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1. 发明申请

WO2010070380A3 DOC1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2010070380A3
公开(公告)日：2010-06-24
申请号：PCT/IB2008/005015
申请日：2008-12-08
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH OF HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , LIBUTTI, Steven, K. , KWON, Mijung , TANDLE, Anita
发明人： LIBUTTI, Steven, K. , KWON, Mijung , TANDLE, Anita
IPC分类号： C07K14/435 , A61K48/00 , G01N33/53 , G01N33/50
摘要： A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.

2. 发明申请

WO2009017823A2 A FOLD-BACK DIABODY DIPHTHERIA TOXIN IMMUNOTOXIN AND METHODS OF USE 审中-公开
标题翻译：一种回复式二异二苯醚毒素免疫霉素及其使用方法
公开(公告)号：WO2009017823A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/009321
申请日：2008-08-01
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH OF HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , NEVILLE, David , WOO, Jung-Hee , FRANKEL, Arthur
发明人： NEVILLE, David , WOO, Jung-Hee , FRANKEL, Arthur
IPC分类号： C07K16/00
CPC分类号： A61K47/48484 , A61K38/00 , A61K47/6829 , A61K47/6849 , A61K47/6855 , A61K47/6869 , A61K47/6879 , A61K2039/505
摘要： Provided are methods and compositions related to diphtheria toxin diabody immunotoxins.
摘要翻译：提供与白喉毒素双抗体免疫毒素相关的方法和组合物。

3. 发明申请

WO2009029266A2 DIAGNOSTIC TOOL FOR DIAGNOSING BENIGN VERSUS MALIGNANT THYROID LESIONS 审中-公开
标题翻译：用于诊断维生素恶性甲状腺炎的诊断工具
公开(公告)号：WO2009029266A2
公开(公告)日：2009-03-05
申请号：PCT/US2008/010139
申请日：2008-08-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH OF HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , JOHNS HOPKINS UNIVERSITY , ZEIGER, Martha, Allen , PRASAD, Nijaguna, B. , LIBUTTI, Steven, K. , UMBRICHT, Christopher, B.
发明人： ZEIGER, Martha, Allen , PRASAD, Nijaguna, B. , LIBUTTI, Steven, K. , UMBRICHT, Christopher, B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.
摘要翻译：本发明涉及在甲状腺良性病变和恶性甲状腺病变中差异表达的基因用于诊断和分期甲状腺癌的用途。

4. 发明申请

WO2010070380A2 DOC1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译： DOC1组合物和治疗癌症的方法
公开(公告)号：WO2010070380A2
公开(公告)日：2010-06-24
申请号：PCT/IB2008/005015
申请日：2008-12-08
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH OF HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , LIBUTTI, Steven, K. , KWON, Mijung , TANDLE, Anita
发明人： LIBUTTI, Steven, K. , KWON, Mijung , TANDLE, Anita
IPC分类号： C07K14/435 , A61K39/00
CPC分类号： C07K14/4703 , A61K35/13 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K16/18 , C07K2317/34 , G01N33/574 , G01N33/57484 , G01N2333/4703 , G01N2800/52
摘要： A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting angiogenesis. A method of inhibiting tumor growth in a subject is provided comprising administering to a subject a nucleic acid encoding a DOC1 polypeptide, whereby a cell in the subject produces the DOC1 polypeptide, thus inhibiting tumor growth.
摘要翻译：提供了包含SEQ ID NO：1的片段的纯化DOC1多肽，其中DOC1多肽不是全长DOC1多肽序列。提供了抑制受试者血管生成的方法，包括向受试者施用编码DOC1多肽的核酸，由此受试者中的细胞产生DOC1多肽，从而抑制血管发生。提供抑制受试者中肿瘤生长的方法，包括向受试者施用编码DOC1多肽的核酸，由此受试者中的细胞产生DOC1多肽，从而抑制肿瘤生长。

5. 发明申请

WO2010019120A1 S0X9, PROSTAGLANDIN D2 AND RETINOIC ACID FOR TREATING PIGMENTARY CONDITIONS AND MELANOMA 审中-公开
标题翻译： S0X9，PROSTAGLANDIN D2和用于处理色素和色素的再生酸
公开(公告)号：WO2010019120A1
公开(公告)日：2010-02-18
申请号：PCT/US2008/009762
申请日：2008-08-15
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH OF HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , HEARING, Vincent, J. , PASSERON, Thierry
发明人： HEARING, Vincent, J. , PASSERON, Thierry
IPC分类号： A61P35/00 , A61K38/17 , C07K14/47
CPC分类号： A61K38/1709
摘要： A method of treating a hypopigmentary condition in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. The hypopigmentary condition can be a result of surgery, trauma or vitiligo. A method of treating a hyperpigmentary condition in a subject comprising administering to the subject an amount of inhibitor of SOX9 activity sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering to the subject an amount of prostaglandin D2 (PGD2) and retinoic acid (RA) sufficient to treat cancer. A method of sensitizing a melanoma cell to RA comprising administering to the subject an amount of SOX9 sufficient to decrease PRAME expression. A method of increasing p21 expression in a subject comprising administering to the subject an amount of SOX9 sufficient to increase p21 expression. Methods of screening for compounds that treat hypopigmentary conditions and/or melanoma are provided.
摘要翻译：公开了一种治疗受试者色素沉着状况的方法，包括对受试者施用足以治疗黑素瘤的量的SOX9。色素沉着状况可能是手术，创伤或白癜风的结果。公开了一种治疗受试者色素沉着过度症状的方法，包括给予受试者一定量的足以治疗黑素瘤的SOX9活性抑制剂。公开了一种治疗受试者黑色素瘤的方法，其包括对受试者施用足以治疗黑素瘤的量的SOX9。一种治疗受试者黑素瘤的方法，其包括以足以治疗黑素瘤的量增加受试者中视黄酸和SOX9的量。一种治疗受试者中的黑素瘤的方法，其包括给予受试者一定量的足以治疗癌症的前列腺素D2（PGD2）和视黄酸（RA）。一种使黑素瘤细胞对RA敏感的方法，包括向受试者施用足以降低PRAME表达的量的SOX9。增加受试者中p21表达的方法，其包括向受试者施用足以增加p21表达的量的SOX9。提供了筛选治疗色素缺乏症和/或黑素瘤的化合物的方法。

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