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1. 发明申请

WO2007064550A3 REPRESENTING BUSINESS TRANSACTIONS 审中-公开
标题翻译：代表业务交易
公开(公告)号：WO2007064550A3
公开(公告)日：2008-12-24
申请号：PCT/US2006045246
申请日：2006-11-22
申请人： BOEING CO , RICE JEFFREY W , SU STEPHEN M , RENFERT THOMAS A , HERSHBERGER CHRISTINA M
发明人： RICE JEFFREY W , SU STEPHEN M , RENFERT THOMAS A , HERSHBERGER CHRISTINA M
IPC分类号： H04K1/00
CPC分类号： G06Q10/06 , G06Q20/10
摘要： Methods, systems, configurations, and computer program products create, represent, and manage Business Object Documents (BODs), coordinating the interfaces between two or more computer systems exchanging transactions thru a messaging architecture. The online validation of a BOD to prevent spoofing is performed by use of a relational database. While some aspects of the invention deal with the general e-business exchange of documents, others add versioning and verification to transactions via a repository that is used for that purpose. The repository is also used for the management of design of the electronic documents during the creations of the system between systems. Thru the use of a relational database business object document verification by relational repository (BODVRR) is able to perform automated validation of a versioned BOD in a business environment.
摘要翻译：方法，系统，配置和计算机程序产品创建，表示和管理业务对象文档（BOD），协调通过消息架构交换交易的两个或多个计算机系统之间的接口。通过使用关系数据库执行BOD的在线验证以防止欺骗。虽然本发明的一些方面涉及文档的一般电子商务交换，但是其他方面通过用于该目的的存储库将交易的版本化和验证添加到事务中。存储库还用于在系统创建期间对电子文档的设计进行管理。通过关系库（BODVRR）的关系数据库业务对象文档验证的使用能够在业务环境中对版本化的BOD进行自动验证。

2. 发明申请

WO2007064550A2 REPRESENTING BUSINESS TRANSACTIONS 审中-公开
标题翻译：代表业务交易
公开(公告)号：WO2007064550A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045246
申请日：2006-11-22
申请人： THE BOEING COMPANY , RICE, Jeffrey, W. , SU, Stephen, M , RENFERT, Thomas, A. , HERSHBERGER, Christina, M.
发明人： RICE, Jeffrey, W. , SU, Stephen, M , RENFERT, Thomas, A. , HERSHBERGER, Christina, M.
CPC分类号： G06Q10/06 , G06Q20/10
摘要： Methods, systems, configurations, and computer program products create, represent, and manage Business Object Documents (BODs), coordinating the interfaces between two or more computer systems exchanging transactions thru a messaging architecture. The online validation of a BOD to prevent spoofing is performed by use of a relational database. While some aspects of the invention deal with the general e-business exchange of documents, others add versioning and verification to transactions via a repository that is used for that purpose. The repository is also used for the management of design of the electronic documents during the creations of the system between systems. Thru the use of a relational database business object document verification by relational repository (BODVRR) is able to perform automated validation of a versioned BOD in a business environment.
摘要翻译：方法，系统，配置和计算机程序产品创建，表示和管理业务对象文档（BOD），协调通过消息架构交换交易的两个或多个计算机系统之间的接口。通过使用关系数据库执行BOD的在线验证以防止欺骗。虽然本发明的一些方面涉及文档的一般电子商务交换，但是其他方面通过用于该目的的存储库将交易的版本化和验证添加到事务中。存储库还用于在系统创建期间对电子文档的设计进行管理。通过关系库（BODVRR）的关系数据库业务对象文档验证的使用能够在业务环境中对版本化的BOD进行自动验证。

3. 发明申请

WO2013033008A9 TANDEM FC BISPECIFIC ANTIBODIES 审中-公开
标题翻译：串联FC双特异性抗体
公开(公告)号：WO2013033008A9
公开(公告)日：2013-06-13
申请号：PCT/US2012052490
申请日：2012-08-27
申请人： MERRIMACK PHARMACEUTICALS INC , HARMS BRIAN , KOHLI NEERAJ , LUGOVSKOY ALEXEY , SU STEPHEN , GEDDIE MELISSA
发明人： HARMS BRIAN , KOHLI NEERAJ , LUGOVSKOY ALEXEY , SU STEPHEN , GEDDIE MELISSA
IPC分类号： C07K16/28 , C07K16/46
CPC分类号： C07K14/00 , C07K16/18 , C07K16/2863 , C07K16/2866 , C07K16/2869 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/94
摘要： Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
摘要翻译：本文提供了包含特异性结合一种或多种细胞表面受体的一个或至少两个结合位点的串联Fc和串联Fc抗体（“TFcAs”），例如串联Fc双特异性抗体（“TFcBA”）。结合位点通过TFc连接，TFc包含第一Fc区和第二Fc区，其中第一和第二Fc区通过TFc接头连接以形成连续多肽并二聚化形成Fc二聚体。示例性TFcBA抑制通过TFcBA的结合位点特异性的细胞表面受体的信号转导。

4. 发明申请

WO2013033008A3 TANDEM FC BISPECIFIC ANTIBODIES 审中-公开
公开(公告)号：WO2013033008A3
公开(公告)日：2013-04-25
申请号：PCT/US2012052490
申请日：2012-08-27
申请人： MERRIMACK PHARMACEUTICALS INC , HARMS BRIAN , KOHLI NEERAJ , LUGOVSKOY ALEXEY , SU STEPHEN , GEDDIE MELISSA
发明人： HARMS BRIAN , KOHLI NEERAJ , LUGOVSKOY ALEXEY , SU STEPHEN , GEDDIE MELISSA
IPC分类号： C07K16/28 , C07K16/46
CPC分类号： C07K14/00 , C07K16/18 , C07K16/2863 , C07K16/2866 , C07K16/2869 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/94
摘要： Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.

5. 发明申请

WO2013033008A2 TANDEM FC BISPECIFIC ANTIBODIES 审中-公开
标题翻译： TANDEM FC BISPECIFIC抗体
公开(公告)号：WO2013033008A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/052490
申请日：2012-08-27
申请人： MERRIMACK PHARMACEUTICALS, INC. , HARMS, Brian , KOHLI, Neeraj , LUGOVSKOY, Alexey , SU, Stephen , GEDDIE, Melissa
发明人： HARMS, Brian , KOHLI, Neeraj , LUGOVSKOY, Alexey , SU, Stephen , GEDDIE, Melissa
IPC分类号： C07K16/28 , C07K16/46
CPC分类号： C07K14/00 , C07K16/18 , C07K16/2863 , C07K16/2866 , C07K16/2869 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/94
摘要： Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
摘要翻译：本文提供了串联Fc和串联Fc抗体（“TFcAs”），例如串联Fc双特异性抗体（“TFcBAs”），其包含特异性结合一种或多种细胞表面受体的一个或至少两个结合位点。结合位点通过TFc连接，TFc包含第一Fc区和第二Fc区，其中第一和第二Fc区通过TFc连接体连接以形成连续的多肽并二聚以形成Fc二聚体。示例性TFcBAs抑制通过其特异性的TFcBA的结合位点的细胞表面受体的信号转导。

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