: a sacrificial component, a polyelectrolyte complex, and one or more drugs, each with a molecular weight of at least 1000 Dalton; characterised in that said composition is obtainable by spray-drying. This composition may be prepared in particle form and as a suspension of particles. Pharmaceutical compositions are also provided for use in extracellular drug delivery. Pharmaceutical compositions are also provided that exhibit a controlled dual drug release.
摘要翻译：本发明公开了一种组合物，其包含：牺牲组分，聚电解质络合物和一种或多种药物，每种药物的分子量至少为1000道尔顿; 其特征在于所述组合物可通过喷雾干燥获得。该组合物可以以颗粒形式和作为颗粒的悬浮液制备。还提供药物组合物用于细胞外药物递送。还提供显示受控双重药物释放的药物组合物。

4. 发明申请

WO2004050121A1 PHARMACEUTICAL COMPOSITIONS OF CELL LYSATE AND PROCESSES FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：细胞膜的药物组合物及其生产和使用的方法
公开(公告)号：WO2004050121A1
公开(公告)日：2004-06-17
申请号：PCT/EP2003/050891
申请日：2003-11-25
申请人： INNOGENETICS N.V. , VERVAET, Chris , REMON, Jean-Paul , DELAEY, Bernard , DE WAELE, Peter
发明人： VERVAET, Chris , REMON, Jean-Paul , DELAEY, Bernard , DE WAELE, Peter
IPC分类号： A61K45/00
CPC分类号： A61K9/2009 , A61K9/0014 , A61K9/19 , A61K31/736 , A61K35/36 , A61K47/36 , A61L26/0023 , A61L26/0057 , A61L26/0085
摘要： The present invention relates to a pharmaceutical composition comprising a nonviable cell lysate and at least one antiflocculant and/or antisedimentation agent(s). The pharmaceutical composition of the present invention comprising the cell lysate is in the form of a solution or a suspension or a lyophilisate, in particular, the homogenized cell lysate compositions are in the form of solutions or suspensions or lyophilisates. The present invention further discloses processes for the production and the use of the pharmaceutical composition.
摘要翻译：本发明涉及包含不可维持的细胞裂解物和至少一种抗絮凝剂和/或抗肿瘤剂的药物组合物。包含细胞裂解物的本发明的药物组合物是溶液或悬浮液或冻干物的形式，特别地，均质化细胞裂解物组合物是溶液或悬浮液或冻干物的形式。本发明还公开了用于生产和使用药物组合物的方法。

5. 发明申请

WO2004028503A1 CONTROLLED DELIVERY SYSTEM FOR BIOACTIVE SUBSTANCES 审中-公开
标题翻译：用于生物物质的控制输送系统
公开(公告)号：WO2004028503A1
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010715
申请日：2003-09-24
申请人： UNIVERSITEIT GENT , REMON, Jean Paul , MEHUYS, Els , VERVAET, Chris
发明人： REMON, Jean Paul , MEHUYS, Els , VERVAET, Chris
IPC分类号： A61K9/00
CPC分类号： A61K9/2054 , A61K9/2013 , A61K9/2866
摘要： A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: - at least a biologically active ingredient, and - an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend with the said hydrophilic cellulose polymer, the weight ratio of the hydrophilic cellulose polymer to the amphiphilic material being from 0.2:1 to 0.6:1, provides improved sustained release of the biologically active ingredient.
摘要翻译：一种生物活性复合固体成形制品，其包含：（a）外层，和（b）填充所述外层的内芯，并包含： - 至少一种生物活性成分，以及至少包含亲水性纤维素聚合物以及与所述亲水性纤维素聚合物共混形式的亲水性物质，亲水性纤维素聚合物与两性物质的重量比为0.2:1至0.6:1，提供了生物活性成分的改善的持续释放。

6. 发明申请

WO2013030267A1 MULTI-LAYERED RELEASE FORMULATION 审中-公开
标题翻译：多层次释放配方
公开(公告)号：WO2013030267A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066848
申请日：2012-08-30
申请人： UNIVERSITEIT GENT , REMON, Jean Paul , VERVAET, Chris
发明人： REMON, Jean Paul , VERVAET, Chris
IPC分类号： A61K9/20 , A61K9/16 , A61K31/196 , A61K31/549 , A61K31/138
CPC分类号： A61K9/2095 , A61K9/209 , A61K9/2846 , A61K9/2853 , A61K9/2893 , A61K31/138 , A61K31/196 , A61K31/549 , A61K2300/00
摘要： The present invention in general relates to a pharmaceutical dosage form comprising a multi-layered release formulation formed by co-extrusion. Said formulation in particular comprises a core layer comprising at least one polymer selected from polycaprolactone, ethylcellulose, or combinations thereof; and a coat layer comprising at least one (co)polymer selected from the list comprising: polyethylene oxide; polyethylene glycol; Basic Butylated Methacrylate (co)polymer; a (co)polymer of polyvinylcaprolactam, PEG and polyvinylacetate; or combinations thereof.
摘要翻译：本发明一般涉及包含通过共挤出形成的多层释放制剂的药物剂型。所述制剂特别包括包含至少一种选自聚己内酯，乙基纤维素或其组合的聚合物的芯层; 和包含至少一种选自以下的（共）聚合物的涂层：包括：聚环氧乙烷; 聚乙二醇; 碱性丁基化甲基丙烯酸酯（共）聚合物; 聚乙烯基己内酰胺（PEG）和聚乙酸乙烯酯的（共）聚合物; 或其组合。

7. 发明申请

WO2013010915A1 INTRAVAGINAL DELIVERY SYSTEM 审中-公开
标题翻译： INTRAVAGINAL交付系统
公开(公告)号：WO2013010915A1
公开(公告)日：2013-01-24
申请号：PCT/EP2012/063702
申请日：2012-07-12
申请人： UNIVERSITEIT GENT , REMON, Jean Paul , VERVAET, Chris , VERSTRAELEN, Hans , TEMMERMAN, Marleen
发明人： REMON, Jean Paul , VERVAET, Chris , VERSTRAELEN, Hans , TEMMERMAN, Marleen
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K47/32 , A61K9/0036 , A61K31/19 , A61K47/38
摘要： The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid - methacrylic ester copolymers.
摘要翻译：本发明一般涉及阴道内递送系统及其用途及其制造和使用方法。特别地，本发明涉及用于控制释放一种或多种有机酸如乳酸的阴道内递送系统; 所述阴道内递送系统的特征在于其包含乙烯乙酸乙烯酯（EVA）共聚物和羧酸聚合物的组合，例如甲基丙烯酸 - 甲基丙烯酸酯共聚物。

8. 发明申请

WO2008000453A2 PROCESS FOR PREPARING A SOLID DOSAGE FORM 审中-公开
标题翻译：制备固体剂型的方法
公开(公告)号：WO2008000453A2
公开(公告)日：2008-01-03
申请号：PCT/EP2007005673
申请日：2007-06-27
申请人： UNIV GENT , REMON JEAN PAUL , VERVAET CHRIS , GONNISSEN YVES
发明人： REMON JEAN PAUL , VERVAET CHRIS , GONNISSEN YVES
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/1623 , A61K9/2095
摘要： This invention provides a process for preparing a solid dosage form, comprising: - preparing an aqueous slurry, solution or suspension of (a) a powder material, and (b) a mixture of one or more polyols and one or more maltodextrins, and - spray drying the resultant aqueous slurry, solution or suspension, thereby obtaining particles which are directly compressible into a solid dosage form being able to disintegrate in an aqueous medium within no more than 15 minutes.
摘要翻译：本发明提供了一种制备固体剂型的方法，包括： - 制备（a）粉末材料的水性浆液，溶液或悬浮液，和（b）一种或多种多元醇和一种或多种麦芽糖糊精的混合物，和喷雾干燥所得的含水浆料，溶液或悬浮液，从而获得直接压缩成固体剂型的颗粒，其能够在不超过15分钟的时间内在含水介质中分解。

9. 发明申请

WO2007104562A1 DRY POWDER COMPOSITIONS AND SYSTEMS FOR POULTRY VACCINATION 审中-公开
标题翻译：干粉组合物和系统用于疫苗接种
公开(公告)号：WO2007104562A1
公开(公告)日：2007-09-20
申请号：PCT/EP2007/002284
申请日：2007-03-15
申请人： UNIVERSITEI GENT , REMON, Jean, Paul , VERVAET, Chris , CORBANIE, Evy
发明人： REMON, Jean, Paul , VERVAET, Chris , CORBANIE, Evy
IPC分类号： A61K39/39 , A61K35/76 , A61K39/00
CPC分类号： A61K39/00 , A61K9/0078 , A61K9/1623 , A61K9/1635 , A61K2039/544 , A61K2039/552 , C12N2760/18134
摘要： This invention provides a dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0. This invention also relates to a method for producing said dry powder compositions and a system for vaccination of poultry by inhalation.
摘要翻译：本发明提供了一种用于通过吸入进行家禽接种的干粉组合物，其包含有效量的家禽疫苗剂和所述家禽疫苗剂的载体量，所述载体包含还原糖或非还原糖和生物相容性的组合聚合物，所述干粉组合物为平均粒度为2〜30μm，粒径多分散性为1.1〜4.0的颗粒状。本发明还涉及一种生产所述干粉组合物的方法和一种通过吸入对家禽进行疫苗接种的系统。

10. 发明申请

WO2004047974A1 PROCESS AND APPARATUS FOR CONTINUOUS WET GRANULATION OF POWER MATERIAL 审中-公开
标题翻译：电力材料连续湿式造粒的工艺及装置
公开(公告)号：WO2004047974A1
公开(公告)日：2004-06-10
申请号：PCT/EP2003/013327
申请日：2003-11-26
申请人： UNIVERSITEIT GENT , REMON, Jean-Paul , VERVAET, Chris , KELEB, Eseldin , VERMEIRE, An
发明人： REMON, Jean-Paul , VERVAET, Chris , KELEB, Eseldin , VERMEIRE, An
IPC分类号： B01J2/10
CPC分类号： B01J2/20 , A23P10/25 , A61K9/1623 , A61K9/1694 , A61K9/20 , B01J2/10
摘要： An apparatus for wet granulating a powder material comprises: - a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and - a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly discharging said granules from the granulation chamber. The apparatus is useful for continuously wet granulating biologically-active ingredient formulations, chemicals, detergents and foodstuffs.
摘要翻译：用于湿粉碎粉末材料的设备包括： - 具有造粒室的桶，并且设置有用于接收所述粉末材料并将其供应到所述造粒室的第一入口（1）和用于接收所述粉末材料的第二入口（2）造粒液体并将其供给到造粒室，所述造粒物具有用于从所述筒排出颗粒的孔口（9），以及用于将所述粉末材料朝向造粒室的端部推进的输送装置（S）所述输送装置（S）在其后端包括第一输送区（4），第一输送区（4）下游的附聚区（5）和第二输送区（8））在其前端，所述第一入口（1）和所述第二入口（2）位于所述第一输送区（4）的上方，其中所述孔（9）具有紧密地配合所述输送装置（S），用于从造粒室直接排出所述颗粒。该设备可用于连续湿法制粒生物活性成分配方，化学品，洗涤剂和食品。

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