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1. 发明申请

WO2005009465A1 METHODS AND COMPOSITIONS FOR INCREASING THE EFFICIENCY OF THERAPEUTIC ANTIBODIES USING NK CELL POTENTIATING COMPOUNDS 审中-公开
标题翻译：使用NK细胞潜在化合物提高治疗性抗体效率的方法和组合物
公开(公告)号：WO2005009465A1
公开(公告)日：2005-02-03
申请号：PCT/IB2004/002636
申请日：2004-07-23
申请人： INNATE PHARMA , UNIVERSITA DEGLI STUDI DI PERUGIA , VELARDI, Andrea , ROMAGNE, François
发明人： VELARDI, Andrea , ROMAGNE, François
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K2035/124 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K2317/732 , C07K2317/76 , C12N5/0646 , G01N33/5047 , G01N2333/70535 , G01N2500/10
摘要： The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.
摘要翻译：本发明一般涉及提高治疗性抗体效率的方法和组合物。通过增加ADCC机制，提高效率。更具体地说，本发明涉及治疗性抗体与阻断NK细胞的抑制性受体或刺激NK细胞的激活受体的化合物的组合的用途，以提高人受试者用治疗性抗体治疗的效率。

2. 发明申请

WO2022101948A1 OMEGA-3 POLYUNSATURATED FATTY ACIDS FOR TREATING / PREVENTING MALE INFERTILITY IN PREPUBERTAL CANDIDATES FOR GONADOTOXIC THERAPIES 审中-公开
公开(公告)号：WO2022101948A1
公开(公告)日：2022-05-19
申请号：PCT/IT2021/050364
申请日：2021-11-09
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA
发明人： LUCA, Giovanni , CALAFIORE, Riccardo , VECCHINI, Alba , MANCUSO, Francesca , ARATO, Iva , CECCARELLI, Veronica
IPC分类号： A61K31/00 , A61K31/015 , A61K31/095 , A61K31/136 , A61K31/198 , A61K31/202 , A61K31/205 , A61K31/337 , A61K31/355 , A61K31/375 , A61K31/475 , A61K31/519 , A61K31/655 , A61K31/7048 , A61K33/243 , A61K33/30 , A61K38/00 , A61K45/06 , A61P15/08
摘要： The present invention relates to ω-3 polyunsaturated fatty acids for use in the prevention and treatment of male infertility in prepubertal subjects undergoing chemotherapeutic and/or radiotherapeutic treatments for the treatment of neoplasms.

3. 发明申请

WO2010131285A1 MURINE MODEL FOR MALE INFERTILITY OBTAINED BY GLUCOCORTICOID-INDUCED LEUCINE ZIPPER GENE INACTIVATION, METHOD FOR THE PREPARATION AND RELATIVE USES 审中-公开
标题翻译：由葡萄糖激活诱导的丝裂殖酵母基因失活获得的雄性不育症的模型，制备和相关用途的方法
公开(公告)号：WO2010131285A1
公开(公告)日：2010-11-18
申请号：PCT/IT2010/000209
申请日：2010-05-12
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA , BRUSCOLI Stefano , RICCARDI, Carlo
发明人： BRUSCOLI Stefano , RICCARDI, Carlo
IPC分类号： C07K14/47 , C12N15/85 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/03 , C07K14/4705 , C12N15/8509
摘要： Murine model obtained by inactivation of Glucocorticoid-lnduced Leucine Zipper gene, method for preparation and uses thereof. The present invention concerns mice to be used as animal model for the study male infertility, mice generated by genetic modification involving the suppression of GILZ gene expression.
摘要翻译：通过灭活糖皮质激素诱导的亮氨酸拉链基因获得的鼠模型，其制备方法及其用途。本发明涉及用作研究男性不育症的动物模型的小鼠，通过涉及抑制GILZ基因表达的遗传修饰产生的小鼠。

4. 发明申请

WO2008096234A3 METHOD FOR SWITCHING THE POSITION OF A VEHICLE'S HEADLAMPS 审中-公开
公开(公告)号：WO2008096234A3
公开(公告)日：2008-08-14
申请号：PCT/IB2008/000254
申请日：2008-02-06
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA , BIDINI, Gianni , BARELLI, Linda , BONUCCI, Fabio
发明人： BIDINI, Gianni , BARELLI, Linda , BONUCCI, Fabio
IPC分类号： G06K9/00 , B60Q1/14
摘要： Method for switching the headlights of a vehicle from full beam to the dipped position and vice versa, said vehicle being provided with at least one image acquisition sensor facing in the direction in which the vehicle is travelling and suitable for detecting the presence of at least one second vehicle, comprising the steps of: a. acquiring by means of said at least one acquisition sensor one or more successive images having a plurality of chromatic shade levels; b. splitting each of said at least one or more images acquired into an array of cells, each cell of said array of cells being associated with an intensity value which corresponds to the chromatic shade level identified for said one or more images during step a) of the method; c. processing each cell of said array of cells to identify the presence of said at least one second vehicle; d. switching the position of the headlights from full beam to the dipped position according to the presence of said at least one second vehicle detected during step c) of the method; characterised in that step c) of the method comprises the step of: e. calculating for each array of cells one or more areas of greater intensity according to the maximum intensity value identified on at least one cell of said array of cells; f. calculating the relative distance between said two vehicles by comparing the areas of greater intensity identified during step e) of the method with one or more previously defined reference values.

5. 发明申请

WO2022254397A1 TRANSDUCER FOR THE MEASUREMENT OF THE VIBRATIONS OF A BODY, OR OF THE PRESSURES OR FORCES ACTING ON THE BODY, AND RELATIVE APPARATUS FOR MEASURING THE VIBRATIONS, OR PRESSURES OR FORCES 审中-公开
公开(公告)号：WO2022254397A1
公开(公告)日：2022-12-08
申请号：PCT/IB2022/055197
申请日：2022-06-03
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA
发明人： ALIMENTI, Federico , MEZZANOTTE, Paolo , PALAZZI, Valentina , ROSELLI, Luca
IPC分类号： G01H1/00 , G01H11/06 , G01H13/00 , G01L1/10
摘要： Transducer (1) for measuring the vibrations of a body (100), or the pressure or the force acting on said body (100), comprising at least one passive component (2) having at least one first port (21) configured to acquire a first signal at known frequency (F) and at least one second port (22) configured for the transmission of a second signal (FA) modulated in the band of said signal at known frequency (F), or configured for the transmission of a signal, said passive component (2) comprising at least one microwave circuit (C), constrainable integrally to said body (100), functionally associated with said at least one first port (21) and said at least one second port (22), and configured for the amplitude or phase modulation of said first signal (F) at known frequency as input to said first port (21) and transforming it into said second signal (FA) as output from said second port (22), depending on the force transmitted from said body to said microwave circuit, at least when said body is subjected to a vibration, or configured to generate a microwave signal (P22) as output from said second port (22), variable depending on the pressure, or force, acting on said body.

6. 发明申请

WO2019234720A1 RECONFIGURABLE RADIO FREQUENCY DISTRIBUTION NETWORK 审中-公开
公开(公告)号：WO2019234720A1
公开(公告)日：2019-12-12
申请号：PCT/IB2019/054798
申请日：2019-06-10
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA
发明人： PALAZZI, Valentina , ROSELLI, Luca , MEZZANOTTE, Paolo , ALIMENTI, Federico
IPC分类号： H01Q3/40 , H01Q3/28 , H01Q3/36
摘要： The reconfigurable radio frequency distribution network (1) comprises: - a conditioning network (2) provided with at least one input port and with a plurality of output ports and configured to split an input signal (IN) into a plurality of output signals (ij) having equal amplitude and respective phases; - a sorting network (3) provided with a plurality of input ports connected to the output ports of the conditioning network (2) and with a plurality of output ports, the sorting network (3) being configured to split each input signal (ij) into a plurality of signals, having equal amplitude and predefined phase shift, in turn addressed to each of the output ports.

7. 发明申请

WO2018109729A1 COLORED CEMENT MORTARS WITH OPTIMIZED THERMAL AND OPTOENERGETIC PROPERTIES 审中-公开
公开(公告)号：WO2018109729A1
公开(公告)日：2018-06-21
申请号：PCT/IB2017/057979
申请日：2017-12-15
申请人： UNIVERISTA' DEGLI STUDI DI ROMA "LA SAPIENZA" , UNIVERSITA' DEGLI STUDI DI PERUGIA
发明人： ROSSO, Federica , FERRERO, Marco , PISELLO, Anna Laura , COTANA, Franco
IPC分类号： C04B28/04
CPC分类号： C04B28/04 , C04B2111/802 , C04B2111/82 , C04B14/22 , C04B2103/54 , C04B14/022 , C04B14/30 , C04B14/305 , C04B14/308
摘要： A method for preparing a colored cement mortar, comprising the step of mixing white Portland cement, glass aggregates and at least one pigment composition. The pigment composition comprises a mixture of an infrared-reflecting white pigment, having an intrinsic reflectance of more than 40% in the entire range 800-2500nm, with at least one colored pigment selected from the group consisting of black pigment having an intrinsic reflectance of less than 10% in the entire range 800-2500nm, red pigment having an intrinsic reflectance of less than 55% in the entire range 800-2500nm, and blue pigment having an intrinsic reflectance of less than 70% in the entire range 800-2500nm.

8. 发明申请

WO2017055930A1 TRANSGENIC MOUSE MODEL OF NEUROINFLAMMATORY DISORDERS OF MOTORIAL FUNCTION 审中-公开
标题翻译：动物功能神经炎性疾病的转基因鼠模型
公开(公告)号：WO2017055930A1
公开(公告)日：2017-04-06
申请号：PCT/IB2016/001594
申请日：2016-09-29
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA , EUROPEAN MOLECULAR BIOLOGY LABORATORY
发明人： RICCARDI, Carlo , BERESHCHENKO, Oxana , BRUSCOLI, Stefano , NERLOV, Claus
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0356 , A01K2267/0368
摘要： A subject-matter of the present invention is a transgenic mouse model of neuroinflammatory disorders of motor function, in particular of demyelinating diseases, like multiple sclerosis, wherein the transgenic mouse is hemizygous and overexpresses a stabilized form of human beta-catenin from a single Rosa26 allele. A further subject- matter of the invention is the use of said model in the evaluation of potential pharmacological agents for the treatment of these pathologies, as well as diagnostic methods.
摘要翻译：本发明的主题是运动功能的神经炎症性疾病，特别是脱髓鞘性疾病如多发性硬化的转基因小鼠模型，其中转基因小鼠是半合子的，并且从单个Rosa26过表达人β-连环蛋白的稳定形式等位基因。本发明的另一个主题是所述模型在用于治疗这些病理学的潜在药理学试剂的评估中的用途以及诊断方法。

9. 发明申请

WO2015025259A1 INDOLE-3-ALDEHYDE FOR TREATING DYSREACTIVE IMMUNE DISORDERS 审中-公开
标题翻译：用于治疗散发性免疫缺陷病毒的吲哚-3-醛
公开(公告)号：WO2015025259A1
公开(公告)日：2015-02-26
申请号：PCT/IB2014/063953
申请日：2014-08-18
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA
发明人： ROMANI, Luigina , PUCCETTI, Paolo
IPC分类号： A61K45/06 , A61K31/404 , A61K35/74 , A61P29/00
CPC分类号： A61K31/404 , A61K35/74 , A61K35/747 , A61K45/06
摘要： The therapeutic use of bacteria, specifically but not only lactobacilli, which produce indole-3-aldehyde, or directly of indole-3-aldehyde itself, is proposed as a means of prevention and treatment of immune dysreactive disorders in which the hyper-inflammatory or autoimmune component represents the basic element.
摘要翻译：提出了治疗性使用细菌，特别是不仅产生吲哚-3-醛的乳杆菌，或直接由吲哚-3-醛本身的治疗用途，作为预防和治疗免疫功能异常反应障碍的手段，其中超炎症或自身免疫组分代表基本元素。

10. 发明申请

WO2010018608A1 SYSTEM FOR DETECTING PACING PULSES IN ELECTROCARDIOGRAM SIGNALS 审中-公开
标题翻译：用于检测电子邮件信号中的电流脉冲的系统
公开(公告)号：WO2010018608A1
公开(公告)日：2010-02-18
申请号：PCT/IT2009/000374
申请日：2009-08-07
申请人： UNIVERSITA' DEGLI STUDI DI PERUGIA , BANELLI, Paolo , POLPETTA, Alessandro
发明人： BANELLI, Paolo , POLPETTA, Alessandro
IPC分类号： A61B5/04 , A61B5/0452
CPC分类号： A61B5/04017 , A61B5/0428 , A61B5/7217
摘要： A method and a system for detecting pacing pulses in electrocardiogram (ECG) signals are presented. The method, and system are able to detect pacing pulses even when the ECG waveforms have low signal-to-electromyographic-noise (EMG) ratios. The system can be, in an exemplary embodiment, a part of a generic electrocardiograph. Shortly, in a first step, in order to prevent pacing pulse widening and thus their superimposition to physiological ECG components, the anolog ECG signal of a patient having a pacemaker is digitalised employing a high sampling rate,- thus, in a second step, the method detects the pacing pulses by means of a non-linear filtering (potentially after a linear filtering step) whose output is compared with a threshold.
摘要翻译：提出了一种用于检测心电图（ECG）信号中起搏脉冲的方法和系统。即使ECG波形具有低信噪比（EMG）比率，该方法和系统也能够检测起搏脉冲。在示例性实施例中，该系统可以是通用心电图仪的一部分。很快，在第一步骤中，为了防止起搏脉冲加宽并因此它们叠加到生理ECG分量，具有起搏器的患者的anolog ECG信号被采用高采样率进行数字化，因此在第二步骤中，方法通过将其输出与阈值进行比较的非线性滤波（可能在线性滤波步骤之后）来检测起搏脉冲。

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