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1. 发明申请

WO0183755A3 HUMAN ANTI-CD40 ANTIBODIES AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：人抗CD40抗体及其制备和使用方法
公开(公告)号：WO0183755A3
公开(公告)日：2002-05-23
申请号：PCT/US0113672
申请日：2001-04-27
申请人： GEMINI SCIENCE INC , MIKAYAMA TOSHIFUMI , TAKAHASHI NOBUAKI , CHEN XINGJIE , SCHOENBERGER STEPHEN P
发明人： MIKAYAMA TOSHIFUMI , TAKAHASHI NOBUAKI , CHEN XINGJIE , SCHOENBERGER STEPHEN P
IPC分类号： A61P31/00 , A61P35/00 , A61P37/06 , C07K16/28 , C12N5/20 , C12N15/13 , A61K39/395 , C12N5/10 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2319/00 , C07K2319/30 , G01N2333/70578
摘要： The invention is directed to human antibodies that bind CD40 (e.g., human CD40), methods of producing the antibodies and methods of use. Invention human CD40 antibodies include antibodies that can modulate one or more activities of CD40, such as increasing or decreasing cell proliferation. Invention human CD40 antibodies are therefore useful for increasing or decreasing a CD40 activity in order to alter CD40 activity in vivo .
摘要翻译：本发明涉及结合CD40（例如人CD40）的人抗体，产生抗体的方法和使用方法。本发明人CD40抗体包括可调节CD40的一种或多种活性的抗体，例如增加或减少细胞增殖。因此，本发明人CD40抗体可用于增加或降低CD40活性以便改变体内CD40活性。

2. 发明申请

WO2014024234A1 STEEL PLATE FOR HIGH STRENGTH STEEL PIPE AND HIGH STRENGTH STEEL PIPE 审中-公开
标题翻译：高强度钢管和高强度钢管钢板
公开(公告)号：WO2014024234A1
公开(公告)日：2014-02-13
申请号：PCT/JP2012/005117
申请日：2012-08-10
申请人： NIPPON STEEL & SUMITOMO METAL CORPORATION , MINATO, Izuru , TAKAHASHI, Nobuaki
发明人： MINATO, Izuru , TAKAHASHI, Nobuaki
IPC分类号： C22C38/08
CPC分类号： C22C38/08
摘要： There is provided a steel plate for a high strength steel pipe and the high strength steel pipe having excellent HIC resistance. The high strength steel pipe contains, by mass%, C: 0.020 to 0.070%; Si: 0.05 to 0.50%; Mn: 1.10 to 1.60%; P: 0.008% or less; S: 0.0006% or less; Cu: 0.05 to 0.50%; Cr: 0.05 to 0.50%; Ni: 0.05 to 1.00%; Mo: 0.50% or less; Nb: 0.005 to 0.080%; V: 0.005 to 0.080%; Ti: 0.005 to 0.030%; N: 0.0015 to 0.0070%; Al: 0.005 to 0.060%; and Ca: 0.0005 to 0.0060%, the balance being Fe and impurities, and satisfying the formula (1): 0.6
摘要翻译：提供了一种用于高强度钢管的钢板和具有优异的耐HIC性的高强度钢管。高强度钢管以质量％计含有C：0.020〜0.070％， Si：0.05〜0.50％ Mn：1.10〜1.60％ P：0.008％以下; S：0.0006％以下; Cu：0.05〜0.50％ Cr：0.05〜0.50％ Ni：0.05〜1.00％ Mo：0.50％以下; Nb：0.005〜0.080％ V：0.005〜0.080％ Ti：0.005〜0.030％ N：0.0015〜0.0070％ Al：0.005〜0.060％和Ca：0.0005〜0.0060％，余量为Fe和杂质，满足式（1）：0.6

3. 发明申请

WO0170805A3 SOLUBLE MAST CELL FUNCTION ASSOCIATED ANTIGEN (MAFA) PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：可溶性细胞功能相关抗原（MAFA）药物组合物及其制备和使用方法
公开(公告)号：WO0170805A3
公开(公告)日：2002-03-14
申请号：PCT/US0108596
申请日：2001-03-16
申请人： GEMINI SCIENCE INC , TAKAHASHI NOBUAKI , MIKAYAMA TOSHIFUMI
发明人： TAKAHASHI NOBUAKI , MIKAYAMA TOSHIFUMI
IPC分类号： A61K38/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/48
CPC分类号： C07K16/28 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K2317/54 , C12N2799/026
摘要： This invention provides pharmaceutical compositions and methods for controlling and modifying Natural Killer (NK) cell and T cell functions by manipulation of "mast cell function-associated antigen", or "MAFA", polypeptide-mediated cell signaling. The invention provides pharmaceutical compositions and methods using an agent that specifically binds to an MAFA ligand on a target cell and prevents or inhibits NK- or T cell-expressed cell surface MAFA from binding to the MAFA ligand on the target cell. Preventing or inhibiting an NK- or a T cell-expressed cell surface MAFA from binding to the MAFA ligand on the target cell prevents or inhibits the cell surface MAFA from generating an inhibitory signal to the NK or the T cell. The invention also provides pharmaceutical compositions and methods using an agent that specifically binds to an NK- or a T cell-expressed cell surface MAFA and prevents or inhibits the NK- or T cell-expressed cell surface MAFA from binding to a MAFA ligand or generating an inhibitory signal to the NK or the T cell. The invention also provides pharmaceutical compositions and methods using an agent that specifically binds to an NK- or a T cell-expressed cell surface MAFA and inhibits an NK cell or T cell activity.
摘要翻译：本发明提供了通过操纵“肥大细胞功能相关抗原”或“MAFA”，多肽介导的细胞信号传导来控制和修饰天然杀伤（NK）细胞和T细胞功能的药物组合物和方法。本发明提供药物组合物和方法，其使用特异性结合靶细胞上的MAFA配体并阻止或抑制NK细胞或T细胞表达的细胞表面MAFA与靶细胞上的MAFA配体结合的试剂。预防或抑制NK细胞或T细胞表达的细胞表面MAFA与靶细胞上的MAFA配体的结合阻止或抑制细胞表面MAFA向NK细胞或T细胞产生抑制性信号。本发明还提供了药物组合物和方法，其使用特异性结合NK-或T细胞表达的细胞表面MAFA并阻止或抑制NK-或T细胞表达的细胞表面MAFA与MAFA配体结合或产生对NK或T细胞的抑制信号。本发明还提供了使用特异性结合NK-或T细胞表达的细胞表面MAFA并抑制NK细胞或T细胞活性的药剂的药物组合物和方法。

4. 发明申请

WO1997025231A1 PARKING DEVICE FOR AUTOMATIC TRANSMISSION 审中-公开
标题翻译：自动变速器停车装置
公开(公告)号：WO1997025231A1
公开(公告)日：1997-07-17
申请号：PCT/JP1997000041
申请日：1997-01-10
申请人： AISIN AW CO., LTD. , TOYOTA JIDOSHA KABUSHIKI KAISHA , TANIGUCHI, Takao , TSUKAMOTO, Kazumasa , YOKOYAMA, Humitomo , OZAKI, Kazuhisa , KUROYANAGI, Akihiro , HONGOYA, Akihito , HOJO, Yasuo , SAYO, Syoichi , HUKUMURA, Kagenori , NAKAWAKI, Yasunori , TABATA, Atsushi , NAKAMURA, Yasunari , TAKAHASHI, Nobuaki , MIYATA, Hideki
发明人： AISIN AW CO., LTD. , TOYOTA JIDOSHA KABUSHIKI KAISHA
IPC分类号： B60T01/06
CPC分类号： F16H63/3416 , B60T1/005 , Y10T74/19637 , Y10T74/2137
摘要： A parking device for an automatic transmission for preventing the generation of abnormal noises and shocks when a parking range is released after a vehicle is parked so as not to make the driver feel incongruous, the device comprising a parking gear (16), a parking pawl (17) swingably disposed and having a rachet (18) adapted to selectively come into mesh engagement with a tooth space (22) of the parking gear (16), a mesh engagement blocking means for taking a blocking position where the mesh engagement between the rachet (18) and the tooth space (22) is blocked and a blocking release position where the blocking of mesh engagement is released and a mesh engagement blocking releasing means adapted to interlock with the rotation of the parking gear (16) for setting the mesh engagement blocking means at the blocking release position, wherein the rachet (18) and the tooth space (22) are brought into mesh engagement with each other when a residual torque retained between the parking gear (16) and driving wheels is released.
摘要翻译：一种用于自动变速器的停车装置，用于在车辆停放后停放停车范围时防止产生异常噪音和冲击，从而不致使驾驶员感到不协调，该装置包括驻车档（16），停车掣（17），其可摆动地设置并具有适于选择性地与所述驻车齿轮（16）的齿空间（22）啮合的刺刀（18）;网状接合阻挡装置，用于采取阻挡位置，漏斗（18）和齿隙（22）被阻挡，并且释放啮合的阻塞的阻挡释放位置和适于与驻车档（16）的旋转互锁的网眼接合阻止释放装置，用于设置网接合阻挡装置处于阻挡释放位置，其中当驻车齿轮（1）和驻车齿轮（1）之间保持的剩余转矩保持在一起时，冲绳（18）和齿隙（22）彼此啮合 6）和驱动轮被释放。

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