专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1998017650A1 BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS 审中-公开
标题翻译： BIS（ACRIDINECARBOXAMIDE）和BIS（PHENAZINECARBAMAMIDE）作为抗菌剂
公开(公告)号：WO1998017650A1
公开(公告)日：1998-04-30
申请号：PCT/GB1997002886
申请日：1997-10-17
申请人： XENOVA LIMITED , DENNY, William, Alexander , GAMAGE, Swarnalatha, Akuritaya , SPICER, Julie, Ann , BAGULEY, Bruce, Charles , FINLAY, Graeme, John
发明人： XENOVA LIMITED
IPC分类号： C07D219/04
CPC分类号： C07C227/18 , C07D219/04 , C07C229/58
摘要： A compound which is a bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivative of formula (I), wherein each X, which may be the same or different in a given molecule, is -CH= or -N= each of R1 to R4 which may be the same or different, H, C1-C4 alkyl, OH, SH, NH2, C1-C4 alkoxy, aryloxy, NHR, N(R)2, SR, SO2R wherein R is C1-C4 alkyl, CF3, NO2 or halogen, or R1 and R2 together form a methylenedioxy group; each of R5 and R6, which may be the same or different, is H or C1-C4 alkyl; Z is (CH2)n, (CH2)nO(CH2)n, (CH2)nN(R7) (CH2)n, (CH2)nN(R7) (CH2)mN(R7) (CH2)n or (CH2)nN(CH2CH2)2N(CH2)n wherein R7 is H or C1-C4 alkyl and n and m, which may be the same or different, are each an integer of 1 to 4; or a pharmaceutically acceptable acid addition salt or N-oxide thereof; has activity as an antitumour and antibacterial agent.
摘要翻译：作为式（I）的双（吖啶甲酰胺）或双（吩嗪甲酰胺）衍生物的化合物，其中每个X在给定的分子中可以相同或不同，为-CH =或-N = R 1至R 4 其可以相同或不同，H，C 1 -C 4烷基，OH，SH，NH 2，C 1 -C 4烷氧基，芳氧基，NHR，N（R）2，SR，SO 2 R，其中R是C 1 -C 4烷基，CF 3，或卤素，或R1和R2一起形成亚甲二氧基; R 5和R 6可以相同或不同，为H或C 1 -C 4烷基; Z为（CH 2）n，（CH 2）n O（CH 2）n，（CH 2）n N（R 7）（CH 2）n，（CH 2）n N（R 7） nN（CH 2 CH 2）2 N（CH 2）n，其中R 7为H或C 1 -C 4烷基，n和m可相同或不同，为1〜4的整数。或其药学上可接受的酸加成盐或N-氧化物; 具有抗肿瘤和抗菌剂的作用。

2. 发明申请

WO2005089763A1 IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：咪达唑啶和咪唑嗪衍生物作为抗菌剂
公开(公告)号：WO2005089763A1
公开(公告)日：2005-09-29
申请号：PCT/IB2005/000596
申请日：2005-03-07
申请人： WARNER-LAMBERT COMPANY LLC , SCIOTTI, Richard, John , STARR, Jeremy, Tyson , RICHARDSON, Christopher , REWCASTLE, Gordon, William , PALMER, Brian, Desmond , SUTHERLAND, Hamish, Scott , SPICER, Julie, Ann , CHEN, Huifen
发明人： SCIOTTI, Richard, John , STARR, Jeremy, Tyson , RICHARDSON, Christopher , REWCASTLE, Gordon, William , PALMER, Brian, Desmond , SUTHERLAND, Hamish, Scott , SPICER, Julie, Ann , CHEN, Huifen
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式I化合物及其制备方法。还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用，包括用作抗菌剂。

3. 发明申请

WO2011075784A1 COMPOUNDS, PREPARATIONS AND USES THEREOF 审中-公开
标题翻译：化合物，制剂及其用途
公开(公告)号：WO2011075784A1
公开(公告)日：2011-06-30
申请号：PCT/AU2010/001731
申请日：2010-12-22
申请人： PETER MACCALLUM CANCER INSTITUTE , SPICER, Julie Ann , HUTTUNEN, Kristiina Maria , LYONS, Dani Michelle , TRAPANI, Joseph Albert , SMYTH, Mark John , DENNY, William Alexander
发明人： SPICER, Julie Ann , HUTTUNEN, Kristiina Maria , LYONS, Dani Michelle , TRAPANI, Joseph Albert , SMYTH, Mark John , DENNY, William Alexander
IPC分类号： A61K31/4166 , A61P3/10 , C07D333/16 , A61K31/4178 , A61P37/06 , C07D333/18 , A61K31/5355 , C07D233/86 , A61K31/5415 , C07D307/89
CPC分类号： A61K31/4166 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/5355 , A61K31/5377 , A61K31/5415 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , Y02A50/411
摘要： The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susceptible to a disease or disorder, or having a disease or disorder associated with undesirable perforin activity.
摘要翻译：本发明提供了新的式（I）化合物，包含这些化合物的药物组合物和使用这些化合物作为药剂或药物来抑制穿孔素活性和治疗患有疾病或病症风险或易感的受试者的方法，或具有与不良穿孔素活性相关的疾病或病症。

4. 发明申请

WO2003062189A1 N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS 审中-公开
标题翻译： N-（4-取代苯基） - 亚磺酸羟基酸酯
公开(公告)号：WO2003062189A1
公开(公告)日：2003-07-31
申请号：PCT/IB2003/000210
申请日：2003-01-13
申请人： WARNER-LAMBERT COMPANY LLC , BARRETT, Stephen, Douglas , KAUFMAN, Michael, David , REWCASTLE, Gordon, William , SPICER, Julie, Ann
发明人： BARRETT, Stephen, Douglas , KAUFMAN, Michael, David , REWCASTLE, Gordon, William , SPICER, Julie, Ann
IPC分类号： C07C237/32
CPC分类号： C07C259/10
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.
摘要翻译：本发明涉及4-取代苯基氨基苯肟酸衍生物的氧化酯，药物组合物及其使用方法。

5. 发明申请

WO2003062191A1 N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS 审中-公开
标题翻译： N-（4-取代苯基） - 亚磺酸羟基酸酯
公开(公告)号：WO2003062191A1
公开(公告)日：2003-07-31
申请号：PCT/IB2003/000211
申请日：2003-01-13
申请人： WARNER-LAMBERT COMPANY LLC , BARRETT, Stephen, Douglas , KAUFMAN, Michael, David , MILBANK, Jared, Bruce, John , REWCASTLE, Gordon, William , SPICER, Julie, Ann , TECLE, Haile
发明人： BARRETT, Stephen, Douglas , KAUFMAN, Michael, David , MILBANK, Jared, Bruce, John , REWCASTLE, Gordon, William , SPICER, Julie, Ann , TECLE, Haile
IPC分类号： C07C259/10
CPC分类号： C07C317/36 , C07C259/10 , C07C323/36 , Y10S514/825
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxymic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及4-取代苯基氨基苯甲酸衍生物的氧化酯，药物组合物及其使用方法。

6. 发明申请

WO1998017649A1 PROCESS FOR THE PREPARATION OF N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE 审中-公开
标题翻译：制备N- [2-（二甲基氨基）乙基]亚胺-4-羧酰胺的方法
公开(公告)号：WO1998017649A1
公开(公告)日：1998-04-30
申请号：PCT/GB1997002884
申请日：1997-10-17
申请人： XENOVA LIMITED , DENNY, William, Alexander , GAMAGE, Swarnalatha, Akuratiya , SPICER, Julie, Ann , WRIGHT, Michael , HAYMAN, David, Frank
发明人： XENOVA LIMITED
IPC分类号： C07D219/04
CPC分类号： C07D219/04 , C07C227/18 , C07C229/58
摘要： A process for producing an acridine carboxamide of formula (I) wherein each of R , R , R and R , which may be the same or different, is hydrogen or an organic substituent, x is an integer of 1 to 6 and Y is N(R)2 wherein R is C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, which process comprises: (a) cyclising a compound of formula (II) wherein R , R , R and R are as defined above and R is C1-C6 alkyl, aryl or aryl-C1-C3 alkyl, by treatment with a Lewis acid in an organic solvent, to obtain a compound of formula (III) wherein R , R , R , R and R are as defined above; (b) treating either (i) the compound of formula (III) as defined above with a primary alkylamine of the formula (IV): NH2(CH2)xY, wherein x and Y are as defined above; or (ii) the carboxylic acid, obtainable by hydrolysing the compound of formula (III) as defined above under basic conditions, with a primary alkyl amine of formula the (IV) as defined above in the presence of a suitable coupling agent to obtain a compound of formula (I) as defined above; and (c) if desired, converting one compound of formula (I) into another compound of formula (I), and/or converting a compound of formula (I) into a pharmaceutically acceptable salt thereof. The aldehyde of formula (II) is obtained by oxidation of the corresponding alcohol, which in turn is produced by mild reduction of the corresponding carboxylic acid via an immidazolide intermediate.
摘要翻译：制备式（I）的吖啶甲酰胺的方法，其中R 1，R 2，R 5和R 6各自可以相同或不同，是氢或有机取代基， x是1至6的整数，Y是N（R）2，其中R是C 1 -C 6烷基或其药学上可接受的盐，该方法包括：（a）使式（II）的化合物环化，其中R 1 >，R 2，R 5和R 6如上所定义，R 3是C 1 -C 6烷基，芳基或芳基-C 1 -C 3烷基，通过在有机溶剂中用路易斯酸处理，得到其中R 1，R 2，R 3，R 5和R 6如上定义的式（III）化合物; （b）用式（IV）的伯烷基胺：NH 2（CH 2）x Y（其中x和Y如上定义）处理（i）如上定义的式（III）化合物; 或（ii）通过在碱性条件下水解上述式（III）化合物而得到的羧酸与式（IV）的伯烷基胺在合适的偶联剂存在下水解，得到如上定义的式（I）化合物; 和（c）如果需要，将一种式（I）化合物转化为另一种式（I）化合物，和/或将式（I）化合物转化为其药学上可接受的盐。通过氧化相应的醇获得式（II）的醛，其依次通过咪唑啉中间体温和还原相应的羧酸而产生。

7. 发明申请

WO2005000818A1 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS 审中-公开
标题翻译： 5-取代的-4'-（取代的苯基）！用于MEK抑制剂的氨基-2-吡啶酮衍生物
公开(公告)号：WO2005000818A1
公开(公告)日：2005-01-06
申请号：PCT/IB2004/002060
申请日：2004-06-18
申请人： WARNER-LAMBERT COMPANY LLC , BLACK, Shannon, Leigh , KAUFMAN, Michael, David , ORTWINE, Daniel, Fred , PLUMMER, Mark, Stephen , QUIN, John, III , REWCASTLE, Gordon, William , SHAHRIPOUR, Aurash, Bavarsad , SPICER, Julie, Ann , WHITEHEAD, Christopher, Emil
发明人： BLACK, Shannon, Leigh , KAUFMAN, Michael, David , ORTWINE, Daniel, Fred , PLUMMER, Mark, Stephen , QUIN, John, III , REWCASTLE, Gordon, William , SHAHRIPOUR, Aurash, Bavarsad , SPICER, Julie, Ann , WHITEHEAD, Christopher, Emil
IPC分类号： C07D213/78
CPC分类号： C07D213/78 , C07D213/80 , C07D213/82 , C07D213/87 , C07D401/12 , C07D413/04
摘要： The present invention relates to 5-substituted-4-(substituted) phenylamino-2-pyridone derivatives of formula (I), pharmaceutical compositions and methods of use thereof as MEK inhibitors. Formula (I) wherein W is formula (II), formula (III), formula (IV), or formula (V); and R 1-5 and Z are as defined in the claims.
摘要翻译：本发明涉及式（I）的5-取代-4-（取代）苯基氨基-2-吡啶酮衍生物，药物组合物及其用作MEK抑制剂的方法。式（I）其中W是式（II），式（III），式（IV）或式（V）; R1-5和Z如权利要求中所定义。

8. 发明申请

WO03062191A8 N-(4-SUBSTITUTED PHENYL)-ANTHRANILIC ACID HYDROXAMATE ESTERS 审中-公开
标题翻译： N-（4-取代苯基） - 亚磺酸羟基酸酯
公开(公告)号：WO03062191A8
公开(公告)日：2004-01-15
申请号：PCT/IB0300211
申请日：2003-01-13
申请人： WARNER LAMBERT CO , BARRETT STEPHEN DOUGLAS , KAUFMAN MICHAEL DAVID , MILBANK JARED BRUCE JOHN , REWCASTLE GORDON WILLIAM , SPICER JULIE ANN , TECLE HAILE
发明人： BARRETT STEPHEN DOUGLAS , KAUFMAN MICHAEL DAVID , MILBANK JARED BRUCE JOHN , REWCASTLE GORDON WILLIAM , SPICER JULIE ANN , TECLE HAILE
IPC分类号： A61P9/04 , A61K31/165 , A61K31/166 , A61K31/18 , A61K31/21 , A61K31/27 , A61K31/66 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C229/58 , C07C233/65 , C07C237/28 , C07C259/10 , C07C311/45 , C07C317/36 , C07C323/36 , C07C323/39
CPC分类号： C07C317/36 , C07C259/10 , C07C323/36 , Y10S514/825
摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及4-取代苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式