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1. 发明申请

WO2007063405A2 DIAGNOSIS AND TREATMENT OF EXOCRINE PANCREATIC DYSFUNCTION AND DIABETES 审中-公开
标题翻译：胰腺胰腺功能障碍和糖尿病的诊断和治疗
公开(公告)号：WO2007063405A2
公开(公告)日：2007-06-07
申请号：PCT/IB2006/003437
申请日：2006-12-01
申请人： UNIVERSITY OF BERGEN , NJOLSTAD, Pål, R. , RAEDER, Helge , JOHANSSON, Stefan , HOLM, Pål, Ivar , MOLVEN, Anders
发明人： NJOLSTAD, Pål, R. , RAEDER, Helge , JOHANSSON, Stefan , HOLM, Pål, Ivar , MOLVEN, Anders
CPC分类号： C12Q1/6883 , C12N9/20 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to association of one or more polymorphisms located in the human CEL gene to the occurrence of exocrine pancreatic dysfunction and a endocrine pancreatic dysfunction in the form of diabetes. The invention relates both to methods for diagnosing a predisposition to said diseases, classifying said diseases and to methods and compositions for treating subjects with said diseases. Furthermore the invention relates to screens for identifying compounds effective in treating said diseases. The invention describes specific single nucleotide polymorphisms the presence of which in the genome of an individual is strongly associated with the predisposition of said individual to exocrine pancreatic dysfunction and diabetes.
摘要翻译：本发明涉及位于人CEL基因中的一种或多种多态性与外分泌胰腺功能障碍的发生和糖尿病形式的内分泌胰腺功能障碍的关联。本发明涉及用于诊断所述疾病倾向的方法，对所述疾病进行分类，以及用于治疗患有所述疾病的受试者的方法和组合物。此外，本发明涉及用于鉴定有效治疗所述疾病的化合物的筛选。本发明描述了特定的单核苷酸多态性，其在个体的基因组中的存在与所述个体对外分泌胰腺功能障碍和糖尿病的倾向强烈相关。

2. 发明申请

WO2005106517A2 METHOD OF MR IMAGING 审中-公开
标题翻译：灌注磁共振成像输入和组织残留功能的BLIND确定
公开(公告)号：WO2005106517A2
公开(公告)日：2005-11-10
申请号：PCT/GB2005/001680
申请日：2005-05-04
申请人： UNIVERSITY OF BERGEN , COCKBAIN, Julian , TAXT, Torfinn , GRÜNER, Renate
发明人： TAXT, Torfinn , GRÜNER, Renate
IPC分类号： G01R33/28
CPC分类号： G01R33/5601
摘要： The invention provides, in a method of perfusion magnetic resonance imaging of a region of interest in a vascularized animal subject, said method comprising administering a contrast agent bolus into the vascular system of said subject; determining the magnetic resonance signal strength s i (t) for voxels (i) of said region of interest at a series of time values (t) over period from before contrast agent arrival in said region of interest to at least the end of the first pass of said contrast agent through said region of interest; from the determined values s i (t) for said signal strength and an arterial input function v(t), determining values for the tissue residue function r i (t) for each said voxel; and optionally generating an image of said region of interest from the determined values of r i (t); the improvement comprising generating from s i (t) a voxel specific arterial function v i (t) and using said voxel specific arterial function to determine the values of the tissue residue function r i (t).
摘要翻译：本发明在血管化动物受试者的感兴趣区域的灌注磁共振成像方法中提供，所述方法包括将造影剂推注施用于所述受试者的血管系统; 确定在造影剂到达所述感兴趣区域之前的时段内的一系列时间值（t）的所述感兴趣区域的体素（i）的磁共振信号强度si（t）至少到第一遍的结束的所述造影剂通过所述感兴趣区域; 根据所述信号强度的确定值si（t）和动脉输入函数v（t），确定每个所述体素的组织残差函数ri（t）的值; 以及可选地从所确定的ri（t）的值生成所述感兴趣区域的图像; 改进包括从si（t）生成体素特异性动脉功能vi（t）并使用所述体素特异性动脉功能来确定组织残留功能ri（t）的值。

3. 发明申请

WO2022087108A1 METHODS FOR TREATING A SUBJECT WITH LOCAL INVASIVE BREAST CANCER BASED ON PDGFRB LEVELS 审中-公开
公开(公告)号：WO2022087108A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/055810
申请日：2021-10-20
申请人： PRELUDE CORPORATION , UNIVERSITY OF BERGEN , STRELL, Carina , ÖSTMAN, Carl Arne , STENMARK TULLBERG, Axel Emanuel , HOLMBERG, Erik Carl Viktor , KARLSSON, Per Oswald , MALMSTRÖM, Per-Olof , FERNÖ, Lars Mårten
发明人： AKSLEN, Lars Andreas , BREMER, Troy, M. , EDELMANN, Reidunn Jetne
IPC分类号： C12Q1/6886 , A61P35/04
摘要： Provided herein are various methods for treating a subject for local and/or regional recurrence of invasive breast cancer or a subject with invasive breast cancer, identifying a subject who will not be adequately responsive to radiation therapy, recommending a treatment to a subject, preventing an invasive breast cancer recurrence in a subject, preventing a local and/or regional recurrence of an invasive breast cancer in a subject, or modifying a treatment for a subject based on PDGFRb levels. In some embodiments, the methods are based on PDGFRb levels.

4. 发明申请

WO2018019987A1 COMPOUNDS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION 审中-公开
标题翻译：治疗糖脂代谢异常的化合物
公开(公告)号：WO2018019987A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/069147
申请日：2017-07-28
申请人： UNIVERSIDAD AUTÓNOMA DE MADRID , UNIVERSITY OF BERGEN
发明人： PÉREZ GONZÁLEZ, María Belén , GÁMEZ ABASCAL, María Alejandra , YUSTE CHECA, Patricia , BRASIL, Sandra , UGARTE PÉREZ, Magdalena , MARTÍNEZ RUIZ, Aurora , UNDERHAUG, Jarl
IPC分类号： C07D213/75 , C07C275/30
CPC分类号： C07D213/75 , C07C275/30
摘要： The present invention relates to the medicinal use of small organic compounds, in particular amide and urea derivatives, for the treatment of congenital disorders of glycosylation, and in particular PMM2 congenital disorder of glycosylation.
摘要翻译：本发明涉及小型有机化合物，特别是酰胺和尿素衍生物的医药用途，用于治疗先天性糖基化障碍，特别是PMM2糖基化先天性障碍。

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