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1. 发明申请

WO2002079411A2 MICROARRAY GENE EXPRESSION PROFILING IN CLEAR CELL RENAL CELL CARCINOMA: PROGNOSIS AND DRUG TARGET IDENTIFICATION 审中-公开
标题翻译：微生物基因表达谱在清除细胞细胞癌中的表达：预防和药物目标鉴定
公开(公告)号：WO2002079411A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/009576
申请日：2002-03-29
申请人： VAN ANDEL INSTITUTE , HAAB, Brian , RHODES, Daniel , TEH, Bin, Tean , TAKASHI, Masayuki
发明人： HAAB, Brian , RHODES, Daniel , TEH, Bin, Tean , TAKASHI, Masayuki
IPC分类号： C12N
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G06F19/00 , Y02A90/26 , C12Q2565/501
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-agressive CC-RCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor and normal tissue and methods of using them are disclosed.
摘要翻译：提供了微阵列中的核酸探针或这种探针的新型组。探针或探针组对透明细胞肾细胞癌（CC-RCC）患者的预后有用，其中侵袭性和非侵袭性CC-RCC肿瘤类型的特征在于与一种或多种这些探针。公开了用于进行肿瘤和正常组织的表达谱的微阵列和试剂盒及其使用方法。

2. 发明申请

WO2006124022A1 MICROARRAY GENE EXPRESSION PROFILING IN SUBTYPES OF CLEAR CELL RENAL CELL CARCINOMA 审中-公开
标题翻译：微细胞基因表达谱在细胞细胞癌细胞亚型中的表达
公开(公告)号：WO2006124022A1
公开(公告)日：2006-11-23
申请号：PCT/US2005/016889
申请日：2005-05-13
申请人： VANANDEL RESEARCH INSTITUTE , TEH, Bin, Tean , TAN, MinHan
发明人： TEH, Bin, Tean , TAN, MinHan
IPC分类号： C12Q1/68 , C12N15/12 , C12N15/11 , G01N33/531
CPC分类号： G01N33/57438 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , G06F19/00 , Y02A90/26
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-aggressive CC-RCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor and normal tissue and methods of using them are disclosed.
摘要翻译：提供了微阵列中的核酸探针或这种探针的新型组。探针或探针组对透明细胞肾细胞癌（CC-RCC）患者的预后有用，其中侵袭性和非侵袭性CC-RCC肿瘤类型的特征在于与一种或多种这些探针。公开了用于进行肿瘤和正常组织的表达谱的微阵列和试剂盒及其使用方法。

3. 发明申请

WO2006112842A2 MICROARRAY GENE EXPRESSION PROFILING IN CLASSES OF PAPILLARY RENAL CELL CARCINOMA 审中-公开
标题翻译：微生物基因表达谱在毛细血管细胞癌中的表现
公开(公告)号：WO2006112842A2
公开(公告)日：2006-10-26
申请号：PCT/US2005/013260
申请日：2005-04-18
申请人： VANANDEL RESEARCH INSTITUTE , TEH, Bin Tean , TAN, MinHan
发明人： TEH, Bin Tean , TAN, MinHan
IPC分类号： G06F19/00
CPC分类号： G06F19/20 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with papillary cell renal cell carcinoma (PRCC), wherein aggressive and non-aggressive PRCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor tissue and methods of using them are disclosed.
摘要翻译：提供了微阵列中的核酸探针或这种探针的新型组。探针或探针组可用于乳头状细胞肾细胞癌（PRCC）患者的预后，其中侵袭性和非侵袭性PRCC肿瘤类型的特征在于与这些探针中的一种或多种杂交的基因的差异表达谱。公开了用于进行肿瘤组织的表达谱的微阵列和试剂盒及其使用方法。

4. 发明申请

WO2012038744A2 DETECTING MUTATIONS 审中-公开
标题翻译：检测突变
公开(公告)号：WO2012038744A2
公开(公告)日：2012-03-29
申请号：PCT/GB2011051774
申请日：2011-09-21
申请人： GENOME RES LTD , VAN ANDEL RES INST , FUTREAL ANDREW , STRATTON MICHAEL , TEH BIN TEAN
发明人： FUTREAL ANDREW , STRATTON MICHAEL , TEH BIN TEAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： In one aspect the present invention provides a method for detecting a mutation associated with renal cancer in a subject, comprising screening a test sample derived from the subject for the presence of one or more mutations in a PBRMl gene or a product thereof.
摘要翻译：一方面，本发明提供了用于检测受试者中与肾癌相关的突变的方法，其包括筛选来源于受试者的测试样品中PBRM1基因或其产物中存在一个或多个突变。

5. 发明申请

WO2006112867A2 MICROARRAY GENE EXPRESSION PROFILING IN CLASSES OF PAPILLARY RENAL CELL CARCINOMA 审中-公开
标题翻译：微阵列基因表达谱在乳头状肾细胞癌中的表达
公开(公告)号：WO2006112867A2
公开(公告)日：2006-10-26
申请号：PCT/US2005/020840
申请日：2005-06-13
申请人： VANANDEL RESEARCH INSTITUTE , TEH, Bin, Tean , TAN, Minhan
发明人： TEH, Bin, Tean , TAN, Minhan
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with papillary cell renal cell carcinoma (PRCC), wherein aggressive and non-aggressive PRCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor tissue and methods of using them are disclosed.
摘要翻译：提供了在微阵列中的核酸探针或这类探针的新组。探针或探针组可用于乳头状细胞肾细胞癌（PRCC）患者的预后，其中侵袭性和非侵袭性PRCC肿瘤类型的特征在于与一种或多种这些探针杂交的基因的差异表达谱。公开了用于进行肿瘤组织表达谱的微阵列和试剂盒以及使用它们的方法。

6. 发明申请

WO2004032842A2 MOLECULAR SUB-CLASSIFICATION OF KIDNEY TUMORS AND THE DISCOVERY OF NEW DIAGNOSTIC MARKERS 审中-公开
标题翻译： KIDNEY肿瘤的分子分类和新诊断标记的发现
公开(公告)号：WO2004032842A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031476
申请日：2003-10-06
申请人： VAN ANDEL INSTITUTE , TEH, Bin, Tean , TAKAHASHI, Masayuki
发明人： TEH, Bin, Tean , TAKAHASHI, Masayuki
IPC分类号： A61K
CPC分类号： G01N33/57438 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： Genes that are differentially expressed in subtypes of renal cell carcinomas are disclosed as are their polypeptide products. This information is utilized to produce nucleic acid and antibody probes and sets of such probes that are specific for these genes and their products. Methods employing these probes, including hybridization and immunological methods, are used to determine the subtype of a renal cell tumor sample from a subject based on the differential expression of such genes that is characteristic of the cancer subtype.
摘要翻译：在肾细胞癌的亚型中差异表达的基因也被公开为它们的多肽产物。该信息用于产生对这些基因及其产物特异的核酸和抗体探针和这样的探针组。使用这些探针的方法，包括杂交和免疫学方法，用于基于癌基因特征的这些基因的差异表达来确定来自受试者的肾细胞肿瘤样品的亚型。

7. 发明申请

WO2002079411A3 MICROARRAY GENE EXPRESSION PROFILING IN CLEAR CELL RENAL CELL CARCINOMA: PROGNOSIS AND DRUG TARGET IDENTIFICATION 审中-公开
公开(公告)号：WO2002079411A3
公开(公告)日：2002-10-10
申请号：PCT/US2002/009576
申请日：2002-03-29
申请人： VAN ANDEL INSTITUTE , HAAB, Brian , RHODES, Daniel , TEH, Bin, Tean , TAKASHI, Masayuki
发明人： HAAB, Brian , RHODES, Daniel , TEH, Bin, Tean , TAKASHI, Masayuki
IPC分类号： A61K39/395
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-agressive CC-RCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor and normal tissue and methods of using them are disclosed.

8. 发明申请

WO2016118078A1 METHOD AND KIT FOR PATHOLOGIC GRADING OF BREAST NEOPLASM 审中-公开
标题翻译：乳腺癌的病理学分级方法和工具包
公开(公告)号：WO2016118078A1
公开(公告)日：2016-07-28
申请号：PCT/SG2015/050368
申请日：2015-10-04
申请人： TEH, Bin Tean , TAN, Boon Ooi Patrick , TAN, Puay Hoon
发明人： TEH, Bin Tean , TAN, Boon Ooi Patrick , TAN, Puay Hoon , TAN, Jing , ONG, Choon Kiat , LIM, Weng Khong , NG, Chuan Young Cedric
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： The present disclosure is a method comprising the steps of performing one or more nucleic-acid based assays to identify mutations present in the breast tissue acquired from the subject corresponding to a first test module and a second test module associated with detection of at least one predetermined mutation of one or more genes, wherein each test module is configured to provide a positive outcome corresponding to at least one predetermined mutation detected in the tissue or a negative outcome corresponding to absence of detectable predetermined mutation in the sample; and identifying the type of neoplasm of the breast tissue based upon the provided outcome of the both test modules. Preferably, the first test module is associated with detection of mutation in MED12 gene and/or RARA gene, while the second test module is associated with detection of mutation in FLNA gene, SETD2 gene and/or MLL2 gene.
摘要翻译：本公开是一种方法，其包括以下步骤：执行一个或多个基于核酸的测定，以鉴定从与第一测试模块相对应的从受试者获得的乳腺组织中存在的突变，以及与检测至少一个预定的一个或多个基因的突变，其中每个测试模块被配置为提供对应于组织中检测到的至少一个预定突变的阳性结果或对应于样品中不可检测到的预定突变的否定结果; 并且基于两个测试模块的提供的结果来识别乳腺组织的肿瘤的类型。优选地，第一测试模块与检测MED12基因和/或RARA基因中的突变相关，而第二测试模块与FLNA基因，SETD2基因和/或MLL2基因中的突变的检测相关。

9. 发明申请

WO2012038744A3 DETECTING MUTATIONS ASSOCIATED WITH RENAL CANCER IN A PBRM1 GENE 审中-公开
公开(公告)号：WO2012038744A3
公开(公告)日：2012-03-29
申请号：PCT/GB2011/051774
申请日：2011-09-21
申请人： GENOME RESEARCH LIMITED , VAN ANDEL RESEARCH INSTITUTE , FUTREAL, Andrew , STRATTON, Michael , TEH, Bin Tean
发明人： FUTREAL, Andrew , STRATTON, Michael , TEH, Bin Tean
IPC分类号： C12Q1/68
摘要： In one aspect the present invention provides a method for detecting a mutation associated with renal cancer in a subject, comprising screening a test sample derived from the subject for the presence of one or more mutations in a PBRMl gene or a product thereof.

10. 发明申请

WO2006112842A8 MICROARRAY GENE EXPRESSION PROFILING IN CLASSES OF PAPILLARY RENAL CELL CARCINOMA 审中-公开
标题翻译：微生物基因表达谱在毛细血管细胞癌中的表现
公开(公告)号：WO2006112842A8
公开(公告)日：2007-03-29
申请号：PCT/US2005013260
申请日：2005-04-18
申请人： VANANDEL RES INST , TEH BIN TEAN , TAN MINHAN
发明人： TEH BIN TEAN , TAN MINHAN
IPC分类号： G06F19/20
CPC分类号： G06F19/20 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with papillary cell renal cell carcinoma (PRCC), wherein aggressive and non-aggressive PRCC tumor types are characterized by differential expression profiles of genes that hybridize with one or more of these probes. Microarrays and kits for carrying out expression profiling of tumor tissue and methods of using them are disclosed.
摘要翻译：提供了微阵列中的核酸探针或这种探针的新型组。探针或探针组可用于乳头状细胞肾细胞癌（PRCC）患者的预后，其中侵袭性和非侵袭性PRCC肿瘤类型的特征在于与这些探针中的一种或多种杂交的基因的差异表达谱。公开了用于进行肿瘤组织的表达谱的微阵列和试剂盒及其使用方法。

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