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1. 发明申请

WO2009117185A3 NONDEGRADABLE HYDROGELS FOR MEDICAL DEVICE APPLICATION 审中-公开
标题翻译：医疗器械应用的非可控水压
公开(公告)号：WO2009117185A3
公开(公告)日：2010-07-01
申请号：PCT/US2009033337
申请日：2009-02-06
申请人： MEDTRONIC VASCULAR INC , UDIPI KISHORE , TRUDEL JULIE , GUO YA
发明人： UDIPI KISHORE , TRUDEL JULIE , GUO YA
IPC分类号： A61L31/04 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L71/02
摘要： Disclosed are nondegradable hydrogels used to coat or form at least a portion of a medical device. The hydrogels may be formed from functionalized PEG based macromers. These hydrogels are easy to sterilize, transport and store. Methods of forming these hydrogels as described herein are included.
摘要翻译：公开了用于涂覆或形成医疗装置的至少一部分的不可降解水凝胶。水凝胶可以由官能化的基于PEG的大分子单体形成。这些水凝胶易于消毒，运输和储存。包括如本文所述形成这些水凝胶的方法。

2. 发明申请

WO2003047462A1 POLYSACCHARIDE-BASED POLMERIZABLE HYDROGELS 审中-公开
标题翻译：基于聚合物的可聚合水凝胶
公开(公告)号：WO2003047462A1
公开(公告)日：2003-06-12
申请号：PCT/US2002/007320
申请日：2002-03-12
申请人： CLEMSON UNIVERSITY , MASSIA, Stephen , TRUDEL, Julie , BURDICK, Julie-Anne, M.
发明人： MASSIA, Stephen , TRUDEL, Julie , BURDICK, Julie-Anne, M.
IPC分类号： A61F2/02
CPC分类号： A61K31/785 , A61K31/765
摘要： A hydrogel is provided in which varying ratios of acrylyol-modified dextran molecules and acrylyol-modified hyaluronan products are cross-linked to from a hydrogel conjugate. The incorporation of the derivatized hyaluronan molcules allows a hydrogel to be constructed which may be degradged by hydrolysis and enzymatic pathways. This mechanism offers novel hydrogel which may be useful in medical applications including the prevention of surgical adhesions, controlled drug delivery, tissue coatings, tissue adherence, and tissue supporting structure, and the coating of medical devices and related articles prior to placement within a patient.
摘要翻译：提供了一种水凝胶，其中Acrylyol修饰的葡聚糖分子和丙烯醇修饰的透明质酸产物的不同比例与水凝胶缀合物交联。衍生化的透明质酸溶液的并入允许构建水凝胶，其可通过水解和酶途径降解。该机制提供了新颖的水凝胶，其可用于医疗应用，包括预防手术粘连，受控药物递送，组织涂层，组织粘附和组织支持结构，以及在放置在患者体内之前涂覆医疗器械和相关物品。

3. 发明申请

WO2011136882A1 SYSTEM AND METHOD FOR STENT MANUFACTURE 审中-公开
标题翻译：系统和方法的制造
公开(公告)号：WO2011136882A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/029545
申请日：2011-03-23
申请人： MEDTRONIC VASCULAR INC. , TRUDEL, Julie
发明人： TRUDEL, Julie
IPC分类号： A61L31/04 , A61L31/16 , A61F2/06
CPC分类号： A61L31/04 , A61F2/82 , A61F2240/001 , A61L31/16 , A61L2300/60 , A61L2300/608 , B29C33/44 , B29L2031/7542
摘要： The system and method for stent manufacture includes a method of supercritical stent manufacture including mixing a polymer and a supercritical fluid to form a supercritical mixture; electrically charging a mold to a first polarity, the mold having a mold wall defining a mold plenum; discharging the supercritical mixture through a nozzle; electrically charging the supercritical mixture to a second polarity opposite the first polarity; repeatedly directing the charged supercritical mixture into the mold plenum to form a plurality of polymer layers on the mold wall, the plurality of polymer layers having a predetermined thickness; and separating the plurality of polymer layers from the mold wall.
摘要翻译：用于支架制造的系统和方法包括超临界支架制造方法，包括混合聚合物和超临界流体以形成超临界混合物; 将模具充电至第一极性，所述模具具有限定模具增压室的模具壁; 通过喷嘴排出超临界混合物; 将超临界混合物充电至与第一极性相反的第二极性; 重复地将带电的超临界混合物引导到模具室中，以在模具壁上形成多个聚合物层，多个聚合物层具有预定的厚度; 并将多个聚合物层与模具壁分离。

4. 发明申请

WO2010059391A1 LARGE ANIMAL MODEL FOR HUMAN-LIKE ADVANCED ATHEROSCLEROTIC PLAQUE 审中-公开
标题翻译：人类先进的人体动物模型大动物模型
公开(公告)号：WO2010059391A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/062624
申请日：2009-10-29
申请人： MEDTRONIC VASCULAR INC. , TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
发明人： TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
IPC分类号： A01K67/027 , A01K49/00
CPC分类号： A01K67/027 , A01K2217/00 , A01K2227/108 , A01K2267/03 , A01K2267/0375
摘要： An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound.
摘要翻译：一种用于心血管疾病的动物模型，其包含在非人哺乳动物的血管片段内的选定位置处形成的一个或多个血管斑块损伤。通过向非人哺乳动物施用高胆固醇血症饮食来形成血管斑块损伤，在预先暴露于高胆固醇血症饮食之后对选定部位的血管壁施加损伤，并将水凝胶施加到损伤的血管壁。本发明的另一方面提供了一种用于评估对动脉粥样硬化病变形成的影响的测试化合物的方法，包括向非人类哺乳动物施用高胆固醇血症饮食，并且在限定的时间段之后，使用气囊导管分离血管的一段对隔离区段内的血管壁造成损伤，并在血管段内施用水凝胶。该方法还包括在损伤部位的血管壁上形成血管斑块损伤，将测试化合物递送至非人类哺乳动物，并在暴露于测试化合物的确定的时间段后监测受伤部位的动脉粥样硬化病变大小和组成。

5. 发明申请

WO2009117185A2 NONDEGRADABLE HYDROGELS FOR MEDICAL DEVICE APPLICATION 审中-公开
标题翻译：医疗器械应用的非可控水压
公开(公告)号：WO2009117185A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/033337
申请日：2009-02-06
申请人： MEDTRONIC VASCULAR INC. , UDIPI, Kishore , TRUDEL, Julie , GUO, Ya
发明人： UDIPI, Kishore , TRUDEL, Julie , GUO, Ya
IPC分类号： A61L31/04 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L71/02
摘要： Disclosed are nondegradable hydrogels used to coat or form at least a portion of a medical device. The hydrogels may be formed from functionalized PEG based macromers. These hydrogels are easy to sterilize, transport and store. Methods of forming these hydrogels as described herein are included.
摘要翻译：公开了用于涂覆或形成医疗装置的至少一部分的不可降解水凝胶。水凝胶可以由官能化的基于PEG的大分子单体形成。这些水凝胶易于消毒，运输和储存。包括如本文所述形成这些水凝胶的方法。

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