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1. 发明申请

WO2011127151A3 COMBINATIONS OF PRESERVATIVES FOR OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：眼科组合物防腐剂组合
公开(公告)号：WO2011127151A3
公开(公告)日：2012-07-12
申请号：PCT/US2011031396
申请日：2011-04-06
申请人： ALLERGAN INC , TIEN WALTER L , GRAHAM RICHARD S , SRIKUMAR RAMAKRISHNAN
发明人： TIEN WALTER L , GRAHAM RICHARD S , SRIKUMAR RAMAKRISHNAN
IPC分类号： A61K9/00
CPC分类号： A01N47/44 , A61K9/0048 , A61K9/08 , A61K47/18 , A01N2300/00 , A01N33/12
摘要： The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and polyhexamethylene biguanide (PHMB) wherein the combined concentrations of benzalkonium ion and polyhexamethylene biguanide (PHMB) in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophtalmic solution as compared to said ophthalmic soulution having the same concentration of benzalkonium ion and polyhexamethylene biguanide (PHMB), alone.
摘要翻译：本发明提供一种用于保护眼用溶液免于微生物侵袭的防腐组合物，其包含苯扎氯铵和聚六亚甲基双胍（PHMB）的组合，其中所述组合物中苯扎氯铵离子和聚六亚甲基双胍（PHMB）的组合浓度足以提供防止微生物攻击的保护当与仅具有相同浓度的苯扎氯铵和聚六亚甲基双胍（PHMB））的所述眼科洗剂相比，将所述组合物加入到眼底溶液中时。

2. 发明申请

WO2011127139A2 COMBINATIONS OF PRESERVATIVE COMPOSITIONS FOR OPHTHALMIC FORMULATIONS 审中-公开
标题翻译：保健组合物用于眼科配方的组合
公开(公告)号：WO2011127139A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031379
申请日：2011-04-06
申请人： ALLERGAN, INC. , TIEN, Walter L. , GRAHAM, Richard S. , SRIKUMAR, Ramakrishnan
发明人： TIEN, Walter L. , GRAHAM, Richard S. , SRIKUMAR, Ramakrishnan
IPC分类号： A61K9/00
CPC分类号： A01N59/00 , A61K9/0048 , A01N33/12 , A01N2300/00
摘要： The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and An oxy-chlorite moiety, e.g. purite wherein the combined concentrations of benzalkonium ion and An oxy-chlorite moiety, e.g. purite in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophthalmic solution as compared to said ophthalmic solution having the same concentration of benzalkonium ion and An oxy-chlorite moiety, e.g. purite, alone.
摘要翻译：本发明提供了一种用于保护眼用溶液免于微生物侵袭的防腐组合物，其包括苯扎氯铵和氧亚氯酸盐部分的组合，例如，其中苯扎氯铵离子和氧亚氯酸盐部分的组合浓度，例如，所述组合物中的纯度足以在将所述组合物加入到眼用溶液中时提供防止微生物侵袭的保护作用，与具有相同浓度的苯扎氯铵和氧亚氯酸盐部分的眼用溶液相比，例如，纯净，单独。

3. 发明申请

WO2008014200A3 CYCLOSPORIN COMPOSITIONS 审中-公开
公开(公告)号：WO2008014200A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/074079
申请日：2007-07-23
申请人： ALLERGAN, INC. , GRAHAM, Richard, S. , MORGAN, Aileen , ATTAR, Mayssa , TIEN, Walter , SCHIFFMAN, Rhett, M.
发明人： GRAHAM, Richard, S. , MORGAN, Aileen , ATTAR, Mayssa , TIEN, Walter , SCHIFFMAN, Rhett, M.
IPC分类号： A61K9/00 , A61K38/13
摘要： Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.

4. 发明申请

WO2006001963A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS 审中-公开
标题翻译：包含环磷酰胺的药物组合物
公开(公告)号：WO2006001963A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/018025
申请日：2005-05-19
申请人： ALLERGAN, INC. , TIEN, Walter, L. , GRAHAM, Richard , CHANG, James, N.
发明人： TIEN, Walter, L. , GRAHAM, Richard , CHANG, James, N.
IPC分类号： A61K9/08
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/355 , A61K38/13 , A61K2300/00
摘要： A liquid comprising a therapeutically effective concentration of a cyclosparin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an aqueous solution, and wherein no hydrophilic organic solvent is present at a concentration greater than half of that of the cyclosporin is also disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for ophthalmic use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. A composition comprising a therapeutically effective concentration of cyclosparin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for parenteral use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicarrients related thereto, are also disclosed herein.
摘要翻译：包含治疗有效浓度的环糊精和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是水溶液，并且其中没有亲水性有机溶剂以大于环孢菌素一半浓度的浓度存在。一种组合物，其包含治疗有效浓度的环孢菌素A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是用于眼用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在大于或等于环孢菌素的浓度。一种组合物，其包含治疗有效浓度的环糊精A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是用于肠胃外使用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在大于或等于环孢菌素的浓度。使用所述组合物治疗疾病或病症的方法以及与之有关的药物也在本文中公开。

5. 发明申请

WO1995031211A1 LACRIMAL GLAND SPECIFIC EMULSIONS FOR TOPICAL APPLICATION TO OCULAR TISSUE 审中-公开
标题翻译： LACRIMAL GLAND特异性乳剂用于局部应用于眼科组织
公开(公告)号：WO1995031211A1
公开(公告)日：1995-11-23
申请号：PCT/US1995006302
申请日：1995-05-17
申请人： ALLERGAN, INC. , DING, Shulin , TIEN, Walter, L. , OLEJNIK, Orest
发明人： ALLERGAN, INC.
IPC分类号： A61K38/13
CPC分类号： A61K9/0048 , A61K38/13 , Y10S514/912 , Y10S514/941 , Y10S514/943 , Y10S514/975
摘要： A pharmaceutical composition is disclosed in the form of a nonirrtating emulsion which includes at least one cyclosporin in admixture with a higher fatty acid glyceride and polysorbate 80. More particularly, the cyclosporin may be cyclosporing A and the higher fatty acid glyceride may be castor oil. Composition has been found to be of a high comfort level and low irritation potential suitable for delivery of medications to sensitive areas such as ocular tissues with enhanced absorption in the lacrimal gland. In addition, the composition has stability for up to nine months without crystallization of cyclosporin.
摘要翻译：公开了一种无水乳剂形式的药物组合物，其包括与高级脂肪酸甘油酯和聚山梨醇酯80混合的至少一种环孢菌素。更具体地，环孢菌素可以是环孢菌素A，高级脂肪酸甘油酯可以是蓖麻油。已经发现组合物具有高舒适度和低刺激潜能，适用于将药物递送至敏感区域，例如泪腺增强吸收的眼组织。此外，组合物在不结晶环孢菌素的情况下稳定长达九个月。

6. 发明申请

WO2009099467A2 CYCLOSPORIN COMPOSITIONS 审中-公开
标题翻译：环磷酰胺组合物
公开(公告)号：WO2009099467A2
公开(公告)日：2009-08-13
申请号：PCT/US2008/076756
申请日：2008-09-18
申请人： ALLERGAN, INC. , GRAHAM, Richard, S. , TIEN, Walter, L. , MORGAN, Aileen , SCHIFFMAN, Rhett , HOLLANDER, David, A. , ATTAR, Mayssa
发明人： GRAHAM, Richard, S. , TIEN, Walter, L. , MORGAN, Aileen , SCHIFFMAN, Rhett , HOLLANDER, David, A. , ATTAR, Mayssa
IPC分类号： A61K9/00 , A61K38/13
CPC分类号： A61K38/13 , A61K9/0048 , A61K47/10 , A61K47/26 , A61K47/38
摘要： Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.
摘要翻译：本文公开了与环孢菌素相关的治疗方法，组合物和药物。

7. 发明申请

WO2007016073A1 PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING CYCLOSPORIN 审中-公开
标题翻译：包含环磷酰胺的药物乳剂组合物
公开(公告)号：WO2007016073A1
公开(公告)日：2007-02-08
申请号：PCT/US2006/028788
申请日：2006-07-25
申请人： ALLERGAN, INC. , TIEN, Walter, L. , GRAHAM, Richard , CHANG, James, N.
发明人： TIEN, Walter, L. , GRAHAM, Richard , CHANG, James, N.
IPC分类号： A61K9/00 , A61K38/13
CPC分类号： A61K38/13 , A61K9/0019 , A61K9/0048
摘要： A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethyleηe stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
摘要翻译：本文描述了包含环孢菌素A，聚山梨醇酯80，聚氧乙烯硬脂酸酯和油的组合物; 其中所述组合物是眼科可接受的乳液。使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

8. 发明申请

WO2020047146A1 EMULSION FORMULATIONS OF MULTIKINASE INHIBITORS 审中-公开
公开(公告)号：WO2020047146A1
公开(公告)日：2020-03-05
申请号：PCT/US2019/048635
申请日：2019-08-28
申请人： CLOUDBREAK THERAPEUTICS, LLC , NI, Jinsong , DINH, Van , TIEN, Walter
发明人： NI, Jinsong , DINH, Van , TIEN, Walter
IPC分类号： A61K9/107 , A61K9/10 , A61P27/02
摘要： Compositions comprising a therapeutically effective amount of a multikinase inhibitor, such as nintedanib or axitinib or pazopanib, are provided, wherein the composition is an emulsion, such as a nanoemulsion, with lipophilic carrier (e.g., castor oil), a polyoxyl oil (e.g., polyolyl-35 castor oil), optionally with a surfactant (e.g., polysorbate 80), optionally with a cyclic oligosaccharide, such as a cyclodextrin (e.g., 2-hydroxypropyl-beta-cyclodextrin), as a solubilizer. Methods for treating ocular conditions with the compositions are also provided.

9. 发明申请

WO2011127151A2 COMBINATIONS OF PRESERVATIVES FOR OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：眼科组合物防腐剂组合
公开(公告)号：WO2011127151A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031396
申请日：2011-04-06
申请人： ALLERGAN, INC. , TIEN, Walter, L. , GRAHAM, Richard, S. , SRIKUMAR, Ramakrishnan
发明人： TIEN, Walter, L. , GRAHAM, Richard, S. , SRIKUMAR, Ramakrishnan
IPC分类号： A61K9/00
CPC分类号： A01N47/44 , A61K9/0048 , A61K9/08 , A61K47/18 , A01N2300/00 , A01N33/12
摘要： The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and polyhexamethylene biguanide (PHMB) wherein the combined concentrations of benzalkonium ion and polyhexamethylene biguanide (PHMB) in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophtalmic solution as compared to said ophthalmic soulution having the same concentration of benzalkonium ion and polyhexamethylene biguanide (PHMB), alone.
摘要翻译：本发明提供一种用于保护眼用溶液免于微生物侵袭的防腐组合物，其包含苯扎氯铵和聚六亚甲基双胍（PHMB）的组合，其中所述组合物中苯扎氯铵离子和聚六亚甲基双胍（PHMB）的组合浓度足以提供防止微生物攻击的保护当与仅具有相同浓度的苯扎氯铵和聚六亚甲基双胍（PHMB））的所述眼科洗剂相比，将所述组合物加入到眼底溶液中时。

10. 发明申请

WO2011127139A3 COMBINATIONS OF PRESERVATIVE COMPOSITIONS FOR OPHTHALMIC FORMULATIONS 审中-公开
标题翻译：保健组合物用于眼科配方的组合
公开(公告)号：WO2011127139A3
公开(公告)日：2012-06-14
申请号：PCT/US2011031379
申请日：2011-04-06
申请人： ALLERGAN INC , TIEN WALTER L , GRAHAM RICHARD S , SRIKUMAR RAMAKRISHNAN
发明人： TIEN WALTER L , GRAHAM RICHARD S , SRIKUMAR RAMAKRISHNAN
IPC分类号： A61K9/00
CPC分类号： A01N59/00 , A61K9/0048 , A01N33/12 , A01N2300/00
摘要： The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and An oxy-chlorite moiety, e.g. purite wherein the combined concentrations of benzalkonium ion and An oxy-chlorite moiety, e.g. purite in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophthalmic solution as compared to said ophthalmic solution having the same concentration of benzalkonium ion and An oxy-chlorite moiety, e.g. purite, alone.
摘要翻译：本发明提供了一种用于保护眼用溶液免于微生物侵袭的防腐组合物，其包括苯扎氯铵和氧亚氯酸盐部分的组合，例如，其中苯扎氯铵离子和氧亚氯酸盐部分的组合浓度，例如，当所述组合物加入到眼用溶液中时，与所述具有相同浓度的苯扎氯铵和氧亚氯酸盐部分的眼用溶液相比，所述组合物中的纯度足以提供防止微生物侵袭的保护。纯净，单独。

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