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1. 发明申请

WO2004030685A2 USE OF IL-2 RECEPTOR ANTIBODIES 审中-公开
标题翻译： IL-2受体抗体的使用
公开(公告)号：WO2004030685A2
公开(公告)日：2004-04-15
申请号：PCT/EP2003/010888
申请日：2003-10-01
申请人： F. HOFFMANN-LA ROCHE AG , THE UNIVERSITY OF MISSISSIPPI , THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
发明人： CHAPMAN, Stanley, Willetts , CLEARY, John, D. , GORDON, Robert, D.
IPC分类号： A61K38/00
CPC分类号： A61K31/7048 , A61K39/3955 , A61K2300/00
摘要： This invention relates to a method for treating a patient having a fungal infection. The invention comprises administering to the patient a therapeutically effective amount of a polyene antifungal (e.g., amphotericin B) in association with a therapeutically effective amount of a interleukin-2 inhibitor (e.g., chimeric or humanized monoclonal antibody that binds to the p55 subunit of the human interleukin-2 receptor and inhibits binding of interleukin-2 to an interleukin-2 receptor).
摘要翻译：本发明涉及一种治疗患有真菌感染的患者的方法。本发明包括向患者施用治疗有效量的多烯抗真菌剂（例如两性霉素B），其与治疗有效量的白细胞介素-2抑制剂（例如，嵌合或人源化单克隆抗体结合，其与p55亚基的p55亚基结合人白细胞介素-2受体并抑制白细胞介素-2与白细胞介素-2受体的结合）。

2. 发明申请

WO1999011668A1 DNA MOLECULES ENCODING IMIDAZOLINE RECEPTIVE POLYPEPTIDES AND POLYPEPTIDES ENCODED THEREBY 审中-公开
标题翻译： DNA分子编码咪唑啉受体多肽和编码的多肽
公开(公告)号：WO1999011668A1
公开(公告)日：1999-03-11
申请号：PCT/US1997015695
申请日：1997-09-03
申请人： THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER , PILETZ, John, E. , IVANOV, Tina, R.
发明人： THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
IPC分类号： C07K14/705
CPC分类号： C07K14/705
摘要： A genomic DNA encoding a human imidazoline receptor is described. cDNAs encoding the receptor and fragments thereof are also provided. An amino acid sequence predicted to be 120,000 MW for nearly the entire protein is identified, as well as a middle fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Methods of preparing antibodies against the transfected protein are also described. Also, a screening method for identifying additional subtypes of this receptor are identified. Also, screening methods for identifying drugs that interact with the imidazoline receptor are described.
摘要翻译：描述了编码人咪唑啉受体的基因组DNA。还提供了编码受体及其片段的cDNA。确定几乎整个蛋白质预测为120,000MW的氨基酸序列，以及被认为含有受体的咪唑啉结合位点的中间片段。蛋白质在其序列中是非常独特的，并且可以代表受体蛋白质的新家族中的第一个。描述了克隆cDNA并在宿主细胞中表达咪唑啉受体的方法。还描述了制备抗转染蛋白的抗体的方法。此外，鉴定了用于鉴定该受体的其他亚型的筛选方法。此外，描述了鉴定与咪唑啉受体相互作用的药物的筛选方法。

3. 发明申请

WO2007090094A2 THERMALLY-TARGETED DELIVERY OF MEDICAMENTS, INCLUDING DOXORUBICIN 审中-公开
标题翻译：药物的热定向递送，包括DOXORUBICIN
公开(公告)号：WO2007090094A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061240
申请日：2007-01-29
申请人： THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER , RAUCHER, Drazen , BIDWELL III, Gene , PRIEBE, Waldemar , FOKT, Isabela
发明人： RAUCHER, Drazen , BIDWELL III, Gene , PRIEBE, Waldemar , FOKT, Isabela
IPC分类号： A61K38/17
CPC分类号： A61K41/0052 , A61K47/6435 , A61K47/645 , A61K47/65
摘要： Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat protein, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) spacer and a cysteine residue conjugated to therapeutic such as doxorubicin, or a analog thereof.
摘要翻译：弹性蛋白样多肽（ELP）用作用于热靶向递送治疗剂的载体，包括细胞毒性化学治疗药物如多柔比星。基于ELP的递送载体的实例可以包括：（1）细胞穿透肽，例如Tat蛋白，（2）ELP，和（3）溶酶体可降解的甘氨酰苯丙氨酰基亮氨酰甘氨酸（GFLG）间隔物和与治疗性结合的半胱氨酸残基作为多柔比星或其类似物。

4. 发明申请

WO2002058592A3 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF 审中-公开
公开(公告)号：WO2002058592A3
公开(公告)日：2002-08-01
申请号：PCT/US2002/003923
申请日：2002-01-28
申请人： UAB RESEARCH FOUNDATION , THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER , PUCKETT, Aaron, D., Jr. , LEMONS, Jack , BU, Lujia , MAYS, Jimmy, W.
发明人： PUCKETT, Aaron, D., Jr. , LEMONS, Jack , BU, Lujia , MAYS, Jimmy, W.
IPC分类号： A61B17/56
摘要： A cement mixing and delivering sytem according to the present invention includes a tube (20) having an exit nozzle (50) and an aperture. An end plate ( plate 1) is adapted to seal against the interior of the tube aperture and the end plate (plate 1) has a plurality of needles (32) protruding therefrom into the tube (20). A rotatable and slidable divider ( plates 2 & 3) is received within the tube intermediate between the end plate ( plate 1) and the exit nozzle (50). The divider includes at least two plates ( plates 2 & 3). Each of the plates ( plates 2 & 3) has a plurality of apertures ( 36 & 38) that upon alignment the needles (32) of the first plate ( plate 1) are urged through the apertures (36 & 38) of the at least two divider plates ( plates 2 & 3).

5. 发明申请

WO1997031945A1 DNA ENCODING A HUMAN IMIDAZOLINE RECEPTOR 审中-公开
标题翻译：编码人类咪唑啉受体的DNA
公开(公告)号：WO1997031945A1
公开(公告)日：1997-09-04
申请号：PCT/US1997003156
申请日：1997-02-28
申请人： THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
发明人： THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER , PILETZ, John, E. , IVANOV, Tina, R.
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family or receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
摘要翻译：描述了编码人咪唑啉受体的cDNA。鉴定整个咪唑啉受体蛋白的氨基酸序列，以及被认为含有受体的咪唑啉结合位点的C-末端片段。蛋白质在其序列中是非常独特的，并且可以代表新家族或受体蛋白质中的第一种。描述了克隆cDNA并在宿主细胞中表达咪唑啉受体的方法。另外，描述了鉴定与咪唑啉受体相互作用的药物的筛选方法。

6. 发明申请

WO2018157137A1 CITRULLINE FOR TREATMENT OF SICKLE CELL CRISIS 审中-公开
公开(公告)号：WO2018157137A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019969
申请日：2018-02-27
申请人： VANDERBILT UNIVERSITY , THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
发明人： SUMMAR, Marshall , BARR, Frederick , MAJUMDAR, Suvankar
IPC分类号： A61K31/195 , A61K31/197 , A61K31/198
摘要： A method for administration of citrulline for the treatment of sickle cell disease and other complications of sickle cell disease thereof.

7. 发明申请

WO2002058592A2 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF 审中-公开
标题翻译：骨水泥及其混合和输送系统
公开(公告)号：WO2002058592A2
公开(公告)日：2002-08-01
申请号：PCT/US2002/003923
申请日：2002-01-28
申请人： UAB RESEARCH FOUNDATION , THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER , PUCKETT, Aaron, D., Jr. , LEMONS, Jack , BU, Lujia , MAYS, Jimmy, W.
发明人： PUCKETT, Aaron, D., Jr. , LEMONS, Jack , BU, Lujia , MAYS, Jimmy, W.
IPC分类号： A61F
CPC分类号： A61L24/06 , A61B17/8825 , A61L2430/02 , B01F15/0213 , C09J4/06 , C08L33/12
摘要： A bone cement formulation stored as a solid component pack having 0.3 to 20 solid component pack weight percent of an elastomer and a polymer bead core having a polyacrylate terminated surface. The second component pack is a liquid component pack including an acrylate monomer. An alternate solid component pack includes 3 to 25 solid component pack weight percent of a polyacrylate and a rubber toughened polymethyl methacrylate. A cement mixing and delivering system according to the present invention includes a tube having an exit nozzle and an aperture. An end plate is adapted to seal against the interior of the tube aperture and the end plate has a plurality of needles protruding therefrom into the tube. A rotatable and slidable divider is received within the tube intermediate between the end plate and the exit nozzle. The divider includes at least two plates. Each of the plates has a plurality of apertures that upon alignment the needles of the first plate are urged through the apertures of the at least two divider plates.
摘要翻译：一种作为固体组分包装储存的骨水泥配方，其具有0.3至20个固体组分包装重量百分比的弹性体和具有聚丙烯酸酯封端表面的聚合物珠芯。第二组分包是包含丙烯酸酯单体的液体组分。一种替代的固体组分包装包括3至25个固体组分包装重量百分比的聚丙烯酸酯和橡胶增韧的聚甲基丙烯酸甲酯。根据本发明的水泥混合和输送系统包括具有出口喷嘴和孔的管。端板适于密封管孔的内部，并且端板具有从其中突出到管中的多个针。可旋转和可滑动的分隔件容纳在管板中间在端板和出口喷嘴之间。分隔器包括至少两个板。每个板具有多个孔，在对准时，第一板的针被推动通过至少两个分隔板的孔。

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