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1. 发明申请

WO2007099401A3 ONCOLYTIC ATTENUATED REOVIRUSES FOR TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增生性疾病的肿瘤性衰竭性病毒
公开(公告)号：WO2007099401A3
公开(公告)日：2008-03-13
申请号：PCT/IB2006004149
申请日：2006-07-31
申请人： UNIV TECHNOLOGIES INT , KIM MANBOK , JOHNSTON RANDAL N
发明人： KIM MANBOK , JOHNSTON RANDAL N
IPC分类号： C12N7/00 , A61K35/76 , A61P35/00 , C12N7/04
CPC分类号： C12N7/00 , A61K35/765 , C12N2720/12232 , C12N2720/12264
摘要： Compositions and methods are provided that relate to an attenuated reovirus exhibiting oncolytic activity toward cancer cells while displaying reduced lytic activity toward non-malignant cells. Exemplified is an attenuated human reovirus derived from persistently infected fibrosarcoma cells that lacks wild-type reovirus S1 and S4 genes and consequently lacks a detectable reoviral outer capsid sl protein and expresses a mutated reoviral outer capsid s3 protein.
摘要翻译：提供了组合物和方法，其涉及对癌细胞展现溶瘤活性的减毒呼肠孤病毒，同时显示对非恶性细胞的溶解活性降低。示例是来源于持续感染的纤维肉瘤细胞的减毒人呼肠孤病毒，其缺乏野生型呼肠孤病毒S1和S4基因，因此缺少可检测的呼肠孤病毒外壳SL蛋白并表达突变的呼肠孤病毒外衣壳蛋白s3蛋白。

2. 发明申请

WO2004062462A8 MONCLONAL ANITBODIES TO RNA BINDING PROTEIN GW182 审中-公开
公开(公告)号：WO2004062462A8
公开(公告)日：2005-04-07
申请号：PCT/IB2004000100
申请日：2004-01-16
申请人： UNIV TECHNOLOGIES INT , FRITZLER MARVIN J
发明人： FRITZLER MARVIN J
IPC分类号： A61B20060101 , C07K16/18 , G01N33/53 , G01N33/564
CPC分类号： G01N33/564 , C07K16/18 , G01N33/6875
摘要： The present invention includes antibodies to human GW182 protein and the use of those antibodies in clinical and diagnostic assays.

3. 发明申请

WO2007030935A3 METHODS AND APPARATUSES FOR PROCESSING SPREAD SPECTRUM SIGNALS 审中-公开
标题翻译：处理扩频信号的方法和设备
公开(公告)号：WO2007030935A3
公开(公告)日：2007-05-03
申请号：PCT/CA2006001511
申请日：2006-09-13
申请人： UNIV TECHNOLOGIES INT , SHANMUGAM SURENDRAN KONAVATTAM , NIELSEN JORGEN , LACHAPELLE GERARD , WATSON ROBERT
发明人： SHANMUGAM SURENDRAN KONAVATTAM , NIELSEN JORGEN , LACHAPELLE GERARD , WATSON ROBERT
IPC分类号： H04B1/16
CPC分类号： H04B1/7075 , G01S19/24 , G01S19/30 , H04B1/709 , H04B2201/70715
摘要： A method and apparatus of processing the received spread spectrum signals using an innovative pre-filtering and multi-correlation differential detection (MCDD) technique is disclosed. The primary embodiment of the invention comprises of a pre-filter and pluralities of complex differential detectors for primary processing of SS signal. Other embodiments of the method and apparatus include pre-filter bank, correlator bank and correlation combiner. More specifically (but not limited to), it is directed towards to the enhancement of acquisition and/or tracking performance of SS receivers.
摘要翻译：公开了一种使用创新的预滤波和多相关差分检测（MCDD）技术处理接收的扩频信号的方法和设备。本发明的主要实施例包括用于SS信号的初级处理的预滤波器和多个复数差分检测器。该方法和设备的其他实施例包括预滤波器组，相关器组和相关组合器。更具体地（但不限于），其目的在于增强SS接收机的采集和/或跟踪性能。

4. 发明申请

WO2004062462A2 MONCLONAL ANITBODIES TO RNA BINDING PROTEIN GW182 审中-公开
标题翻译： RNA结合蛋白GW182的单克隆抗体
公开(公告)号：WO2004062462A2
公开(公告)日：2004-07-29
申请号：PCT/IB2004000100
申请日：2004-01-16
申请人： UNIV TECHNOLOGIES INT , FRITZLER MARVIN J
发明人： FRITZLER MARVIN J
IPC分类号： A61B20060101 , C07K16/18 , G01N33/53 , G01N33/564 , A61B
CPC分类号： G01N33/564 , C07K16/18 , G01N33/6875
摘要： The present invention includes antibodies to human GW182 protein and the use of those antibodies in clinical and diagnostic assays.
摘要翻译：本发明包括人GW182蛋白的抗体和这些抗体在临床和诊断测定中的用途。

5. 发明申请

WO0220537A3 LINKER PHOSPHORAMIDITES FOR OLIGONUCLEOTIDE SYNTHESIS 审中-公开
标题翻译：用于寡核苷酸合成的连接磷酸酰胺
公开(公告)号：WO0220537A3
公开(公告)日：2002-09-06
申请号：PCT/CA0101263
申请日：2001-09-10
申请人： UNIV TECHNOLOGIES INT , PON RICHARD T , YU SHUYUAN
发明人： PON RICHARD T , YU SHUYUAN
IPC分类号： C07H19/073 , C07B61/00 , C07H19/00 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C07H19/06 , C07H19/16
CPC分类号： C07H19/10 , C07B2200/11 , C07H19/00 , C07H19/20 , C07H21/00 , C40B40/00
摘要： A novel approach for combining the ease of cleavage of carboxylic acid linker arms with the single phosphoramidite coupling chemistry of the universal supports useful in oligonucleotide synthesis. There is disclosed a new class of phosphoramidite reagents, linker phosphoramidites, which contain a bifunctional linker arm with a protected nucleoside linked through a 3'-ester bond on one end and a reactive phosphoramidite group or other phosphate precursor group on the other end. The phosphoramidite group on the linker phosphoramidite may be activated under the same conditions and has similar reactivity as conventional nucleoside-3'-phosphoramidite reagents lacking the intermediate linker arm. The 3'-ester linkage contained within the linker phosphoramidite has similar properties to the linkages on prederivatized supports. The ester linkage is stable to all subsequent synthesis steps, but upon treatment with a cleavage reagent, such as ammonium hydroxide, the ester linkage is hydrolyzed. This releases the oligonucleotide product with the desired 3'-hydroxyl terminus and leaves the phosphate portion of the reagent attached to the support, which is subsequently discarded.
摘要翻译：将羧酸接头臂的易切割性与用于寡核苷酸合成的通用载体的单一亚磷酰胺偶联化学结合起来的新方法。公开了一类亚磷酰胺试剂，连接亚磷酰胺，其含有双功能连接臂，其具有通过一端上的3'-酯键连接的被保护的核苷酸和另一端的反应性亚磷酰胺基团或其它磷酸酯前体基团。连接亚磷酰胺上的亚磷酰胺基团可以在相同条件下被活化，并且与缺少中间连接臂的常规核苷-3'-亚磷酰胺试剂具有相似的反应性。连接子亚磷酰胺中含有的3'-酯键具有与预衍生载体上的连接相似的性质。酯键对所有随后的合成步骤是稳定的，但是当用切割试剂如氢氧化铵处理时，酯键被水解。这释放出具有所需的3'-羟基末端的寡核苷酸产物并留下附着在载体上的试剂的磷酸部分，随后将其弃去。

6. 发明申请

WO9963078A3 RETINAL CALCIUM CHANNEL (ALPHA)1F-SUBUNIT GENE 审中-公开
标题翻译：离子钙通道（ALPHA）1F亚基因
公开(公告)号：WO9963078A3
公开(公告)日：2000-04-13
申请号：PCT/CA9900514
申请日：1999-06-02
申请人： UNIV TECHNOLOGIES INT , BECH HANSEN TORBEN , NAYLOR MARGARET JANE
发明人： BECH-HANSEN TORBEN , NAYLOR MARGARET JANE
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C12Q1/68
CPC分类号： C07K14/705
摘要： This present invention relates to calcium channel compositions. In particular, this invention relates to a mammalian gene, herein referred to as CACNA1F, encoding an (alpha)1F-subunit of a retinal calcium channel. Mutations of CACNA1F may cause a type of X-linked congenital stationary night blindness known as incomplete CSNB, and may also cause Aaland Island Eye Disease, which may be clinically indistinguishable from incomplete CSNB.
摘要翻译：本发明涉及钙通道组合物。特别地，本发明涉及编码视网膜钙通道的（α）1F亚基的哺乳动物基因，本文称为CACNA1F。 CACNA1F的突变可能导致称为不完全CSNB的X型先天性固定夜盲型，也可能导致阿兰德岛眼病，这可能在临床上与不完全的CSNB无法区分。

7. 发明申请

WO9963078A9 RETINAL CALCIUM CHANNEL (ALPHA)1F-SUBUNIT GENE 审中-公开
标题翻译：视网膜钙通道（ALPHA）1F亚单位基因
公开(公告)号：WO9963078A9
公开(公告)日：2000-03-09
申请号：PCT/CA9900514
申请日：1999-06-02
申请人： UNIV TECHNOLOGIES INT , BECH HANSEN TORBEN , NAYLOR MARGARET JANE
发明人： BECH-HANSEN TORBEN , NAYLOR MARGARET JANE
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C12Q1/68
CPC分类号： C07K14/705
摘要： This present invention relates to calcium channel compositions. In particular, this invention relates to a mammalian gene, herein referred to as CACNA1F, encoding an (alpha)1F-subunit of a retinal calcium channel. Mutations of CACNA1F may cause a type of X-linked congenital stationary night blindness known as incomplete CSNB, and may also cause Aaland Island Eye Disease, which may be clinically indistinguishable from incomplete CSNB.
摘要翻译：本发明涉及钙通道组合物。具体而言，本发明涉及编码视网膜钙通道的α1F亚基的哺乳动物基因，本文称为CACNA1F。 CACNA1F突变可能导致一种X连锁的先天性静止性失明，称为不完全性CSNB，也可能导致Aaland Island眼病，与临床上不完全的CSNB可能无法区分。

8. 发明申请

WO9940212A3 BACTERIOPHAGE VECTORS GENERATED BY BACTERIOPHAGE/PLASMID RECOMBINATION 审中-公开
标题翻译：细菌/浆液重组产生的细菌向量
公开(公告)号：WO9940212A3
公开(公告)日：1999-12-23
申请号：PCT/CA9900091
申请日：1999-02-03
申请人： UNIV TECHNOLOGIES INT
发明人： RANCOURT DERRICK E , TSUZUKI TERUHISA
IPC分类号： A61K48/00 , C12N7/01 , C12N15/10 , C12N15/85 , C12N15/90 , C12N7/00
CPC分类号： C12N15/1082 , A61K48/00 , C12N15/1034 , C12N15/85 , C12N15/902 , C12N2830/38
摘要： The present invention relates to methods for the generation of lambda ( lambda ) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins, methods for the identification of a lambda or P1 bacteriophage vector having a desired nucleic acid from an assortment or library of bacteriophage each having a different nucleic acid insert and the use of such vectors in gene targeting and the expression of genes and protein.
摘要翻译：本发明涉及用于产生可用于真核细胞的靶向诱变的λ（λ）或P1噬菌体载体的方法和基因和蛋白质的表达，用于鉴定具有所需核酸的λ或P1噬菌体载体的方法，各自具有不同核酸插入物的噬菌体的分类或文库，以及这些载体在基因靶向中的用途以及基因和蛋白质的表达。

9. 发明申请

WO9739130A2 METHOD FOR EXPRESSING AND SECRETING KERATINASE 审中-公开
标题翻译：表达和分泌克拉霉素的方法
公开(公告)号：WO9739130A2
公开(公告)日：1997-10-23
申请号：PCT/US9706477
申请日：1997-04-16
申请人： UNIV NORTH CAROLINA STATE , UNIV TECHNOLOGIES INT , SHIH JASON C H , LIN XIANG , WONG SUI LAM
发明人： SHIH JASON C H , LIN XIANG , WONG SUI-LAM
IPC分类号： C12N1/21 , C12N9/56 , C12N15/57 , C12N15/62 , C12N15/75
CPC分类号： C12N9/54 , C07K2319/02
摘要： The present invention provides a Bacillus subtilis host cell capable of expressing and secreting keratinase. The host cell contains a recombinant DNA molecule comprising vector DNA and DNA encoding Bacillus licheniformis PWD-1 keratinase enzyme operatively associated therewith. The present invention also provides a method for producing keratinase enzyme. The method includes the steps of (a) culturing a Bacillus subtilis host cell containing a recombinant DNA molecule comprising vector DNA and DNA encoding Bacillus licheniformis PWD-1 keratinase enzyme operatively associated therewith, and (b) collecting keratinase enzyme from the cell culture.
摘要翻译：本发明提供能够表达和分泌角蛋白酶的枯草芽孢杆菌宿主细胞。宿主细胞包含重组DNA分子，其包含与其可操作地相关联的载体DNA和编码地衣芽孢杆菌PWD-1角蛋白酶的DNA。本发明还提供了生产角蛋白酶的方法。该方法包括以下步骤：（a）培养含有重组DNA分子的枯草芽孢杆菌宿主细胞，所述重组DNA分子包含载体DNA和编码与其可操作地相关联的地衣芽孢杆菌PWD-1角蛋白酶的DNA，和（b）从细胞培养物收集角蛋白酶。

10. 发明申请

WO9110140A3 METHODS FOR MODELLING TERTIARY STRUCTURES OF BIOLOGICALLY ACTIVE LIGANDS INCLUDING AGONISTS AND ANTAGONISTS THERETO AND NOVEL SYNTHETIC ANTAGONISTS BASED ON ANGIOTENSIN 审中-公开
标题翻译：用于建模生物活性配体的临床结构的方法，包括基于ANGIOTENSIN的激动剂和拮抗剂和新型合成拮抗剂
公开(公告)号：WO9110140A3
公开(公告)日：1992-04-02
申请号：PCT/CA9000457
申请日：1990-12-28
申请人： UNIV TECHNOLOGIES INT
发明人： MOORE GRAHAM J , MATSOUKAS JOHN M
IPC分类号： G01N21/64 , G01N24/08 , G01N33/68
CPC分类号： G01N24/08 , G01N21/6408 , G01N33/68
摘要： Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method as well as novel synthetic antagonists based on angiotensin.

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