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1. 发明申请

WO2019030379A1 MATERIALS AND METHODS FOR STRATIFYING AND TREATING CANCERS 审中-公开
公开(公告)号：WO2019030379A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071758
申请日：2018-08-10
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST
发明人： LEE, Alex , HUANG, Paul , CHEANG, Maggie , JONES, Robin
IPC分类号： C12Q1/6886
摘要： The present invention relates to materials and methods for stratifying and treating cancers and to methods of identifying/selecting patients for treatment of cancer with tyrosine kinase inhibitors. Gene expression profiles, TP53 mutations and FGFR1 and PDGFRA expression are used to identify/select/stratify the cancers and patients.

2. 发明申请

WO2019096397A1 COUMARIN DERIVATIVE FOR THERAPY OR PROPHYLAXIS OF A CELL PROLIFERATIVE DISORDER 审中-公开
公开(公告)号：WO2019096397A1
公开(公告)日：2019-05-23
申请号：PCT/EP2017/079506
申请日：2017-11-16
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST
发明人： BANERJI, Udai
IPC分类号： A61K31/37 , A61K31/573 , A61P35/04 , A61P35/00
摘要： The present invention provides a medicament for the treatment or prevention of a cell proliferative disorder, the medicament comprising as an active ingredient a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein the medicament is used in such a manner that: (a) said compound or salt is administered twice weekly for 3 weeks, (b) administration of said compound or salt is paused for the following 1 week, and (c) steps (a) and (b) are subsequently repeated at least once.

3. 发明申请

WO2020112566A1 PERSONALIZED CTDNA DISEASE MONITORING VIA REPRESENTATIVE DNA SEQUENCING 审中-公开
公开(公告)号：WO2020112566A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/062857
申请日：2019-11-22
申请人： VENTANA MEDICAL SYSTEMS, INC. , THE FRANCIS CRICK INSTITUTE LIMITED , THE ROYAL MARSDEN NHS FOUNDATION TRUST , F. HOFFMANN LA ROCHE AG
发明人： ALEXANDER, Nelson R. , STANISLAW, Stacey , LITCHFIELD, Kevin Richard , TURAJLIC, Samra
IPC分类号： C12Q1/6883
摘要： Disclosed herein is a method of deriving a plurality of genetic variants from a homogenized input sample. Also disclosed herein are methods of identifying a plurality of genetic variants in a sample comprising: homogenizing one or more input samples to provide a homogenized sample; preparing genomic material isolated from the homogenized input sample for sequencing; and identifying the plurality of genetic variants within sequencing data derived after sequencing the prepared genomic material.

4. 发明申请

WO2019096449A1 COUMARIN DERIVATIVE FOR THERAPY OR PROPHYLAXIS OF A CELL PROLIFERATIVE DISORDER 审中-公开
公开(公告)号：WO2019096449A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/062805
申请日：2018-05-16
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST
发明人： BANERJI, Udai
IPC分类号： A61K31/37 , A61K31/573 , A61P35/04 , A61P35/00
摘要： The present invention provides a medicament for the treatment or prevention of a cell proliferative disorder, the medicament comprising as an active ingredient a compound represented by formula or a pharmaceutically acceptable salt thereof, wherein the medicament is used in such a manner that: (a) said compound or salt is administered twice weekly for 3 weeks, (b) administration of said compound or salt is paused for the following 1 week, and (c) steps (a) and (b) are subsequently repeated at least once.

5. 发明申请

WO2005048161A1 A METHOD AND MEANS FOR IMAGE PROCESSING 审中-公开
标题翻译：一种用于图像处理的方法和手段
公开(公告)号：WO2005048161A1
公开(公告)日：2005-05-26
申请号：PCT/GB2004/004760
申请日：2004-11-11
申请人： THE INSTITUTE OF CANCER RESEARCH; ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , KHAZEN, Michael , LEACH, Martin Osmund
发明人： KHAZEN, Michael , LEACH, Martin Osmund
IPC分类号： G06F19/00
CPC分类号： G06T7/0016 , G06T2207/10088
摘要： A method and means enabling identification in an NMR image, being one of a time-sequence of images recording induced changes in pixel values of successive images of a subject (such as post-contrast dynamic images), the contribution to the image arising from the presence within the image subject of a specified tissue (e.g. fat). This identification is done using a statistical measure derived from the dynamic data (e.g. pixel value changes due to contrast agent uptake) taken from a plurality of the separate images forming the time-sequence.
摘要翻译：可以在NMR图像中进行识别的方法和装置，其是记录受试者的连续图像的像素值（例如，对比度后动态图像）中感应的变化的图像的时间序列之一，对由存在于指定组织（例如脂肪）的图像主体内。使用从形成时间序列的多个单独图像中获取的动态数据（例如由于造影剂摄取引起的像素值变化）导出的统计测量来完成该识别。

6. 发明申请

WO2005026765A1 DYNAMIC MR IMAGING INVOLVING CONSTRAINED RECONSTRUCTION USING POCS ALGORITHM 审中-公开
标题翻译：涉及使用POCS算法的约束重建的动态MR成像
公开(公告)号：WO2005026765A1
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003998
申请日：2004-09-17
申请人： THE INSTITUTE OF CANCER RESEARCH; ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , DEGENHARD, Andreas , WHITE, Mark James , LEACH, Martin Osmund
发明人： DEGENHARD, Andreas , WHITE, Mark James , LEACH, Martin Osmund
IPC分类号： G01R33/56
CPC分类号： G01R33/5619 , G01R33/56
摘要： There is disclosed a method of processing image data for use in the reconstruction of an image, the image data comprising complex-valued data items possessing an amplitude component and a phase component, the method comprising the steps of: (a) generating image data items for a first image of the object including only low spatial resolution image data items which represent the object at low image resolution; (b) generating image data items for a second image of the object including low spatial resolution image data items which represent the object at low image resolution and high spatial resolution image data items which represent the object at high image resolution; (c) modifying said phase component or said amplitude component of image data items generated in step (b) according to low spatial resolution image data items generated in step (a) thereby to estimate high spatial resolution image data for use in reconstructing said first image at high spatial resolution, wherein said modifying involves a projection onto convex sets (POCS).
摘要翻译：公开了一种处理用于重建图像的图像数据的方法，该图像数据包括具有振幅分量和相位分量的复值数据项，该方法包括以下步骤：（a）产生图像数据项用于对象的第一图像，仅包括以低图像分辨率表示对象的低空间分辨率图像数据项; （b）生成包含低图像分辨率的低空间分辨率图像数据项和表示高分辨率物体的高空间分辨率图像数据的物体的第二图像的图像数据项; （c）根据步骤（a）中生成的低空间分辨率图像数据项来修改在步骤（b）中生成的图像数据项的所述相位分量或所述振幅分量，从而估计用于重构所述第一图像的高空间分辨率图像数据在高空间分辨率下，其中所述修改涉及到凸集（POCS）上的投影。

7. 发明申请

WO2005015502A1 A METHOD AND APPARATUS FOR IMAGE PROCESSING 审中-公开
标题翻译：一种用于图像处理的方法和装置
公开(公告)号：WO2005015502A1
公开(公告)日：2005-02-17
申请号：PCT/GB2004/003421
申请日：2004-08-06
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , KHAZEN, Michael , LEACH, Martin Osmund
发明人： KHAZEN, Michael , LEACH, Martin Osmund
IPC分类号： G06T11/20
CPC分类号： G06T7/0016 , G06T7/30 , G06T2207/10088 , G06T2207/30068
摘要： There is disclosed a method and apparatus for image processing of e.g. MRI images. A method and apparatus is disclosed enabling one to determine if an image contrast/intensity change of a chosen point within an imaged subject volume (e.g. a lesion) is an artefact of motion in the imaged subject. An apparatus and method for fast visual assessment of the imaged subject volume's alignment quality (within a time-sequence of images) is provided, and an interactive display tool enabling effective use of this method is provided.
摘要翻译：公开了一种用于图像处理的方法和装置。 MRI图像。公开了一种方法和装置，其使得能够确定成像对象体积（例如病变）内的所选点的图像对比度/强度变化是否是被成像对象中的运动的伪像。提供了一种用于快速视觉评估成像对象体积的对准质量（在图像的时间序列内）的装置和方法，并且提供了能够有效使用该方法的交互式显示工具。

8. 发明申请

WO2019158705A1 PATIENT CLASSIFICATION AND PROGNOSTIC METHOD 审中-公开
公开(公告)号：WO2019158705A1
公开(公告)日：2019-08-22
申请号：PCT/EP2019/053845
申请日：2019-02-15
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , ARC-NET CENTRE FOR APPLIED RESEARCH ON CANCER UNIVERSITÀ DEGLI STUDI DI VERONA
发明人： SADANANDAM, Anguraj , NYAMUNDANDA, Gift , YOUNG, Kate , SCARPA, Aldo , RAGULAN, Chanthirika
IPC分类号： G01N33/574
摘要： The present invention relates to methods for predicting prognosis and overall survival among tumour/cancer patients, and methods for classifying and stratifying these patients, particularly patients having pancreatic neuroendocrine tumors (PanNETs). The invention also relates to therapeutic methods for treating classified patients. Measuring gene expression levels of at least some of a selected group 198 genes is shown to be useful in the stratification of patients into groups with prognostic significance, and making a prediction of prognosis.

9. 发明申请

WO2008132469A1 ESTIMATION OF A MEASURE OF CONTRAST AGENT CONCENTRATION USING AN ANALYTICAL MATHEMATICAL MODEL 审中-公开
标题翻译：使用分析数学模型估计对比剂浓度的测量
公开(公告)号：WO2008132469A1
公开(公告)日：2008-11-06
申请号：PCT/GB2008/001476
申请日：2008-04-25
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , LEACH, Martin, Osmund , ORTON, Matthew, Richard , D'ARCY, James , COLLINS, David
发明人： LEACH, Martin, Osmund , ORTON, Matthew, Richard , D'ARCY, James , COLLINS, David
IPC分类号： G01R33/28 , A61B6/03 , G01T1/161
CPC分类号： G01R33/5601 , A61B5/0263 , A61B5/415 , A61B5/418 , G01R33/56366 , G06F19/321 , G06F19/3468 , G06T7/0012 , G06T2207/10076 , G06T2207/10088 , G06T2207/30104 , G16H50/50
摘要： A vascular input function, to estimate a measure of contrast agent concentration, which is decomposed into a function component representing the bolus of contrast-enhancing agent and a function component representing equilibration of the bolus by leakage from the circulatory system of the subject in to other parts of the body of the subject (referred to as the "body transfer function"). Restricting the components to suitable analytical (e.g. algebraic) mathematical functions ensures that the calculations can be carried out analytically.
摘要翻译：血管输入功能，用于估计造影剂浓度的量度，其被分解成代表对比度增强剂的团块的功能组分和表示通过从受试者的循环系统到另一个的泄漏的药丸平衡的功能组分主体的身体部位（简称“身体传递功能”）。将组件限制到合适的分析（例如代数）数学函数，确保了计算能够在分析上进行。

10. 发明申请

WO2007054662A1 TIME-SEQUENTIAL VOLUME RENDERING 审中-公开
标题翻译：时间顺序体积渲染
公开(公告)号：WO2007054662A1
公开(公告)日：2007-05-18
申请号：PCT/GB2006/003405
申请日：2006-09-14
申请人： THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL , THE ROYAL MARSDEN NHS FOUNDATION TRUST , KHAZEN, Michael , LEACH, Martin Osmund
发明人： KHAZEN, Michael , LEACH, Martin Osmund
IPC分类号： G06T15/00
CPC分类号： G06T15/08
摘要： There is disclosed a method and apparatus for generating data for a two-dimensional image which identifies different classes of property of an imaged subject, this being done by separately rendering volumetric data classified into those different classes and, from all of those separate renderings, choosing one datum for use in the two-dimensional image as an image pixel. This being repeatable for each datum to be used in the two-dimensional image - thereby, for example, to selectively build-up the data for whole of the two-dimensional image as a mixture/combination of different classes of data. The data for the two-dimensional image may be colour coded for visually distinguishing data of different classes. Thus when applied to the image enhancement of tissues subjected to contrast agent uptake in patients kinetic information may be incorporated into the volume renderings to enable tissues of different enhancement and kinetic characteristics to be identified as such.
摘要翻译：公开了一种用于生成二维图像的数据的方法和装置，其识别成像对象的不同属性类别，这通过分别绘制分类为不同类别的体积数据来完成，并且从所有这些单独的渲染中选择用于二维图像中的一个数据作为图像像素。对于要在二维图像中使用的每个数据，这是可重复的，从而例如为了整个二维图像选择性地建立数据，作为不同类别的数据的混合/组合。用于二维图像的数据可以进行颜色编码，用于视觉区分不同类别的数据。因此，当应用于在患者中进行造影剂摄取的组织的图像增强时，可以将动力学信息并入体积渲染中，以使得能够识别不同增强和动力学特征的组织。

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