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1. 发明申请

WO2011063989A8 TREATMENT OF NERVE INJURIES 审中-公开
标题翻译：治疗神经损伤
公开(公告)号：WO2011063989A8
公开(公告)日：2012-07-19
申请号：PCT/EP2010007265
申请日：2010-11-30
申请人： UNIVERSITAETSKLINIKUM HAMBURG , SCHACHNER MELITTA , KLEENE RALF , MISHRA BIBHUDATTA
发明人： SCHACHNER MELITTA , KLEENE RALF , MISHRA BIBHUDATTA
IPC分类号： A61K38/17 , A61P25/00
CPC分类号： A61K38/17 , A61K48/00 , C07K14/4702
摘要： This invention relates to treatment of nerve injuries and regeneration of nerves and nerve function in the acutely and chronically lesioned central and peripheral nervous system. The invention provides a pharmaceutical composition comprising histone, e.g., H1. It was surprisingly shown that histones, in particular histone Hl, can be used for the preparation of a pharmaceutical composition for treatment and/or prevention of acute and chronic injuries to the central and peripheral nervous system, for promoting growth and/or regrowth of nerves and enhancing formation of synapses and synaptic plasticity, and for neuroprotection.
摘要翻译：本发明涉及急性和慢性损伤的中枢和周围神经系统的神经损伤和神经再生和神经功能的治疗。本发明提供包含组蛋白例如H1的药物组合物。惊奇地发现，组蛋白，特别是组蛋白H1可以用于制备用于治疗和/或预防中枢和周围神经系统的急性和慢性损伤的药物组合物，用于促进神经的生长和/或再生长并增强突触的形成和突触可塑性，并用于神经保护。

2. 发明申请

WO2005111574A2 METHOD AND DEVICE FOR INVESTIGATION OF SLUDGE DEPOSITS ON MATERIALS FOR ENDOPROSTHESES AND ENDOPROSTHESIS 审中-公开
标题翻译：方法和装置SLUDGEABLAGERUNGEN的UNTESUCHUNG对内置假体和内假体材料
公开(公告)号：WO2005111574A2
公开(公告)日：2005-11-24
申请号：PCT/DE2005000912
申请日：2005-05-17
申请人： UNIVERSITAETSKLINIKUM HAMBURG , SEITZ UWE , WIENHOLD UWE , GROSSE CARSTEN
发明人： SEITZ UWE , WIENHOLD UWE , GROSSE CARSTEN
IPC分类号： A61L27/50 , A61L31/14 , G01N17/00
CPC分类号： G01N17/008
摘要： The invention relates to a method and device for the investigation of sludge deposition on materials for coating endoprostheses. At least one endoprosthesis is placed in an incubation chamber which is at least partly filled with infected bile. The incubation chamber is rocked gently on a rocking platform for a period of about 35 days. The bile fluid is regularly partly exchanged. The endoprosthesis is embodied in a coated plastic. The coating comprises 70 to 80 % by weight of hydrophobic components and 30 % to 20 % by weight of hydrophilic components. The coating may particularly have a sol-gel embodiment. An application in bile duct prostheses is possible.
摘要翻译：该方法和设备被用于Sludgeablagerungen的调查材料假体的涂层。至少一种涂覆的支架被定位在孵化容器中，其至少部分地填充有受感染的胆汁。孵化向后移动一段约35天慢慢透视表和hergeschwenkt。胆汁在每种情况下定期更换为一个部件。内用假体是塑料涂层的形成。所述涂层具有70％至80％（重量）的疏水性组分的30％至20％（重量）的亲水性组分。特别地，可在溶胶 - 凝胶基体上形成涂层。应用程序可以为胆管进行。

3. 发明申请

WO2005015151A3 METHOD FOR PURIFYING MESENCHYMAL STEM CELLS 审中-公开
标题翻译：纯化过程的间充质干细胞
公开(公告)号：WO2005015151A3
公开(公告)日：2005-04-28
申请号：PCT/EP2004008865
申请日：2004-08-06
申请人： UNIVERSITAETSKLINIKUM HAMBURG , LANGE CLAUDIA , ZANDER AXEL ROLF
发明人： LANGE CLAUDIA , ZANDER AXEL ROLF
IPC分类号： C12N5/0775 , C12N5/08 , A61K35/28
CPC分类号： C12N5/0663
摘要： The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner compared to prior art are first provided and can also be differentiated, after a longer cultivation period, in three mesenchymal directions.
摘要翻译：本发明涉及一种用于净化间充质干细胞的方法，它提供了本领域的细胞产量，其中获得的细胞同时保持多向和典型抗原特性的特征在于增加的增殖能力的状态。这提供了可用的第一时间间质干细胞，其可以是更好的增加相比于现有技术，但仍然可以在三个方向上的间充质此外分化，即使经过长时间的培养。

4. 发明申请

WO2013087857A3 ANTIBODIES AGAINST C. DIFFICILE TOXINS 审中-公开
标题翻译：单克隆抗体抗毒素艰难梭菌
公开(公告)号：WO2013087857A3
公开(公告)日：2013-09-19
申请号：PCT/EP2012075584
申请日：2012-12-14
申请人： UNIVERSITAETSKLINIKUM HAMBURG , NOLTE FRIEDRICH , UNGER MANDY
发明人： NOLTE FRIEDRICH , UNGER MANDY
IPC分类号： A61K39/08 , C07K16/12 , C07K16/40
CPC分类号： C07K16/1282 , A61K2039/505 , C07K16/40 , C07K2317/22 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antigen-binding polypeptides which comprise the CDR1, CDR2 and CDR3 region of a VHH domain of a camelid heavy chain antibody. The polypeptides specifically bind in the region of amino acids 1-800 of a Clostridium difficile toxin exhibiting glycosyltransferase activity. The antigen-binding polypeptides are particularly suited for therapeutic treatment of a disease caused by a Clostridium difficile toxin exhibiting glycosyltransferase activity, and for the diagnosis of such a disease. The invention further relates to the use of such antigen-binding polypeptides in methods for detecting a Clostridium difficile toxin exhibiting glycosyltransferase activity in a biological sample. The invention also relates to methods for purifying and/or concentrating a Clostridium difficile toxin exhibiting glycosyltransferase activity, wherein the antigen-binding polypeptides are used.
摘要翻译：本发明涉及一种包括骆驼科重链抗体的V HH结构域的CDR1，CDR2和CDR3区的抗原结合多肽。多肽在氨基酸具有艰难梭菌毒素的糖基转移酶活性的1-800的区域特异性结合。的抗原结合多肽是特别适合于具有，通过梭菌difficileverursacht的糖基转移酶活毒素的疾病的治疗性治疗，以及用于这样的疾病的诊断。此外，本发明涉及的方法中使用这样的抗原结合多肽的用于检测糖基转移酶活包括梭菌的difficilein的生物样品的毒素。提供了一种用于一个糖基转移酶活包括艰难梭菌的毒素，其中所述抗原结合多肽也可用于纯化和/或浓缩处理。

5. 发明申请

WO2004035799A3 VIRAL VECTORS AND THE USE OF THE SAME FOR GENE THERAPY 审中-公开
标题翻译：病毒载体和它们用于基因治疗
公开(公告)号：WO2004035799A3
公开(公告)日：2004-06-10
申请号：PCT/EP0311252
申请日：2003-10-10
申请人： UNIVERSITAETSKLINIKUM HAMBURG , WAEHLER REINHARD , SCHNIEDERS FRANK
发明人： WAEHLER REINHARD , SCHNIEDERS FRANK
IPC分类号： C07K14/54 , C07K14/55 , C07K14/705 , C12N15/861 , A61K48/00 , C12N15/86
CPC分类号： C12N15/86 , C07K14/5434 , C07K14/55 , C07K14/70532 , C07K14/70575 , C12N2710/10043 , C12N2840/203 , C12N2840/206
摘要： The invention relates to viral vectors comprising nucleic acid sequences coding for single chain interleukin-12 (single chain IL-12 or scIL12) and a costimulator protein, and to the use of said vectors for gene therapy, especially for the treatment of tumours. The invention further relates to adenoviral vectors containing nucleic acid sequences having a sequence homology of at least 90 % in relation to the sequence displayed in figs. 19 and 20 (IL-12), in fig. 21 (4-1BB ligand) and in fig. 22 (IL-2) and optionally also one of the sequences displayed in fig. 23A (B7-1) or 23B (B7-2).
摘要翻译：本发明涉及包含编码核酸序列的病毒载体的单链白细胞介素-12（单链IL-12，“单链IL-12”或scIL12）和编码共刺激蛋白，以及用于基因治疗中使用这些载体的特别是对于肿瘤的治疗。本发明还涉及含有其表现出至少90％的序列同源性的是，图19和20（IL-12）在图21（4-1BB配体）的并且在图核酸序列adenövirale载体。22（IL- 包括2）和任选的进一步示出的一个（在图23A序列B7-1）或23B（B7-2）。

6. 发明申请

WO2013014134A2 POLYOMA VIRUS JC PEPTIDES AND PROTEINS IN VACCINATION AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：多形性病毒JC蛋白质和蛋白质在疫苗接种和诊断中的应用
公开(公告)号：WO2013014134A2
公开(公告)日：2013-01-31
申请号：PCT/EP2012064445
申请日：2012-07-23
申请人： UNIVERSITAETSKLINIKUM HAMBURG , JELCIC ILIJAS , MARTIN ROLAND , SCHIPPLING SVEN , SOSPEDRA MIREIA , YOUSEF SARA , UNIV ZUERICH
发明人： JELCIC ILIJAS , MARTIN ROLAND , SCHIPPLING SVEN , SOSPEDRA MIREIA , YOUSEF SARA
IPC分类号： A61K38/04 , A61K38/16 , C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K38/2046 , A61K39/12 , A61K2039/55511 , A61K2039/55527 , C07K7/08 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2710/22034 , C12N2710/22071 , C12Q1/70
摘要： The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable ofeliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.
摘要翻译：本发明涉及疫苗接种或免疫领域，特别是治疗性疫苗接种和诊断领域。公开了能够针对多瘤病毒JC（JCV）进行保护性免疫应答的药物组合物和试剂盒，其可用于例如用于治疗或预防进行性多灶性脑白质脑病（PML）和/或进行性多灶性脑白质脑病 - 免疫重建炎症综合征 PML-IRIS）。患有这种PML或PML-IRIS的危险的个体可以例如是免疫受损的或免疫抑制的患者或具有适合免疫抑制治疗的自身免疫疾病的患者。本发明还涉及包含JCV蛋白的至少一种CD4 +表位的组合物及其治疗，预防和诊断用途。

7. 发明申请

WO2010015632A2 INTERFERON 审中-公开
标题翻译：干扰素
公开(公告)号：WO2010015632A2
公开(公告)日：2010-02-11
申请号：PCT/EP2009060104
申请日：2009-08-04
申请人： UNIVERSITAETSKLINIKUM HAMBURG , INST RECERCA HOSPITAL UNI VALL , MARTIN ROLAND , COMABELLA LOPEZ MANUEL , MONTALBAN GAIRIN XAVIER
发明人： MARTIN ROLAND , COMABELLA LOPEZ MANUEL , MONTALBAN GAIRIN XAVIER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： Subject of the invention are methods for predicting if a treatment of multiple sklerosis with type I interferon is successful, methods of treatment, microarrays and kits for performing the methods.
摘要翻译：本发明的主题是预测用I型干扰素治疗多发性硬化症是否成功的方法，治疗方法，用于实施所述方法的微阵列和试剂盒。

8. 发明申请

WO2012098226A2 VISUALIZATION OF LIPID METABOLISM 审中-公开
标题翻译：脂质代谢的可视化
公开(公告)号：WO2012098226A2
公开(公告)日：2012-07-26
申请号：PCT/EP2012050863
申请日：2012-01-20
申请人： UNIVERSITAETSKLINIKUM HAMBURG , CT FUER ANGEWANDTE NANOTECHNOLOGIE CAN GMBH , BRUNS OLIVER , HOHENBERG HEINRICH , REIMER RUDOLPH , TROMSDORF ULRICH , WELLER HORST , ADAM GERHARD , ITTRICH HARALD , KAUL MICHAEL , NIELSEN PETER , FREUND BARBARA , BARTELT ALEXANDER , HEEREN JOERG , PETTE HEINRICH INST
发明人： BRUNS OLIVER , HOHENBERG HEINRICH , REIMER RUDOLPH , TROMSDORF ULRICH , WELLER HORST , ADAM GERHARD , ITTRICH HARALD , KAUL MICHAEL , NIELSEN PETER , FREUND BARBARA , BARTELT ALEXANDER , HEEREN JOERG
IPC分类号： A61K49/00
CPC分类号： A61K49/14 , A61K49/0004 , A61K49/1839
摘要： The present invention relates to the field of in vivo determination of enzyme activity. It also allows visualization of organisms, organs, tissues and cells. In particular, the present invention provides a method of in vivo visualization and a composition suitable for in vivo determination and/or visualization of enzyme activity by methods such as Magnetic Resonance Imaging, also called Magnetic Resonance Tomography (MRI or MRT), or Magnetic Particle Imaging (MPI). In particular, the activity of the enzyme lipoprotein lipase affects the signals received and allows conclusions on the lipid metabolism of an organism, an organ system, an organ, a tissue and a cell of interest, This method can be employed, e.g., for diagnosis of cardiac disorders, of tumor prognosis and of disorders of the lipid metabolism. The composition used comprises superparamagnetic iron oxide nanocrystals (SPIO) incorporated in the core of lipid micelles designated nanosomes.
摘要翻译：本发明涉及酶活性的体内测定领域。它还允许生物，器官，组织和细胞的可视化。特别地，本发明提供了一种体内可视化方法和适用于体内测定和/或可视化酶活性的组合物，其通过诸如磁共振成像（Magnetic Resonance Imaging），也称为磁共振层析成像（MRI或MRT）或磁性颗粒成像（MPI）。特别地，酶脂蛋白脂肪酶的活性影响所接收的信号，并且允许对生物体，器官系统，器官，组织和感兴趣的细胞的脂质代谢的结论。该方法可用于例如诊断的心脏疾病，肿瘤预后和脂质代谢紊乱。所使用的组合物包括掺入指定为纳米体的脂质胶束核心的超顺磁性氧化铁纳米晶体（SPIO）。

9. 发明申请

WO2004035609A3 USE OF POLY-ALPHA2,8-SIALIC ACID MIMETIC PEPTIDES TO MODULATE NCAM FUNCTIONS. 审中-公开
标题翻译：使用聚-α2,8-唾液酸模拟肽来调节NCAM功能。
公开(公告)号：WO2004035609A3
公开(公告)日：2004-08-26
申请号：PCT/IB0305108
申请日：2003-10-16
申请人： CENTRE NAT RECH SCIENT , UNIV AIX MARSEILLE II , SCHAFER N , UNIVERSITAETSKLINIKUM HAMBURG , ROUGON GENEVIEVE , TORREGROSSA PASCAL , SCHACHNER MELITTA , SCHAFER NIELSEN CLAUS
发明人： ROUGON GENEVIEVE , TORREGROSSA PASCAL , SCHACHNER MELITTA , SCHAFER NIELSEN CLAUS
IPC分类号： A61K38/10 , A61K39/00 , C07K1/04 , C07K7/00 , C07K7/06 , C07K7/08 , C07K7/64 , C12N5/10 , C12N15/09
CPC分类号： C07K7/06 , A61K39/00 , C07K1/047 , C07K7/08
摘要： The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-alpha2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-alpha2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
摘要翻译：本发明涉及由5至30个氨基酸残基，优选9至15个，最优选约12个氨基酸残基组成的肽的用途，所述肽包含与NCAM连接的聚-α2,8唾液酸的B表位，其被抗聚-α2,8唾液酸（PSA）抗体识别，用于制备调节NCAM功能的药物，用于预防和/或治疗神经退行性疾病，脑和脊柱病变，与年龄有关的学习和记忆问题以及癌症。

10. 发明申请

WO2011063989A3 TREATMENT OF NERVE INJURIES 审中-公开
标题翻译：治疗神经损伤
公开(公告)号：WO2011063989A3
公开(公告)日：2011-10-06
申请号：PCT/EP2010007265
申请日：2010-11-30
申请人： UNIVERSITAETSKLINIKUM HAMBURG , SCHACHNER MELITTA , KLEENE RALF , MISHRA BIBHUDATTA
发明人： SCHACHNER MELITTA , KLEENE RALF , MISHRA BIBHUDATTA
IPC分类号： A61K38/17 , A61P25/00
CPC分类号： A61K38/17 , A61K48/00 , C07K14/4702
摘要： This invention relates to treatment of nerve injuries and regeneration of nerves and nerve function in the acutely and chronically lesioned central and peripheral nervous system. The invention provides a pharmaceutical composition comprising histone, e.g., H1. It was surprisingly shown that histones, in particular histone Hl, can be used for the preparation of a pharmaceutical composition for treatment and/or prevention of acute and chronic injuries to the central and peripheral nervous system, for promoting growth and/or regrowth of nerves and enhancing formation of synapses and synaptic plasticity, and for neuroprotection.
摘要翻译：本发明涉及急性和慢性损伤的中枢和周围神经系统的神经损伤和神经再生和神经功能的治疗。本发明提供包含组蛋白例如H1的药物组合物。惊奇地发现，组蛋白，特别是组蛋白H1可以用于制备用于治疗和/或预防中枢和周围神经系统的急性和慢性损伤的药物组合物，用于促进神经的生长和/或再生长并增强突触的形成和突触可塑性，并用于神经保护。

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