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1. 发明申请

WO2005014786A3 ENHANCED ENGINEERED CHROMOSOME FORMATION FROM ALPHA SATELLITE WITH ARTIFICIALLY INCREASED DENSITY OF CENP-B BOXES 审中-公开
标题翻译：增强了由ALPHA卫星形成的工程化色素，具有CENP-B盒的人为增加的密度
公开(公告)号：WO2005014786A3
公开(公告)日：2005-09-22
申请号：PCT/US2004022314
申请日：2004-08-09
申请人： ATHERSYS INC , VAN BOKKELEN GIL B , BASU JOYDEEP
发明人： VAN BOKKELEN GIL B , BASU JOYDEEP
IPC分类号： C12N20060101 , C12N15/66 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/85 , C12N2800/204 , C12N2800/208 , C12N2800/90 , C12Q1/6837
摘要： The invention relates to the discovery that the distribution of CENP-B boxes on the alpha-satellite DNA affects efficiency of the centromere and thereby, affects efficiency of chromosome formation. Therefore, engineered chromosome vectors with altered distribution of CENP-B boxes are described that can alter the rate of chromosome formation as desired. Engineered HORs, chromosome vectors, and chromosomes as well as methods of making the same are described and claimed.
摘要翻译：本发明涉及以下发现：CEN-B盒在α卫星DNA上的分布影响着丝粒的效率，从而影响染色体形成的效率。因此，描述了具有改变的CENP-B盒分布的工程染色体载体，其可以根据需要改变染色体形成的速率。描述和要求保护工程化的HOR，染色体载体和染色体及其制备方法。

2. 发明申请

WO1996040965A1 SYNTHETIC MAMMALIAN CHROMOSONE AND METHODS FOR CONSTRUCTION 审中-公开
标题翻译：合成马匹兰染色体及其构建方法
公开(公告)号：WO1996040965A1
公开(公告)日：1996-12-19
申请号：PCT/US1996010248
申请日：1996-06-07
申请人： VAN BOKKELEN, Gil, B. , HARRINGTON, John, J. , WILLARD, Huntington, F.
IPC分类号： C12N15/90
CPC分类号： C12N15/66 , C12N15/85 , C12N15/90 , C12N2800/204 , C12N2800/208
摘要： The invention relates to the field of gene therapy, gene expression, and vectors for these uses. In particular, the invention relates to a method for producing structurally intact large repeating units of DNA, especially useful for the stable cloning of alpha satellite DNA, and to the development and use of a synthetic or artificial chromosome for gene expression and gene therapy in mammals, and especially humans. The invention allows the controlled construction of stable synthetic or artificial chromosomes constructed from isolated segments of purified DNA. Functional minimal segments preferably include centromeric DNA, telomeric DNA, and genomic DNA. The artificial chromosome performs the essential chromosomal functions of naturally-occurring chromosomes so as to permit the chromosome to function as an effective vector for gene therapy.
摘要翻译：本发明涉及用于这些用途的基因治疗领域，基因表达和载体。特别地，本发明涉及用于产生结构完整的大的重复单元的DNA的方法，特别可用于稳定克隆α卫星DNA，以及开发和使用用于哺乳动物基因表达和基因治疗的合成或人造染色体，特别是人类。本发明允许由分离的纯化DNA段构建的稳定的合成或人造染色体的受控构建。功能性最小区段优选包括着丝粒DNA，端粒DNA和基因组DNA。人造染色体执行天然存在染色体的基本染色体功能，以使染色体作为基因治疗的有效载体。

3. 发明申请

WO2005014786A2 ENHANCED ENGINEERED CHROMOSOME FORMATION FROM ALPHA SATELLITE WITH ARTIFICIALLY INCREASED DENSITY OF CENP-B BOXES 审中-公开
标题翻译：增强CENP-B盒密度提高的阿尔法卫星的工程染色体形成
公开(公告)号：WO2005014786A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/022314
申请日：2004-08-09
申请人： ATHERSYS, INC. , VAN BOKKELEN, Gil, B. , BASU, Joydeep
发明人： VAN BOKKELEN, Gil, B. , BASU, Joydeep
IPC分类号： C12N
CPC分类号： C12N15/85 , C12N2800/204 , C12N2800/208 , C12N2800/90 , C12Q1/6837
摘要： The invention relates to the discovery that the distribution of CENP-B boxes on the alpha-satellite DNA affects efficiency of the centromere and thereby, affects efficiency of chromosome formation. Therefore, engineered chromosome vectors with altered distribution of CENP-B boxes are described that can alter the rate of chromosome formation as desired. Engineered HORs, chromosome vectors, and chromosomes as well as methods of making the same are described and claimed.
摘要翻译：本发明涉及CENP-B盒在α-卫星DNA上的分布影响着丝粒效率并由此影响染色体形成效率的发现。因此，描述了CENP-B盒分布改变的工程染色体载体，其可以根据需要改变染色体形成的速率。描述和声明工程HOR，染色体载体和染色体以及制造它们的方法。

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