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1. 发明申请

WO2012090046A1 METHOD FOR TRIGGERING DEPENDENT SPECTRA FOR DATA ACQUISITION 审中-公开
标题翻译：用于触发依赖光谱数据采集的方法
公开(公告)号：WO2012090046A1
公开(公告)日：2012-07-05
申请号：PCT/IB2011/003107
申请日：2011-12-22
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , COX, David, M. , TATE, Stephen, A. , GLUECKMANN, Matthias
发明人： COX, David, M. , TATE, Stephen, A. , GLUECKMANN, Matthias
IPC分类号： H01J49/00
CPC分类号： G01N23/00 , H01J49/0031 , H01J49/0045 , H01J49/025
摘要： Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.
摘要翻译：提供了实时触发信息依赖质谱扫描的方法和系统。分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。质谱仪从分离装置接收分离样品混合物。在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。如果两个或更多个时变离子信号的特征满足选择标准，则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。

2. 发明申请

WO2012063108A2 SYSTEMS AND METHODS FOR RAPIDLY SCREENING SAMPLES BY MASS SPECTROMETRY 审中-公开
标题翻译：通过质谱快速筛选样品的系统和方法
公开(公告)号：WO2012063108A2
公开(公告)日：2012-05-18
申请号：PCT/IB2011002594
申请日：2011-11-02
申请人： DH TECHNOLOGIES DEV PTE LTD , BONNER RONALD , TATE STEPHEN A
发明人： BONNER RONALD , TATE STEPHEN A
IPC分类号： H01J49/00
CPC分类号： H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/04
摘要： Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.
摘要翻译：系统和方法用于快速筛选样品。指示非色谱的快速样品引入装置使用处理器将多个样品的每个样品提供给串联质谱仪。快速样品引入装置可以包括流动注射分析装置，离子迁移率分析装置或快速样品清除装置。指示串联质谱仪在使用处理器的多个采样的质量范围的两个或更多个质量选择窗口上进行碎片扫描。跨质量范围的两个或多个质量选择窗口可以具有固定或可变窗口宽度。在指示串联质谱仪进行碎片扫描之前，可以指示串联质谱仪获得质量范围的质谱。

3. 发明申请

WO2012164378A2 REMOVAL OF IONS FROM SURVEY SCANS USING VARIABLE WINDOW BAND-PASS FILTERING TO IMPROVE INTRASCAN DYNAMIC RANGE 审中-公开
标题翻译：使用可变窗口带通滤波器从调查扫描仪中移除离子以改善内部动态范围
公开(公告)号：WO2012164378A2
公开(公告)日：2012-12-06
申请号：PCT/IB2012001054
申请日：2012-05-30
申请人： DH TECHNOLOGIES DEV PTE LTD , TATE STEPHEN A , BLOOMFIELD NIC G
发明人： TATE STEPHEN A , BLOOMFIELD NIC G
IPC分类号： H01J49/00
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/429
摘要： Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.
摘要翻译：系统和方法用于使质量范围内的过滤离子带通。使用串联质谱仪可以接收全质谱进行质量范围的全扫描。选择全频谱的质量选择窗口，并选择一组调谐参数值。指示串联质谱仪使用一组调谐参数值执行质量选择窗口的扫描。接收从串联质谱仪扫描的光谱。为包括质量范围的质量选择窗口的光谱值的质量范围创建带通滤波光谱。系统和方法也用于跨越质量范围的两个或多个质量选择窗口带通滤波器离子，并从两个带通质量选择窗口之间的质量选择窗口滤除离子。

4. 发明申请

WO2012164375A1 USE OF VARIABLE XIC WIDTHS OF TOF-MSMS DATA FOR THE DETERMINATION OF BACKGROUND INTERFERENCE IN SRM ASSAYS 审中-公开
标题翻译：使用TOF-MSMS数据的可变XIC宽度来确定SRM测定中的背景干扰
公开(公告)号：WO2012164375A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/001049
申请日：2012-05-30
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , TATE, Stephen, A. , COX, David, M.
发明人： TATE, Stephen, A. , COX, David, M.
IPC分类号： H01J49/00
CPC分类号： H01J49/02 , G06F19/703 , H01J49/0031
摘要： Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.
摘要翻译：系统和方法识别不包括干扰的产物离子。从串联质谱仪接收样品中分析物质量范围的完整产品离子谱。使用第一XIC窗口宽度，对全产物离子谱中的产物离子计算第一组一个或多个峰参数。使用第二XIC窗口宽度为产品离子计算第二组一个或多个峰值参数。如果第一组一个或多个峰值参数和第二组一个或多个峰值参数基本上相同，则产物离子被识别为不包括干扰。通过将产物与分析物的前体离子相关联，产物离子进一步确认或确定为来自分析物而不是来自样品的基质。

5. 发明申请

WO2012063108A3 SYSTEMS AND METHODS FOR RAPIDLY SCREENING SAMPLES BY MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2012063108A3
公开(公告)日：2012-05-18
申请号：PCT/IB2011/002594
申请日：2011-11-02
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , BONNER, Ronald , TATE, Stephen, A.
发明人： BONNER, Ronald , TATE, Stephen, A.
IPC分类号： H01J49/00
摘要： Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.

6. 发明申请

WO2012032394A2 SYSTEMS AND METHODS FOR USING VARIABLE MASS SELECTION WINDOW WIDTHS IN TANDEM MASS SPECTROMETRY 审中-公开
标题翻译：用于在串联质谱法中使用可变质量选择窗口宽度的系统和方法
公开(公告)号：WO2012032394A2
公开(公告)日：2012-03-15
申请号：PCT/IB2011/002057
申请日：2011-09-07
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , BONNER, Ronald , TATE, Stephen, A.
发明人： BONNER, Ronald , TATE, Stephen, A.
CPC分类号： H01J49/0081 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045
摘要： Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
摘要翻译：系统和方法用于使用可变质量选择窗口宽度来分析样本。指示串联质谱仪使用处理器对具有不同质量选择窗口宽度的样品执行至少两个碎裂扫描。串联质谱仪包括质量分析器，可以选择不同的质量选择窗口宽度。不同质量选择窗口宽度的选择可以基于样品化合物的一个或多个性质。这些性质可以包括由预期化合物的分子量分布计算的样品化合物分子量分布，或者从一种或多种已知化合物的分子量列表确定。也可指示串联质谱仪在指示串联质谱仪执行样品的至少两个碎片扫描之前对样品进行分析。

7. 发明申请

WO2012164378A3 REMOVAL OF IONS FROM SURVEY SCANS USING VARIABLE WINDOW BAND-PASS FILTERING TO IMPROVE INTRASCAN DYNAMIC RANGE 审中-公开
公开(公告)号：WO2012164378A3
公开(公告)日：2012-12-06
申请号：PCT/IB2012/001054
申请日：2012-05-30
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , TATE, Stephen, A. , BLOOMFIELD, Nic, G.
发明人： TATE, Stephen, A. , BLOOMFIELD, Nic, G.
IPC分类号： H01J49/00
摘要： Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.

8. 发明申请

WO2012032394A3 SYSTEMS AND METHODS FOR USING VARIABLE MASS SELECTION WINDOW WIDTHS IN TANDEM MASS SPECTROMETRY 审中-公开
标题翻译：使用可变质量选择窗口宽度在质谱仪中的系统和方法
公开(公告)号：WO2012032394A3
公开(公告)日：2012-05-10
申请号：PCT/IB2011002057
申请日：2011-09-07
申请人： DH TECHNOLOGIES DEV PTE LTD , BONNER RONALD , TATE STEPHEN A
发明人： BONNER RONALD , TATE STEPHEN A
IPC分类号： H01J49/00
CPC分类号： H01J49/0081 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045
摘要： Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
摘要翻译：系统和方法用于使用可变质量选择窗口宽度来分析样本。指示串联质谱仪使用处理器对具有不同质量选择窗口宽度的样品进行至少两次碎片扫描。串联质谱仪包括质量分析器，允许质量选择窗口宽度可变。不同质量选择窗口宽度的选择可以基于样品化合物的一种或多种性质。性质可以包括根据预期化合物的分子量分布计算的样品化合物分子量分布，或由一种或多种已知化合物的分子量列表确定。也可以指示串联质谱仪在指示串联质谱仪进行样品的至少两次碎片扫描之前对样品进行分析。

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