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    • 6. 发明申请
    • ALKYLATION OF AMINO ACIDS
    • 氨基酸的烷基化
    • WO1995012570A2
    • 1995-05-11
    • PCT/GB1994002397
    • 1994-11-02
    • THE ASSOCIATED OCTEL COMPANY LIMITEDPATEL, Rajeshkumar, NatwarlalWILEY, Jonathan, RichardRADLEY, Peter, MichaelTYSON, Robert, Graham
    • THE ASSOCIATED OCTEL COMPANY LIMITED
    • C07C227/16
    • C07C227/40C07C227/18
    • This invention provides improvements in certain processes for alkylating amino acids whereby yields based on amino acid are improved. More specifically, the invention provides a process for the preparation of amino acid derivatives in free acid or salt form, in which the nitrogen atoms of two or more amino acid molecules are linked by a hydrocarbyl or substituted hydrocarbyl group, which comprises reacting, in an aqueous medium at a pH in the range 7-14, a compound of the formula X-A-Y where X and Y are halo atoms which may be the same or different and A is a hydrocarbyl or substituted hydrocarbyl group, in which X and Y are attached to aliphatic or cycloaliphatic carbon atoms, with an amino acid (or salt thereof), wherein the reaction is carried out in the presence of dissolved cations of an alkaline earth metal or of a transition metal and/or wherein the unreacted amino acid is recovered and recycled.
    • 本发明提供了用于烷基化氨基酸的某些方法的改进,从而提高了基于氨基酸的产率。 更具体地,本发明提供了一种制备游离酸或盐形式的氨基酸衍生物的方法,其中两个或多个氨基酸分子的氮原子通过烃基或取代的烃基连接,其包括在 水性介质在7-14范围内的pH,式XAY的化合物,其中X和Y是可以相同或不同的卤原子,A是烃基或取代的烃基,其中X和Y连接到 脂族或脂环族碳原子与氨基酸(或其盐)反应,其中反应在碱土金属或过渡金属的溶解阳离子存在下进行,和/或其中未反应的氨基酸被回收和再循环 。