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1. 发明申请

WO2008097897A3 PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1(PAI-1) 审中-公开
公开(公告)号：WO2008097897A3
公开(公告)日：2008-10-02
申请号：PCT/US2008052904
申请日：2008-02-04
申请人： WYETH CORP , THAKUR ARUN , KU MANNCHING SHERRY , WU HSUEH-LING
发明人： THAKUR ARUN , KU MANNCHING SHERRY , WU HSUEH-LING
IPC分类号： A61K31/405 , A61K9/16 , A61K9/20 , A61K9/48 , A61P25/28 , A61P43/00
CPC分类号： A61K9/1617 , A61K9/14 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/4816 , A61K31/405
摘要： Pharmaceutical compositions containing compounds of formula (I) are provided: wherein the constituent variables are as defined herein. The compounds are inhibitors of plasminogen activator inhibitor-1 (PAI-1 ) and the compositions are useful for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis and coronary heart disease, Alzheimer's disease and pulmonary fibrosis.

2. 发明申请

WO2008125255A8 FLOW ASSESSMENT APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2008125255A8
公开(公告)日：2008-10-23
申请号：PCT/EP2008/002792
申请日：2008-04-09
申请人： WYETH , THAKUR, Arun, A
发明人： THAKUR, Arun, A
IPC分类号： G01G13/08
摘要： A flow assessment apparatus (10) is provided for quantitatively assessing the flow properties of particulate material, such as pharmaceutical formulations and constituent powders. The apparatus (10) includes a vibratory feed device (12) having an inclined dispensing member (16). Particulate material is induced to flow along the inclined member (16) onto a watch glass (18) positioned on a top pan balance (20). The mass of material dispensed onto the watch glass (18) is recorded over a given time period, for example a set time period of 1 minute, or a visually assessed time period where it is deemed that sufficient material has been dispensed. The mass and time data is used to calculate a value representative of a relative flow property of the material, which can be used in the development of pharmaceutical formulations.

3. 发明申请

WO2008125255A1 FLOW ASSESSMENT APPARATUS AND METHOD 审中-公开
标题翻译：流量评估装置和方法
公开(公告)号：WO2008125255A1
公开(公告)日：2008-10-23
申请号：PCT/EP2008002792
申请日：2008-04-09
申请人： WYETH CORP , THAKUR ARUN A
发明人： THAKUR ARUN A
IPC分类号： G01G13/08
CPC分类号： G01G13/024 , G01N11/04
摘要： A flow assessment apparatus (10) is provided for quantitatively assessing the flow properties of particulate material, such as pharmaceutical formulations and constituent powders. The apparatus (10) includes a vibratory feed device (12) having an inclined dispensing member (16). Particulate material is induced to flow along the inclined member (16) onto a watch glass (18) positioned on a top pan balance (20). The mass of material dispensed onto the watch glass (18) is recorded over a given time period, for example a set time period of 1 minute, or a visually assessed time period where it is deemed that sufficient material has been dispensed. The mass and time data is used to calculate a value representative of a relative flow property of the material, which can be used in the development of pharmaceutical formulations.
摘要翻译：提供流量评估装置（10），用于定量评估颗粒材料（例如药物制剂和组成粉末）的流动性质。装置（10）包括具有倾斜分配构件（16）的振动进给装置（12）。诱导颗粒材料沿着倾斜构件（16）流动到位于顶部平衡盘（20）上的手表玻璃（18）上。分配到表玻璃（18）上的材料的质量在给定的时间段内记录，例如设定的时间段为1分钟，或视觉评估的时间段，其中认为已经分配了足够的材料。质量和时间数据用于计算代表材料的相对流动性质的值，其可用于开发药物制剂。

4. 发明申请

WO2008097897A9 PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1(PAI-1) 审中-公开
标题翻译：含有取代的吲哚酸衍生物作为疟原虫激活剂抑制剂-1（PAI-1）抑制剂的药物组合物
公开(公告)号：WO2008097897A9
公开(公告)日：2008-11-20
申请号：PCT/US2008052904
申请日：2008-02-04
申请人： WYETH CORP , THAKUR ARUN , KU MANNCHING SHERRY , WU HSUEH-LING
发明人： THAKUR ARUN , KU MANNCHING SHERRY , WU HSUEH-LING
IPC分类号： A61K31/405 , A61K9/16 , A61K9/20 , A61K9/48 , A61P25/28 , A61P43/00
CPC分类号： A61K9/1617 , A61K9/14 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/4816 , A61K31/405
摘要： Pharmaceutical compositions containing compounds of formula (I) are provided: wherein the constituent variables are as defined herein. The compounds are inhibitors of plasminogen activator inhibitor-1 (PAI-1 ) and the compositions are useful for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis and coronary heart disease, Alzheimer's disease and pulmonary fibrosis.
摘要翻译：提供了含有式（I）化合物的药物组合物：其中组成变量如本文所定义。该化合物是纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂，并且该组合物可用于治疗由纤维蛋白溶解疾病如深静脉血栓形成和冠心病，阿尔茨海默病和肺纤维化引起的病症。

5. 发明申请

WO2008097897A2 PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1(PAI-1) 审中-公开
标题翻译：含有取代的吲哚酸衍生物的药物组合物作为PLASMINOGEN ACTIVATOR INHIBITOR-1（PAI-1）的抑制剂，
公开(公告)号：WO2008097897A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/052904
申请日：2008-02-04
申请人： WYETH , THAKUR, Arun , KU, Mannching, Sherry , WU, Hsueh-ling
发明人： THAKUR, Arun , KU, Mannching, Sherry , WU, Hsueh-ling
IPC分类号： A61K31/405 , A61P25/28 , A61P43/00 , A61K9/16 , A61K9/20 , A61K9/48
CPC分类号： A61K9/1617 , A61K9/14 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/4816 , A61K31/405
摘要： Pharmaceutical compositions containing compounds of formula (I) are provided: wherein the constituent variables are as defined herein. The compounds are inhibitors of plasminogen activator inhibitor-1 (PAI-1 ) and the compositions are useful for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis and coronary heart disease, Alzheimer's disease and pulmonary fibrosis.
摘要翻译：提供含有式（I）化合物的药物组合物：其中组成变量如本文所定义。这些化合物是纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂，并且该组合物可用于治疗由纤维蛋白溶解性疾病如深静脉血栓形成和冠心病，阿尔茨海默病和肺纤维化引起的病症。

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