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1. 发明申请

WO2005076827A3 FBSA COMPOSITIONS FOR USE IN PROMOTING FIBRINOGEN AGGREGATION AND POTENTIATING FIBRIN POLYMERIZATION 审中-公开
标题翻译：用于促进纤维蛋白聚集和增强纤维蛋白聚合的FBSA组合物
公开(公告)号：WO2005076827A3
公开(公告)日：2005-10-20
申请号：PCT/US2005002647
申请日：2005-02-02
申请人： UNIV PAVIA , BATES SARAH E , SPEZIALE PIETRO
发明人： SPEZIALE PIETRO
IPC分类号： A61K38/00 , C07K14/00 , C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61L24/001 , A61L24/106
摘要： A composition containing the FbsA protein from Streptococcus agalactiae is provided which is effective in potentiating the polymerization of fibrin or in promoting fibrinogen aggregates so as to be useful as a wound sealant, and a pharmaceutically acceptable vehicle, carrier or excipient. Methods of treating patients by administering an amount of FbsA effective to promote aggregation of fibrinogen so as to promote blood clotting and wound sealing, or an amount effective to potentiate polymerization of fibrin so as to be useful as a fibrin wound sealant or an adjuvant for a fibrin wound sealant are also provided, and said methods are particularly advantageous in treating wounds without the need for sutures or staples in a variety of medical applications.
摘要翻译：提供了含有来自无乳链球菌的FbsA蛋白质的组合物，其有效地加强纤维蛋白的聚合或促进纤维蛋白原聚集体，从而可用作伤口密封剂和药学上可接受的载体，载体或赋形剂。通过给予一定量的有效促进纤维蛋白原凝集从而促进凝血和伤口密封的FbsA或有效增强纤维蛋白聚合的量以便用作纤维蛋白伤口密封剂或佐剂用于治疗患者的方法还提供纤维蛋白伤口密封剂，并且所述方法在治疗伤口方面是特别有利的，而不需要缝合或钉在各种医疗应用中。

2. 发明申请

WO2005039412A9 A MOTOR FUNCTION TEST SYSTEM 审中-公开
标题翻译：电机功能测试系统
公开(公告)号：WO2005039412A9
公开(公告)日：2005-06-23
申请号：PCT/IT0300660
申请日：2003-10-24
申请人： HUMANITAS MIRASOLE SPA , UNIV PAVIA , PANELLA LORENZO , BUIZZA ANGELO , LOMBARDI REMO , BELTRAMI GIORGIO , GANDOLFI ROBERTO
发明人： PANELLA LORENZO , BUIZZA ANGELO , LOMBARDI REMO , BELTRAMI GIORGIO , GANDOLFI ROBERTO
IPC分类号： A61B5/103 , A61B5/11
CPC分类号： A61B5/4023 , A61B5/1036 , A61B5/1116 , A61B5/1124
摘要： The present finding relates to a motor function test system as well as to a method of acquisition and collection of the signals and their processing into the corresponding parameters for a motor function test. In particular, said system and method relate to the quantification of the performance of a subject during the evaluation of balance as defined by the Tinetti test.
摘要翻译：本发明涉及一种电动机功能测试系统，以及一种将信号及其处理的采集和采集方法用于电机功能测试的相应参数。特别地，所述系统和方法涉及在由Tinetti测试定义的平衡评估期间对受试者的表现的量化。

3. 发明申请

WO2004108652A3 ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF METHYL DIHYDROEPIJASMONATE 审中-公开
标题翻译：用于制备甲基二氢氨基甲酸酯的选择性方法
公开(公告)号：WO2004108652A3
公开(公告)日：2005-03-24
申请号：PCT/EP2004050975
申请日：2004-06-01
申请人： UNIV PAVIA , VIDARI GIOVANNI , ZANONI GIUSEPPE , PORTA ALESSIO
发明人： VIDARI GIOVANNI , ZANONI GIUSEPPE , PORTA ALESSIO
IPC分类号： C07C67/303 , C07C67/313
CPC分类号： C07C67/303 , C07B2200/07 , C07C2601/08 , C07C69/716
摘要： An enantioselective process is described for the preparation of methyl dihydroepijasmonate, a compound widely used in cosmetic and perfumes for its fragrant properties.
摘要翻译：描述了一种对映选择性方法，用于制备广泛用于化妆品和香料中用于其芳香性质的化合物的二氢表肟酸甲酯。

4. 发明申请

WO2010085977A1 HEAD IMPULSE TESTING DEVICE FOR ASSESSING THE FUNCTIONALITY OF THE SEMICIRCULAR CANALS AND FOR THE REHABILITATION OF VESTIBULAR LOSS 审中-公开
标题翻译：用于评估半圆形管的功能性和用于恢复大脑损失的头部冲击测试装置
公开(公告)号：WO2010085977A1
公开(公告)日：2010-08-05
申请号：PCT/EP2009000611
申请日：2009-01-30
申请人： UNIV PAVIA , RAMAT STEFANO , MANDALA MARCO
发明人： RAMAT STEFANO , MANDALA MARCO
IPC分类号： A61B3/028 , A61B5/11
CPC分类号： A61B5/11 , A61B3/028 , A61B5/4023 , A61B5/6803 , A61B2562/0219
摘要： The present invention concerns a system as well as a method for the evaluation of the vestibular functionality in a subject. The system comprises a display unit for showing a visual target such as an optotype to the patient, a device for measuring rotational acceleration that rotates integrally with the patient's head, and a recording unit. The method of the invention may also be suitably used for the rehabilitation of the peripheral vestibular functionality.
摘要翻译：本发明涉及用于评估受试者的前庭功能的系统和方法。该系统包括用于向患者显示诸如视标的视觉目标的显示单元，用于测量与患者头部整体旋转的旋转加速度的装置以及记录单元。本发明的方法也可适用于外周前庭功能的康复。

5. 发明申请

WO2006106400A3 CAPSULES CONTAINING SEMINAL MATERIAL FOR ARTIFICIAL INSEMINATION 审中-公开
标题翻译：包含用于人工清除的研究材料的胶囊
公开(公告)号：WO2006106400A3
公开(公告)日：2007-03-22
申请号：PCT/IB2006000768
申请日：2006-04-03
申请人： UNIV DEGLI STUDI MILANO , UNIV PAVIA , VIGO DANIELE , TORRE MARIA LUISA , FAUSTINI MASSIMO , MUNARI ELEONORA , RUSSO VINCENZO , CONTE UBALDO
发明人： VIGO DANIELE , TORRE MARIA LUISA , FAUSTINI MASSIMO , MUNARI ELEONORA , RUSSO VINCENZO , CONTE UBALDO
IPC分类号： A61K9/50 , A61D19/02 , A61K35/52
CPC分类号： A61K35/52 , A61D19/022 , A61K9/501 , A61K9/5036 , A61K9/5089
摘要： Capsules or microcapsules comprising: a) a nucleus containing seminal material or the spermatozoa of animal species chosen from the group consisting of equids, buffalo, ovicaprids, canids, felids, lagomorphs, laboratory animal species chosen from mice and rats, and possibly man, b) a membrane of a bivalent or trivalent metal alginate.
摘要翻译：胶囊或微胶囊包含：a）含有选自下组的精液或精子的细胞核，其选自马匹，水牛，卵磷脂，犬科动物，蛙科动物，拉姆霉素，选自小鼠和大鼠的实验室动物，以及可能的人，b ）二价或三价金属藻酸盐的膜。

6. 发明申请

WO2005041942A3 THREE-DIMENSIONAL MAMMALIAN OVARIAN FOLLICULAR CELL AND OVARIAN FOLLICLE CULTURE SYSTEMS IN A BIOCOMPATIBLE MATRIX 审中-公开
标题翻译：生物化学矩阵中的三维MAMMALIAN OVARIAN细胞和OVARIAN FOLLICLE文化系统
公开(公告)号：WO2005041942A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004012384
申请日：2004-11-02
申请人： UNIV DEGLI STUDI MILANO , UNIV PAVIA , UNIV BOLOGNA , VIGO DANIELE , RUSSO VINCENZO , FAUSTINI MASSIMO , STACCHEZZINI SIMONA , CONTE UBALDO , TORRE MARIA LUISA , ACCORSI PIER ATTILIO , GALEATI GIOVANNA , SPINACI MARCELLA
发明人： VIGO DANIELE , RUSSO VINCENZO , FAUSTINI MASSIMO , STACCHEZZINI SIMONA , CONTE UBALDO , TORRE MARIA LUISA , ACCORSI PIER ATTILIO , GALEATI GIOVANNA , SPINACI MARCELLA
IPC分类号： A61K9/16 , A61K9/50 , A61K35/48 , C12N5/00 , C12N5/075 , C12N11/00 , C12N5/08
CPC分类号： C12N5/0609 , A61K9/5036 , A61K35/48 , C12N5/0012 , C12N2502/243 , C12N2533/74
摘要： A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro, and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules are constituted by: a nucleus containing stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos and/or a biocompatible and/or biodegradable polymer; a semi-permeable membrane constituted by a divalent or trivalent metal ion salt of alginic acid, optionally cross-linked on the inner and/or outer surface and/or on both surfaces, optionally vehicularising a second or more cellular species. The cells and follicles prepared and cultivated using this methodology are used for the in vitro and/or in vivo production of peptides, proteins, antibodies, hormones and hormone precursors, metabolites and catabolites typical of these cellular structures, plasma membranes, nuclear membranes, cytoplasmic organelles, somatic cell nuclei or gametes and embryos.
摘要翻译：一种封装和固定能够在体外自动组织成三维结构的哺乳动物干细胞，卵泡滤泡细胞，配子，卵泡或哺乳动物胚胎的方法，并以类似于描述体内生物体。胶囊由以下组成：含有干细胞，卵泡滤泡细胞，配子，卵泡或哺乳动物胚胎和/或生物相容性和/或可生物降解的聚合物的细胞核; 由藻酸的二价或三价金属离子盐构成的半透膜，任选地在内表面和/或外表面上和/或两个表面上交联，任选地驱动第二种或更多种细胞物质。使用该方法制备和培养的细胞和滤泡用于体外和/或体内产生肽，蛋白质，抗体，激素和激素前体，这些细胞结构，质膜，核膜，细胞质的典型代谢物和分解代谢物细胞器，体细胞核或配子和胚胎。

7. 发明申请

WO2005010167A3 ANTIBODIES TO THE FBSA PROTEIN OF STREPTOCOCCUS AGALACTIAE AND THEIR USE IN TREATING OR PREVENTING INFECTIONS 审中-公开
标题翻译：抗结核药物FBSA蛋白的抗体及其在治疗或预防感染中的应用
公开(公告)号：WO2005010167A3
公开(公告)日：2005-06-16
申请号：PCT/US2004023701
申请日：2004-07-23
申请人： UNIV PAVIA , UNIV ULM , INHIBITEX INC , SPEZIALE PIETRO , REINSCHEID DIETER
发明人： SPEZIALE PIETRO , REINSCHEID DIETER
IPC分类号： A61K39/40 , C07K16/12 , G01N33/554 , G01N33/569 , G01N33/53
CPC分类号： C07K16/1275 , A61K2039/505 , C07K2317/76
摘要： Monoclonal and polyclonal antibodies are provided which can bind to the FbsA protein of Streptococcus agalactiae (GBS) and which can be used to prevent adherence of the bacteria to host cells and thus be useful in the treatment and protection against infection from S. agalactiae. The antibodies of the invention can also be raised against the fibrinogen binding domain of FbsA or the repeat region therein, and in addition to preventing bacterial adherence, the antibodies to FbsA are advantageous in that they can be used to prevent platelet aggregation and thrombus formation.
摘要翻译：提供可以结合无乳链球菌（GBS）的FbsA蛋白的单克隆和多克隆抗体，其可用于防止细菌粘附于宿主细胞，因此可用于治疗和防止无乳链球菌感染。本发明的抗体也可以针对FbsA的纤维蛋白原结合域或其中的重复区域产生，除了防止细菌粘附外，FbsA的抗体的优点在于它们可用于预防血小板聚集和血栓形成。

8. 发明申请

WO2006131528A3 MUTATIONS ASSOCIATED WITH THE LONG QT SYNDROME AND DIAGNOSTIC USE THEREOF 审中-公开
标题翻译：与长QT综合征相关的突变及其诊断用途
公开(公告)号：WO2006131528A3
公开(公告)日：2007-03-29
申请号：PCT/EP2006062956
申请日：2006-06-07
申请人： FOND SALVATORE MAUGERI CLINICA , UNIV PAVIA , PRIORI SILVIA GIULIANA
发明人： PRIORI SILVIA GIULIANA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention is based on the identification of new mutations in KCNQ1 (also termed KvLQTI), KCNH2 (also termed HERG), SCN5A, KCNE1 (also termed minK), KCNE2 (also termed MiRP) genes that encode ionic channels involved in cardiac electrical activity and are potentially responsible for the Long QT Syndrome. According to a main aspect, the invention relates to nucleic acids, oligonucleotides and polynucleotides and mRNA, containing sequences of KCNQ1 , KCNH2 SCN5A, KCNE1 , KCNE2 genes and cDNAs in a mutated form and to respective variant proteins thereof. A preferred embodiment of the present invention is represented by a diagnostic method based on the identification of a group of about 70 non-private mutations in the KCNQ1 , KCNH2 and SCN5A genes, detected at high frequency. The method, which is able to identify about 40% of the probands, is non exclusively based on identification of mutations that are described and characterized in this invention where said identification has both prognostic and diagnostic value for the Long QT Syndrome.
摘要翻译：本发明基于鉴定KCNQ1（也称为KvLQTI），KCNH2（也称为HERG），SCN5A，KCNE1（也称为minK），KCNE2（也称为MiRP）基因的新突变，其编码涉及心脏电的离子通道活动，并可能对长QT综合征负责。根据主要方面，本发明涉及包含KCNQ1，KCNH2 SCN5A，KCNE1，KCNE2基因和突变形式的cDNA及其各自变体蛋白质的序列的核酸，寡核苷酸和多核苷酸和mRNA。本发明的优选实施方案以基于鉴定在高频检测的KCNQ1，KCNH2和SCN5A基因中约70个非私人突变的组的诊断方法表示。能够鉴定约40％的先证者的方法不仅仅基于本发明描述和表征的突变的鉴定，其中所述鉴定对于长QT综合征具有预后和诊断价值。

9. 发明申请

WO2005123034A2 MICROPARTICULATE SYSTEMS FOR THE ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：用于生物活性物质的口服管理的微生物系统
公开(公告)号：WO2005123034A2
公开(公告)日：2005-12-29
申请号：PCT/IT2005000353
申请日：2005-06-20
申请人： UNIV DEGLI STUDI MILANO , UNIV PAVIA , VIGO DANIELE , RUSSO VINCENZO , FAUSTINI MASSIMO , PACE MARIO FRANCESCO , MUNARI ELEONORA , TORRE MARIA LUISA , CONTE UBALDO
发明人： VIGO DANIELE , RUSSO VINCENZO , FAUSTINI MASSIMO , PACE MARIO FRANCESCO , MUNARI ELEONORA , TORRE MARIA LUISA , CONTE UBALDO
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K9/1652 , A61K9/1623 , A61K9/1635 , A61K9/1694
摘要： The present invention relates to microparticulate systems consisting of a gastroresistant, biocompatible and biodegradable polymer matrix, comprising a gastroresistant and enterosoluble polymer, a cryoprotector or lyoprotector, a divalent or trivalent metal salt of i biocompatible and biodegradable polymer having acid groups, and biologically active substances. Such gastroresistant microparticulate systems are used for the administration, preferably oral, of biologically active substances to animal species. The special composition of such microparticulate systems allows the protection of said biologically active substances from degradation by proteases and gastric acid, allowing their release into the intestine, where they may perform their activities.
摘要翻译：本发明涉及由抗胃，生物相容性和可生物降解的聚合物基质组成的微粒体系，其包含胃耐溶性和肠溶性聚合物，冷冻保护剂或溶血保护剂，具有酸基的生物相容性和可生物降解的聚合物的二价或三价金属盐和生物活性物质。这种胃肠微粒体系用于向动物物种施用，优选口服生物活性物质。这种微粒体系的特殊组成允许所述生物活性物质的保护不被蛋白酶和胃酸降解，允许其释放到肠中，在那里它们可以进行其活性。

10. 发明申请

WO2007072535A8 MICROPARTICULATE SYSTEMS FOR THE ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
公开(公告)号：WO2007072535A8
公开(公告)日：2007-09-20
申请号：PCT/IT2006000874
申请日：2006-12-22
申请人： UNIV DEGLI STUDI MILANO , UNIV PAVIA , UNIV DEGLI STUDI SALERNO , VIGO DANIELE , FAUSTINI MASSIMO , SCOCCA SARAH , MUNARI ELEONORA , TORRE MARIA LUISA , CONTE UBALDO , DE SIMONE FRANCESCO , AQUINO RITA PATRIZIA , LAURO MARIA ROSARIA
发明人： VIGO DANIELE , FAUSTINI MASSIMO , SCOCCA SARAH , MUNARI ELEONORA , TORRE MARIA LUISA , CONTE UBALDO , DE SIMONE FRANCESCO , AQUINO RITA PATRIZIA , LAURO MARIA ROSARIA
IPC分类号： A61K9/16
CPC分类号： A61K9/1635 , A23K10/18 , A23K10/37 , A23K20/147 , A23K20/163 , A23K20/174 , A23K20/30 , A23K50/00 , A61K9/1617 , A61K9/1652 , Y02P60/877
摘要： The present invention relates to gastroresistant and enterosoluble microparticulate systems for the encapsulation of biologically active substances selected from: flavonoids, vitamins, antioxidants, immunostimulants, starchy and non-starchy polysaccharides, probiotics, prebiotics, intestinal trophism regulators, oligoelements, enzymes and bioactive peptides. Such microparticulate systems allow the administration of the aforementioned nutraceutic substances to animals such as porcines, bovines, caprines, ovines, equids, canids, felines, camelids, lagomorphs, rodents, fowl, and other mammals, including humans, fish and crustaceans, increasing the bioavailability.

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