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1. 发明申请

WO2011127333A3 COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：用于治疗疾病，管理和药物组合物的化合物
公开(公告)号：WO2011127333A3
公开(公告)日：2012-02-02
申请号：PCT/US2011031654
申请日：2011-04-08
申请人： UNIV LOUISVILLE RES FOUND , TRENT JOHN O , MEIER JASON B , NAPIER KELBY B
发明人： TRENT JOHN O , MEIER JASON B , NAPIER KELBY B
IPC分类号： A61K31/36 , A61K31/41 , A61K31/4184 , A61K31/496 , A61P35/00
CPC分类号： C07D403/12 , A61K31/132 , A61K31/335 , A61K31/4015 , A61K31/4045 , A61K31/41 , A61K31/4184 , A61K31/4188 , A61K31/4196 , A61K31/454 , A61K31/47 , A61K31/472 , A61K31/473 , A61K31/4965 , A61K31/498 , A61K31/4985 , C07D217/24
摘要： Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).
摘要翻译：本发明的一些实施方案包括治疗疾病的方法和给予式（I）化合物的方法。在本发明的一些方面，可以通过给予包含式（I）化合物的组合物来治疗疾病。本发明一些实施方案的药物组合物包含式（I）的化合物。

2. 发明申请

WO2003086174A3 A NEW METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES 审中-公开
公开(公告)号：WO2003086174A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010745
申请日：2003-04-08
申请人： UNIVERSITY OF LOUISVILLE , BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
发明人： BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
IPC分类号： C07K16/00
摘要： Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.

3. 发明申请

WO2012031215A1 HYBIRD FRAGMENT-LIGAND MODELING FOR CLASSIFYING CHEMICAL COMPOUNDS 审中-公开
标题翻译：用于分类化学化合物的HYBIRD FRAGMENT-LIGAND建模
公开(公告)号：WO2012031215A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050350
申请日：2011-09-02
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , CUNNINGHAM, Albert , TRENT, John, O.
发明人： CUNNINGHAM, Albert , TRENT, John, O.
IPC分类号： C07K1/00 , G01N33/48 , G01N31/00
CPC分类号： G06F19/704 , C40B30/02 , G06F19/707 , Y02A90/26
摘要： A structure activity relationship model is used for determining whether unknown chemical compounds are of a desired classification where the structure activity relationship model is based on a set of known chemical compounds having known structural or biological descriptors. The structure activity relationship model determines whether unknown chemical compounds are of the desired classification, where the system and method compare descriptors of the known chemical compounds to structural and/or biological descriptors of the unknown chemical compounds to determine whether the test chemical compounds are of the desired classification. structure activity relationship model is used studying how particular agents may induce disease or act as therapeutic agents. Furthermore, the model may also be used to study in general how groups of agents induce disease or act as therapeutic agents and to study the etiology and treatment of disease in general.
摘要翻译：结构活动关系模型用于确定未知化合物是否具有期望的分类，其中结构活性关系模型基于具有已知结构或生物描述符的一组已知化合物。结构活动关系模型确定未知化合物是否具有所需的分类，其中系统和方法将已知化合物的描述符与未知化合物的结构和/或生物描述符进行比较，以确定测试化合物是否为期望分类。结构活动关系模型用于研究特定药剂如何诱导疾病或作为治疗剂。此外，该模型还可以用于一般地研究药剂组如何诱导疾病或作为治疗剂，并且一般地研究疾病的病因和治疗。

4. 发明申请

WO2011103557A1 SMALL MOLECULE INHIBITORS OF PFKFB3 AND GLYCOLYTIC FLUX AND THEIR METHODS OF USE AS ANTI-CANCER THERAPEUTICS 审中-公开
标题翻译： PFKFB3和GLYCOLYIC FLUX的小分子抑制剂及其作为抗癌治疗剂的方法
公开(公告)号：WO2011103557A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025691
申请日：2011-02-22
申请人： ADVANCED CANCER THERAPEUTICS, LLC , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , CHAND, Pooran , CHESNEY, Jason, A. , CLEM, Brian, F. , TAPOLSKY, Gilles, H. , TELANG, Sucheta , TRENT, John, O.
发明人： CHAND, Pooran , CHESNEY, Jason, A. , CLEM, Brian, F. , TAPOLSKY, Gilles, H. , TELANG, Sucheta , TRENT, John, O.
IPC分类号： A01N43/38 , A61K31/405
CPC分类号： C07D209/60 , C07D401/06 , C07D471/04
摘要： Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound.
摘要翻译：本文提供了具有下式的式（1）的6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酯酶3（PFKFB3）的小分子抑制剂。本文还提供了含有式I化合物的药物组合物，以及治疗癌症的方法，抑制PFK.FB3酶活性的方法，抑制糖酵解通量的方法，以及通过施用有效量的式I化合物治疗肿瘤的方法。

5. 发明申请

WO2011127333A2 COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：用于治疗疾病，管理和药物组合物的化合物
公开(公告)号：WO2011127333A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031654
申请日：2011-04-08
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , TRENT, John, O. , MEIER, Jason, B. , NAPIER, Kelby, B.
发明人： TRENT, John, O. , MEIER, Jason, B. , NAPIER, Kelby, B.
CPC分类号： C07D403/12 , A61K31/132 , A61K31/335 , A61K31/4015 , A61K31/4045 , A61K31/41 , A61K31/4184 , A61K31/4188 , A61K31/4196 , A61K31/454 , A61K31/47 , A61K31/472 , A61K31/473 , A61K31/4965 , A61K31/498 , A61K31/4985 , C07D217/24
摘要： Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).
摘要翻译：本发明的一些实施方案包括治疗疾病的方法和给予式（I）化合物的方法。在本发明的一些方面，可以通过给予包含式（I）化合物的组合物来治疗疾病。本发明一些实施方案的药物组合物包含式（I）的化合物。

6. 发明申请

WO2008156783A3 FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES 审中-公开
标题翻译：具有抗神经活性的PFKFB3抑制剂家族
公开(公告)号：WO2008156783A3
公开(公告)日：2009-07-16
申请号：PCT/US2008007594
申请日：2008-06-18
申请人： UNIV LOUISVILLE RES FOUND , CHESNEY JASON , TRENT JOHN O , TELANG SUCHETA , CLEM BRIAN , MEIER JASON
发明人： CHESNEY JASON , TRENT JOHN O , TELANG SUCHETA , CLEM BRIAN , MEIER JASON
IPC分类号： A61K31/00 , A61K31/12 , A61K31/121 , A61P33/00
CPC分类号： A61K31/121 , A61K31/00 , A61K31/12
摘要： A methods and compounds for inhibiting 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
摘要翻译：描述了抑制6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3（PFKFB3）的方法和化合物。还描述了抑制细胞增殖，治疗癌症和筛选化合物以确定其抑制PFKFB3的能力的方法。

7. 发明申请

WO2007140263A9 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME 审中-公开
标题翻译：巨噬细胞迁移抑制因子拮抗剂及其使用方法
公开(公告)号：WO2007140263A9
公开(公告)日：2008-04-03
申请号：PCT/US2007069672
申请日：2007-05-24
申请人： UNIV LOUISVILLE RES FOUND , MITCHELL ROBERT A , TRENT JOHN O , MEIER JASON B
发明人： MITCHELL ROBERT A , TRENT JOHN O , MEIER JASON B
IPC分类号： A61K31/513
CPC分类号： A61K31/513
摘要： Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.
摘要翻译：使用MIF抑制性化合物来提供抑制巨噬细胞迁移抑制因子（MIF）多肽的一种或多种生物活性的方法。该方法包括治疗癌症和炎性疾病的治疗方法。

8. 发明申请

WO2007140263A3 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME 审中-公开
公开(公告)号：WO2007140263A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069672
申请日：2007-05-24
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , MITCHELL, Robert A. , TRENT, John O. , MEIER, Jason B.
发明人： MITCHELL, Robert A. , TRENT, John O. , MEIER, Jason B.
IPC分类号： A01N43/54
摘要： Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.

9. 发明申请

WO2005035579A1 A METHOD FOR THE TREATMENT OF MALIGANT DISEASES BY INHIBITING NUCLEOLIN 审中-公开
标题翻译：通过抑制核糖核酸治疗恶性疾病的方法
公开(公告)号：WO2005035579A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033174
申请日：2004-10-08
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
发明人： BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , A61K39/39558 , A61K45/06 , A61N5/10 , C07K14/47 , C12N15/113 , C12Q1/6886 , G01N33/5005 , G01N33/57492
摘要： Use for anti-nucleolin angents, such as antibodies, antisense molecules and interfering RNA molucules, in the treatment of cancers. The treatment is preferably combined with the administration of a chemotoxic or chemotherapeutic agent, or with radiation therapy.
摘要翻译：用于治疗癌症中的抗核仁毒素（如抗体，反义分子和干扰RNA微粒体）。治疗优选与施用化学治疗剂或化疗剂或放射治疗组合。

10. 发明申请

WO2003086174A2 A NEW METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES 审中-公开
标题翻译：一种诊断和预防恶性疾病的新方法
公开(公告)号：WO2003086174A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/010745
申请日：2003-04-08
申请人： UNIVERSITY OF LOUISVILLE , BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
发明人： BATES, Paula, J. , MILLER, Donald, M. , TRENT, John, O. , XU, Xiaohua
IPC分类号： A61B
CPC分类号： C07K14/47 , C12Q1/6886 , G01N33/5005 , G01N33/57492
摘要： Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
摘要翻译：提供了通过用细胞质膜探测细胞核的存在来确定细胞的肿瘤状态来诊断癌症的方法，以及进行这种测试的试剂盒。

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