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1. 发明申请

WO2006113540A2 USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION 审中-公开
标题翻译：使用恢复组织灌注和氧化的药剂
公开(公告)号：WO2006113540A2
公开(公告)日：2006-10-26
申请号：PCT/US2006014257
申请日：2006-04-13
申请人： UNIV DUKE , DEWHIRST MARK W , STAMLER JONATHAN S , MCMAHON TIMOTHY J , SONVEAUX PIERRE
发明人： DEWHIRST MARK W , STAMLER JONATHAN S , MCMAHON TIMOTHY J , SONVEAUX PIERRE
IPC分类号： A61K38/42 , A61K31/21
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
摘要翻译：目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。还提供了可在本公开的方法中使用的可吸入气体。

2. 发明申请

WO2004100991A1 USE OF ENDOTHELIN-1 ANTAGONISTS FOR IMPROVING CANCER THERAPY 审中-公开
标题翻译：使用内皮素-1拮抗剂改善癌症治疗
公开(公告)号：WO2004100991A1
公开(公告)日：2004-11-25
申请号：PCT/EP2004/004554
申请日：2004-04-29
申请人： UNIVERSITE CATHOLIQUE DE LOUVAIN , FERON, Olivier , DESSY, Chantal , SONVEAUX, Pierre
发明人： FERON, Olivier , DESSY, Chantal , SONVEAUX, Pierre
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： The present invention relates to a method and composition for treating or for diagnosing cancer. In particular, the present invention relates to methods and compositions for improving the efficacy of conventional cancer therapy and diagnosis. The invention comprises the use of an endothelin antagonist, and in particular of a specific ET-A endothelin antagonist and/or a non-specific ET-A/ET-B endothelin antagonist for treating or for diagnosing cancer or for improving the efficacy of conventional cancer therapy and diagnosis.
摘要翻译：本发明涉及用于治疗或诊断癌症的方法和组合物。特别地，本发明涉及用于改善常规癌症治疗和诊断的功效的方法和组合物。本发明包括内皮素拮抗剂，特别是特异性ET-A内皮素拮抗剂和/或非特异性ET-A / ET-B内皮素拮抗剂的用途，用于治疗或诊断癌症或改善常规的功效癌症治疗和诊断。

3. 发明申请

WO2007123777A3 INHIBITION OF HIF-1 ACTIVATION FOR ANTI-TUMOR AND ANTI-INFLAMMATORY RESPONSES 审中-公开
标题翻译： HIF-1激活抗肿瘤和抗炎反应的抑制作用
公开(公告)号：WO2007123777A3
公开(公告)日：2008-10-16
申请号：PCT/US2007008034
申请日：2007-03-30
申请人： UNIV DUKE , LI CHUAN-YUAN , LI FANG , SONVEAUX PIERRE , DEWHIRST MARK W
发明人： LI CHUAN-YUAN , LI FANG , SONVEAUX PIERRE , DEWHIRST MARK W
IPC分类号： A61K38/43 , A61K49/00 , A61P43/00 , C12N5/06 , C12N15/11 , C12Q1/68
CPC分类号： A61K41/0038 , A61K45/06 , A61K2300/00
摘要： The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation in a cell, increasing sensitivity of a tumor cell to radiation and/or chemotherapy, delaying tumor growth, inhibiting tumor blood vessel growth, inhibiting inflammatory responses in a cell through the use of compositions that prevent the nitrosylation of HIF-1, and methods for screening for new inhibitors of HIF-1 activiation. Additionally, the compositions disclosed herein relate to compositions that can be employed in, and are identified by, the disclosed methods.
摘要翻译：目前公开的主题通常涉及用于在缺氧细胞中抑制缺氧诱导因子1（HIF-1）基因的表达和/或活化的方法和组合物。更具体地说，本文公开的方法涉及细胞中HIF-1活化的抑制，增加肿瘤细胞对放射和/或化学疗法的敏感性，延缓肿瘤生长，抑制肿瘤血管生长，抑制细胞中炎性反应使用防止HIF-1的亚硝基化的组合物，以及用于筛选新的HIF-1激活抑制剂的方法。另外，本文公开的组合物涉及可以用于所公开的方法并由所公开的方法鉴定的组合物。

4. 发明申请

WO2006113540A3 USE OF NTROSYLATED HEMOGLOBIN 审中-公开
公开(公告)号：WO2006113540A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014257
申请日：2006-04-13
申请人： DUKE UNIVERSITY , DEWHIRST, Mark, W. , STAMLER, Jonathan, S. , MCMAHON, Timothy, J. , SONVEAUX, Pierre
发明人： DEWHIRST, Mark, W. , STAMLER, Jonathan, S. , MCMAHON, Timothy, J. , SONVEAUX, Pierre
IPC分类号： A61K48/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

5. 发明申请

WO2007123777A2 INHIBITION OF HIF-1 ACTIVATION FOR ANTI-TUMOR AND ANTI-INFLAMMATORY RESPONSES 审中-公开
标题翻译： HIF-1激活抗肿瘤和抗炎反应的抑制作用
公开(公告)号：WO2007123777A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/008034
申请日：2007-03-30
申请人： DUKE UNIVERSITY , LI, Chuan-Yuan , LI, Fang , SONVEAUX, Pierre , DEWHIRST, Mark, W.
发明人： LI, Chuan-Yuan , LI, Fang , SONVEAUX, Pierre , DEWHIRST, Mark, W.
IPC分类号： A61K38/43 , A61K49/00 , A61P43/00 , C12N15/11 , C12N5/06 , C12Q1/68
CPC分类号： A61K41/0038 , A61K45/06 , A61K2300/00
摘要： The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation in a cell, increasing sensitivity of a tumor cell to radiation and/or chemotherapy, delaying tumor growth, inhibiting tumor blood vessel growth, inhibiting inflammatory responses in a cell through the use of compositions that prevent the nitrosylation of HIF-1, and methods for screening for new inhibitors of HIF-1 activiation. Additionally, the compositions disclosed herein relate to compositions that can be employed in, and are identified by, the disclosed methods.
摘要翻译：目前公开的主题通常涉及用于在缺氧细胞中抑制缺氧诱导因子1（HIF-1）基因的表达和/或活化的方法和组合物。更具体地说，本文公开的方法涉及细胞中HIF-1激活的抑制，增加肿瘤细胞对放射和/或化学疗法的敏感性，延迟肿瘤生长，抑制肿瘤血管生长，抑制细胞中的炎性反应使用防止HIF-1亚硝基化的组合物，以及筛选HIF-1激活新抑制剂的方法。此外，本文公开的组合物涉及可以用于所公开的方法并由所公开的方法鉴定的组合物。

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