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1. 发明申请

WO2022085007A1 DEVICE, SYSTEMS AND METHODS FOR DETECTION OF NUCLEIC ACID MOLECULES OF INTEREST 审中-公开
公开(公告)号：WO2022085007A1
公开(公告)日：2022-04-28
申请号：PCT/IL2021/051253
申请日：2021-10-21
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： ROFMAN, Baruch , BERCOVICI, Moran , BEN-ASSA, Nadav , GEVA-ZATORSKY, Naama , NADDAF, Rawi , GEFEN, Tal
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6865 , C12Q1/6844 , C12Q1/68 , C12Q1/00
摘要： A sample testing module, for use with a device for enabling detection and monitoring of at least one target element in a sample, includes a reaction pad and a support. The reaction pad includes a preparation zone that is contiguous with a plurality of reaction zones via respective branch elements. The preparation zone is configured for: accommodating sample preparation agents and at least a sample to be tested, and for enabling mixing thereof to provide a prepared sample; accommodating a second quantity of a transporting liquid and for enabling contact of the prepared sample with the transporting liquid to provide the flowable prepared sample. Each reaction zone is configured for accommodating therein a respective reaction mixture adapted for the reaction, to produce at least one respective product. The support includes a first heating system (for enabling heating of the preparation zone to a first temperature) and a second heating system (for enabling heating of the amplification zones to a second temperature).

2. 发明申请

WO2022043993A1 PCNHCP METAL COMPLEXES AND USES THEREOF 审中-公开
公开(公告)号：WO2022043993A1
公开(公告)日：2022-03-03
申请号：PCT/IL2021/051024
申请日：2021-08-22
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： DE RUITER, Graham , GARHWAL, Subhash
IPC分类号： C07B59/00 , C07F15/02 , B01J31/00 , B01J31/18 , B01J31/22
摘要： The present invention provides PCNHCP pincer metal complexes, which are useful as catalysts in various chemical reactions such as hydrogen isotope exchange (HIE) in C(sp3)-H and/or C(sp2)-H bond of an organic compound, e.g., a pharmaceutically active compound; hydroboration of alkynes with excellent selectivity; and alkene isomerization with high stereo- and regioselectivity.

3. 发明申请

WO2019049016A1 ULTRASOUND DETECTION BY OPTICAL PASSIVE-DEMODULATION INTERFEROMETRY USING PHOTONIC INTEGRATED CIRCUITS (PIC) 审中-公开
公开(公告)号：WO2019049016A1
公开(公告)日：2019-03-14
申请号：PCT/IB2018/056704
申请日：2018-09-03
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： ROZENTAL, Amir , HAZAN, Yoav
IPC分类号： G02F1/11 , G01B9/02 , A61B8/00
CPC分类号： A61B5/0097 , A61B8/00 , G01H9/004
摘要： An apparatus for optical detection of ultrasound includes one or more optical resonators (OR - 200), one or more optical passive-demodulation interferometers (OPDI - 22), and one or more respective electro-optical readout circuits (EORC - 24). The one or more optical resonators (OR) are configured to modulate respective carrier frequencies of optical signals indicative of US waves impinging thereon. The one or more OPDI are implemented in one or more photonic integrated circuits (PIC), wherein each OPDI is configured to demodulate the optical signal output by the respective OR, so as to generate a respective intensity-modulated optical signal. Each OPDI includes an interferometer (32) having imbalanced arms (323, 325) that are recombined using an optical hybrid (34). The one or more respective EORC are each configured to measure the intensity demodulated optical signal produced by the respective OPDI, and to output a respective electrical signal.

4. 发明申请

WO2019043715A1 TRANSITION-METAL OXIDES-COATED HYDROGEN-TERMINATED DIAMOND SURFACE AND USES THEREOF 审中-公开
公开(公告)号：WO2019043715A1
公开(公告)日：2019-03-07
申请号：PCT/IL2018/050971
申请日：2018-09-02
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： KALISH, Rafi , TORDJMAN, Moshe
IPC分类号： H01B1/04 , H01L21/02 , H01L29/16
摘要： The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen- terminated surface and a layer of tungsten trioxide, rhenium trioxide, or chromium oxide coating said hydrogen-terminated surface. Such conducting materials are useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.

5. 发明申请

WO2015128842A1 METHOD DEVICE AND SYSTEM FOR MONITORING SUB-CLINCAL PROGRESSION AND REGRESSION OF HEART FAILURE 审中-公开
标题翻译：用于监测亚临床进展和心脏衰竭回归的方法装置和系统
公开(公告)号：WO2015128842A1
公开(公告)日：2015-09-03
申请号：PCT/IB2015/051456
申请日：2015-02-27
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , RAMBAM HEALTH CORPORATION
发明人： LANDESBERG, Amir , ZIBOLI, Yaakov , RISPLER, Shmuel
IPC分类号： G06F19/00
CPC分类号： G16H50/30 , A61B5/0022 , A61B5/0024 , A61B5/0816 , A61B5/1118 , A61B5/113 , A61B5/4866 , A61B5/6823 , A61B5/7253 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B2505/07 , A61B2562/0219 , G06F19/00 , G16H10/60 , G16H40/63 , G16H50/20
摘要： A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.
摘要翻译：一种方法，包括基于感测到的本地加速度传感器的信息来感测本地加速度或传感器位置的改变，包括姿态和位移，以及安装在患者的胸部或腹部上的局部加速度传感器，以及计算多相运动的能量，并分类通过计算过多能量指数（EEi）来比较心脏代偿失调的严重程度，该能量指数将多相运动中出现的过度能量与基础呼吸频率下的吸气所需的能量进行比较。

6. 发明申请

WO2014080303A1 SUB-NYQUIST RADAR PROCESSING USING DOPPLER FOCUSING 审中-公开
标题翻译：使用多普勒聚焦的次NYQUIST RADAR处理
公开(公告)号：WO2014080303A1
公开(公告)日：2014-05-30
申请号：PCT/IB2013/059602
申请日：2013-10-24
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： ELDAR, Yonina , BAR-ILAN, Omer
IPC分类号： G01S13/44
CPC分类号： G01S13/53 , G01S7/2923 , G01S2007/2883
摘要： A method includes receiving a signal, which includes reflections of multiple pulses from one or more targets (24). A Doppler focusing function, in which the reflections of the multiple pulses from each target accumulate in-phase to produce a respective peak associated with a respective delay and a respective Doppler frequency of the target, is evaluated based on the received signal. Respective delays and Doppler frequencies of the targets are estimated based on the Doppler focusing function.
摘要翻译：一种方法包括接收包括来自一个或多个目标（24）的多个脉冲的反射的信号。基于所接收的信号来评估多普勒聚焦功能，其中来自每个目标的多个脉冲的反射同相累积以产生与相应延迟和目标的相应多普勒频率相关联的相应峰值。基于多普勒聚焦函数估计目标的相应延迟和多普勒频率。

7. 发明申请

WO2014064688A1 ELECTROMECHANICAL BATTERY 审中-公开
标题翻译：电动电池
公开(公告)号：WO2014064688A1
公开(公告)日：2014-05-01
申请号：PCT/IL2013/050852
申请日：2013-10-22
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： ELATA, David
IPC分类号： H01M10/04
CPC分类号： H01G5/16 , Y02T10/7022
摘要： An electromechanical battery based on a parallel plate capacitor, in which mutual motion of the oppositely charged plates with change in the charge held by the capacitor is controlled by a mechanical spring having a nonlinear force-displacement relationship, predetermined such that the voltage across the capacitor remains constant with changes in the charge held by the capacitor. The charge held by the capacitor generates an attractive electrostatic force between the plates which is in equilibrium with the mechanical force exerted on the plates by the mechanical spring. The mechanical spring may be a beam with one end wrapped on a cam, such that the free length of the beam changes with flexing of the beam, or it may be the elastic flexing of the plates themselves. Protrusions having predetermined heights and positions may be used to tailor the force-displacement relationship of the flexing plates.
摘要翻译：一种基于平行板电容器的机电电池，其中具有由电容器保持的电荷变化的带相反电荷的板的相互运动由具有非线性力 - 位移关系的机械弹簧控制，使得电容器两端的电压由电容器保持的电荷变化保持不变。由电容器保持的电荷在板之间产生有吸引力的静电力，它们通过机械弹簧与施加在板上的机械力平衡。机械弹簧可以是一端缠绕在凸轮上的梁，使得梁的自由长度随着梁的弯曲而变化，或者其可以是板本身的弹性弯曲。可以使用具有预定高度和位置的突起来定制挠曲板的力 - 位移关系。

8. 发明申请

WO2013151780A1 ELECTRONIC PROTEIN FRACTIONATION 审中-公开
标题翻译：电子蛋白质分解
公开(公告)号：WO2013151780A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/032906
申请日：2013-03-19
申请人： BIO-RAD LABORATORIES, INC. , TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
发明人： PAULUS, Aran , BOGOEV, Roumen , BROD, Elad , SIVAN, Uri
IPC分类号： C07K1/28
CPC分类号： B01D61/54 , B01D61/42 , B01D61/445 , B01D61/46 , B01D2311/18 , C07K1/28 , G01N27/44795
摘要： Aspects of the invention are described throughout this document. In some embodiments, an apparatus is provided. In some embodiments, the apparatus comprises: a chamber divided into a first sub-chamber and a second sub-chamber by a dividing membrane, wherein the dividing membrane blocks or substantially blocks flow of fluid between the first and second sub-chamber; and wherein the first sub-chamber is in electrical communication with a first electrode; the second sub-chamber is in electrical communication with a second electrode; the first sub-chamber is in fluid communication with a first ion injector/extractor; the second sub-chamber is in fluid communication with a second ion injector/extractor; and and the second sub-chamber comprises an outlet.
摘要翻译：在本文中描述了本发明的各方面。在一些实施例中，提供了一种装置。在一些实施例中，该装置包括：通过分隔膜分成第一子室和第二子室的室，其中分隔膜阻挡或基本上阻挡在第一和第二子室之间的流体流动; 并且其中所述第一子室与第一电极电连通; 所述第二子室与第二电极电连通; 第一子室与第一离子注入器/提取器流体连通; 第二子室与第二离子注入器/提取器流体连通; 并且第二子室包括出口。

9. 发明申请

WO2013046201A1 DEVICE FOR PREVENTION OF SHUNT STENOSIS 审中-公开
标题翻译：用于预防交感神经阻滞的装置
公开(公告)号：WO2013046201A1
公开(公告)日：2013-04-04
申请号：PCT/IL2012/000352
申请日：2012-09-27
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , SHECHTMAN, Adi , SHOHAM, Moshe , GADOT, Harel
发明人： SHECHTMAN, Adi , SHOHAM, Moshe , GADOT, Harel
IPC分类号： A61M29/02
CPC分类号： A61M1/0078 , A61B17/320725 , A61M1/3655 , A61M1/367 , A61M25/0116 , A61M25/0155 , A61M25/1011 , A61M25/104 , A61M2025/1072 , A61M2025/109 , A61M2025/1097 , A61M2209/10
摘要： A method and a kit for the prevention of venous stenosis associated with the use of hemodialysis AV shunts. The kit may use a bifurcated needle for providing access to the shunt or blood vessel. One of the arms is used for returning the blood to the subject after dialysis treatment, while the other arm is used for inserting a device for cleaning the vein, the device being either an autonomous crawling device, or a passive tethered device moved down the vein by the blood flow. The autonomous crawling device may be a series of sequentially inflatable chambers, the stenosis being cleared by pressure from the outer walls of the chambers when inflated and moved. The passive device may be an element having a flexible disc-like structure, whose flexible peripheral edge slides along the inner walls of the blood vessel, compressing or clearing the material attached thereto.
摘要翻译：一种用于预防与使用血液透析AV分流相关的静脉狭窄的方法和试剂盒。该试剂盒可以使用分叉针来提供对分流器或血管的通路。其中一个手臂用于在透析治疗后将血液返回给受试者，而另一只手臂用于插入用于清洁静脉的装置，该装置是自主爬行装置或沿静脉移动的被动束缚装置通过血流。自主爬行装置可以是一系列顺序可充气的腔室，当充气和移动时，狭窄被来自腔室的外壁的压力清除。无源器件可以是具有柔性盘状结构的元件，其柔性周边沿着血管的内壁滑动，压缩或清除附着于其上的材料。

10. 发明申请

WO2012153337A2 ANTI-MICROBIAL PEPTIDES AND USES OF SAME 审中-公开
标题翻译：抗微生物肽及其用途
公开(公告)号：WO2012153337A2
公开(公告)日：2012-11-15
申请号：PCT/IL2012/050167
申请日：2012-05-10
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , ADIR, Noam , NAVON, Sharon , SWARTZMANN, Tali
发明人： ADIR, Noam , NAVON, Sharon , SWARTZMANN, Tali
IPC分类号： A61K38/06 , A61K38/07 , A61K38/08 , C12Q1/68
CPC分类号： C07K5/08 , A61K38/06 , A61K38/07 , A61K38/08 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： A method of treating a bacterial infection in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide being between 3 and 5 amino acids, wherein at least one amino acid of said 3 and 5 amino acids is selected from the group consisting of tryptophan, cysteine, proline and methionine.
摘要翻译：公开了治疗受试者细菌感染的方法。该方法包括向受试者施用治疗有效量的3至5个氨基酸的肽，其中所述3和5个氨基酸的至少一个氨基酸选自色氨酸，半胱氨酸，脯氨酸和甲硫氨酸。

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