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1. 发明申请

WO2011069046A1 COMPOSITION AND METHODS FOR THE PREVENTION AND TREATMENT OF MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND DIABETIC MACULAR EDEMA 审中-公开
标题翻译：用于预防和治疗谷氨酸减少症，糖尿病性肾病和糖尿病肾病的组合物和方法
公开(公告)号：WO2011069046A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058856
申请日：2010-12-03
申请人： DEVORE, Dale P. , DEWOOLFSON, Bruce H. , THOMPSON, Vance , EUCLID SYSTEMS CORPORATION
发明人： DEVORE, Dale P. , DEWOOLFSON, Bruce H. , THOMPSON, Vance
IPC分类号： A61K38/00 , A61K38/14 , A61P9/10
CPC分类号： A61K38/1709
摘要： Methods of stabilizing and organizing collagen fibrils in extracellular matrix of retinal tissues, particularly Bruch's membranes, and stabilizing retinal pigment epithelial layers lining Bruch's membrane are disclosed. The stabilization and organization may be effected by treating retinal tissues with a protein that crosslinks and organizes collagen fibrils, such as decorin. The stabilization and organization methods include treatment of retinal tissues before, during, or after diagnosis of dry macular degeneration, diagnosis of early stages of diabetic retinopathy and diabetic macular edema to prevent, retard, or limit progression of disorganization of Bruch's membrane and disorganization of retinal pigment epithelial cells lining Bruch's membrane.
摘要翻译：公开了稳定和组织视网膜组织的细胞外基质中的胶原纤维的方法，特别是Bruch膜，并稳定了布鲁赫膜上的视网膜色素上皮层。稳定和组织可以通过用交联和组织胶原原纤维（例如核心蛋白聚糖）的蛋白质处理视网膜组织来实现。稳定化和组织方法包括在干性黄斑变性诊断之前，期间或之后治疗视网膜组织，诊断糖尿病性视网膜病变的早期阶段和糖尿病性黄斑水肿，以预防，延缓或限制Bruch's膜的组织进展和视网膜组织紊乱色素上皮细胞衬里布鲁赫膜。

2. 发明申请

WO2020102482A1 TRACKABLE AMMUNITION 审中-公开
公开(公告)号：WO2020102482A1
公开(公告)日：2020-05-22
申请号：PCT/US2019/061382
申请日：2019-11-14
申请人： THOMPSON, Vance
发明人： THOMPSON, Vance
IPC分类号： F42B30/02 , F42B7/04 , F42B8/12 , F42B30/10
摘要： Disclosed are ammunition and ammunition tracking systems. The ammunition and ammunition tracking system may include a first projectile and a marker. The marker may be associated with the first projectile. The marker may contain a unique signature such that the first projectile may be identifiable from a second projectile.

3. 发明申请

WO2020061130A1 STRUCTURES AND METHODS FOR TEAR SHAPING FOR REFRACTIVE CORRECTION 审中-公开
公开(公告)号：WO2020061130A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051622
申请日：2019-09-18
申请人： THOMPSON, Vance
发明人： THOMPSON, Vance
IPC分类号： G02C7/04
摘要： A tear shaping structure or structures that shape a tear film of an eye thereby enabling a desired refractive effect. The tear shaping structure includes a supporting structure supporting a plurality of capillary action members, the capillary action members being spaced apart and arranged in such a way as to create a desired refractive lens effect by shaping the tear film of an eye.

4. 发明申请

WO2017160574A1 CONTACT LENS WITH FLEXIBLE CENTER AND RIGID PERIPHERY 审中-公开
标题翻译：联系透镜与灵活的中心和刚性周围
公开(公告)号：WO2017160574A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/021484
申请日：2017-03-09
申请人： THOMPSON, Vance, M.
发明人： THOMPSON, Vance, M.
IPC分类号： G02C7/04 , C08L101/00
CPC分类号： G02C7/049 , B29D11/00048 , B29D11/00134 , B29K2995/0065 , G02B1/043 , C08L33/08 , C08L33/10
摘要： A contact lens, including a central portion formed from a flexible or soft oxygen permeable material and a peripheral portion formed from a substantially rigid material. The central portion and the peripheral portion are coupled to each other at a coupling portion.
摘要翻译：隐形眼镜包括由柔性或软性氧气可渗透材料形成的中心部分和由基本刚性材料形成的外围部分。中央部分和周边部分在连接部分相互连接。

5. 发明申请

WO2016144483A1 TEAR SHAPING FOR REFRACTIVE CORRECTION 审中-公开
标题翻译：用于折射校正的形状
公开(公告)号：WO2016144483A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/017792
申请日：2016-02-12
申请人： THOMPSON, Vance, M.
发明人： THOMPSON, Vance, M.
IPC分类号： G02C7/04 , A61F9/00
CPC分类号： G02C7/047
摘要： A lens for refractive tear shaping, having a curved lens body with a peripheral edge and a central opening therein. The central opening is shaped and sized and has a tear shaping edge structured to form a tear meniscus within the central opening. The tear meniscus being formed by interaction of a tear film of the eye and the tear shaping edge and having a posterior curvature conforming to an anterior corneal curvature and an anterior curvature. The anterior curvature is dependent on the size and shape of the central opening and structure of the tear shaping edge.
摘要翻译：一种用于折射成形的透镜，其具有带有周边边缘的弯曲透镜体和其中的中心开口。中心开口的形状和尺寸并且具有构造成在中心开口内形成泪液弯液面的泪液成形边缘。泪液弯月面由眼睛的泪膜与泪液成形边缘的相互作用形成，具有与前角膜曲率和前曲率相符的后曲率。前曲率取决于中心开口的尺寸和形状以及撕裂成形边缘的结构。

6. 发明申请

WO2009094468A1 SYSTEM AND METHOD FOR POSITIONING AN EYE THERAPY DEVICE 审中-公开
标题翻译：用于定位眼睛治疗装置的系统和方法
公开(公告)号：WO2009094468A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031716
申请日：2009-01-22
申请人： AVEDRO, INC. , MULLER, David , THOMPSON, Vance
发明人： MULLER, David , THOMPSON, Vance
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B90/11 , A61B2017/306 , A61F9/0079 , A61F9/008 , A61F9/009 , A61F9/013 , A61F2009/00853 , A61F2009/00872
摘要： A system for aligning an eye therapy instrument over a selected area or feature of an eye provides an attachment element that is removably attached to a surface of an eye. A receiving element is coupled to the attachment element and movable relative to the attachment element. The receiving element includes a coupling element configured to operably couple an eye therapy instrument to the receiving element and adjustably move the eye therapy instrument into a selected position with respect to the attachment element. The system makes adjustments to ensure accurate delivery of treatment from the eye therapy device to areas of the eye. In one embodiment, the receiving element allows lateral adjustments to be made along one or more axes. Additionally or alternatively, the receiving element allows angular or rotational adjustments to be made about one or more axes.
摘要翻译：用于将眼部治疗仪器对准眼睛的选定区域或特征的系统提供可拆卸地附接到眼睛表面的附接元件。接收元件联接到附接元件并且可相对于附接元件移动。接收元件包括耦合元件，其被配置为可操作地将眼部治疗器械耦合到接收元件并且可调节地将眼部治疗仪器相对于附接元件移动到选定位置。系统进行调整，以确保从眼部治疗装置到眼睛区域的准确传送。在一个实施例中，接收元件允许沿着一个或多个轴进行横向调整。附加地或替代地，接收元件允许围绕一个或多个轴进行角度或旋转调节。

7. 发明申请

WO2007120457A2 COMPOSITION AND METHOD FOR STABILIZING CORNEAL TISSUE AFTER REFRACTIVE SURGERY 审中-公开
标题翻译：用于稳定手术后的角膜组织的组合物和方法
公开(公告)号：WO2007120457A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008049
申请日：2007-04-03
申请人： EUCLID SYSTEMS CORPORATION , DEWOOLFSON, Bruce , DEVORE, Dale , THOMPSON, Vance
发明人： DEWOOLFSON, Bruce , DEVORE, Dale , THOMPSON, Vance
IPC分类号： A61K38/39
CPC分类号： A61K38/39 , A61K9/0048 , A61K38/1709 , A61K38/45 , C07K14/4725
摘要： Methods of stabilizing collagen fibrils in a cornea comprising administering a composition comprising a protein that crosslinks collagen fibrils and a pharmaceutically acceptable carrier are disclosed. Patients that would benefit from the practice of the methods include patients' having a refractive surgical procedure, patients with keratectasia, and patients with keratodconus. In some embodiments, a protein that crosslinks collagen fibrils by binding to each of two different fibrils to form a bridge there between is use in the method. An example of a protein of this type is decorin. In other embodiments, a protein that crosslinks collagen fibrils by catalyzing the formation of a covalent bond between an amino acid in one collagen fibril and an amino acid in a second collagen fibril is used. Proteins that catalyze formation of covalent bonds between collagen fibrils include transglutaminase.
摘要翻译：稳定胶原纤维在角膜中的方法包括施用包含交联胶原纤维的蛋白质和药学上可接受的载体的组合物。从方法实践中受益的患者包括患有屈光外科手术的患者，角膜结膜炎患者和角化角膜瘤患者。在一些实施方案中，通过与两种不同的原纤维中的每一种结合以在其间形成桥梁来交联胶原原纤维的蛋白质在该方法中使用。这种蛋白质的一个例子是核心蛋白聚糖。在其它实施方案中，使用通过催化在一个胶原原纤维中的氨基酸与第二胶原原纤维中的氨基酸之间形成共价键来交联胶原纤维的蛋白质。催化胶原纤维之间共价键形成的蛋白质包括转谷氨酰胺酶。

8. 发明申请

WO2016144484A1 ORTHOKERATILOGY LENS WITH DISPLACED SHAPING ZONE 审中-公开
标题翻译：带偏心形状区域的ORTHOKERATILOGY镜头
公开(公告)号：WO2016144484A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/017805
申请日：2016-02-12
申请人： THOMPSON, Vance, M.
发明人： THOMPSON, Vance, M.
IPC分类号： G02C7/04
CPC分类号： G02C7/047 , G02C7/00 , G02C7/021 , G02C7/04 , G02C7/048
摘要： A contact lens for application in practice of orthokeratology on an eye, including a curved shell having a concave surface and a convex surface. The concave surface includes a carrier zone and a back shaping zone, the back shaping zone having a first curvature and the carrier zone having at least one second curvature. The curved shell has a geometric center and the back shaping zone has a shaping zone center and the back shaping zone center is offset peripherally from the geometric center. The curved shell can have an overall diameter that approximates a corneal limbal diameter of the eye to which the contact lens is to be applied.
摘要翻译：一种用于在眼睛上实施角膜矫正术的隐形眼镜，包括具有凹面和凸面的弯曲外壳。凹面包括载体区和后成形区，后成形区具有第一曲率，载体区具有至少一个第二曲率。弯曲的壳体具有几何中心，并且后部成形区域具有成形区域中心，并且后部成形区域中心在几何中心周围偏移。弯曲的外壳可以具有接近隐形眼镜要施加的眼睛的角膜边缘直径的总直径。

9. 发明申请

WO2015066616A1 CONJUNCTIVAL COVER AND METHODS THEREFOR 审中-公开
标题翻译：连接罩及其方法
公开(公告)号：WO2015066616A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063696
申请日：2014-11-03
申请人： THOMPSON, Vance, M.
发明人： THOMPSON, Vance, M.
IPC分类号： A61F9/00 , G02C7/04 , A61F2/14
CPC分类号： A61F2/1451 , A61F9/0017 , G02C7/04
摘要： A conjunctival cover including an annular generally curved shell having a conjunctival portion structured to conform to and overly at least part of the conjunctiva of an eye. The annular generally partially spherical shell defines a generally central opening. The central opening is sized to leave a cornea of the eye substantially or partially uncovered when the conjunctival cover is applied to the eye. The conjunctival cover may include drug diffusion qualities. The conjunctival cover may include electronic components embedded therein or thereon including a sensor and an antenna in communication with the sensor and structured to transmit information to a remotely located receiver, transceiver or transponder.
摘要翻译：一种结膜盖，其包括环形的大致弯曲的壳体，其具有构造成符合眼睛结膜和至少部分眼结膜的结膜部分。环形的大致部分球形的外壳限定了大致中央的开口。当结膜覆盖物施加到眼睛上时，中心开口的尺寸设置成使眼睛的角膜基本上或部分地未被覆盖。结膜覆盖物可以包括药物扩散性质。结膜罩可以包括嵌入其中或其上的电子部件，包括与传感器通信的传感器和天线，并被构造成将信息传输到位于远程的接收器，收发器或应答器。

10. 发明申请

WO2012162529A1 SYSTEMS AND METHODS FOR RESHAPING AN EYE FEATURE 审中-公开
标题翻译：用于修复眼睛特征的系统和方法
公开(公告)号：WO2012162529A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/039391
申请日：2012-05-24
申请人： AVEDRO, INC. , MULLER, David , THOMPSON, Vance
发明人： MULLER, David , THOMPSON, Vance
IPC分类号： A61F9/008 , A61F9/01 , A61F9/007
CPC分类号： A61F9/013 , A61F9/00804 , A61F9/00836 , A61F2009/00853 , A61F2009/00872
摘要： Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.
摘要翻译：系统和方法包括在角膜的选定区域中产生切口的切割工具; 将矫正力应用于角膜的眼科治疗系统; 以及控制器，其确定角膜的选择区域用于切口和来自眼睛治疗系统的重塑力，使得重塑力和切口相结合以实现角膜的矫正重塑。其他系统和方法包括测量眼睛以确定角膜重塑所需的量; 根据所需的重塑量确定一个或多个剂量的交联剂和一个或多个相应剂量的光活化光; 将交联剂施用于角膜; 以及从光源将光活化光输送到眼睛的区域，所述光活化光与交联剂结合以引起角膜的矫正重塑。

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