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1. 发明申请

WO2005089738A2 USE AND ADMINISTRATION OF BACTERIAL EFFLUX PUMP INHIBITORS 审中-公开
标题翻译：使用和管理细菌油泵抑制剂
公开(公告)号：WO2005089738A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008873
申请日：2005-03-16
申请人： MPEX PHARMACEUTICALS, INC. , BOSTION, Keith , GLINKA, Tomasz , LOMOVSKAYA, Olga , SURBER, Mark
发明人： BOSTION, Keith , GLINKA, Tomasz , LOMOVSKAYA, Olga , SURBER, Mark
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/421 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial, and novel medical methods.
摘要翻译：本发明提供了与抗微生物剂共同施用的外排泵抑制剂，用于治疗由耐药性病原体引起的感染，新型外排泵抑制剂，具有抗微生物剂的外排泵抑制剂的组合剂型和新颖的医学方法。

2. 发明申请

WO2009086470A3 AEROSOLIZED NITRITE AND NITRIC OXIDE - DONATING COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：气溶性硝酸盐和硝酸氧化物 - 配位化合物及其用途
公开(公告)号：WO2009086470A3
公开(公告)日：2009-09-03
申请号：PCT/US2008088340
申请日：2008-12-24
申请人： AIRES PHARMACEUTICALS INC , SURBER MARK W , ELLIOTT GARY T , BARKER GEOFFREY EUGENE
发明人： SURBER MARK W , ELLIOTT GARY T , BARKER GEOFFREY EUGENE
IPC分类号： A61K33/18 , A61P11/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/008
摘要： Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
摘要翻译：本文公开了适用于气溶胶化的亚硝酸盐，亚硝酸盐或产生亚硝酸盐或一氧化一氮的化合物的制剂，并且用于这种制剂用于气雾剂施用亚硝酸盐，亚硝酸盐或用于治疗肺的亚硝酸盐或一氧化氮的化合物动脉高血压，鼻内或肺部细菌感染，或治疗或预防参与移植的心脏，脑和器官的缺血再灌注损伤。特别地，描述了特别配制并输送到呼吸道用于适应症的吸入亚硝酸盐，亚硝酸盐或亚硝酸盐或一氧化氮供体化合物。组合物包括本文所述的所有制剂，试剂盒和装置组合。方法包括用于生产和使用所述组合物的吸入程序和制造方法。

3. 发明申请

WO2007095156A2 TASTE MASKING OF AEROSOLIZED FLUOROQUINOLONES 审中-公开
标题翻译：气溶胶荧光素的掩蔽
公开(公告)号：WO2007095156A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003649
申请日：2007-02-12
申请人： MPEX PHARMACEUTICALS, INC. , SURBER, Mark , BOSTIAN, Keith , LOMOVSKAYA, Olga , GRIFFITH, David , DUDLEY, Mike
发明人： SURBER, Mark , BOSTIAN, Keith , LOMOVSKAYA, Olga , GRIFFITH, David , DUDLEY, Mike
IPC分类号： A61K9/00 , A61K9/12 , A61K9/127 , A61K9/51 , A61K9/16 , A61K31/00
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/08 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
摘要翻译：本文公开了适用于气溶胶化和使用这种制剂的氟喹诺酮类制剂用于气雾剂施用氟喹诺酮抗微生物剂以治疗肺细菌感染。特别地，描述了专门配制并递送用于肺细菌感染的吸入性左氧氟沙星。方法包括用于生产和使用所述组合物的吸入方案和制造方法。

4. 发明申请

WO2006125132A2 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 审中-公开
标题翻译：水溶性氟化物及其用途
公开(公告)号：WO2006125132A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/019351
申请日：2006-05-18
申请人： MPEX PHARMACEUTICALS, INC. , SURBER, Mark, W. , BOSTIAN, Keith, A. , LOMOVSKAYA, Olga , GRIFFITH, David, C. , DUDLEY, Michael N.
发明人： SURBER, Mark, W. , BOSTIAN, Keith, A. , LOMOVSKAYA, Olga , GRIFFITH, David, C. , DUDLEY, Michael N.
IPC分类号： A61K31/538 , A61K31/4375 , A61K31/47 , A61K9/12 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/14 , A61K9/145 , A61K31/5383 , A61K33/06 , A61K33/14 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
摘要翻译：本文公开了适用于气溶胶化和使用这种制剂的氟喹诺酮类制剂用于气雾剂施用氟喹诺酮抗微生物剂以治疗肺细菌感染。特别地，描述了专门配制并递送用于肺细菌感染的吸入性左氧氟沙星。方法包括用于生产和使用所述组合物的吸入方案和制造方法。

5. 发明申请

WO2010042553A1 AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS 审中-公开
标题翻译：用于改进药物动力学的气溶胶氟喹诺酮配方
公开(公告)号：WO2010042553A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/059744
申请日：2009-10-06
申请人： MPEX PHARMACEUTICALS, INC. , GRIFFITH, David, C. , DUDLEY, Michael, N. , SURBER, Mark, W. , BOSTIAN, Keith, A. , RODNY, Olga
发明人： GRIFFITH, David, C. , DUDLEY, Michael, N. , SURBER, Mark, W. , BOSTIAN, Keith, A. , RODNY, Olga
IPC分类号： A61K9/00 , A61K47/02 , A61K31/4375 , A61K31/47 , A61K31/538
CPC分类号： A61K31/5383 , A61K9/0073 , A61K9/0078 , A61K31/4375 , A61K31/47 , A61K31/536 , A61K31/538 , A61K47/02 , Y02A50/401 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.
摘要翻译：本发明涉及抗微生物剂领域。特别地，本发明涉及用二价或三价阳离子配制的雾化氟喹诺酮类药物，并且具有改善的肺可用性，用于治疗和管理肺和上呼吸道的细菌感染。

6. 发明申请

WO2009086470A2 AEROSOLIZED NITRITE AND NITRIC OXIDE - DONATING COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：气溶胶亚硝酸盐和一氧化氮供体化合物及其用途
公开(公告)号：WO2009086470A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088340
申请日：2008-12-24
申请人： AIRES PHARMACEUTICALS, INC. , SURBER, Mark, W. , ELLIOTT, Gary, T. , BARKER, Geoffrey, Eugene
发明人： SURBER, Mark, W. , ELLIOTT, Gary, T. , BARKER, Geoffrey, Eugene
IPC分类号： A61K33/18 , A61P11/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/008
摘要： Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
摘要翻译：本文公开了适用于雾化的亚硝酸盐，亚硝酸盐或产生亚硝酸盐或一氧化氮的化合物的制剂，以及这些制剂用于气雾剂给药亚硝酸盐，亚硝酸盐或亚硝酸盐或一氧化氮用于治疗肺动脉高压，鼻内或肺部细菌感染，或用于治疗或预防心脏，脑和参与移植的器官的缺血性再灌注损伤。具体而言，描述了专门配制并递送至呼吸道以用于适应症的吸入亚硝酸盐，亚硝酸盐或亚硝酸盐或一氧化氮供体化合物。组合物包括本文所述的所有制剂，试剂盒和装置组合。方法包括用于生产和使用所述组合物的吸入程序和生产过程。

7. 发明申请

WO2005089738A3 USE AND ADMINISTRATION OF BACTERIAL EFFLUX PUMP INHIBITORS 审中-公开
标题翻译：使用和管理细菌油泵抑制剂
公开(公告)号：WO2005089738A3
公开(公告)日：2007-08-23
申请号：PCT/US2005008873
申请日：2005-03-16
申请人： MPEX PHARMACEUTICALS INC , BOSTION KEITH , GLINKA TOMASZ , LOMOVSKAYA OLGA , SURBER MARK
发明人： BOSTION KEITH , GLINKA TOMASZ , LOMOVSKAYA OLGA , SURBER MARK
IPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61P31/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/421 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61K2300/00
摘要： This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial, and novel medical methods.
摘要翻译：本发明提供了与抗微生物剂共同施用的外排泵抑制剂，用于治疗由耐药性病原体引起的感染，新型外排泵抑制剂，具有抗微生物剂的外排泵抑制剂的组合剂型和新颖的医学方法。

8. 发明申请

WO2003072014A2 MINICELL COMPOSITIONS AND METHODS 审中-公开
标题翻译： MINICELL组合物和方法
公开(公告)号：WO2003072014A2
公开(公告)日：2003-09-04
申请号：PCT/US2002/016877
申请日：2002-05-28
申请人： MPEX BIOSCIENCE, INC. , SABBADINI, Roger, A. , SURBER, Mark , BERKLEY, Neil , SEGALL, Anca , KLEPPER, Robert , GIACALONE, Matthew , GERHART, William
发明人： SABBADINI, Roger, A. , SURBER, Mark , BERKLEY, Neil , SEGALL, Anca , KLEPPER, Robert , GIACALONE, Matthew , GERHART, William
IPC分类号： A61K
CPC分类号： C40B40/02 , C12N15/00 , C12N15/1037 , C12P21/02 , G01N33/5005 , G01N33/543 , G01N33/5432 , G01N33/60
摘要： The invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnostic and therapeutic uses, as well as research tools and agents for drug discovery.
摘要翻译：本发明提供用于生产染色体和无核细胞的组合物和方法，所述染色体和非核细胞用于诸如诊断和治疗用途的应用，以及用于药物发现的研究工具和试剂。

9. 发明申请

WO2010098835A3 WELL TEST SYSTEM 审中-公开
公开(公告)号：WO2010098835A3
公开(公告)日：2010-09-02
申请号：PCT/US2010/000525
申请日：2010-02-23
申请人： MEANS, Stephen, R. , SURBER, Mark, L. , HAGENSTON, Michael, G. , RILEY, Robert, C. , CROSSMAN, Michael, E. , BRITT, Lee, M.
发明人： MEANS, Stephen, R. , SURBER, Mark, L. , HAGENSTON, Michael, G. , RILEY, Robert, C. , CROSSMAN, Michael, E. , BRITT, Lee, M.
IPC分类号： E21B49/08
摘要： The well test system (10) has a net oil computer NOC (20) that captures and stores information from disparate well instrumentation devices, measures produced oil, water, and gas quantities based on the information and controls well processes based on the quantity measurements. The NOC (20) includes operational software that collects instrumentation data from a plurality of wells. Configuration software downloads user programmable configuration information to the NOC (20), enabling the NOC (20) to record data from a wide variety of flow devices, water test meters, or the like. User programmable alarms are included. A plurality of controllers can control processes associated with individual wells. A wireless communication system electronically sends data and test results to cell phones, radio devices, and the like. A daily test data log provides a historical database, which is analyzed to formulate "Data Confidence" information for each well. The net oil computer (20) is operable with two-phase or three-phase separators.

10. 发明申请

WO2010098835A2 WELL TEST SYSTEM 审中-公开
标题翻译：良好的测试系统
公开(公告)号：WO2010098835A2
公开(公告)日：2010-09-02
申请号：PCT/US2010000525
申请日：2010-02-23
申请人： MEANS STEPHEN R , SURBER MARK L , HAGENSTON MICHAEL G , RILEY ROBERT C , CROSSMAN MICHAEL E , BRITT LEE M
发明人： MEANS STEPHEN R , SURBER MARK L , HAGENSTON MICHAEL G , RILEY ROBERT C , CROSSMAN MICHAEL E , BRITT LEE M
IPC分类号： E21B49/08
CPC分类号： E21B49/008
摘要： The well test system (10) has a net oil computer NOC (20) that captures and stores information from disparate well instrumentation devices, measures produced oil, water, and gas quantities based on the information and controls well processes based on the quantity measurements. The NOC (20) includes operational software that collects instrumentation data from a plurality of wells. Configuration software downloads user programmable configuration information to the NOC (20), enabling the NOC (20) to record data from a wide variety of flow devices, water test meters, or the like. User programmable alarms are included. A plurality of controllers can control processes associated with individual wells. A wireless communication system electronically sends data and test results to cell phones, radio devices, and the like. A daily test data log provides a historical database, which is analyzed to formulate "Data Confidence" information for each well. The net oil computer (20) is operable with two-phase or three-phase separators.
摘要翻译：井测试系统（10）具有净油计算机NOC（20），其捕获并存储来自不同井仪表装置的信息，基于该信息测量产生的油，水和气体量，并且基于量测量来控制井过程。 NOC（20）包括从多个井收集仪器数据的操作软件。配置软件向NOC（20）下载用户可编程的配置信息，使得NOC（20）能够记录来自各种流量设备，水测试仪表等的数据。包括用户可编程报警。多个控制器可以控制与各个井有关的过程。无线通信系统将数据和测试结果电子地发送到蜂窝电话，无线电设备等。日常测试数据记录提供了一个历史数据库，对每个井进行了分析，以制定“数据置信度”信息。净油计算机（20）可与两相或三相分离器一起操作。

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