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1. 发明申请

WO2004099774A2 PROCESS FOR THE IDENTIFICATION OF NEW MEDICAL TARGETS 审中-公开
标题翻译：鉴定新医疗目标的过程
公开(公告)号：WO2004099774A2
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004883
申请日：2004-05-07
申请人： CELLZOME AG , SUPERTI-FUGA, Giulio , KRUSE, Ulrich , RYBIN, Vladimir , NEUBAUER, Gitte
发明人： SUPERTI-FUGA, Giulio , KRUSE, Ulrich , RYBIN, Vladimir , NEUBAUER, Gitte
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N33/6803 , G01N33/94 , G01N2333/525 , G01N2500/04
摘要： The present invention relates to a process for the isolation and identification of pharmaceutically relevant target compounds (TC) from a sample, said sample being derived from a living organism, wherein said target compound(s) bind(s) to a compound of interest (COI) under physiological conditions, said compound of interest (COI) being associated with a given impaired condition or disease. Furthermore, the present invention relates to a process for the identification of a pharmaceutically effective compound useful for preventing and/or treating a given impaired condition or disease, wherein said compound is identified by its binding to a relevant target compound (TC) that has been identified and isolated according to the above mentioned process.
摘要翻译：本发明涉及从样品中分离和鉴定药学上相关的目标化合物（TC）的方法，所述样品衍生自活生物体，其中所述目标化合物与感兴趣的化合物结合（ COI），所述感兴趣的化合物（COI）与给定的受损条件或疾病相关。此外，本发明涉及用于鉴定可用于预防和/或治疗给定的受损病症或疾病的药学上有效的化合物的方法，其中所述化合物通过与已经经过的相关目标化合物（TC）的结合来鉴定根据上述过程鉴定和分离。

2. 发明申请

WO2004099774A3 PROCESSES FOR THE IDENTIFICATION OF MEDICAL TARGETS BY SCREENING AN ACTIVE AGENT FOR BINDING INTERACTIONS 审中-公开
标题翻译：通过筛选用于结合相互作用的活性剂来鉴定医疗目标的过程
公开(公告)号：WO2004099774A3
公开(公告)日：2006-01-12
申请号：PCT/EP2004004883
申请日：2004-05-07
申请人： CELLZOME AG , SUPERTI-FUGA GIULIO , KRUSE ULRICH , RYBIN VLADIMIR , NEUBAUER GITTE
发明人： SUPERTI-FUGA GIULIO , KRUSE ULRICH , RYBIN VLADIMIR , NEUBAUER GITTE
IPC分类号： G01N33/543 , G01N33/68 , G01N33/94 , G01N33/53
CPC分类号： G01N33/543 , G01N33/6803 , G01N33/94 , G01N2333/525 , G01N2500/04
摘要： The present invention relates to a process for the isolation and identification of pharmaceutically relevant target compounds (TC) from a sample, said sample being derived from a living organism, wherein said target compound(s) bind(s) to a compound of interest (COI) under physiological conditions, said compound of interest (COI) being associated with a given impaired condition or disease. This process involves the isolation and the purification of the complex(es) formed by the compound. The present invention also relates to a process for the identification of a pharmaceutically effective compound useful for preventing and/or treating a given impaired condition or disease, wherein said compound is identified by its binding to a relevant target compound (TC) that has been identified and isolated according to the above mentioned process. Furthermore, the present application concerns a process for the identification of new uses (i.e. medical indications) of an active agent involving identifying diseases associated with the binding partner(s) of the active agent.
摘要翻译：本发明涉及从样品中分离和鉴定药学上相关的目标化合物（TC）的方法，所述样品衍生自活生物体，其中所述目标化合物与感兴趣的化合物结合（ COI），所述感兴趣的化合物（COI）与给定的受损条件或疾病相关。该方法涉及由化合物形成的络合物的分离和纯化。本发明还涉及用于鉴定可用于预防和/或治疗给定的受损病症或疾病的药学有效化合物的方法，其中所述化合物通过与已鉴定的相关目标化合物（TC）的结合来鉴定并根据上述方法分离。此外，本申请涉及用于鉴定涉及鉴定与活性剂的结合配偶体相关的疾病的活性剂的新用途（即医学适应症）的方法。

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