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1. 发明申请

WO2020037160A3 RAPID DIAGNOSTICS OF MYCOBACTERIA WITH LECTIN CONJUGATED PARTICLES 审中-公开
公开(公告)号：WO2020037160A3
公开(公告)日：2020-02-20
申请号：PCT/US2019/046719
申请日：2019-08-15
申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE , JAYAWARDENA, Hapuarachchige, Surangi , RATHNAYAKE, Kavini, Madushika , PATEL, Unnati , SENTELL, Andrew , JOHNSON, James , MUSTAIN, Melinda , DEVARASETTY, Veer Venkata, Naga Manohar
发明人： JAYAWARDENA, Hapuarachchige, Surangi , RATHNAYAKE, Kavini, Madushika , PATEL, Unnati , SENTELL, Andrew , JOHNSON, James , MUSTAIN, Melinda , DEVARASETTY, Veer Venkata, Naga Manohar
IPC分类号： C12N15/11 , C12Q1/68 , G01N33/52
摘要： The present disclosure is generally directed to methods and systems for the rapid detection of mycobacteria in samples using lectin-conjugated silica coated magnetic nanoparticles (SMNPs). In this work, carbohydrates on the cell wall of the mycobacteria serve as binding sites for lectins conjugated on the surface of lectin-conjugated SMNPs. As the target species of mycobacteria bind to lectin-conjugated SMNPs, a precipitate forms, which can be magnetically separated from the bulk test solution to visually indicate the presence of the target species of mycobacteria. The present disclosure is utilized as an inexpensive and rapid point of care system in one embodiment. In another embodiment, the methods and systems are integrated into a lateral flow assay for rapid detection of the target species of mycobacteria. In yet another embodiment, the methods and systems are utilized to create a microfluidic detection device with increased sensitivity to mycobacteria in a sample.

2. 发明申请

WO2020037160A2 RAPID DIAGNOSTICS OF MYCOBACTERIA WITH LECTIN CONJUGATED PARTICLES 审中-公开
公开(公告)号：WO2020037160A2
公开(公告)日：2020-02-20
申请号：PCT/US2019/046719
申请日：2019-08-15
申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE , JAYAWARDENA, Hapuarachchige, Surangi , RATHNAYAKE, Kavini, Madushika , PATEL, Unnati , SENTELL, Andrew , JOHNSON, James , MUSTAIN, Melinda , DEVARASETTY, Veer Venkata, Naga Manohar
发明人： JAYAWARDENA, Hapuarachchige, Surangi , RATHNAYAKE, Kavini, Madushika , PATEL, Unnati , SENTELL, Andrew , JOHNSON, James , MUSTAIN, Melinda , DEVARASETTY, Veer Venkata, Naga Manohar
IPC分类号： C12Q1/06
摘要： The present disclosure is generally directed to methods and systems for the rapid detection of mycobacteria in samples using lectin-conjugated silica coated magnetic nanoparticles (SMNPs). In this work, carbohydrates on the cell wall of the mycobacteria serve as binding sites for lectins conjugated on the surface of lectin-conjugated SMNPs. As the target species of mycobacteria bind to lectin-conjugated SMNPs, a precipitate forms, which can be magnetically separated from the bulk test solution to visually indicate the presence of the target species of mycobacteria. The present disclosure is utilized as an inexpensive and rapid point of care system in one embodiment. In another embodiment, the methods and systems are integrated into a lateral flow assay for rapid detection of the target species of mycobacteria. In yet another embodiment, the methods and systems are utilized to create a microfluidic detection device with increased sensitivity to mycobacteria in a sample.

3. 发明申请

WO2013126897A1 SYSTEMS AND METHODS FOR DETERMINING CONTAINER CONTENTS, LOCATIONS, AND SURROUNDINGS 审中-公开
标题翻译：用于确定集装箱内容，位置和环境的系统和方法
公开(公告)号：WO2013126897A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027664
申请日：2013-02-25
申请人： ADHERETECH INC. , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE
发明人： STEIN, Joshua , LANGHAUSER, John , MORENA, Michael , JOVANOV, Emil
IPC分类号： A61J1/03 , A61J7/04
CPC分类号： A61J7/0409 , A61J7/0418 , A61J7/0481 , A61J2200/30 , A61J2200/70 , A61J2200/74 , A61J2200/76 , F04C2270/0421 , G06F19/00 , G06F19/3462 , G06Q10/10
摘要： Systems and methods are provided for determining whether and/or when a patient is taking his or her medication and, when appropriate, providing reminders and/or alerts to the patient to improve adherence to a medication regimen. In some embodiments, a medication container is provided that includes a capacitance sensor for sensing the contents of the medication container (e.g., pill count or quantity of liquid medication). The capacitance sensor may include interleaved or interdigitated electrodes oriented vertically, horizontally, or angularly (e.g., diagonally) relative to an axis of the medication container. Reminders and/or alerts to the patient may be triggered based at least in part on the contents of the medication container, when a cap of the container was last opened and/or closed, the location of the medication container, and/or the container's surroundings.
摘要翻译：提供了系统和方法，用于确定患者是否和/或何时服用他或她的药物，并且在适当时向患者提供提醒和/或警报以改善对药物治疗方案的依从性。在一些实施例中，提供了一种药物容器，其包括用于感测药物容器的内容物的电容传感器（例如，药片计数或液体药物的量）。电容传感器可以包括相对于药物容器的轴线垂直，水平或成角度地（例如，对角线）定向的交错或交叉指向的电极。至少部分地基于药物容器的内容触发对患者的提醒和/或警报，当容器的帽最后打开和/或关闭时，药物容器的位置和/或容器的位置环境。

4. 发明申请

WO2006124672A2 APPARATUS AND METHOD FOR INCUBATING CELL CULTURES 审中-公开
标题翻译：用于诱导细胞培养的装置和方法
公开(公告)号：WO2006124672A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018546
申请日：2006-05-12
申请人： UNIVERSITY OF ALABAMA IN HUNTSVILLE , ANDERSON, James , BISHOP, Amy
发明人： ANDERSON, James , BISHOP, Amy
IPC分类号： C12M1/36
CPC分类号： C12M23/22 , C12M23/24 , C12M23/42 , C12M23/54 , C12M41/46
摘要： A portable, self-contained incubation apparatus has a cell container in which a cell culture can grow. The cell container resides on a base along with other components that maintain the environmental conditions inside of the container within a desired range. The self-contained incubation apparatus is portable allowing the conditions within the cell container to be precisely controlled even as it is being moved from one location to another. Further, at least one transparent surface of the cell container enables observation of the cell culture. Thus, the culture can be observed while the environmental conditions within the container are being controlled by components of the incubation apparatus. Since the cells can be observed without breaking the air-tight seal of the container, observation of the cells can be performed as often as is desired without introducing contaminants to the culture or otherwise significantly affecting the growth environment within the container. Indeed, observation of the cells can be performed as often as is desired without introducing contaminants to the culture or otherwise significantly affecting the growth environment within the container.
摘要翻译：便携式，独立的培养装置具有细胞培养物可以生长的细胞容器。电池容器与其他将容器内部的环境条件保持在所需范围内的部件一起位于基座上。独立的孵化装置是便携式的，允许细胞容器内的条件即使在从一个位置移动到另一个位置时也被精确地控制。此外，细胞容器的至少一个透明表面能够观察细胞培养。因此，当容器内的环境条件由培养装置的组分控制时，可以观察培养物。由于可以在不破坏容器的气密密封的情况下观察细胞，所以可以根据需要经常观察细胞，而不会将污染物引入培养物或以其他方式显着影响容器内的生长环境。实际上，细胞的观察可以按照需要进行，而不会将污染物引入培养物或以其他方式显着影响容器内的生长环境。

5. 发明申请

WO2006119314A2 METHOD AND DEVICE FOR DETERMINING OXYGEN SATURATION OF HEMOGLOBIN, FOR DETERMINING HEMATOCRIT OF BLOOD, AND/OR FOR DETECTING MACULAR DEGENERATION 审中-公开
标题翻译：用于测定血红蛋白氧气饱和度的方法和装置，用于测定血液中的血红蛋白和/或用于检测黄变性
公开(公告)号：WO2006119314A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016883
申请日：2006-05-02
申请人： UAB RESEARCH FOUNDATION , THE UNIVERSITY OF ALABAMA IN HUNTSVILLE , HILLMAN, Sharon , DENNINGHOFF, Kurt, R.
发明人： DENNINGHOFF, Kurt, R. , HILLMAN, Lloyd
IPC分类号： G01N33/50
CPC分类号： G01N33/4925 , G01N2021/3144 , G01N2021/3148
摘要： A method and device for accurately determining oxygen saturation of hemoglobin by the measurement of the optical density of a sample, such as a blood vessel, in response to illumination by light having at least three wavelengths (λi, λ2, λ3, ...) within a range of about 460 nm to about 523 nm. The hematocrit of a sample may be determined from optical density measurements at the three or more wavelengths in conjunction with a known path length. The device may be an intravenous or intra-arterial fiber optic catheter used to deliver the interrogating light signal to the blood and to detect the reflected signal. A method and device of determining the thickness of the retinal well using spectroscopic information are also disclosed.
摘要翻译：通过测量诸如血管的样品的光密度来响应于具有至少三个波长（λi，λ2，θ3，...的光）的照明来精确地确定血红蛋白的氧饱和度的方法和装置。 ..）在约460nm至约523nm的范围内。样品的血细胞比容可以通过结合已知的路径长度在三个或更多个波长处的光密度测量来确定。该装置可以是用于将询问光信号传递到血液并检测反射信号的静脉内或动脉内纤维导管。还公开了使用光谱信息确定视网膜的厚度的方法和装置。

6. 发明申请

WO2006085934A2 RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS 审中-公开
标题翻译： RAB9蛋白晶体结构和识别RAB9调节剂的方法
公开(公告)号：WO2006085934A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/021191
申请日：2005-06-16
申请人： THE UNIVERSITY OF ALABAMA IN HUNTSVILLE , MEEHAN, Edward, J. , CHEN, Liqing , DIGIAMMARINO, Enrico, L. , HODGE, Thomas, W.
发明人： MEEHAN, Edward, J. , CHEN, Liqing , DIGIAMMARINO, Enrico, L. , HODGE, Thomas, W.
IPC分类号： G01N33/48 , C12N9/12 , G06F19/00
CPC分类号： C12N9/16 , C07K2299/00 , G01N2500/04
摘要： The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5'-(β, γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.
摘要翻译：本发明涉及与GDP或GTP类似物鸟苷5' - （β，β-亚氨基）三磷酸（GppNHp）复合的结晶Rab9，Rab9-GDP和Rab9-GppNHp复合物中Rab9的三维坐标和结构，并将其用于药物设计。特别地，本发明涉及用于生产足够质量的Rab9晶体的方法，以在其GTP结合（开/主动）和GDP-结合（关/非活性）两者中获得Rab9的三维结构确定为高分辨率）构象。本发明还涉及用Rab9-GDP和Rab9-GppNHp复合物中的Rab9的三维坐标编码的计算机可读介质，其中使用图形显示软件程序，三维坐标创建可以在能够将电子文件表示为三维图像的计算机。

7. 发明申请

WO2004053166A1 NUCLEIC ACID DETECTOR AND METHOD OF DETECTING TARGETS WITHIN A SAMPLE 审中-公开
标题翻译：核酸检测器和在样品中检测目标的方法
公开(公告)号：WO2004053166A1
公开(公告)日：2004-06-24
申请号：PCT/US2003/038960
申请日：2003-12-08
申请人： UNIVERSITY OF ALABAMA IN HUNTSVILLE , PUSEY, Marc, L. , CHITTUR, Krishnan, K. , DOWELL, Jeffrey, J. , NG, Joseph, D.
发明人： PUSEY, Marc, L. , CHITTUR, Krishnan, K. , DOWELL, Jeffrey, J. , NG, Joseph, D.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2525/301
摘要： A nucleic acid detector and a method of using the detector are disclosed for detecting the presence of target nucleic acid sequences within a sample. The nucleic acid detector comprises a substrate-bound, hairpin-shaped nucleic acid captor in conjunction with a labeled universal nucleic acid detector probe. The captor has a segment that is complementary to at least a portion of the target nucleic acid and is denatured and hybridized to the target under test conditions. Hybridization of the captor to the target maintains the captor in an open conformation which exposes an end portion of the captor to the universal detector probe. The detector probe is able to hybridize with the exposed end portion of the captor if the captor has hybridized with a target. The labeled detector probe is detectable by external detection methods. Detector probes having identical universal detector probe sequences may be used to identify the presence of multiple targets having various target sequences within a sample. An assay embodying the detector and method is also contemplated.
摘要翻译：公开了用于检测样品中靶核酸序列的存在的核酸检测器和使用该检测器的方法。核酸检测器包括与标记的通用核酸检测器探针结合的底物结合的发夹形核酸螯合体。捕获器具有与目标核酸的至少一部分互补的区段，并在测试条件下变性并与靶标杂交。捕获器与目标物的混合将捕获器保持开放的构型，将捕获器的端部暴露于通用探测器探头。如果捕获器与目标物质杂交，则检测器探头能够与捕获器的暴露端部杂交。标记的检测器探针可通过外部检测方法检测。具有相同通用检测器探针序列的检测器探针可用于鉴定在样品内具有各种靶序列的多个靶的存在。还考虑了体现检测器和方法的测定法。

8. 发明申请

WO2009058291A3 CONTROLLED MOLECULAR WEIGHT AMINO ACID POLYMERS HAVING FUNCTIONALIZABLE BACKBONES AND END GROUPS AND PROCESSES FOR PREPARING THE SAME 审中-公开
公开(公告)号：WO2009058291A3
公开(公告)日：2009-05-07
申请号：PCT/US2008/012258
申请日：2008-10-29
申请人： UNIVERSITY OF ALABAMA IN HUNTSVILLE , SCHOLZ, Carmen , VAYABOURY, Willy
发明人： SCHOLZ, Carmen , VAYABOURY, Willy
IPC分类号： C08J9/00 , C08L89/00
摘要： The present disclosure relates to processes for preparing metal-free, mono-dispersed polymers of amino acids. The polymers include homopolymers, random copolypeptides, block copolypeptides, block copolymers with at least one peptidyl block, grafted copolypeptides, and polypetidyl dendrimers. The disclosed process does not make use of a heavy metal catalyst, inter alia, copper or nickel containing reagents. The disclosed process encompasses a 'living polymerization' such that the growth of each polymer chain is not truncated or otherwise halted by undesirable side reactions or limitations due to the length or size of the growing polymer chain, provides amino acid comprising polymers having a narrow polydispersity, is conducted at lower temperatures, and avoids the premature secondary folding that inhibits the formation of polymers having a low polydispersity index. This abstract is intended to provide key words and search terms for use in searching patent and patent application data bases and is not intended to limit the subject matter of the disclosure.

9. 发明申请

WO2002063070A1 NICKEL COBALT PHOSPHOROUS LOW STRESS ELECTROPLATING 审中-公开
标题翻译：镍钴钴磷光体低压电镀
公开(公告)号：WO2002063070A1
公开(公告)日：2002-08-15
申请号：PCT/US2001/004296
申请日：2001-02-08
申请人： THE UNIVERSITY OF ALABAMA IN HUNTSVILLE , UNITED STATES GOVERNMENT , ENGELHAUPT, Darell, E. , RAMSEY, Brian, D.
发明人： ENGELHAUPT, Darell, E. , RAMSEY, Brian, D.
IPC分类号： C25D3/16
CPC分类号： C25D3/12 , C25D3/562
摘要： An electrolytic plating process is provided for electrodepositing a nickel or nickel cobalt alloy which contains at least 2 % to 25 % by atomic volume of phosphorous. The process solution contains nickel and optionally cobalt sulfate, hypophosphorous acid or a salt thereof, boric acid or a salt thereof, a monodentate organic acid or a salt thereof, and a multidentate organic acid or a salt thereof. The pH of the plating bath is from about 3.0 to about 4.5. An electroplating process is also provided which includes electroplating from the bath a nickel cobalt phosphorous alloy. This process can achieve a deposit with high microyield of at least about 84 kg/mm 2 (120 ksi) and a density lower than pure nickel of about 8.0 gm/cc. This process can be used to plate a deposit of essentially zero stress at plating temperatures from ambient to 70 °C.
摘要翻译：提供一种电解电镀方法，用于电沉积含有至少2％至25％原子体积的磷的镍或镍钴合金。该工艺溶液含有镍和任选的硫酸钴，次磷酸或其盐，硼酸或其盐，单齿有机酸或其盐，以及多齿有机酸或其盐。电镀浴的pH为约3.0至约4.5。还提供了一种电镀工艺，其中包括从镀浴中电镀镍钴磷合金。该过程可以实现至少约84kg / mm 2（120ksi）的高微量玻璃沉积物和低于约8.0gm / cc的纯镍的密度。该方法可用于在从室温至70℃的电镀温度下对基本上为零的应力沉积。

10. 发明申请

WO2013033665A9 A METHOD OF FACILITATING THE BIOCONVERSION OF CRUDE BIODIESEL-DERIVED GLYCEROL BY MICROORGANISMS 审中-公开
公开(公告)号：WO2013033665A9
公开(公告)日：2013-03-07
申请号：PCT/US2012/053563
申请日：2012-09-01
申请人： THE BOARD OF TRUSTREES OF UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA, IN HUNTSVILLE , SCHOLZ, Carmen , VENKATARAMANAN, Keerthi, Prasad , BOTHUN, Geoffrey, D.
发明人： SCHOLZ, Carmen , VENKATARAMANAN, Keerthi, Prasad , BOTHUN, Geoffrey, D.
IPC分类号： C07C31/22
摘要： The present disclosure generally pertains to a method of facilitating the bioconversion of glycerol by microorganisms. In one embodiment, biodiesel derived crude glycerol is purified by removing fatty acids through acid precipitation. The fatty acid-free crude glycerol is then utilized as a carbon source for the culture of microorganisms and the production of value added substances. Additionally, the unsaturated fatty acids within the biodiesel-derived crude glycerol are converted to saturated fatty acids, allowing for fermentation behavior similar to that of pure glycerol. Both the cultured microorganisms and the culture media containing the purified crude glycerol may be analyzed for crude glycerol bioconversion products. The disclosure also relates to a method of increasing product yield through the addition of a second carbon source to the microorganism culture media.

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