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1. 发明申请

WO2009147248A2 AMINO ACID SEQUENCES DIRECTED AGAINST ENVELOPE PROTEINS OF A VIRUS AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：针对病毒感染的病毒和包含病毒的多肽的氨基酸序列指导治疗病毒
公开(公告)号：WO2009147248A2
公开(公告)日：2009-12-10
申请号：PCT/EP2009056975
申请日：2009-06-05
申请人： ABLYNX NV , HULTBERG ANNA , MAASSEN BRAM , VANLANDSCHOOT PETER , DEPLA ERIK , STORTELERS CATELIJNE , VERRIPS CORNELIS THEODORUS , VAN GUCHT STEVEN , MELERO JOSE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE , WEISS ROBERT ANTHONY , TEMPERTON NIGEL JAMES , SAELENS XAVIER , SCHEPENS BERT , SZYROKI ALEXANDER , HARMSEN MICHAEL MARIE
发明人： HULTBERG ANNA , MAASSEN BRAM , VANLANDSCHOOT PETER , DEPLA ERIK , STORTELERS CATELIJNE , VERRIPS CORNELIS THEODORUS , VAN GUCHT STEVEN , MELERO JOSE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , WEISS ROBERT ANTHONY , TEMPERTON NIGEL JAMES , SAELENS XAVIER , SCHEPENS BERT , SZYROKI ALEXANDER , HARMSEN MICHAEL MARIE
IPC分类号： A61K39/395 , C07K16/08
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K16/1009 , C07K16/1018 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：本发明部分地涉及针对和/或可以特异性结合病毒的包膜蛋白的氨基酸序列，以及包含或基本上由以下组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列一个或多个这样的氨基酸序列。

2. 发明申请

WO2008053018A2 IMPROVED PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI 审中-公开
标题翻译：通过真菌真菌改良分泌的蛋白质的生产
公开(公告)号：WO2008053018A2
公开(公告)日：2008-05-08
申请号：PCT/EP2007061765
申请日：2007-10-31
申请人： DSM IP ASSETS BV , SAGT CORNELIS MARIA JACOBUS , VERRIPS CORNELIS THEODORUS , MULLER WALRAVEN HENRY , PEIJ VAN NOEL NICOLAAS MARIA E
发明人： SAGT CORNELIS MARIA JACOBUS , VERRIPS CORNELIS THEODORUS , MULLER WALRAVEN HENRY , PEIJ VAN NOEL NICOLAAS MARIA E
IPC分类号： C12N15/09
CPC分类号： C12P21/00 , C07K14/38 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/2405 , C12N9/90 , C12N15/80
摘要： The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
摘要翻译：本发明涉及一种改善丝状真菌细胞分泌目的蛋白质的方法，包括诱导细胞中的表型，所述细胞选自降低的ERAD，不诱导升高的ERAD的升高的UPR，其中 ERAD优选降低。本发明还涉及包含上述表型的丝状真菌细胞。本发明还涉及其表达可以在丝状真菌细胞中调节以获得上述表型的多核苷酸和多肽。

3. 发明申请

WO2007035092A3 VHH FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH PROTEIN AGGREGATES 审中-公开
标题翻译： VHH用于诊断，预防和治疗与蛋白质聚集相关的疾病
公开(公告)号：WO2007035092A3
公开(公告)日：2007-07-12
申请号：PCT/NL2006000475
申请日：2006-09-25
申请人： ACADEMISCH ZIEKENHUIS LEIDEN , UNIV UTRECHT HOLDING BV , VERHEESEN PETER , LUTJE HULSIK DAVID , OMMEN GARRITJAN BOUDEWIJN VAN , VERRIPS CORNELIS THEODORUS , VAN DER MAAREL SILVERE MARIA
发明人： VERRIPS CORNELIS THEODORUS , VAN DER MAAREL SILVERE MARIA
IPC分类号： G01N33/543 , C12Q1/70
CPC分类号： C07K16/18 , C07K2317/22 , C07K2317/569 , C07K2317/82
摘要： The present invention provides heavy chain variable domain antibodies (VHH) for preventing and/or dissolving aggregates. VHH of the invention are preferably used in the treatment of human diseases that are associated with the formation of aggregates in the body. The invention further provides, among others, means and methods for selecting and using VHH.
摘要翻译：本发明提供了用于预防和/或溶解聚集体的重链可变结构域抗体（VHH）。本发明的VHH优选用于治疗与体内聚集体形成有关的人类疾病。其中，本发明还提供了用于选择和使用VHH的手段和方法。

4. 发明申请

WO2009138494A3 AMINO ACID SEQUENCES DIRECTED AGAINST TOLL-LIKE RECEPTORS AND THEIR USE FOR THE TREATMENT OF DISEASES RELATED TO TOLL-LIKE RECEPTORS 审中-公开
公开(公告)号：WO2009138494A3
公开(公告)日：2009-11-19
申请号：PCT/EP2009/055926
申请日：2009-05-15
申请人： ABLYNX N.V. , VANLANDSCHOOT, Peter , VERRIPS, Cornelis, Theodorus , HULTBERG, Anna , MAASSEN, Bram , BEYAERT, Rudi
发明人： VANLANDSCHOOT, Peter , VERRIPS, Cornelis, Theodorus , HULTBERG, Anna , MAASSEN, Bram , BEYAERT, Rudi
IPC分类号： C07K16/28 , A61P31/00 , A61P37/04
摘要： The present invention relates to amino acid sequences that are directed against and/or that can specifically bind to Toll-like receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

5. 发明申请

WO1994001567A1 PROCESS FOR IMMOBILIZING ENZYMES TO THE CELL WALL OF A MICROBIAL CELL BY PRODUCING A FUSION PROTEIN 审中-公开
标题翻译：通过产生融合蛋白将酶固定在微生物细胞的细胞壁上的方法
公开(公告)号：WO1994001567A1
公开(公告)日：1994-01-20
申请号：PCT/EP1993001763
申请日：1993-07-07
申请人： UNILEVER PLC , UNILEVER N.V. , KLIS, Franciscus, Maria , SCHREUDER, Maarten, Pleun , TOSCHKA, Holger, York , VERRIPS, Cornelis, Theodorus
发明人： UNILEVER PLC , UNILEVER N.V.
IPC分类号： C12N15/62
CPC分类号： C12N9/2465 , C07K14/395 , C07K2319/00 , C07K2319/02 , C07K2319/035 , C12N9/0006 , C12N9/20 , C12N11/16 , C12N15/62 , Y02P20/588
摘要： A method is provided for immobilizing an enzyme, comprising immobilizing the enzyme or a functional part thereof to the cell wall of a microbial cell using recombinant DNA techniques. The enzyme is immobilized by linking it to the C-terminal part of a protein that ensures anchoring in the cell wall. Also provided is a recombinant polynucleotide comprising a structural gene encoding an enzyme protein, a part of a gene encoding the C-terminal part of a protein capable of anchoring in a eukaryotic or prokariotic cell wall, as well as a signal sequence, in addition to a chimeric protein encoded by the recombinant polynucleotide and a vector and a microorganism containing the polynucleotide. The microorganism is suitable for carrying out enzymatic processes on an industrial scale.
摘要翻译：提供了一种用于固定酶的方法，包括使用重组DNA技术将酶或其功能部分固定在微生物细胞的细胞壁上。通过将酶连接到确保锚定在细胞壁中的蛋白质的C末端部分来固定酶。还提供了一种重组多核苷酸，其包含编码酶蛋白的结构基因，编码能够锚定在真核细胞或原核细胞壁中的蛋白质的C末端部分的基因的一部分，以及信号序列，除了由重组多核苷酸编码的嵌合蛋白质和载体以及含有多核苷酸的微生物。该微生物适于在工业规模上进行酶法。

6. 发明申请

WO2011049449A1 VHH FOR APPLICATION IN TISSUE REPAIR, ORGAN REGENERATION, ORGAN REPLACEMENT AND TISSUE ENGINEERING 审中-公开
标题翻译：用于组织修复，组织再生，组织替代和组织工程的VHH
公开(公告)号：WO2011049449A1
公开(公告)日：2011-04-28
申请号：PCT/NL2010/050700
申请日：2010-10-21
申请人： UNIVERSITY OF TWENTE , UNIVERSITEIT UTRECHT HOLDING B.V. , KARPERIEN, Hermanus Bernardus Johannes , VERRIPS, Cornelis Theodorus , EL KHATTABI, Mohamed , DOOMS RODRIGUES, Emilie , DE BOER, Jan , VAN BLITTERSWIJK, Clemens Antoni , DE BRUIN, Renée
发明人： KARPERIEN, Hermanus Bernardus Johannes , VERRIPS, Cornelis Theodorus , EL KHATTABI, Mohamed , DOOMS RODRIGUES, Emilie , DE BOER, Jan , VAN BLITTERSWIJK, Clemens Antoni , DE BRUIN, Renée
IPC分类号： C07K16/18 , C07K16/22 , A61L31/10 , A61L31/16 , C07K16/44
CPC分类号： C07K16/22 , A61L27/227 , A61L27/54 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2300/432 , C07K16/18 , C07K16/44 , C07K2317/22 , C07K2317/41 , C07K2317/569 , C07K2319/01
摘要： The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.
摘要翻译：本发明涉及与生长因子结合或是生长因子的拮抗剂或与植入物结合的VHH。

7. 发明申请

WO2005075515A3 IMMUNOGLOBULINS AND METHOD FOR THEIR MODIFICATION 审中-公开
公开(公告)号：WO2005075515A3
公开(公告)日：2005-08-18
申请号：PCT/EP2005/000561
申请日：2005-01-18
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , DOLK, Edward , FRENKEN, Leo, Gerardus, Joseph , VERRIPS, Cornelis, Theodorus
发明人： DOLK, Edward , FRENKEN, Leo, Gerardus, Joseph , VERRIPS, Cornelis, Theodorus
IPC分类号： C07K16/00
摘要： Heavy chain immunoglobulins that comprise an amino acid with a side chain which is not positively charged, in the first tryptic site, especially at position 27, show increased stability in the gastrointestinal tract.

8. 发明申请

WO9429457A3 PROCESS FOR PRODUCING FUSION PROTEINS COMPRISING SCFV FRAGMENTS BY A TRANSFORMED MOULD 审中-公开
标题翻译：通过变形模具生产包含SCFV片段的融合蛋白的方法
公开(公告)号：WO9429457A3
公开(公告)日：1995-03-09
申请号：PCT/EP9401906
申请日：1994-06-09
申请人： UNILEVER PLC , UNILEVER NV , TNO , FRENKEN LEON GERARDUS JOSEPH , GORCOM ROBERT F M VAN , HESSING JOHANNA G M , DEN HONDEL CORNELIS ANTONIUS M , MUSTERS WOUTER , VERBAKEL JOHANNES MARIA A , VERRIPS CORNELIS THEODORUS
发明人： FRENKEN LEON GERARDUS JOSEPH , VAN GORCOM ROBERT F M , HESSING JOHANNA G M , VAN DEN HONDEL CORNELIS ANTONI , MUSTERS WOUTER , VERBAKEL JOHANNES MARIA A , VERRIPS CORNELIS THEODORUS
IPC分类号： C12N15/09 , C07K14/38 , C07K16/00 , C07K16/26 , C07K19/00 , C12N15/62 , C12N15/80 , C12P21/00 , C12P21/02 , C12R1/685 , C07K15/28
CPC分类号： C07K16/26 , C07K16/00 , C07K2319/036 , C07K2319/50 , C07K2319/75 , C12N15/80
摘要： The present invention provides a process for producing fusion proteins comprising ScFv fragments by a transformed Aspergillus mould containing a DNA sequence encoding the ScFV fragment under control of at least one expression and/or secretion regulating region derived from a mould selected from the group consisting of promoter sequences, terminator sequences and signal sequence-encoding DNA sequences or functional derivatives or analogues thereof. Such regulating region can be derived from the endoxylanase II gene (exlA gene) of Aspergillus niger var. awamori present on plasmid pAW14B or can be the combination of both a promoter and a signal sequence-encoding DNA sequence derived from a glucoamylase gene ex Aspergillus plus a terminator sequence of a trpC gene ex Aspergillus. Preferably a fusion protein comprising 'secreted mould protein - (KEX2 -) ScFv' is produced. Also provided are new products comprising an ScFv fragment or fusion product thereof, compositions, e.g. consumer products, containing both old and new products so produced. Preferably the ScFv fragment recognizes a compound present in the human eco-system, such as microorganisms or enzymes. Such compounds can be present in the oral cavity, e.g. involved in the formation of plaque, caries, gingivitis, periodontal diseases, or bad breath, or on the human skin, e.g. involved in the formation of malodour, inflammation or hair loss, or can be a hormone, e.g. HCG.

9. 发明申请

WO1994025591A1 PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF CAMELIDAE 审中-公开
标题翻译：生产抗原或其功能性片段，其衍生自CAMELIDAE重链免疫球蛋白
公开(公告)号：WO1994025591A1
公开(公告)日：1994-11-10
申请号：PCT/EP1994001442
申请日：1994-04-28
申请人： UNILEVER PLC , UNILEVER N.V. , HAMERS, Raymond , HAMERS-CASTERMAN, Cécile , MUYLDERMANS, Serge, Victor, M. , FRENKEN, Leon, Gerardus, J. , VERRIPS, Cornelis, Theodorus
发明人： UNILEVER PLC , UNILEVER N.V.
IPC分类号： C12N15/13
CPC分类号： C07K16/00 , C07K2319/00 , C07K2319/02
摘要： A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an expressible DNA sequence encoding the antibody or (functionalized) fragment thereof, wherein the antibody or (functionalized) fragment thereof is derived from a heavy chain immunoglobulin of Camelidae and is devoid of light chains, and wherein the lower eukaryotic host is a mould, preferably belonging to the genera Aspergillus or Trichoderma, or a yeast, preferably belonging to the yeast genera Saccharomyces, Kluyveromyces, Hansenula, or Pichia. The heavy chain fragment can contain at least the whole variable domain. A complementary determining region (CDR) different from the CDR belonging to the natural antibody ex Camelidae can be grafted on the framework of the variable domain of the heavy chain immunoglobulin. The catalytic antibodies can be raised in Camelidae against transition state molecules. The functionalized antibody or fragment thereof can comprise a fusion protein of both a heavy chain immunoglobulin from Camelidae or a fragment thereof and another polypeptide, e.g., an enzyme, preferably an oxido-reductase. Also provided are new products obtainable by a process as described, and compositions containing a product produced by a process as described, which composition may contain a new product as provided.
摘要翻译：提供了使用含有编码抗体或其（功能化的）片段的可表达DNA序列的转化的低等真核宿主制备抗体或其片段或功能化片段的方法，其中抗体或其（官能化）片段衍生自骆驼科的重链免疫球蛋白，没有轻链，其中低等真核宿主是模具，优选属于曲霉属或木霉属，或酵母，优选属于酵母属酵母属，酵母属，汉逊酵母属或毕赤酵母属。重链片段至少可以包含整个可变结构域。可以将不同于属于骆驼科目天然抗体的CDR的互补决定区（CDR）移植到重链免疫球蛋白的可变区的框架上。催化抗体可以在Camelidae中针对过渡态分子产生。功能化抗体或其片段可以包含来自骆驼科的重链免疫球蛋白或其片段和另一多肽（例如酶，优选氧化还原酶）的融合蛋白。还提供了可通过所述方法获得的新产品，以及含有通过所述方法生产的产品的组合物，该组合物可含有所提供的新产品。

10. 发明申请

WO1984004538A1 IMPROVEMENTS IN THE EXPRESSION OF NEWLY INTRODUCED GENES IN YEAST CELLS 审中-公开
标题翻译：在YEAST细胞中新引入基因表达的改进
公开(公告)号：WO1984004538A1
公开(公告)日：1984-11-22
申请号：PCT/EP1984000153
申请日：1984-05-21
申请人： UNILEVER N.V. , EDENS, Luppo , RUSSELL, Stephen, William , VISSER, Christiaan , VERRIPS, Cornelis, Theodorus
发明人： UNILEVER N.V.
IPC分类号： C12N15/00
CPC分类号： C12N9/6481 , C07K14/43 , C07K2319/00 , C07K2319/02 , C12N15/625 , C12N15/81 , C12N15/815
摘要： The invention relates to an improved expression system for newly introduced genes in yeast and comprises a yeast regulon, and preferably a transcription terminator, derived from one of the GAPDH genes of S. cerevisiae. The about 850 nucleotides long GAPDH regulon described proved to be almost ten times as effective as smaller regulons described previously. Said regulon and/or terminator can be introduced into yeasts either as part of plasmide molecules or by incorporating into the yeast genome. Vectors containing the expression system preferably comprises an autonomously replicating sequence derived from K. lactis (KARS) or an origin of replication originating from the S. cerevisiae 2 micron yeast plasmid. After transformation of yeasts, in particular of the genera Kluyveromyces and Saccharomyces, with said vectors, the yeasts transformed can produce foreign proteins more effectively. In the case of thaumatin the presence of a signal polypeptide (the pre-part) appears to be essential for expression in yeast. DNA sequences encoding other signal polypeptides are also described. The use of codons preferred by yeast in both structural genes, preferably those encoding thaumatin-like proteins and chymosin-like proteins, and DNA sequences encoding signal polypeptides is also described.
摘要翻译：本发明涉及一种用于酵母中新引入的基因的改进的表达系统，其包含衍生自酿酒酵母的GAPDH基因之一的酵母调节子，并且优选是转录终止子。所描述的大约850个核苷酸长的GAPDH调节子证明比以前描述的较小的调节子的几十倍有效。所述调节子和/或终止子可以作为浆细胞分子的一部分引入酵母中，或通过掺入酵母基因组中。含有表达系统的载体优选包含衍生自乳酸克鲁维酵母（KARS）的自主复制序列或源自酿酒酵母2微米酵母质粒的复制起点。在酵母转化后，尤其是克鲁维酵母属和酵母属，用所述载体转化后，转化的酵母可以更有效地产生外源蛋白。在奇异果蛋白的情况下，信号多肽（前体部分）的存在似乎对酵母中表达是必需的。还描述了编码其他信号多肽的DNA序列。还描述了在两个结构基因中优选使用密码子的密码子，优选编码类似蛋白质的蛋白质和凝乳酶样蛋白质的那些，以及编码信号多肽的DNA序列。

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