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1. 发明申请

WO2015006482A1 CERTAIN IMPROVED HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES 审中-公开
标题翻译：某些人类改良的EGFRvIII抗体携带分子
公开(公告)号：WO2015006482A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/046003
申请日：2014-07-09
申请人： DUKE UNIVERSITY , THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
发明人： BIGNER, Darell D. , SAMPSON, John , KUAN, Chien-Tsun , CAI, Mingqing , CHOI, Bryan D. , GEDEON, Patrick C. , PASTAN, Ira H.
IPC分类号： C07K16/46 , C12N15/13 , A61P35/00 , A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2809 , C07K16/2863 , C07K16/40 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are promising therapeutic agents.
摘要翻译：我们已经构建了编码双特异性抗体接合分子的多核苷酸，其具有特异性地与表达人EGFRvIII突变蛋白的肿瘤细胞特异性结合的一个臂，以及特异性结合T细胞活化配体CD3的第二臂。该多核苷酸经密码子优化用于在CHO细胞中表达。接合分子的亚基被组织以实现更高的效率。这些是有希望的治疗剂。

2. 发明申请

WO2007124345A2 BETA-AMYLOID PET IMAGING AGENTS 审中-公开
标题翻译： BETA-AMYLOID PET成像剂
公开(公告)号：WO2007124345A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/066939
申请日：2007-04-19
申请人： THE GOVERNMENT OF THE UNITED STATES, as represented by the secretary of HEALTH AND HUMAN SERVICES , CAI, Lisheng , PIKE, Victor, W. , INNIS, Robert, B.
发明人： CAI, Lisheng , PIKE, Victor, W. , INNIS, Robert, B.
IPC分类号： C07D471/04
CPC分类号： A61K49/04 , A61K49/0433 , A61K51/00 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/66 , C07D471/04
摘要： Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
摘要翻译：公开了咪唑并吡啶基苯胺的新型衍生物和苯并噻唑基苯胺的新衍生物，当用作β-淀粉样蛋白的正电子发射断层摄影的成像剂时，其具有改善的行为。还公开了在微波条件下对于芳基硫醚的钯催化反应方案，通常提供相对于还原的高取代率，可用于咪唑并吡啶基苯胺衍生物以及其它相关结构的化合物。

3. 发明申请

WO2007092315A2 IMMUNOSTIMULATION BY CPG OLIGONUCLEOTIDE-VIRUS COMPLEXES 审中-公开
标题翻译： CPG寡核苷酸 - 病毒复合体免疫
公开(公告)号：WO2007092315A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002907
申请日：2007-02-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES , RAZ, Eyal , DATTA, Sandip , TAKABAYASHI, Kenji , LIFSON, Jeffrey D.
发明人： RAZ, Eyal , DATTA, Sandip , TAKABAYASHI, Kenji , LIFSON, Jeffrey D.
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/55561 , A61K2039/57 , A61K2039/6025 , C12N2310/351 , C12N2740/15034
摘要： Immunogenic compositions including an inactivated virus, such as an inactivated retrovirus and at least one phosphorothioate modified oligonucleotide (PS-ODN) are provided. Methods for the production of such immunogenic compositions are disclosed, as are methods for their use to elicit an immune response.
摘要翻译：提供包含灭活病毒如灭活逆转录病毒和至少一种硫代磷酸酯修饰寡核苷酸（PS-ODN）的免疫原性组合物。公开了生产这种免疫原性组合物的方法，以及它们用于引发免疫应答的方法。

4. 发明申请

WO2006124641A2 ANTI-MESOTHELIN ANTIBODIES USEFUL FOR IMMUNOLOGICAL ASSAYS 审中-公开
标题翻译：用于免疫测定的抗丝氨酸抗体
公开(公告)号：WO2006124641A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018502
申请日：2006-05-11
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , PASTAN, Ira, H. , ONDA, Masanori
发明人： PASTAN, Ira, H. , ONDA, Masanori
CPC分类号： C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/30
摘要： The present invention provides antibodies that have a surprisingly good combination of affinity for mesothelin and ability to be used in immunological assays for detecting the presence of mesothelin in biological samples. The invention further provides methods of using the antibodies, and kits comprising them. The antibodies can also be used to target toxins and other agents to cells expressing mesothelin, and can be used in methods and medicaments for inhibiting the growth of such cells.
摘要翻译：本发明提供具有令人惊奇的对间皮素亲和力的组合的抗体以及用于检测生物样品中间皮素的存在的免疫测定中的能力。本发明还提供了使用抗体的方法和包含它们的试剂盒。抗体还可以用于将毒素和其它试剂靶向表达间皮素的细胞，并且可以用于抑制这种细胞生长的方法和药物中。

5. 发明申请

WO2006099434A1 MUCUS SLURPING ENDOTRACHEAL TUBE 审中-公开
标题翻译： MUCUS浆液内管
公开(公告)号：WO2006099434A1
公开(公告)日：2006-09-21
申请号：PCT/US2006/009166
申请日：2006-03-14
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES , KOLOBOW, Theodor , LI BASSI, Gianluigi , CURTO, Francesco
发明人： KOLOBOW, Theodor , LI BASSI, Gianluigi , CURTO, Francesco
IPC分类号： A61M16/04
CPC分类号： A61M16/0463 , A61M16/0484 , A61M2016/0027
摘要： An endotracheal tube assembly (10) is disclosed which suctions away bacteria multiplying mucus before such mucus can accumulate on the inside walls of the endotracheal tube (14). In the preferred embodiment, one or more suctioning tubes (20, 21) are formed into the walls of an endotracheal tube so that they extend along length of the endotracheal tube. A plurality of mucus slurping holes (34) are then formed at or near the distal end of the endotracheal tube and connected to the suctioning tubes. In operation, suctioning through the mucus slurping holes is preferably performed intermittently during patient expiration. By timing this intermittent suctioning with patient expiration, the suctioning flow will be in the same direction as patient breathing. While the mucus slurper of the present invention has been found to be effective at keeping the inner walls of the endotracheal tube free of mucus deposits, it can nonetheless be combined with other cleaning and disinfectant techniques for greater assurance of cleanliness.
摘要翻译：公开了一种气管内管组件（10），其在这样的粘液可能积聚在气管内管（14）的内壁上之前吸收细菌使粘液变脏。在优选实施例中，一个或多个抽吸管（20,21）形成在气管内管的壁中，使得它们沿着气管插管的长度延伸。然后在气管内管的远端处或附近形成多个粘液淤泥孔（34），并连接到抽吸管。在操作中，优选在患者呼气期间间歇地进行通过粘液淤泥孔的抽吸。通过定时这种间歇性吸入与患者呼气，吸入流量将与患者呼吸方向相同。虽然已经发现本发明的粘液淤泥在保持气管内管的内壁没有粘液沉积物方面是有效的，但是它仍然可以与其它清洁和消毒技术组合以更好地保证清洁。

6. 发明申请

WO2005090393A2 MULTIMERIC PROTEIN TOXINS TO TARGET CELLS HAVING MULTIPLE IDENTIFYING CHARACTERISTICS 审中-公开
标题翻译：多种蛋白质毒素对具有多种鉴定特征的目标细胞
公开(公告)号：WO2005090393A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/004216
申请日：2005-02-09
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES , LEPPLA, Stephen H. , LIU, Shi-Hui , BUGGE, Thomas H.
发明人： LEPPLA, Stephen H. , LIU, Shi-Hui , BUGGE, Thomas H.
IPC分类号： C07K14/195
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/665 , C07K14/32 , C07K16/30 , C07K2319/00 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases.
摘要翻译：本发明提供包含改良的细菌毒素的组合物和用于使用经修饰的细菌毒素靶向特定细胞群体并用于治疗疾病的方法。

7. 发明申请

WO2004113547A2 POTENT COMBINATIONS OF MRNA TRANSPORT ELEMENTS 审中-公开
标题翻译： MRNA运输元件的POTENT组合
公开(公告)号：WO2004113547A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/015776
申请日：2004-05-19
申请人： THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES , FELBER, Barbara , SMULEVITCH, Sergey, V. , PAVLAKIS, George
发明人： FELBER, Barbara , SMULEVITCH, Sergey, V. , PAVLAKIS, George
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N15/63 , C12N15/67 , C12N15/85 , C12N2740/16043 , C12N2740/16122 , C12N2740/16222 , C12N2830/48
摘要： This invention provides expression vectors that comprise a combination of RNA transport elements that improve expression.
摘要翻译：本发明提供了包含改善表达的RNA转运元件组合的表达载体。

8. 发明申请

WO2007084364A3 IMPROVED IL-12 FOR EXPRESSION IN MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2007084364A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000825
申请日：2007-01-12
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , FELBER, Barbara, K. , PAVLAKIS, George, N. , ROSATI, Margherita
发明人： FELBER, Barbara, K. , PAVLAKIS, George, N. , ROSATI, Margherita
IPC分类号： C07K14/54 , C12N15/67
摘要： The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence.

9. 发明申请

WO2006015382A2 INTEGRIN ALPHA-V BETA-3 ANTAGONISTS FOR USE IN IMAGING AND THERAPY 审中-公开
标题翻译：用于成像和治疗的INTEGRIN ALPHA-V BETA-3拮抗剂
公开(公告)号：WO2006015382A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027868
申请日：2005-08-03
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , DANTHI, S., Narasimhan , KING, C., Li , BURNETT, Christopher, A.
发明人： DANTHI, S., Narasimhan , KING, C., Li , BURNETT, Christopher, A.
IPC分类号： C07D239/00
CPC分类号： C07D239/14
摘要： Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-β-alanine nucleus exhibit increased binding affinity for the αvβ3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.
摘要翻译：在磺酰氨基-β-丙氨酸核上的分子结构包括四氢吡啶基氨基乙氧基苯甲酰基的整联蛋白受体拮抗剂在用磺酰基部分用N-氨基烷基氨基甲酰基或丁基氧基羰基氨基烷基氨基甲酰基或类似基团进一步取代时，表现出对avβ3受体的结合亲和力。

10. 发明申请

WO2005076895A2 MUCUS SHAVING APPARATUS FOR ENDOTRACHEAL TUBES 审中-公开
标题翻译：用于内窥镜的MUCUS SHAVING装置
公开(公告)号：WO2005076895A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003395
申请日：2005-02-04
申请人： THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH , KOLOBOW, Theodor , BERRA, Lorenzo
发明人： KOLOBOW, Theodor , BERRA, Lorenzo
IPC分类号： A61M16/04
CPC分类号： A61M16/0488 , A61B90/70 , A61B2090/701 , A61M16/0445 , A61M16/0463 , A61M2205/0205 , A61M2205/073 , A61M2205/32 , A61M2209/10
摘要： An endotracheal tube cleaning apparatus (10) which can be periodically inserted into the inside of an endotracheal tube (30) to shave away mucus deposits. In a preferred embodiment, this cleaning apparatus (10) comprises a flexible central tube (12) with an inflatable balloon (40) at its distal end. Affixed to the inflatable balloon are one or more shaving rings (70), each having a squared leading edge (72) to shave away mucus accumulations (60). In operation, the uninflated cleaning apparatus (10) of the present invention is inserted into the endotracheal tube until its distal end is properly aligned with or slightly beyond the distal end of the endotracheal tube. After proper alignment, the balloon (40) is inflated by a suitable inflation device, such as a syringe (14), until the balloon's shaving rings are pressed against the inside surface of the endotracheal tube. The cleaning apparatus is then pulled out of the endotracheal tube and, in the process, the balloon's shaving rings shave off the mucus deposits from the inside of the endotracheal tube. The cleaning apparatus of the present invention can advantageously be used with endotracheal tubes having bactericidal films on the tubes' inside walls.
摘要翻译：气管内管清洁装置（10），其可以周期性地插入到气管内管（30）的内部以刮除粘液沉积物。在优选实施例中，该清洁装置（10）包括在其远端具有可膨胀气囊（40）的柔性中心管（12）。与充气气囊相连的是一个或多个剃须环（70），每个剃须环具有平方的前缘（72）以刮去粘液积聚物（60）。在操作中，将本发明的未充气清洁装置（10）插入到气管内管中，直到其远端适当地对准或稍微超过气管内管的远端。在正确对准之后，气球（40）通过适当的充气装置（例如注射器（14））充气，直到球囊的剃须环压在气管内管的内表面上。然后将清洁装置从气管内管中拉出，并且在该过程中，气球的剃刮环从气管内管内部刮去粘液沉积物。本发明的清洁装置可有利地与管内壁上具有杀菌膜的气管内管一起使用。

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