专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006137840A2 DIPHENYL ETHER ANTIMICROBIAL COMPOUNDS 审中-公开
标题翻译：二苯醚类抗微生物化合物
公开(公告)号：WO2006137840A2
公开(公告)日：2006-12-28
申请号：PCT/US2005/030011
申请日：2005-08-23
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , TONGE, Peter, J. , SULLIVAN, Todd , JOHNSON, Francis
发明人： TONGE, Peter, J. , SULLIVAN, Todd , JOHNSON, Francis
IPC分类号： A61K31/075 , C07C43/23
CPC分类号： C07C43/295 , C07C43/23 , C07C205/38
摘要： The present invention is directed to compounds having the formula: wherein A 1 , A 3 , A 6 , and A 8 independently represent CH or N; A 2 represents N or C-X 1 a - R 1 ; A 4 represents N or C-X 2 b -R 2 ; R 1 and R 2 independently represent H, or a hydrocarbon containing a minimum of one carbon atom and a maximum of twenty six carbon atoms, wherein the hydrocarbon is unsubstituted, or is substituted with one or more of -OH, -NH 2 , -SH, halo, or -COOH; X 1 and X 2 independently represent -O-, - S-, -NH-, -C(O)O-, -C(O)-, -C(O)NH-, or -SO 2 NH-; a and b independently represent 0 or 1, provided that when a and b are both 0, then R 1 and R 2 are not both H; when a is 1, then R 1 is not H; and when b is 1, then R 2 is not H; A 5 and A 9 independently represent CR 3 or N; R 3 represents H, methyl, ethyl, or halo; A7 represents CR 4 or N; R 4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted with halo, nitro, hydroxy, amino, or amido; provided that A 2 and A 4 are not both N; and not more than three of A 5 , A 6 , A 7 , A 8 , and A 9 are N. The invention is also directed to pharmaceutical compositions comprising a compound according to (1) and a pharmaceutically acceptable carrier. The invention is also directed to methods of inhibiting the growth of a bacterium containing an enoyl reductase enzyme encoded by a fabI gene, a fabK gene, a fabL gene, or a combination thereof, in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a compound according to formula (1).
摘要翻译：本发明涉及具有下式的化合物：其中A 1，A 3，A 6和A 8， SUP>独立代表CH或N; A 2表示N或C-X 1

2. 发明申请

WO2006137840A3 DIPHENYL ETHER ANTIMICROBIAL COMPOUNDS 审中-公开
标题翻译：二苯醚类抗微生物化合物
公开(公告)号：WO2006137840A3
公开(公告)日：2007-09-13
申请号：PCT/US2005030011
申请日：2005-08-23
申请人： UNIV NEW YORK STATE RES FOUND , TONGE PETER J , SULLIVAN TODD , JOHNSON FRANCIS
发明人： TONGE PETER J , SULLIVAN TODD , JOHNSON FRANCIS
IPC分类号： A01N31/14 , A61K31/075
CPC分类号： C07C43/295 , C07C43/23 , C07C205/38
摘要： The present invention is directed to compounds having the formula: wherein A 1 , A 3 , A 6 , and A 8 independently represent CH or N; A 2 represents N or C-X 1
摘要翻译：本发明涉及具有下式的化合物：其中A 1，A 3，A 6和A 8， SUP>独立代表CH或N; A ^{2 表示N或C-X 1}

3. 发明申请

WO2021226076A1 POSITRON IMAGING TOMOGRAPHY IMAGING AGENT COMPOSITION AND METHOD FOR DETECTION OF BACTERIAL INFECTION 审中-公开
公开(公告)号：WO2021226076A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/030642
申请日：2021-05-04
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , TONGE, Peter, J. , LI, Yong , DARYAEE, Fereidoon , SMITH-JONES, Peter Michael , MEIMETIS, Labros
发明人： TONGE, Peter, J. , LI, Yong , DARYAEE, Fereidoon , SMITH-JONES, Peter Michael , MEIMETIS, Labros
IPC分类号： A61K31/04 , A61K31/216 , A61K31/24 , A61K51/00 , C07B59/00 , G06T7/00
摘要： This invention provides a composition comprising the compound having the structure: ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier. This invention also provides a method of detecting the presence of or location of bacteria cells in a subject which comprises determining if an amount of the compound or determining where an amount of the compound having the structure: is present in the subject at a period of time after administration of the compound or salt thereof to the subject, thereby detecting the presence of or location of the bacteria cells based on the amount of the compound determined to be present in the subject or detecting the location of the bacteria cells based on the location of the compound determined to be present in the subject.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式