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1. 发明申请

WO2004000992A8 TISSUE MICROARRAY BUILDER MANUAL SET 审中-公开
标题翻译：组织MICROARRAY BUILDER手册
公开(公告)号：WO2004000992A8
公开(公告)日：2005-04-07
申请号：PCT/HU0300044
申请日：2003-06-17
申请人： SZEKERES GYOERGY , HALAS ZSUZSANNA , ZORN LASZLONE
发明人： SZEKERES GYOERGY , HALAS ZSUZSANNA , ZORN LASZLONE
IPC分类号： C12M1/34 , G01N1/28 , G01N1/36 , C12M1/00
CPC分类号： G01N1/36 , G01N2001/288 , G01N2001/366 , G01N2001/368
摘要： The tissue micro-array (TMA) building manual set, which includes a well-known SZK tissue core punch extractor and a TMA block mould (1) characterized as follows: the TMA block mould (1) consists of a lower (2) and an upper (3) part, the lower part (2) is equipped with mandrels (4) at right angles to the base unit arranged in the middle into lines and columns, the upper part (3) has a margin-containing (7) cleavage (6), which receives the mandrels (4) when the TMA block mould (1) is assembled, the margin (7) and size of the cleavage (6) fit to the shape and size of the paraffin block holder (PBK), and the lower (2) and upper (3) parts are connected to each other with directing nipples (5) and threaded arms (9) fixed horizontally.
摘要翻译：组织微阵列（TMA）建筑手册，其中包括一个众所周知的SZK组织芯打孔提取器和一个TMA块模具（1），其特征如下：TMA块模具（1）由下（2）和上部（3）部分，下部（2）配备有与中间布置成线和列的基部单元成直角的心轴（4），上部（3）具有边缘（7）当组装TMA块模具（1）时接收心轴（4）的裂缝（6），裂缝（6）的边缘（7）和尺寸适合石蜡块保持器（PBK）的形状和尺寸，，并且下部（2）和上部（3）部分通过水平固定的引导接头（5）和螺纹臂（9）彼此连接。

2. 发明申请

WO2005106026B1 USE OF GENES AS MOLECULAR MARKERS IN DIAGNOSIS OF SCHIZOPHRENIA AND DIAGNOSTIC KIT FOR THE SAME 审中-公开
标题翻译：作为分子标记使用基因分子标记物及其诊断试剂盒
公开(公告)号：WO2005106026B1
公开(公告)日：2006-01-19
申请号：PCT/HU2005000044
申请日：2005-05-02
申请人： Y OF SCIENCES BIOLOG RES CT OF , PUSKAS LASZLO , ZVARA AGNES , SANTHA MIKLOS , SZEKERES GYOERGY , JANKA ZOLTAN
发明人： PUSKAS LASZLO , ZVARA AGNES , SANTHA MIKLOS , SZEKERES GYOERGY , JANKA ZOLTAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Drug-naive and drug-free schizophrenic PBL were screened to identify additional markers that are differentially expressed compared to healthy individuals using microarray and quantitative real-time PCR (QRT-PCR) techniques. Genes for dopamine D 2 receptor (DRD2) and inwardly rectifying potassium channel (Kir2.3) were found to be overexpressed in microarray analysis. Increased mRNA levels were confirmed by QRT-PCR using SybrGreen method and dual labeled TaqMan probes. The invention relates to a method for diagnosing schizophrenia in a subject comprising assessing level or the expression level of at least one of the following genes or proteins: Kir2.3 or DRD2 or a gene encoding Kir2.3 or DRD2. The invention further relates to agents and uses thereof, said agents specifically binding to said proteins or nucleic acids encoding them, diagnostic kits and screening methods. Use of both molecular markers allow prediction of schizophrenia and help to follow the efficiency of drugs in therapy in order to provide a more tailored medication for schizophrenic patients.
摘要翻译：筛选无天真和无药物精神分裂症的PBL，以鉴定与使用微阵列和定量实时PCR（QRT-PCR）技术的健康个体差异表达的其他标志物。发现多巴胺D 2受体（DRD2）和内向整流钾通道（Kir2.3）的基因在微阵列分析中过表达。使用SybrGreen方法和双重标记的TaqMan探针通过QRT-PCR证实增加的mRNA水平。本发明涉及一种诊断受试者精神分裂症的方法，包括评估至少一种以下基因或蛋白质的水平或表达水平：Kir2.3或DRD2或编码Kir2.3或DRD2的基因。本发明还涉及其药剂及其用途，所述药剂特异性结合所述蛋白质或编码它们的核酸，诊断试剂盒和筛选方法。使用两种分子标记物可以预测精神分裂症，并有助于遵循药物在治疗中的效率，以便为精神分裂症患者提供更加定制的药物。

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