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    • 3. 发明申请
    • IMPROVED PROCESS FOR THE REDUCTIVE AMINATION OF HALOGEN-CONTAINING SUBSTRATES
    • 用于含卤素底物的还原胺化的改进方法
    • WO2016071410A1
    • 2016-05-12
    • PCT/EP2015/075734
    • 2015-11-04
    • TAMINCO
    • MOONEN, KristofDUMOLEIJN, KimPRATI, LauraVILLA, Alberto
    • C07C209/26C07C211/29
    • C07C209/26A01N37/42C07B43/04C07C211/29C07C249/04
    • Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Pt, Rh, Ir, and Ru, and in absence of any catalytic amount of any second metal from the list consisting of Ag, Ni, Co, Sn, Bi, Cu, Au, and combinations thereof. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of active agrochemical compounds and microbicides of the methoximinophenylglyoxylic ester series.
    • 公开了一种用于在有机进料基质中进行第一官能团的还原胺化的方法,该进料底物包含至少一个含有卤素原子的另外的官能团,其中卤素原子选自氯,溴, 碘及其组合,在Pd和Pt,Rh,Ir和Ru列表中含有至少一种金属的氢气和非均相催化剂存在下,在不存在任何催化量的任何第二种金属的情况下, 的Ag,Ni,Co,Sn,Bi,Cu,Au及其组合。 该方法优选用于2-氯 - 苯甲醛的还原胺化以形成2-氯 - 苄基二甲胺,作为制备活性农药化合物和邻苯二甲酰苯基乙醛酸酯系列的杀微生物剂的中间体。