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1. 发明申请

WO2010055106A1 PROCESS FOR THE PRODUCTION OF CYCLOPROPANE DERIVATIVES 审中-公开
标题翻译：生产环丙基衍生物的方法
公开(公告)号：WO2010055106A1
公开(公告)日：2010-05-20
申请号：PCT/EP2009/065075
申请日：2009-11-12
申请人： DSM FINE CHEMICALS AUSTRIA NFG. GMBH & CO KG , THATHAGAR, Mehul , POECHLAUER, Peter , BRAUNE, Sascha
发明人： THATHAGAR, Mehul , POECHLAUER, Peter , BRAUNE, Sascha
IPC分类号： C07B37/10 , C07B61/00 , C07D333/78
CPC分类号： C07B37/10 , C07D333/78 , Y02P20/582
摘要： A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula :CR 1 R 2 , in a reaction vessel, optionally in the presence of a solvent, wherein, R 1 and R 2 are each independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, -C(O)R 7 or -NR 8 2 ; R 3 , R 4 , R 5 and R 6 are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, -C(O)R 9 , -NR 10 2, -SR 11 , -S(O)R 11 , or -SO 2 R 11 , or R 3 and R 6 are as defined above and R 4 and R 5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R 7 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, aryloxy, heteroaryl or -NR 10 2 ; R 8 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R 9 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, aryloxy or heteroaryl; R 10 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R 12 ; R 11 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and R 12 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process.
摘要翻译：任选地在溶剂存在下，通过使式（II）的烯烃与式CR1R2的卡宾反应，在反应容器中制备式（I）的环丙烷衍生物的方法，其中， R 1和R 2各自独立地为氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，杂环基，碳环基，杂环基，-C（O）R 7或-NR 8 2; R 3，R 4，R 5和R 6各自独立地为氢，C 1 -C 6烷基，C 1 -C 6烷氧基，C 2 -C 6烯基，芳基，芳氧基，杂芳基，杂环基，碳环基，杂环基，-C（O） -SR 11，-S（O）R 11或-SO 2 R 11，或R 3和R 6如上所定义，并且R 4和R 5一起形成环，该环为碳环基，杂环基，芳族或杂芳族; R 7是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基，芳氧基，杂芳基或-NR 10 2; R 8是氢，C 1 -C 6烷基，C 1 -C 6链烯基，芳基，杂芳基，碳环基或杂环基; R9是氢，羟基，C1-C6烷基，C1-C6烷氧基，芳基，芳氧基或杂芳基; R 10是氢，C 1 -C 6烷基，C 2 -C 6烯基，芳基，杂芳基，碳环基，杂环基或C（O）R 12; R11是氢，C1-C6烷基，C2-C6烯基，芳基，杂芳基，碳环基或杂环基; 并且在铜金属或氧化铜的存在下，R 12是氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，芳基或芳氧基，其中该方法是连续方法。

2. 发明申请

WO2012059485A3 CONTINUOUS PRODUCTION AND REACTION OF A DIAZO COMPOUND 审中-公开
公开(公告)号：WO2012059485A3
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069186
申请日：2011-11-01
申请人： DSM IP ASSETS B.V. , DSM FINE CHEMICALS AUSTRIA NFG. GMBH & CO KG , REINTJENS, Rafael, Wilhelmus, Elisabeth, Ghislain , DIELEMANS, Hubertus, Johannes, Adrianus , THATHAGAR, Mehul , KONINGS, Jeroen, Hubertina, Gerardus
发明人： REINTJENS, Rafael, Wilhelmus, Elisabeth, Ghislain , DIELEMANS, Hubertus, Johannes, Adrianus , THATHAGAR, Mehul , KONINGS, Jeroen, Hubertina, Gerardus
IPC分类号： C07C67/00 , C07C69/78 , C07C245/14 , C07C245/16
摘要： A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.

3. 发明申请

WO2012095176A1 OSCILLATING FLOW MINIREACTOR 审中-公开
标题翻译：振荡流动小型机
公开(公告)号：WO2012095176A1
公开(公告)日：2012-07-19
申请号：PCT/EP2011/050386
申请日：2011-01-13
申请人： DSM IP Assets B.V. , REINTJENS, Rafael, Wilhelmus, Elisabeth, Ghislain , THATHAGAR, Mehul
发明人： REINTJENS, Rafael, Wilhelmus, Elisabeth, Ghislain , THATHAGAR, Mehul
IPC分类号： B01J19/00 , B01F5/06 , B01F11/00 , B01F13/00
CPC分类号： B01J19/243 , B01F5/0647 , B01F11/0071 , B01F13/0059 , B01F2215/0431 , B01J19/0093 , B01J2219/00013 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , Y10T29/49826
摘要： The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a pluraltiy of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm. A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.
摘要翻译：本发明涉及一种装置，其包括：a）具有由通道限定的通道的未离子反应器或微反应器，以及b）振荡流动装置，其中所述通道路径包括多个方向变化。反应器通道的水合物直径为0.1mm至10mm。还公开了一种制造所述装置的方法以及所述装置在悬架上进行处理的用途。

4. 发明申请

WO2012059485A2 CONTINUOUS PRODUCTION AND REACTION OF A DIAZO COMPOUND 审中-公开
标题翻译：连氮化合物的连续生产和反应
公开(公告)号：WO2012059485A2
公开(公告)日：2012-05-10
申请号：PCT/EP2011069186
申请日：2011-11-01
申请人： DSM IP ASSETS BV , DSM FINE CHEM AUSTRIA GMBH , REINTJENS RAFAEL WILHELMUS ELISABETH GHISLAIN , DIELEMANS HUBERTUS JOHANNES ADRIANUS , THATHAGAR MEHUL , KONINGS JEROEN HUBERTINA GERARDUS
发明人： REINTJENS RAFAEL WILHELMUS ELISABETH GHISLAIN , DIELEMANS HUBERTUS JOHANNES ADRIANUS , THATHAGAR MEHUL , KONINGS JEROEN HUBERTINA GERARDUS
IPC分类号： C07C67/00 , C07C69/78 , C07C245/14 , C07C245/16
CPC分类号： C07C245/16 , C07C67/00 , C07C245/14 , C07D231/06 , C07C69/78
摘要： A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
摘要翻译：一种制备重氮化合物反应产物的方法，该方法包括：a。向第一反应器连续供应重氮化合物的前体; 一种与水混溶的溶剂; 一个基地和水; 湾混合重氮化合物的前体; 与水混溶的溶剂; 该碱和水生成重氮化合物; C。连续地从第一反应器中通过疏水膜除去形成的重氮化合物到第二反应器中; d。不断从第一反应器中取出所有未通入第二反应器的反应产物; 即在非水混溶性溶剂中向第二反应器连续供应基材; F。混合上述组分以产生重氮化合物的反应产物; 和g。从第二反应器中连续地除去不与水混溶的溶剂和重氮化合物的反应产物，以及适于实施这种方法的设备。

5. 发明申请

WO2009080755A1 FORMATION OF NITRATE ESTERS IN MICROREACTORS AND MILLIREACTORS USING A CONTINUOUS PRODUCT EXTRACTION IN A TURBULENT FLOW REGIME 审中-公开
标题翻译：在湍流流程中使用连续产物萃取在微生物和乳清液中形成硝酸盐
公开(公告)号：WO2009080755A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068034
申请日：2008-12-19
申请人： DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG , BRAUNE, Sascha , STEINHOFER, Stefan , POECHLAUER, Peter , REINTJENS, Rafael Wilhelmus Elisabeth Ghislain , LINSSEN, Nicole Theodora Wilhelmina , THATHAGAR, Mehul
发明人： BRAUNE, Sascha , STEINHOFER, Stefan , POECHLAUER, Peter , REINTJENS, Rafael Wilhelmus Elisabeth Ghislain , LINSSEN, Nicole Theodora Wilhelmina , THATHAGAR, Mehul
IPC分类号： C07C201/02 , C07C203/04
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00966 , B01J2219/00984 , C07C201/02 , C07C203/04
摘要： A process for the continuous production of a compound of Formula (II), HO-R 1 -ONO 2 (II) wherein R 1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO-R 1 -OH (I) wherein R 1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.
摘要翻译：在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中，反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该直截面直流微反应器的内径等于混合微反应器的平均水力直径长度等于混合微反应器的长度。

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