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1. 发明申请

WO2006091727A2 SINGLE BRANCH HEPARIN-BINDING GROWTH FACTOR ANALOGS 审中-公开
标题翻译：单分支HEPARIN-BINDING生长因子模拟
公开(公告)号：WO2006091727A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006397
申请日：2006-02-22
申请人： BIOSURFACE ENGINEERING TECHNOLOGIES, INC. , TAKAHASHI, Kazuyuki , ZAMORA, Paul, O.
发明人： TAKAHASHI, Kazuyuki , ZAMORA, Paul, O.
IPC分类号： A61K38/24 , B05D3/00 , A61F2/00
CPC分类号： C07K14/522 , A61K38/00 , C07K14/49 , C07K14/51
摘要： A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
摘要翻译：具有从单个氨基酸残基分支的两个基本相似的序列（同二聚体序列）的肝素结合生长因子（HBGF）类似物，其中序列是与肝素结合生长因子受体（HBGFR）结合的特定HBGF的类似物，或者可以结合HBGFR而不是任何特定HBGF的类似物。同型二聚体序列可以衍生自HBGF的任何部分。合成的HBGF类似物可以是激素，细胞因子，淋巴因子，趋化因子或白细胞介素的类似物，并且可以结合任何HBGFR。还提供了用于医疗装置，药物组合物及其使用方法的制剂。

2. 发明申请

WO2004061147A1 ALUMINUM PIPE AND PROCESS FOR PRODUCING SAME 审中-公开
标题翻译：铝管及其制造方法
公开(公告)号：WO2004061147A1
公开(公告)日：2004-07-22
申请号：PCT/JP2003/016921
申请日：2003-12-26
申请人： SHOWA DENKO K.K. , TAKAHASHI, Kazuyuki
发明人： TAKAHASHI, Kazuyuki
IPC分类号： C22F1/04
CPC分类号： F28F21/084 , C22C21/00 , C22F1/04 , F28F9/0246 , F28F9/0256
摘要： An inlet pipe 6 and an outlet pipe 7 for use in condensers are made from an alloy containing 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities. The inlet pipe 6 and the outlet pipe have an electrical conductivity of 30 to 43% IACS. The inlet pipe 6 and an outlet pipe 7 are each produced from a pipe blank made from an alloy containing 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities, by holding the pipe blank heated at 550 to 600 C in the atmosphere or in an inert gas atmosphere for 10 to 600 minutes and thereafter cooling the pipe blank. The inlet pipe 6 and the outlet pipe 7 can be produced easily at a low cost and have satisfactory resistance to pitting corrosion.
摘要翻译：用于冷凝器的入口管6和出口管7由含有0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金制成。入口管6和出口管的导电率为30〜43％IACS。入口管6和出口管7均由含有0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金制成，通过将加热至550〜600℃的管坯保持在气氛或惰性气体气氛中10〜600分钟，然后冷却管坯。入口管6和出口管7可以以低成本容易地制造并具有令人满意的耐点腐蚀性。

3. 发明申请

WO2006001541A3 ALUMINUM HEAT EXCHANGE TUBE AND PROCESS FOR FABRICATING SAME 审中-公开
标题翻译：铝热交换管及其制造方法
公开(公告)号：WO2006001541A3
公开(公告)日：2008-06-05
申请号：PCT/JP2005012285
申请日：2005-06-28
申请人： SHOWA DENKO KK , TAKAHASHI KAZUYUKI
发明人： TAKAHASHI KAZUYUKI
IPC分类号： F28F21/08 , C22C21/00 , C22F1/00 , C22F1/04 , F25B1/00 , F25B39/04
CPC分类号： F28D1/05383 , C22C21/00 , F25B2309/061 , F28D2021/0084 , F28D2021/0085 , F28F1/04 , F28F21/084 , Y10T29/4935
摘要： An aluminum heat exchange tube 4 is made of an alloy comprising 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities, and has electric conductivity of 30 to 43% IACS. The tube 4 is fabricated from a tube blank made of an alloy comprising 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities, by holding the blank heated at 550 to 600 C in the atmosphere or in an inert gas atmosphere for 10 to 600 minutes and subsequently cooling the blank. The tube is easy and inexpensive to make and satisfactory in resistance to pitting corrosion.
摘要翻译：铝热交换管4由包含0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金构成，导电率为30〜43％IACS。管4由包含0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金制成，通过在气氛中或惰性气体气氛中保持加热至550〜600℃的坯料， 10至600分钟，然后冷却空白。该管易于制造并且成本低廉且耐点腐蚀性。

4. 发明申请

WO2006001541A2 ALUMINUM HEAT EXCHANGE TUBE AND PROCESS FOR FABRICATING SAME 审中-公开
标题翻译：铝热交换管及其制造方法
公开(公告)号：WO2006001541A2
公开(公告)日：2006-01-05
申请号：PCT/JP2005/012285
申请日：2005-06-28
申请人： SHOWA DENKO K.K. , TAKAHASHI, Kazuyuki
发明人： TAKAHASHI, Kazuyuki
CPC分类号： F28D1/05383 , C22C21/00 , F25B2309/061 , F28D2021/0084 , F28D2021/0085 , F28F1/04 , F28F21/084 , Y10T29/4935
摘要： An aluminum heat exchange tube 4 is made of an alloy comprising 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities, and has electric conductivity of 30 to 43% IACS. The tube 4 is fabricated from a tube blank made of an alloy comprising 0.90 to 1.50 mass % of Mn, and the balance Al and inevitable impurities, by holding the blank heated at 550 to 600 C in the atmosphere or in an inert gas atmosphere for 10 to 600 minutes and subsequently cooling the blank. The tube is easy and inexpensive to make and satisfactory in resistance to pitting corrosion.
摘要翻译：铝热交换管4由包含0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金构成，导电率为30〜43％IACS。管4由包含0.90〜1.50质量％的Mn，余量为Al和不可避免的杂质的合金管制成，通过在气氛中或惰性气体气氛中保持加热至550〜600℃的坯料， 10至600分钟，然后冷却空白。该管易于制造并且成本低廉且耐点腐蚀性。

5. 发明申请

WO2005082005A3 POSITIVE MODULATOR OF BONE MORPHOGENIC PROTEIN-2 审中-公开
公开(公告)号：WO2005082005A3
公开(公告)日：2005-09-09
申请号：PCT/US2005/005880
申请日：2005-02-22
申请人： BIOSURFACE ENGINEERING TECHNOLOGIES, INC., ET AL. , BROOKHAVEN SCIENCE ASSOCIATES , ZAMORA, Paul, O. , PENA, Louis, A. , LIN, Xinhua , TAKAHASHI, Kazuyuki
发明人： ZAMORA, Paul, O. , PENA, Louis, A. , LIN, Xinhua , TAKAHASHI, Kazuyuki
IPC分类号： C07K5/00 , C07K14/00 , A61K38/00
摘要： Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

6. 发明申请

WO2005082005A2 POSITIVE MODULATOR OF BONE MORPHOGENIC PROTEIN-2 审中-公开
标题翻译：骨形态蛋白-2的正性调节剂
公开(公告)号：WO2005082005A2
公开(公告)日：2005-09-09
申请号：PCT/US2005005880
申请日：2005-02-22
申请人： BIOSURFACE ENG TECH INC , BROOKHAVEN SCIENCE ASS LLC , ZAMORA PAUL O , PENA LOUIS A , LIN XINHUA , TAKAHASHI KAZUYUKI
发明人： ZAMORA PAUL O , PENA LOUIS A , LIN XINHUA , TAKAHASHI KAZUYUKI
IPC分类号： A61K38/00 , A61L27/34 , C07H21/04 , C07K14/50
CPC分类号： C07K14/4705 , A61K31/727 , A61K38/00 , A61K38/1875 , A61K47/48246 , A61K47/64 , A61L27/34 , C07H21/04 , C07K14/475 , C07K14/503 , C07K14/51 , C07K2319/00 , C08L89/00
摘要： Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译：式I和式II的本发明的化合物在说明书中公开，其中所述化合物是骨形态发生蛋白活性的调节剂。化合物是具有非生长因子肝素结合区的合成肽，接头和与骨形态发生蛋白的受体特异性结合的序列。公开了本发明化合物在治疗骨损伤，退行性关节疾病和增强骨形成中的用途。

7. 发明申请

WO2006093814A3 FGF GROWTH FACTOR ANALOGS 审中-公开
标题翻译： FGF生长因子模拟
公开(公告)号：WO2006093814A3
公开(公告)日：2009-04-16
申请号：PCT/US2006006488
申请日：2006-02-24
申请人： BIOSURFACE ENG TECH INC , BROOKHAVEN SCIENCE ASS LLC , ZAMORA PAUL O , TAKAHASHI KAZUYUKI , PENA LOUIS A , LIN XINHUA
发明人： ZAMORA PAUL O , TAKAHASHI KAZUYUKI , PENA LOUIS A , LIN XINHUA
IPC分类号： C07K5/00 , A61K38/00 , C12N15/63
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where Ri, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
摘要翻译：本发明提供下式的成纤维细胞生长因子肝素结合类似物：其中R 1，R 2，R 3，R 4，R 5，X，Y和Z如上所定义，药物组合物，包衣组合物和包括成纤维细胞生长因子肝素 - 上述式的类似物及其方法和用途。

8. 发明申请

WO2006091727A3 SINGLE BRANCH HEPARIN-BINDING GROWTH FACTOR ANALOGS 审中-公开
标题翻译：单分支HEPARIN-BINDING生长因子模拟
公开(公告)号：WO2006091727A3
公开(公告)日：2007-03-01
申请号：PCT/US2006006397
申请日：2006-02-22
申请人： BIOSURFACE ENG TECH INC , TAKAHASHI KAZUYUKI , ZAMORA PAUL O
发明人： TAKAHASHI KAZUYUKI , ZAMORA PAUL O
IPC分类号： A61K38/16 , A61K38/17 , A61K38/18 , C07K14/00 , C07K14/475
CPC分类号： C07K14/522 , A61K38/00 , C07K14/49 , C07K14/51
摘要： A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
摘要翻译：具有从单个氨基酸残基分支的两个基本相似的序列（同二聚体序列）的肝素结合生长因子（HBGF）类似物，其中序列是与肝素结合生长因子受体（HBGFR）结合的特定HBGF的类似物，或者可以结合HBGFR而不是任何特定HBGF的类似物。同型二聚体序列可以衍生自HBGF的任何部分。合成的HBGF类似物可以是激素，细胞因子，淋巴因子，趋化因子或白细胞介素的类似物，并且可以结合任何HBGFR。还提供了用于医疗装置，药物组合物及其使用方法的制剂。

9. 发明申请

WO2006093814A2 FGF GROWTH FACTOR ANALOGS 审中-公开
标题翻译： FGF生长因子模拟
公开(公告)号：WO2006093814A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/006488
申请日：2006-02-24
申请人： BIOSURFACE ENGINEERING TECHNOLOGIES, INC. , BROOKHAVEN NATIONAL LABORATORY , ZAMORA, Paul, O. , TAKAHASHI, Kazuyuki , PENA, Louis, A. , LIN, Xinhua
发明人： ZAMORA, Paul, O. , TAKAHASHI, Kazuyuki , PENA, Louis, A. , LIN, Xinhua
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where Ri, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
摘要翻译：本发明提供下式的成纤维细胞生长因子肝素结合类似物：其中R 1，R 2，R 3，R 4，R 5，X，Y和Z如上所定义，药物组合物，包衣组合物和包括成纤维细胞生长因子肝素 - 上述式的类似物及其方法和用途。

10. 发明申请

WO2005082005A8 POSITIVE MODULATOR OF BONE MORPHOGENIC PROTEIN-2 审中-公开
标题翻译：骨形态发生蛋白-2的阳性调节因子
公开(公告)号：WO2005082005A8
公开(公告)日：2006-05-11
申请号：PCT/US2005005880
申请日：2005-02-22
申请人： BIOSURFACE ENG TECH INC , BROOKHAVEN SCIENCE ASS LLC , ZAMORA PAUL O , PENA LOUIS A , LIN XINHUA , TAKAHASHI KAZUYUKI
发明人： ZAMORA PAUL O , PENA LOUIS A , LIN XINHUA , TAKAHASHI KAZUYUKI
IPC分类号： A61K38/00 , A61L27/34 , C07H21/04 , C07K14/50
CPC分类号： C07K14/4705 , A61K31/727 , A61K38/00 , A61K38/1875 , A61K47/48246 , A61K47/64 , A61L27/34 , C07H21/04 , C07K14/475 , C07K14/503 , C07K14/51 , C07K2319/00 , C08L89/00
摘要： Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译：式I和式II的本发明化合物公开于说明书中，并且其中所述化合物是骨形态发生蛋白活性的调节剂。化合物是具有非生长因子肝素结合区，接头和与骨形态发生蛋白受体特异性结合的序列的合成肽。公开了本发明化合物在治疗骨损伤，退行性关节疾病和增强骨形成中的用途。

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