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1. 发明申请

WO2005060603A2 NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：一氧化氮释放的聚合物化合物，组合物和使用方法
公开(公告)号：WO2005060603A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041069
申请日：2004-12-10
申请人： NITROMED, INC. , GARVEY, David, S. , XINQIN, Fang , SUBHASH, P., Khanapure , RAMANI, R., Ranatunga , SHIOW-JYI, Wey
发明人： GARVEY, David, S. , XINQIN, Fang , SUBHASH, P., Khanapure , RAMANI, R., Ranatunga , SHIOW-JYI, Wey
IPC分类号： C07C203/04 , C07C219/22 , C07C233/05 , C07C235/74 , C07D211/38 , C07D211/46
CPC分类号： C07C203/04 , C07C219/22 , C07C235/74 , C07D211/46 , C07D271/08 , C07D273/00 , C07D333/32
摘要： The invention describes novel pyruvate compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one pyruvate compound comprising at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally substituted with at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) reperfusing injury following ischemia; and/or (m) preserving tissues, organs, organ parts and/or limbs. The nitric oxide releasing group is preferably a nitro group (i.e. N0 .2. ), a nitroso group (i.e. NO) and/or a heterocyclic nitric oxide donor group. The heterocyclic nitric oxide donor group is preferably a furoxan, a sydnonimine, an oxatriazole-5-one and/or an oxatriazole-5-imine.
摘要翻译：本发明描述了包含至少一个一氧化氮释放基团的新型丙酮酸化合物及其药学上可接受的盐，以及包含至少一种包含至少一个一氧化氮释放基团的丙酮酸化合物的新组合物，至少一种一氧化氮供体和/或至少一种治疗剂。本发明还提供了包含至少一种丙酮酸化合物和至少一种一氧化氮供体化合物和/或至少一种治疗剂的新型组合物。本发明还提供新型试剂盒，其包含至少一种丙酮酸化合物，其任选地用至少一种一氧化氮释放基团和任选地至少一种一氧化氮供体和/或至少一种治疗剂取代。本发明还提供了用于（a）治疗心血管疾病的方法; （b）治疗肾血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）缺血后再灌注损伤; 和/或（m）保存组织，器官，器官部分和/或肢体。一氧化氮释放基团优选为硝基（即NO 2 .2），亚硝基（即NO）和/或杂环氧化氮供体基团。杂环氧化氮供体基团优选为呋咱，sydnonimine，恶三唑-5-酮和/或恶三唑-5-亚胺。

2. 发明申请

WO2005060603A3 NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：氮氧化物释放吡咯化合物，组合物和使用方法
公开(公告)号：WO2005060603A3
公开(公告)日：2005-12-01
申请号：PCT/US2004041069
申请日：2004-12-10
申请人： NITROMED INC , GARVEY DAVID S , XINQIN FANG , SUBHASH P KHANAPURE , RAMANI R RANATUNGA , SHIOW-JYI WEY
发明人： GARVEY DAVID S , XINQIN FANG , SUBHASH P KHANAPURE , RAMANI R RANATUNGA , SHIOW-JYI WEY
IPC分类号： C07C203/04 , C07C219/22 , C07C233/05 , C07C235/74 , C07D211/38 , C07D211/46
CPC分类号： C07C203/04 , C07C219/22 , C07C235/74 , C07D211/46 , C07D271/08 , C07D273/00 , C07D333/32
摘要： The invention describes novel pyruvate compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one pyruvate compound comprising at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally substituted with at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) reperfusing injury following ischemia; and/or (m) preserving tissues, organs, organ parts and/or limbs. The nitric oxide releasing group is preferably a nitro group (i.e. N0.2.), a nitroso group (i.e. NO) and/or a heterocyclic nitric oxide donor group. The heterocyclic nitric oxide donor group is preferably a furoxan, a sydnonimine, an oxatriazole-5-one and/or an oxatriazole-5-imine.
摘要翻译：本发明描述了包含至少一种一氧化氮释放基团及其药学上可接受的盐的新的丙酮酸盐化合物，以及包含至少一种包含至少一种一氧化氮释放基团的丙酮酸盐化合物和任选的至少一种一氧化氮供体和/ 或至少一种治疗剂。本发明还提供了包含至少一种丙酮酸化合物和至少一种一氧化氮供体化合物和/或至少一种治疗剂的新型组合物。本发明还提供了包含至少一种丙酮酸盐化合物的新试剂盒，所述丙酮酸盐化合物任选被至少一种一氧化氮释放基团取代，和任选地至少一种一氧化氮供体和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）缺血后再灌注损伤; 和/或（m）保存组织，器官，器官部分和/或肢体。一氧化氮释放基团优选为硝基（即N0.2。），亚硝基（即NO）和/或杂环一氧化氮供体基团。杂环一氧化氮供体基团优选为呋喃糖，苏氨酸，恶唑-5-酮和/或氧杂三唑-5-亚胺。

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