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1. 发明申请

WO2012088388A2 TREATING MULTIPLE MYELOMA 审中-公开
标题翻译：治疗多发性骨髓瘤
公开(公告)号：WO2012088388A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066772
申请日：2011-12-22
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , FONSECA, Rafael , STEWART, Alexander Keith , BERGSAGEL, Peter , CHESI, Marta
发明人： FONSECA, Rafael , STEWART, Alexander Keith , BERGSAGEL, Peter , CHESI, Marta
IPC分类号： A61K31/337 , A61K38/38 , A61K39/395 , A61P35/00
CPC分类号： A61K47/48284 , A61K47/643
摘要： This document relates to methods and materials for treating multiple myeloma. For example, methods and materials for using albumin-bound paclitaxel composition (e.g., Abraxane®, a paclitaxel albumin-stabilized nanoparticle formulation) to treat multiple myeloma are provided.
摘要翻译：本文件涉及治疗多发性骨髓瘤的方法和材料。例如，提供了使用白蛋白结合的紫杉醇组合物（例如，Abraxane，紫杉醇白蛋白稳定的纳米颗粒制剂）治疗多发性骨髓瘤的方法和材料。

2. 发明申请

WO2018005745A1 POTASSIUM-CONTAINING AMPHOACETATE AND BETAINE SURFACTANTS 审中-公开
标题翻译：含钾的AMPHOACATE和BETA表面活性剂
公开(公告)号：WO2018005745A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039910
申请日：2017-06-29
申请人： RHODIA OPERATIONS , WARBURTON, Stewart, Alexander , HUBER, Paul , RAZMUS, David, Michael , TANAVADE, Juie
发明人： WARBURTON, Stewart, Alexander , HUBER, Paul , RAZMUS, David, Michael , TANAVADE, Juie
IPC分类号： A61K8/40 , A61K8/44 , A61Q5/00 , A61Q19/00 , A61Q19/10
摘要： Compositions that include at least one potassium-containing amphoacetate and/or betaine surfactant, water and at least one additional surfactant selected from anionic surfactants, cationic surfactants, non-ionic surfactants, zwitterionic surfactants, and mixtures thereof.
摘要翻译：包含至少一种含钾两性乙酸盐和/或甜菜碱表面活性剂，水和至少一种选自阴离子表面活性剂，阳离子表面活性剂，非离子表面活性剂，两性离子表面活性剂和它们的混合物的另外的表面活性剂的组合物

3. 发明申请

WO2012125405A9 METHODS AND MATERIALS FOR ASSESSING RESPONSIVENESS TO LENALIDOMIDE, THALIDOMIDE, AND/OR OTHER THALIDOMIDE ANALOGS 审中-公开
标题翻译：用于评估对来那度胺，沙利度胺和/或其他类杀真菌剂类似物的反应的方法和材料
公开(公告)号：WO2012125405A9
公开(公告)日：2012-11-08
申请号：PCT/US2012028285
申请日：2012-03-08
申请人： MAYO FOUNDATION , STEWART ALEXANDER KEITH , BERGSAGEL PETER , FONSECA RAFAEL , BRAGGIO ESTEBAN
发明人： STEWART ALEXANDER KEITH , BERGSAGEL PETER , FONSECA RAFAEL , BRAGGIO ESTEBAN
IPC分类号： A61K48/00 , A61K31/7088 , A61K31/7105 , A61K38/16 , A61P35/00
CPC分类号： A61K31/454 , A61K31/198 , A61K31/473 , A61K31/69 , G01N33/57426 , G01N2800/52
摘要： This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.
摘要翻译：本文件提供了与评估对来那度胺，沙利度胺和/或其他IMiD（代表有希望的新型免疫调节剂的沙利度胺的结构和功能类似物）的响应性有关的方法和材料。例如，提供了使用CRBN水平来确定癌细胞（例如多发性骨髓瘤细胞）是否对来那度胺，沙利度胺和/或其他IMiD敏感的方法和材料。

4. 发明申请

WO2012125405A2 METHODS AND MATERIALS FOR ASSESSING RESPONSIVENESS TO LENALIDOMIDE, THALIDOMIDE, AND/OR OTHER THALIDOMIDE ANALOGS 审中-公开
标题翻译：用于评估对亮氨酸，硫代二酯和/或其他硫代二糖类似物的反应的方法和材料
公开(公告)号：WO2012125405A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/028285
申请日：2012-03-08
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , STEWART, Alexander Keith , BERGSAGEL, Peter , FONSECA, Rafael , BRAGGIO, Esteban
发明人： STEWART, Alexander Keith , BERGSAGEL, Peter , FONSECA, Rafael , BRAGGIO, Esteban
IPC分类号： A61K48/00 , A61K31/7105 , A61K31/7088 , A61K38/16 , A61P35/00
CPC分类号： A61K31/454 , A61K31/198 , A61K31/473 , A61K31/69 , G01N33/57426 , G01N2800/52
摘要： This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.
摘要翻译：本文件提供了评估对来那度胺，沙利度胺和/或其他IMiD（代表有希望的新一类免疫调节剂的沙利度胺的结构和功能类似物）的反应性相关的方法和材料。例如，提供了使用CRBN水平来确定癌细胞（例如，多发性骨髓瘤细胞）是否易受来那度胺，沙利度胺和/或其他IMiD的方法和材料。

5. 发明申请

WO2004082059A1 ENERGY STORAGE DEVICES 审中-公开
标题翻译：能源储存装置
公开(公告)号：WO2004082059A1
公开(公告)日：2004-09-23
申请号：PCT/AU2004/000263
申请日：2004-03-03
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , MONASH UNIVERSITY , HOLLENKAMP, Anthony, Frank , HOWLETT, Patrick, Craig , MACFARLANE, Douglas, Robert , FORSYTH, Stewart, Alexander
发明人： HOLLENKAMP, Anthony, Frank , HOWLETT, Patrick, Craig , MACFARLANE, Douglas, Robert , FORSYTH, Stewart, Alexander
IPC分类号： H01M10/26
CPC分类号： H01G9/038 , H01G9/155 , H01G11/56 , H01G11/58 , H01G11/62 , H01M10/052 , H01M10/0567 , H01M10/0568 , H01M2300/0045 , Y02E60/13
摘要： Pyrrolidinium based room temperature ionic liquids, and phosphorous and arsenic analogues, are used as electrolytes in energy storage devices including secondary lithium batteries, supercapacitors and asymmetric battery-supercapacitors. The electrolytes preferably contain lithium ions as the charge-carrying species. The electrolytes are in a liquid state at the operating temperature.
摘要翻译：基于吡咯烷鎓的室温离子液体以及磷和砷类似物被用作包括二次锂电池，超级电容器和非对称电池 - 超级电容器在内的储能装置中的电解质。电解质优选含有锂离子作为电荷携带物质。电解液在工作温度下处于液态。

6. 发明申请

WO2018134578A1 SOCK ANCHOR UNIT 审中-公开
公开(公告)号：WO2018134578A1
公开(公告)日：2018-07-26
申请号：PCT/GB2018/050121
申请日：2018-01-17
申请人： FOSTER, Terence , PERICARD, Benoit Pierre Augustin , MURRAY, Ian Stewart Alexander
发明人： FOSTER, Terence , PERICARD, Benoit Pierre Augustin , MURRAY, Ian Stewart Alexander
IPC分类号： E04G23/02 , E04B1/41 , E04C5/07 , F16B13/14 , E21D21/00 , E04C5/02 , E04C5/16 , F16B5/02
摘要： A sock anchor unit (10) comprises an inner longitudinal hollow spine (12), an outer fabric sleeve (14) arranged to envelop the outside surface of the inner hollow spine (12) such that a gap is defined between the outside surface of the inner hollow spine (12) and an inner surface of the outer fabric sleeve (14) and a plurality of elongated reinforcing members (22), wherein each elongated reinforcing member (22) extends longitudinally within the gap. The inner hollow spine (12) comprises at least one substantially laterally extending opening from inside to outside of the inner hollow spine (12). The opening allows cementitious fluid which is pumped into the anchor unit to fill the gap between the hollow spine (12) and outer fabric sleeve. A fastening member (28, 32) is provided on each end of the sock anchor unit (10). Both fastening members (28, 32) are compatible with each other and each fastening member (28, 32) is configured such that a trailing end of a first sock anchor unit (10) is attachable to a leading end of a second sock anchor unit (10) thereby facilitating creating a multiple piece sock anchor system of a desired length.

7. 发明申请

WO2012088388A9 TREATING MULTIPLE MYELOMA 审中-公开
标题翻译：治疗多发性骨髓瘤
公开(公告)号：WO2012088388A9
公开(公告)日：2012-08-23
申请号：PCT/US2011066772
申请日：2011-12-22
申请人： MAYO FOUNDATION , FONSECA RAFAEL , STEWART ALEXANDER KEITH , BERGSAGEL PETER , CHESI MARTA
发明人： FONSECA RAFAEL , STEWART ALEXANDER KEITH , BERGSAGEL PETER , CHESI MARTA
IPC分类号： A61K31/337 , A61K38/38 , A61K39/395 , A61P35/00
CPC分类号： A61K47/48284 , A61K47/643
摘要： This document relates to methods and materials for treating multiple myeloma. For example, methods and materials for using albumin-bound paclitaxel composition (e.g., Abraxane®, a paclitaxel albumin-stabilized nanoparticle formulation) to treat multiple myeloma are provided.

8. 发明申请

WO2008066727A3 METHODS AND APPARATUS FOR DISPLAYING IMAGES 审中-公开
标题翻译：用于显示图像的方法和装置
公开(公告)号：WO2008066727A3
公开(公告)日：2008-10-23
申请号：PCT/US2007024161
申请日：2007-11-16
申请人： DEXELA LTD , STANTON MARTIN , STEWART ALEXANDER , BULLARD EDWARD
发明人： STANTON MARTIN , STEWART ALEXANDER , BULLARD EDWARD
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G01N23/046 , G01N2223/419
摘要： In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution.
摘要翻译：一方面，提供一种显示数据的方法。该方法包括通过以多个视角将物体暴露于辐射并且检测出离开物体的至少一些辐射以形成投影数据来获得物体的投影数据，操作计算机以重建分辨率重建投影数据为了形成包括表示对象内的位置的多个体素的图像数据，多个体素中的每一个被分配指示相应位置处的主体密度的相关强度，确定用于显示的最大分辨率，投影数据中的信息不支持相邻体素之间的强度，最大分辨率小于重建分辨率，并且以最大分辨率或低于最大分辨率显示图像数据。

9. 发明申请

WO2008045955A8 INHIBITING CYCLIN D POLYPEPTIDES 审中-公开
标题翻译：抑制CYCLIN D多肽
公开(公告)号：WO2008045955A8
公开(公告)日：2008-07-31
申请号：PCT/US2007080978
申请日：2007-10-10
申请人： MAYO FOUNDATION , TIEDEMANN RODGER E , STEWART ALEXANDER KEITH
发明人： TIEDEMANN RODGER E , STEWART ALEXANDER KEITH
IPC分类号： C07K14/00
CPC分类号： A61K31/7076 , A61K31/352 , A61K31/56 , A61K31/573 , A61K38/00 , C07K14/4738 , G01N33/566 , G01N33/6872 , A61K2300/00

10. 发明申请

WO2008066727A2 METHODS AND APPARATUS FOR DISPLAYING IMAGES 审中-公开
标题翻译：用于显示图像的方法和设备
公开(公告)号：WO2008066727A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/024161
申请日：2007-11-16
申请人： DEXELA LIMITED , STANTON, Martin , STEWART, Alexander , BULLARD, Edward
发明人： STANTON, Martin , STEWART, Alexander , BULLARD, Edward
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G01N23/046 , G01N2223/419
摘要： In one aspect, a method of displaying data is provided. The method comprises obtaining projection data of an object by exposing an object to radiation at a plurality of view angles and detecting at least some of the radiation exiting the object to form the projection data, operating a computer to reconstruct the projection data at a reconstruction resolution to form image data comprising a plurality of voxels representing locations within the object, each of the plurality of voxels being assigned an associated intensity indicative of a density of the subject matter at the respective location, determining a maximum resolution for display, above which variation in intensity between adjacent voxels is not supported by information in the projection data, the maximum resolution being less than the reconstruction resolution, and displaying the image data at or below the maximum resolution.
摘要翻译：在一个方面，提供了一种显示数据的方法。该方法包括通过将物体暴露于多个视角处的辐射来获得物体的投影数据，并检测离开物体的至少一些辐射以形成投影数据，操作计算机以重建分辨率重建投影数据以形成包括表示所述对象内的位置的多个体素的图像数据，所述多个体素中的每一个被分配指示所述相应位置处的所述对象物的密度的相关强度，确定用于显示的最大分辨率，投影数据中的信息不支持相邻体素之间的强度，最大分辨率小于重建分辨率，并以最大分辨率或低于最大分辨率显示图像数据。

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