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    • 2. 发明申请
    • CONTROLLED RELEASE POLYMERIC GELS
    • 受控释放聚合物凝胶
    • WO2004081056A3
    • 2004-11-25
    • PCT/IB2004050244
    • 2004-03-12
    • SARTOMER TECHNOLOGY CO INCCRAY VALLEY SACHAO HERBERTTIAN NAN
    • CHAO HERBERTTIAN NAN
    • A01N25/04A61K47/34C08G18/69C08G18/79C08L75/04
    • C08G18/797A01N25/04A61K47/34C08G18/692Y10S525/907
    • The present invention relates to an article comprising an elastomeric matrix and at least one biologically or nonbiologically active agent contained in the matrix, the said matrix being formed by reacting a carboxyl -terminated polymer, selected from either hydrophobic or hydrophilic carboxyl terminated polymers, with a polycarbodiimide, with (a) the said hydrophobic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polybutadi ene, carboxyl - terminated polyisoprene, carboxyl -terminated copolymers of butadiene with acrylonitrile, carboxyl -terminated copolymers of butadiene with styrene, carboxyl - terminated copolymers of isoprene with acrylonitrile, carboxyl -terminated copolymers of isoprene with styrene, and mixtures of the above, the carboxylic acid terminated polymer having an average molecular weight in the range of 1000 to 20000. (b) the said hydrophilic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polyethylene oxides, carboxyl-terminated polyether polyols which are copolymers of ethylene oxide and of an alkylene oxide having 3 -6 carbons atoms, in an amount of not more than 50 mole percent of said copolymer and ha ving molecular weight from 400 to 20000. (c) the said polycarbodiimide being selected from the group consisting of the aromatic, cycloaliphatic, aliphatic and heterocyclic carbodiimides, and mixtures of two of more of the above and the said polycarbodiimid e having an average functionality higher or equal to 2 and the carbodiimide/carboxylic acid molar ratio from polycarbodiimide and from carboxyl -terminated polymer being in the range of 0.7 to 6.
    • 本发明涉及包含弹性体基质和包含在基质中的至少一种生物学或非生物活性剂的制品,所述基质通过使选自疏水性或亲水性羧基封端的聚合物的羧基封端的聚合物与 (a)所述疏水性羧基封端聚合物包含选自羧基封端的聚丁二烯,羧基封端的聚异戊二烯,丁二烯与丙烯腈的羧基封端的共聚物,丁二烯与羧基封端的共聚物 苯乙烯,异戊二烯与丙烯腈的羧基封端的共聚物,异戊二烯与苯乙烯的羧基封端的共聚物,以及上述的混合物,羧酸封端的聚合物的平均分子量为1000-20000。(b)所述亲水性 羧基封端的聚合物,其包含主要组分 选自羧基封端的聚环氧乙烷,环氧乙烷和具有3-6个碳原子的环氧烷的共聚物的羧基封端的聚醚多元醇,其含量不超过所述共聚物的50摩尔%,且ha (c)所述聚碳化二亚胺选自芳族,脂环族,脂族和杂环碳二亚胺,以及上述两种或多种的混合物,所述聚碳二亚胺的平均官能度高于 或等于2,并且来自聚碳二亚胺和羧基封端的聚合物的碳化二亚胺/羧酸摩尔比在0.7至6的范围内。
    • 3. 发明申请
    • CONTROLLED RELEASE POLYMERIC GELS
    • 控制释放聚合物凝胶
    • WO2004081056A2
    • 2004-09-23
    • PCT/IB2004/050244
    • 2004-03-12
    • SARTOMER TECHNOLOGY CO., INC.CRAY VALLEY S.A.CHAO, HerbertTIAN, Nan
    • CHAO, HerbertTIAN, Nan
    • C08F
    • C08G18/797A01N25/04A61K47/34C08G18/692Y10S525/907
    • The present invention relates to an article comprising an elastomeric matrix and at least one biologically or nonbiologically active agent contained in the matrix, the said matrix being formed by reacting a carboxyl -terminated polymer, selected from either hydrophobic or hydrophilic carboxyl terminated polymers, with a polycarbodiimide, with (a) the said hydrophobic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polybutadi ene, carboxyl - terminated polyisoprene, carboxyl -terminated copolymers of butadiene with acrylonitrile, carboxyl -terminated copolymers of butadiene with styrene, carboxyl - terminated copolymers of isoprene with acrylonitrile, carboxyl -terminated copolymers of isoprene with styrene, and mixtures of the above, the carboxylic acid terminated polymer having an average molecular weight in the range of 1000 to 20000. (b) the said hydrophilic carboxyl -terminated polymer comprising a major component selected from the group consisting of carboxyl -terminated polyethylene oxides, carboxyl-terminated polyether polyols which are copolymers of ethylene oxide and of an alkylene oxide having 3 -6 carbons atoms, in an amount of not more than 50 mole percent of said copolymer and ha ving molecular weight from 400 to 20000. (c) the said polycarbodiimide being selected from the group consisting of the aromatic, cycloaliphatic, aliphatic and heterocyclic carbodiimides, and mixtures of two of more of the above and the said polycarbodiimid e having an average functionality higher or equal to 2 and the carbodiimide/carboxylic acid molar ratio from polycarbodiimide and from carboxyl -terminated polymer being in the range of 0.7 to 6.
    • 本发明涉及一种包含弹性体基质和至少一种生物或非生物活性剂的制品,该制剂包含在基质中,所述基质通过使选自疏水或亲水性羧基封端的聚合物的羧基末端化聚合物与 聚碳化二亚胺,其中(a)所述疏水性羧基封端的聚合物包含选自羧基封端的聚丁二烯,羧基封端的聚异戊二烯,丁二烯与丙烯腈的羧基封端的共聚物,丁二烯的羧基封端的共聚物 苯乙烯,异戊二烯与丙烯腈的羧基封端的共聚物,异戊二烯与苯乙烯的羧基封端的共聚物,以及上述的混合物,所述羧酸封端的聚合物的平均分子量在1000至20000的范围内。(b)所述亲水 包含主要组分的羧基封端的聚合物 选自羧基封端的聚环氧乙烷,羧基封端的聚醚多元醇,其是环氧乙烷和具有3-6个碳原子的烯化氧的共聚物,其量不大于所述共聚物的50摩尔%,而ha (c)所述聚碳化二亚胺选自芳族,脂环族,脂族和杂环碳二亚胺,以及上述两种以上的所述聚碳二亚胺e的平均官能度较高的混合物 或等于2,并且来自聚碳二亚胺和羧基封端的聚合物的碳二亚胺/羧酸摩尔比在0.7至6的范围内。