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    • 8. 发明申请
    • USE OF ANTI-CD26 ANTIBODY LEVELS AS AUTOIMMUNE AND/OR INFLAMMATORY DISEASE BIOMARKERS
    • 使用抗-CD26抗体水平作为自身免疫和/或炎性疾病生物标志物
    • WO2017194779A1
    • 2017-11-16
    • PCT/EP2017/061537
    • 2017-05-12
    • SERVIZO GALEGO DE SAÚDE (SERGAS)UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    • PEGO REIGOSA, José MaríaCORDERO SANTAMARÍA, ÓscarVARELA CALVIÑO, Rubén
    • A61K31/00G01N33/564
    • The present invention relates to the use of anti-CD26 antibodies as markers for the screening, diagnosis or monitoring of human subjects having, or suspected to have an autoimmune and/or inflammatory disease, such as rheumatoid arthritis, in particular those in an early stage of the disease. More specifically, itrefersto an invitromethod for the screening of a subjecthaving,or suspected of having an autoimmune and/orinflammatory disease, such as rheumatoid arthritis, comprising the following steps: a)determining the levels of anti-CD26 IgG antibodies in an antibody-containing sample isolated from said subject; b)comparing the levels in said antibody-containing sample with a reference value; wherein an increase of the anti-CD26 IgG antibody levels in the subject sample with regard to said reference value is indicative of disease; and wherein said reference value corresponds to the anti-CD26 IgG antibody mean levels in healthy subjects.
    • 本发明涉及抗CD26抗体作为筛选,诊断或监测患有或疑似患有自身免疫性和/或炎症性疾病如人类风湿性关节炎 特别是那些处于疾病早期阶段的人。 更具体地说,它涉及筛选患有或疑似患有自身免疫性和/或炎症性疾病如类风湿性关节炎的受试者的方法,包括以下步骤:a)测定含有抗体的患者中抗CD26IgG抗体的水平 从所述受试者分离的样品; b)将所述含有抗体的样品中的水平与参考值进行比较; 其中受试者样品中抗CD26IgG抗体水平相对于所述参考值的增加指示疾病; 并且其中所述参考值对应于健康受试者中的抗CD26IgG抗体平均水平。