专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005032594A3 ALKYLATORS LINKED TO POLYAMIDES AS DNA BINDING AGENTS 审中-公开
公开(公告)号：WO2005032594A3
公开(公告)日：2005-04-14
申请号：PCT/US2004/032617
申请日：2004-10-01
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SZEKELY, Zoltan , HARIPRAKASHA, Humcha, K. , MICHEJDA, Christopher, J.
发明人： SZEKELY, Zoltan , HARIPRAKASHA, Humcha, K. , MICHEJDA, Christopher, J.
IPC分类号： A61K47/48 , C07D209/12 , C07D209/60 , C07D405/14 , C07D209/94
摘要： The invention provides an alkylator that is an analog of a compound based on 5-oxo-1a,2,3,5-tetrahydro-1H-3-aza-cyclopropa[c]indene-7-carboxylic acid, 9a-chloromethyl-4-oxo-2,4,9,9a-tetrahydro-1H-2-aza-cyclopropa[1,5]cyclopenta[1,2-a]naphthalene-7-carboxylic acid, or 4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid and conjugates thereof.

2. 发明申请

WO2003072058A3 DNA-BINDING POLYAMIDE DRUG CONJUGATES 审中-公开
公开(公告)号：WO2003072058A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/006006
申请日：2003-02-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, representated by THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICES , SZEKELY, Zoltan , HARIPRAKASHA, Humcha, Krishnamurthy , CHOLODY, Marek, W. , MICHEJDA, Christopher, J.
发明人： SZEKELY, Zoltan , HARIPRAKASHA, Humcha, Krishnamurthy , CHOLODY, Marek, W. , MICHEJDA, Christopher, J.
IPC分类号： A61K38/00
摘要： A conjugate of formula: V-(Y) a -Z-T: (I), T-X-B-(Y) a -Z-T': (II), V-(Y) a Z-(Y') a V': (III), T-X-B-(Y) a -Z-(Y') a -X'-B'-T': (IV), V-(Y) a -Z-(Y') a -X-B-T : (V), V-(Y) a -Z-X-B-Z'-(Y') a -(V') b : (VI), or (W) a -(Y) b -[(Z) c -(Y') d -(X-B) e -(Y") f -(Z') g ] h -(Y ...) i -(W') j : (VII), in which W and W' are independently a DNA intercalator or terminal subunit, V and V' are independently a DNA intercalator, X and X' are independently a DNA alkylator, B and B' are the same or different and each is a heteroaromatic residue that is attached to the Nterminus of an alkylator subunit (X or X'), Y, Y', Y" and Y"' are independently a linker, T and T' are independently terminal subunits, Z and Z' are independently a polyamide group that binds to the minor groove of DNA, a, b, c, d, f, g, i, and j are independently 0 to 5, and e and h are independently 1 to 5, a composition comprising a conjugate of any of formulae (I)-(VII) and a carrier, and a method for treating cancer in a mammal comprising administering an effective amount of a conjugate of any of formulae (I)-(VII) or a composition comprising same.

3. 发明申请

WO2011078893A1 DERIVATIVES OF APF AND METHODS OF USE 审中-公开
标题翻译： APF的衍生物和使用方法
公开(公告)号：WO2011078893A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/045863
申请日：2010-08-18
申请人： THE UNIVERSITY OF MARYLAND, BALTIMORE , KEAY, Susan, K. , MICHEJDA, Christopher , SZEKELY, Zoltan
发明人： KEAY, Susan, K. , MICHEJDA, Christopher , SZEKELY, Zoltan
IPC分类号： A61K38/08
CPC分类号： C07K9/005 , A61K38/00
摘要： Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.
摘要翻译：公开了包含糖肽的新型抗增殖因子的衍生物。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。在具体实施方案中，糖肽包含D-脯氨酸。

4. 发明申请

WO2005032594A2 BUILDING BLOCKS FOR DNA BINDING AGENTS 审中-公开
标题翻译：用于DNA绑定代理的建筑块
公开(公告)号：WO2005032594A2
公开(公告)日：2005-04-14
申请号：PCT/US2004032617
申请日：2004-10-01
申请人： US GOV HEALTH & HUMAN SERV , SZEKELY ZOLTAN , HARIPRAKASHA HUMCHA K , MICHEJDA CHRISTOPHER J
发明人： SZEKELY ZOLTAN , HARIPRAKASHA HUMCHA K , MICHEJDA CHRISTOPHER J
IPC分类号： A61K47/48 , C07D209/12 , C07D209/60 , C07D209/94 , C07D405/14 , C07D487/04
CPC分类号： C07D487/04 , A61K47/54 , C07D209/12 , C07D209/60 , C07D209/94 , C07D405/14
摘要： The invention provides an alkylator that is an analog of a compound based on 5-oxo-1a,2,3,5-tetrahydro-1H-3-aza-cyclopropa[c]indene-7-carboxylic acid, 9a-chloromethyl-4-oxo-2,4,9,9a-tetrahydro-1H-2-aza-cyclopropa[1,5]cyclopenta[1,2-a]naphthalene-7-carboxylic acid, or 4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid and conjugates thereof.
摘要翻译：本发明提供了一种烷基化剂，其是基于5-氧代-1a,2,3,5-四氢-1H-3-氮杂 - 环丙并[c]茚-7-羧酸，9a-氯甲基-4 - 氧代-2,4,9,9a-四氢-1H-2-氮杂 - 环丙[1,5]环戊二烯并[1,2-a]萘-7-羧酸或4-氧代-1,2,4- ，5,8,8a-六氢环丙基[c]吡咯并[3,2-e]吲哚-6-羧酸及其偶联物。

5. 发明申请

WO2012051581A2 INTESTINAL PEPTIDE TARGETING LIGANDS 审中-公开
标题翻译： INTESTINAL PEPTIDE TARGTING LIGANDS
公开(公告)号：WO2012051581A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/056449
申请日：2011-10-14
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , SINKO, Patrick, J. , ZHANG, Xiaoping , SZEKELY, Zoltan
发明人： SINKO, Patrick, J. , ZHANG, Xiaoping , SZEKELY, Zoltan
IPC分类号： A61K38/08
CPC分类号： C07K7/08 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/62 , A61K47/6925 , C07K7/06
摘要： Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed.
摘要翻译：通过肠上皮屏障传递治疗剂的肽配体，其通常未被充分吸收并且必须通过替代手段递送，其中所述替代方法含有分离的氨基酸序列，其中至少一对氨基酸具有相反电荷，并且所述成对体被分离通过包含至少一个疏水性氨基酸的1-12个氨基酸残基的间隔区，并且其中氨基酸序列的长度大于5个且小于20个氨基酸。还公开了用于胃肠输送的药物组合物和用于胃肠递送不良吸收的治疗剂的方法。

6. 发明申请

WO2010022089A3 DERIVATIVES OF APF AND METHODS OF USE 审中-公开
标题翻译： APF衍生物和使用方法
公开(公告)号：WO2010022089A3
公开(公告)日：2010-07-01
申请号：PCT/US2009054207
申请日：2009-08-18
申请人： UNIV MARYLAND , US HEALTH , KEAY SUSAN K , SZEKELY ZOLTAN , MICHEJDA MARIA , KACZMAREK PIOTR
发明人： KEAY SUSAN K , SZEKELY ZOLTAN , KACZMAREK PIOTR , MICHEJDA CHRISTOPHER
IPC分类号： A61K38/14 , A61P35/00
CPC分类号： A61K38/14
摘要： Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.
摘要翻译：公开了膀胱上皮抗增殖因子的衍生物及其使用方法。在具体的实施方案中，糖肽组合物可用于治疗和/或预防包括癌症的医学病症。在其他实施方案中，存在与治疗膀胱病症有关的组合物和方法。在具体的实施方案中，糖肽包含D-哌可酸或L-哌可酸。

7. 发明申请

WO2012051581A3 INTESTINAL PEPTIDE TARGETING LIGANDS 审中-公开
标题翻译： INTESTINAL PEPTIDE TARGTING LIGANDS
公开(公告)号：WO2012051581A3
公开(公告)日：2014-04-03
申请号：PCT/US2011056449
申请日：2011-10-14
申请人： UNIV RUTGERS , SINKO PATRICK J , ZHANG XIAOPING , SZEKELY ZOLTAN
发明人： SINKO PATRICK J , ZHANG XIAOPING , SZEKELY ZOLTAN
IPC分类号： C07K4/00 , C07K7/00
CPC分类号： C07K7/08 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/62 , A61K47/6925 , C07K7/06
摘要： Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed.
摘要翻译：通过肠上皮屏障传递治疗剂的肽配体，其通常未被充分吸收并且必须通过替代手段递送，其中所述替代方法含有分离的氨基酸序列，其中至少一对氨基酸具有相反电荷，并且所述成对体被分离通过包含至少一个疏水性氨基酸的1-12个氨基酸残基的间隔区，并且其中氨基酸序列的长度大于5个且小于20个氨基酸。还公开了用于胃肠输送的药物组合物和用于胃肠递送不良吸收的治疗剂的方法。

8. 发明申请

WO2005016248A3 A NOVEL ANTIPROLIFERATIVE FACTOR AND METHODS OF USE 审中-公开
标题翻译：一种新型抗增殖因子及其使用方法
公开(公告)号：WO2005016248A3
公开(公告)日：2005-09-22
申请号：PCT/US2004021239
申请日：2004-07-01
申请人： UNIV MARYLAND , US GOV HEALTH & HUMAN SERV , KEAY SUSAN K , SZEKELY ZOLTAN , MICHEJDA CHRISTOPHER
发明人： KEAY SUSAN K , SZEKELY ZOLTAN , MICHEJDA CHRISTOPHER
IPC分类号： A61K20060101 , A61K38/16 , C07K7/00 , C07K7/06 , C07K9/00 , G01N33/68 , C07K38/12
CPC分类号： C07K9/005 , A61K38/00 , C07K7/06 , G01N33/6893 , G01N2800/34
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

9. 发明申请

WO2003072058A2 DNA-BINDING POLYAMIDE DRUG CONJUGATES 审中-公开
标题翻译： DNA结合聚酰胺药物结合
公开(公告)号：WO2003072058A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/006006
申请日：2003-02-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, representated by THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICES , SZEKELY, Zoltan , HARIPRAKASHA, Humcha, Krishnamurthy , CHOLODY, Marek, W. , MICHEJDA, Christopher, J.
发明人： SZEKELY, Zoltan , HARIPRAKASHA, Humcha, Krishnamurthy , CHOLODY, Marek, W. , MICHEJDA, Christopher, J.
IPC分类号： A61K
CPC分类号： A61K47/645
摘要： A conjugate of formula: V-(Y) a -Z-T: (I), T-X-B-(Y) a -Z-T': (II), V-(Y) a Z-(Y') a V': (III), T-X-B-(Y) a -Z-(Y') a -X'-B'-T': (IV), V-(Y) a -Z-(Y') a -X-B-T : (V), V-(Y) a -Z-X-B-Z'-(Y') a -(V') b : (VI), or (W) a -(Y) b -[(Z) c -(Y') d -(X-B) e -(Y") f -(Z') g ] h -(Y ...) i -(W') j : (VII), in which W and W' are independently a DNA intercalator or terminal subunit, V and V' are independently a DNA intercalator, X and X' are independently a DNA alkylator, B and B' are the same or different and each is a heteroaromatic residue that is attached to the Nterminus of an alkylator subunit (X or X'), Y, Y', Y" and Y"' are independently a linker, T and T' are independently terminal subunits, Z and Z' are independently a polyamide group that binds to the minor groove of DNA, a, b, c, d, f, g, i, and j are independently 0 to 5, and e and h are independently 1 to 5, a composition comprising a conjugate of any of formulae (I)-(VII) and a carrier, and a method for treating cancer in a mammal comprising administering an effective amount of a conjugate of any of formulae (I)-(VII) or a composition comprising same.
摘要翻译：式（V）（Y）aZT：（I），TXB-（Y）aZ-T'：（II），V-（Y）a Z-（Y'）a V' TXB-（Y）aZ-（Y'）a-X'-B'-T'：（IV），V-（Y）aZ-（Y'）aXBT：（V），V-（Y）aZXB- Z' - （Y'）a-（V'）b：（VI）或（W）a-（Y）b - [（Z）c-（Y'）d-（XB）e-（Y“ ）f-（Z'）g] h-（Y ...）i-（W'）j：（VII），其中W和W'独立地是DNA嵌入剂或末端亚单元，V和V' DNA嵌入剂X和X'独立地是DNA烷基化剂，B和B'相同或不同，并且各自是连接到烷基化子亚单位（X或X'），Y，Y'的N末端的杂芳族残基，，Y“和Y”'独立地是连接体，T和T'独立地是末端亚单元，Z和Z'独立地是结合DNA的小沟的聚酰胺基团，a，b，c，d，f，g i和j独立地为0〜5，e和h独立地为1〜5，包含式（I） - （VII）中任一式的结合物和载体的组合物，以及哺乳动物的癌症治疗方法包括施用有效的（I） - （VII）中任一项的缀合物或包含其的组合物。

10. 发明申请

WO2010022089A9 DERIVATIVES OF APF AND METHODS OF USE 审中-公开
公开(公告)号：WO2010022089A9
公开(公告)日：2010-05-14
申请号：PCT/US2009054207
申请日：2009-08-18
申请人： UNIV MARYLAND , US HEALTH , KEAY SUSAN K , SZEKELY ZOLTAN , MICHEJDA MARIA , KACZMAREK PIOTR
发明人： KEAY SUSAN K , SZEKELY ZOLTAN , KACZMAREK PIOTR , MICHEJDA CHRISTOPHER
IPC分类号： A61K38/14 , A61P35/00
CPC分类号： A61K38/14
摘要： Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式