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1. 发明申请

WO2019153067A1 MICROFLUIDIC DEVICES, SYSTEMS, INFRASTRUCTURES, USES THEREOF AND METHODS FOR GENETIC ENGINEERING USING SAME 审中-公开
公开(公告)号：WO2019153067A1
公开(公告)日：2019-08-15
申请号：PCT/CA2018/051063
申请日：2018-09-04
申请人： VALORBEC, SOCIÉTÉ EN COMMANDITE
发明人： SHIH, Steve , HUSSER, Mathieu , VO, Philippe , SINHA, Hugo
IPC分类号： G01N15/10 , B81C1/00 , C12M1/34 , C12N15/00 , C12Q1/00 , C12Q1/42 , C12Q1/68 , G01N1/00 , G01N21/59 , G03F7/00 , C12P21/00
摘要： There are provided various microfluidics devices. Microfluidics devices that include a culture area for mixing a composition and an assay area for measuring enzyme activity of samples of the bacterial culture are for example provided. The assay area includes an optical density reader. The optical density reader includes a light emitting source and sensor to enable monitoring of the optical density of samples the bacterial culture. Microfluidic devices comprising a first plate comprising at least one hydrophilic site are also provided as well as methods of manufacture thereof. Methods for performing analyses of compositions on microfluidics devices comprising a plate assembly having a first plate and a second plate are also provided.

2. 发明申请

WO2015103711A1 METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE 审中-公开
标题翻译：制备苯并噻唑啉酮（BIA）代谢物的方法，其制备方法
公开(公告)号：WO2015103711A1
公开(公告)日：2015-07-16
申请号：PCT/CA2015/050021
申请日：2015-01-13
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE
发明人： MARTIN, Vincent , NARCROSS, Lauren , EKINS, Andrew , FOSSATI, Elena , ZHU, Yun
IPC分类号： C12N9/02 , C12N1/19 , C12N15/52 , C12N15/53 , C12N15/54 , C12N15/81 , C12N9/10 , C12P17/10
CPC分类号： C12P17/12 , C07B2200/07 , C07D217/02 , C07D217/04 , C07D491/153 , C12N9/1007 , C12N15/52 , C12N15/81 , C12P17/188 , C12Y201/01075 , C12Y201/01116 , C12Y201/01128 , C12Y201/0114
摘要： There is provided a method of preparing a benzylisoquinoline alkaloid (BIA) metabolite comprising: a. culturing a host cell under conditions suitable for protein production, including a pH of between about 7 and about 10 said host cell comprising: b. a first heterologous coding sequence encoding a first enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; c. a second heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; d. a third heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; (d) adding (R,S)-norlaudanosoline to the cell culture; and recovering the metabolite from the cell culture
摘要翻译：提供了制备苄基异喹啉生物碱（BIA）代谢物的方法，其包括：a。在适于蛋白质生产的条件下培养宿主细胞，包括约7至约10的pH，所述宿主细胞包含：b。编码参与转化（R，S） - 纳多拉诺啉代谢物的代谢途径的第一酶的第一异源编码序列; C。第二个异源编码序列，编码参与将（R，S） - 纳多拉诺啉转化成代谢物的代谢途径的第二种酶; 天。第三个异源编码序列，编码参与将（R，S） - 纳多拉诺啉转化成代谢物的代谢途径的第二种酶; （d）向细胞培养物中加入（R，S） - 纳鲁丹啉; 并从细胞培养物中回收代谢物

3. 发明申请

WO2021077230A1 INTEGRATED DROPLET-DIGITAL MICROFLUIDIC SYSTEM FOR ON-DEMAND DROPLET CREATION, MIXING, INCUBATION, AND SORTING OF DROPLETS IN A CELL TRAPPING ARRAY 审中-公开
公开(公告)号：WO2021077230A1
公开(公告)日：2021-04-29
申请号：PCT/CA2020/051428
申请日：2020-10-23
申请人： VALORBEC, SOCIÉTÉ EN COMMANDITE
发明人： SHIH, Steve , SAMLALI, Kenza , AHMADI, Fatemeh
IPC分类号： G01N1/00 , C12M1/00 , C12M1/42 , C12Q1/00 , G01N1/28 , G01N1/34 , G01N15/10
摘要： Microfluidic devices, systems and methods are described herein. The devices, systems and methods provide for trapping particles, including cells. Methods of generating a droplet in a microfluidic device and collecting droplets from microfluidic devices are also disclosed herein.

4. 发明申请

WO2018145194A1 METHODS AND SYSTEMS FOR ADDITIVE MANUFACTURING 审中-公开
公开(公告)号：WO2018145194A1
公开(公告)日：2018-08-16
申请号：PCT/CA2018/000023
申请日：2018-02-07
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE
发明人： PACKIRISAMY, Muthukumaran , HABIBI, Mohsen
IPC分类号： B01J19/12 , B33Y10/00 , B33Y30/00 , B33Y50/02
摘要： Additive manufacturing (AM) exploits materials added layer by layer to form consecutive cross sections of desired shape. However, prior art AM suffers drawbacks in employable materials and final piece-part quality. Embodiments of the invention introduce two new classes of methods, solidification and trapping, to create complex and functional structures of macro/micro and nano sizes using configurable fields irrespective of whether they need a medium or not for transmission. Selective Spatial Solidification forms the piece-part directly within the selected build material whilst Selective Spatial Trapping injects the build material into the chamber and selectively directs it to accretion points in a continuous manner. In each a localized spatiotemporal concentrated field is established by configuring or maneuvering field emitters. These methods are suitable to create any 3D part with high mechanical properties and complex geometries. These layerless methods may be used discretely or in combination with conventional AM and non-AM manufacturing processes.

5. 发明申请

WO2017147690A1 ENGINEERED BETA-GLUCOSIDASES AND METHODS OF USE THEREOF 审中-公开
标题翻译：工程化β-葡糖苷酶及其使用方法
公开(公告)号：WO2017147690A1
公开(公告)日：2017-09-08
申请号：PCT/CA2017/050219
申请日：2017-02-22
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE
发明人： MARTIN, Vincent , LARUE, Kane
IPC分类号： C12N9/42 , C12N15/56 , C12N9/24 , C12P19/02 , C12P19/14 , C12P7/10
CPC分类号： C12P19/14 , C12N9/2402 , C12P7/10 , C12P19/02 , Y02E50/16
摘要： A glycoside hydrolase family 3 (GH3) beta-glucosidase (BGL) polypeptide, comprising: (a) a GH3 BGL triosephosphateisomerase domain comprising a sequence as set forth in KGY 1 Y 2 Y 3 Y 4 LGP (SEQ ID NO: 251); (b) a GH3 BGL coordinating loop domain comprising a sequence as set forth in: GLDMX 1 MPX 2 X 3 X 4 X 5 X 6 X 7 X 8 X 9 X 19 X 11 X 12 X 13 X 14 X 15 X 16 (SEQ ID NO: 252), except that at least one of X 1t o X 16 , when present, is smaller than a corresponding reference amino acid residue in a corresponding GH3 BGL reference coordinating loop domain comprising a sequence as set forth in GLDMX 1ref MPX 2ref X 3ref X 4ref X 5ref X 6ref X 7ref X 8ref X 9ref X 19ref X 11ref X 12ref X 13ref X 14ref X 15ref X 16ref (SEQ ID NO: 252); (c) a GH3 BGL β/α sandwich domain comprising a sequence as set forth in: Z 1 Z 2 Z 3 Z 4 Z 5 Z 6 (SEQ ID NO: 253); and/or (d) a GH3 BGL β/α sandwich domain comprising a sequence as set forth in: A 1 A 2 A 3 A 4 A 5 (SEQ ID NO: 254) and a sequence as set forth in B 1 B 2 B 3 B 4 B 5 (SEQ ID NO: 255), with the proviso that the GH3 BGL polypeptide is not a polypeptide as set forth in any one of sequences of SEQ ID NOs: 22 to 44, and is not a secreted form of the polypeptide of any one of SEQ ID NOs: 22 to 44. The GH3 BGL has an improved resistance to substrate inhibition and/or product inhibition. It may be used in methods of converting biomass into a fermentable sugar.
摘要翻译：
阿糖苷水解酶家族3（GH3）β-葡糖苷酶（BGL）多肽，其包含：（a）一种GH3 BGL磷酸丙糖异构酶结构域包括序列如KGY阐述<子> 1 （SEQ ID NO：251）; YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY （b）包含如下所示序列的GH3 BGL协调环结构域：GLDMX 1 MPX 2×3×4×4， /子> X <子> 5 X <子> 6 X <子> 7 X <子> 8 X <子> 9 X < 子> 19 X <子> 11 X <子> 12 X <子> 13 X <子> 14 X <子> 15 阐述的序列环结构域在对应的GH3 BGL参考相应的参考氨基酸残基1ref MPX <子> 2ref X <子> 3ref X <子> 4ref X <子> 5ref X <子> 6ref X <子> 7ref X <子> 8ref X <子> 9ref X <子> 19ref X <子> 11ref X <子> 12ref X <子> 13ref X <子> 14ref X （参见SEQ ID NO：252）;以及SEQ ID NO：252。（c）GH3 BGLβ/α夹心结构域，其包含如以下所示的序列：Z1ZZ2Z3ZZ，（SEQ ID NO：253）; SEQ ID NO：53（SEQ ID NO：53）; SEQ.ID NO：和/或（d）包含如下所示序列的GH3 BGLβ/α夹心结构域：A _{2 _{3A _{3 （SEQ ID NO：254）和如在B 1 B 2 B B中所示的序列（SEQ ID NO：255），条件是GH3 BGL多肽不是如在 SEQ ID NO：22至44的序列中的任何一个，并且不是SEQ ID NO：22至44中任一个的多肽的分泌形式.GH3BGL对底物抑制和/或产物抑制具有改善的抗性。它可以用于将生物质转化为可发酵糖的方法。}}}

6. 发明申请

WO2016149821A1 METHODS OF MAKING MORPHINAN ALKALOIDS AND ENZYMES THEREFORE 审中-公开
标题翻译：制备莫罗宁碱和其酶的方法
公开(公告)号：WO2016149821A1
公开(公告)日：2016-09-29
申请号：PCT/CA2016/050334
申请日：2016-03-23
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE
发明人： FOSSATI, Elena , NARCROSS, Lauren , MARTIN, Vincent
IPC分类号： C12N9/02 , C12N1/19 , C12N15/53 , C12N15/54 , C12N15/81 , C12N9/04 , C12P17/10 , C12P17/12
CPC分类号： C12Y114/21004 , C12P17/188 , C12Y101/01248 , C12Y106/02004 , C12Y203/0115
摘要： A method of preparing a morphinan alkaloid (MA) metabolite comprising: (a) culturing a host cell under conditions suitable for MA production including a first fermentation at a pH of between about 7.5 and about 10, said host cell comprising: (i) a first heterologous coding sequence encoding a first enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; (ii) a second heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; and/or (iii) a third heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; (b) adding (R)-reticuline to the cell culture; and (c) recovering the metabolite from the cell culture. Plasmids and host cells encoding the enzymes are also provided.
摘要翻译：一种制备吗啡喃生物碱（MA）代谢物的方法，包括：（a）在适于MA生产的条件下培养宿主细胞，包括在约7.5至约10的pH下的第一次发酵，所述宿主细胞包含：（i）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径的第一酶的第一异源编码序列; （ii）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径的第二种酶的第二异源编码序列; 和/或（iii）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径中的第二种酶的第三异源编码序列; （b）向细胞培养物中加入（R） - 丝氨酸; 和（c）从细胞培养物中回收代谢物。还提供了编码酶的质粒和宿主细胞。

7. 发明申请

WO2010148515A1 HEAT-EXCHANGER CONFIGURATION 审中-公开
标题翻译：热交换器配置
公开(公告)号：WO2010148515A1
公开(公告)日：2010-12-29
申请号：PCT/CA2010/000990
申请日：2010-06-23
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE, REPRÉSENTÉE PAR GESTION VALEO S.E.C , VATISTAS, Georgios H. , FAYED, Mohamed
发明人： VATISTAS, Georgios H. , FAYED, Mohamed
IPC分类号： F28D9/00 , F28D1/03 , F28D7/10 , F28F13/06 , F28F3/04 , F28F3/08
CPC分类号： F28F13/12 , F28D9/0012 , F28D9/0093 , F28F9/0253
摘要： A heat exchanger comprises a first plate. A second plate is spaced apart from the first plate and defines a first gap between inner surfaces of the first plate and the second plate in which a first fluid circulates. A major portion of the first gap is free of obstructions. A second fluid contacts an outer surface of the first or second plate for heat exchange with the first fluid. A first peripheral wall on the periphery of the first gap has a curved profile inside the first gap. At least one inlet is radially positioned with respect to the first gap and injects the first fluid in the gap. At least one outlet is centrally positioned in one of the first and the second plate to enable the first fluid to exit the first gap. The first fluid circulates in a swirling flow in the major portion of the first gap.
摘要翻译：热交换器包括第一板。第二板与第一板间隔开，并且在第一板和第二板的内表面之间限定第一间隙，在第一板中第一流体循环。第一个差距的主要部分没有障碍。第二流体接触第一或第二板的外表面以与第一流体进行热交换。第一间隙的周边上的第一周边壁在第一间隙内部具有弯曲轮廓。至少一个入口相对于第一间隙径向定位，并将第一流体注入间隙。至少一个出口位于第一和第二板中的一个中心，以使第一流体能够离开第一间隙。第一流体在第一间隙的主要部分中以旋转流动循环。

8. 发明申请

WO2016149821A8 METHODS OF MAKING MORPHINAN ALKALOIDS AND ENZYMES THEREFORE 审中-公开
标题翻译：制备莫罗芬碱性物质及其酶的方法
公开(公告)号：WO2016149821A8
公开(公告)日：2017-04-06
申请号：PCT/CA2016050334
申请日：2016-03-23
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE
发明人： FOSSATI ELENA , NARCROSS LAUREN , MARTIN VINCENT
IPC分类号： C12N9/02 , C12N1/19 , C12N9/04 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/81 , C12P17/10 , C12P17/12
CPC分类号： C12Y114/21004 , C12P17/188 , C12Y101/01248 , C12Y106/02004 , C12Y203/0115
摘要： A method of preparing a morphinan alkaloid (MA) metabolite comprising: (a) culturing a host cell under conditions suitable for MA production including a first fermentation at a pH of between about 7.5 and about 10, said host cell comprising: (i) a first heterologous coding sequence encoding a first enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; (ii) a second heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; and/or (iii) a third heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R)-reticuline into the metabolite; (b) adding (R)-reticuline to the cell culture; and (c) recovering the metabolite from the cell culture. Plasmids and host cells encoding the enzymes are also provided.
摘要翻译：一种制备吗啡喃生物碱（MA）代谢物的方法，包括：（a）在适于MA生产的条件下培养宿主细胞，包括在约7.5至约10的pH下的第一次发酵，所述宿主细胞包含：（i）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径的第一酶的第一异源编码序列; （ii）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径中的第二种酶的第二异源编码序列; 和/或（iii）编码参与将（R） - 丝氨酸转化为代谢物的代谢途径中的第二种酶的第三种异源编码序列; （b）向细胞培养物中加入（R） - 丝氨酸; 和（c）从细胞培养物中回收代谢物。还提供了编码酶的质粒和宿主细胞。

9. 发明申请

WO2012012907A1 MINIMAL ITERATIVITY ANISOTROPIC DIFFUSION METHOD FOR REDUCING IMAGE OR VIDEO NOISES 审中-公开
标题翻译：用于减少图像或视频噪声的最小迭代度均衡扩展方法
公开(公告)号：WO2012012907A1
公开(公告)日：2012-02-02
申请号：PCT/CA2011/050470
申请日：2011-07-29
申请人： VALORBEC SOCIÉTÉ EN COMMANDITE, REPRÉSENTÉE PAR GESTION VALEO S.E.C. , RIFKAH, Eva , AMER, Aishy
发明人： RIFKAH, Eva , AMER, Aishy
IPC分类号： G06T5/00 , H04N5/262 , H04N5/357
CPC分类号： H04N5/21 , G06T5/002 , G06T2207/10016 , G06T2207/20012 , G06T2207/20192
摘要： There is described a Minimal Iterativity Anisotropic Diffusion (MIAD) approach that estimates the required number of iterations N as a function of the image structure-under-noise ρ and the bound of the noise η . The time step λ is related to the image structure-under-noise ρ and to the bound of noise λ . The stopping time is calculated using T = λ · N , and the edge strength σ is determined as a function of T , η , and ρ .
摘要翻译：描述了一种最小迭代各向异性扩散（MIAD）方法，其估计作为图像结构噪声的函数的所需迭代次数N？和噪音的界限？时间步与图像结构有关 - 低噪声？和噪音的界限？停止时间是用T =？ ·N，并且边缘强度s被确定为T，α和β的函数。

10. 发明申请

WO2021087614A1 INTEGRATED DROPLET-DIGITAL MICROFLUIDIC SYSTEM FOR ON-DEMAND DROPLET CREATION, MIXING, INCUBATION AND SORTING 审中-公开
公开(公告)号：WO2021087614A1
公开(公告)日：2021-05-14
申请号：PCT/CA2020/051506
申请日：2020-11-06
申请人： VALORBEC, SOCIÉTÉ EN COMMANDITE
发明人： SHIH, Steve , AHMADI, Fatemeh , SAMLALI, Kenza
IPC分类号： G01N1/00 , C12M1/34 , C12Q1/00 , G01N1/38 , G01N21/59 , G01N21/64 , G01N27/447
摘要： Microfluidic devices, systems and methods are described herein. More particularly, the microfluidic devices comprise a first layer including a plurality of electrodes, a second layer disposed on top of the first layer, the second layer including a dielectric patterned over the plurality of electrodes; and a third layer disposed on top of the second layer. The third layer includes a droplet generator for generating droplets of a first fluid in a second fluid, the droplet generator including a droplet generating channel for carrying the first fluid towards a main channel housing the second fluid. Actuation of the one or more of the plurality of electrodes controls movement of the first fluid in the droplet generating channel towards the main channel and generation of droplets of the first fluid in the main channel.

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