专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9924076A2 SALICYLATE DERIVATIZED THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译： SALICYLATE DERIVATIZED THERAPATIZED THERAPEUTIC AND DIAGNOSTIC AGENTS
公开(公告)号：WO9924076A2
公开(公告)日：1999-05-20
申请号：PCT/US9823706
申请日：1998-11-06
申请人： CONJUCHEM INC , KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QUI QUI , SETTINERI TINA
发明人： KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QUI QUI , SETTINERI TINA
IPC分类号： A61K35/16 , A61K38/00 , A61K47/48 , A61K49/00 , A61P7/02 , A61P25/04 , A61P43/00 , C07K7/08 , C07K14/665 , C07K14/75 , C07K14/78 , G01N33/50
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/6901
摘要： The present invention relates to novel salicylate compounds which comprise a salicylate moiety and a biologically active agent of interest, where the compound binds and bonds specifically through reaction of the salicylate ester to serum albumin at Lys 199. Albumin is a long-lived moiety present in the blood. Novel salicylate compounds of the present invention provide for long-lived maintenance of the biologically active entity in the host. These compounds find broad applications in prophylactic and therapeutic applications, production of antibodies, reduction of the biologically effective concentration or activity of an endogenous or exogenous blood component, and in other situations where long term administration of a physiologically active compound is of interest.
摘要翻译：本发明涉及包含水杨酸酯部分和感兴趣的生物活性剂的新型水杨酸酯化合物，其中该化合物通过水杨酸酯与Lys 199的血清白蛋白反应而特异性地结合并键合。白蛋白是存在于血液。本发明的新型水杨酸酯化合物提供宿主中生物活性物质的长期维持。这些化合物在预防和治疗应用中广泛应用，产生抗体，降低内源性或外源性血液成分的生物学有效浓度或活性，以及其它感兴趣的生理活性化合物的长期给药的情况。

2. 发明申请

WO1994011399A1 SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY 审中-公开
标题翻译：具有自由功能的特异性交联HEMOGLOBIN
公开(公告)号：WO1994011399A1
公开(公告)日：1994-05-26
申请号：PCT/CA1993000480
申请日：1993-11-12
申请人： KLUGER, Ronald , SONG, Yong, Hong
IPC分类号： C07K13/00
CPC分类号： C07K14/805 , A61K38/00 , A61K47/6445 , C07C69/76
摘要： Hemoglobin is site-specifically crosslinked into its tetrameric form by reaction with a trifunctional reagent which combines electrostatic effects, steric effects and the presence of functional groups so that two of the functional groups react with specific sites on the hemoglobin whilst the third site is left free for reaction with endogenous nucleophilic compounds. A specific example of such a crosslinking reagent is trimesoyl tris(3,5-dibromosalicylate), TTDS, which effects specific crosslinking between the amino groups of lysine-82 on each respective beta sub-unit. While the crosslinking reagent TTDS has three available carboxyl groups for the crosslinking reaction, only two so react, leaving one free carboxyl for reaction with exogenous nucleophiles, e.g. to render the hemoglobin product useful as a carrier for nucleophilic compounds through the body's circulatory system.
摘要翻译：血红蛋白通过与三官能试剂反应进行位置特异性交联成四聚体形式，其结合了静电效应，空间效应和功能基团的存在，使得两个官能团与血红蛋白上的特定位点反应，而第三位点保持游离用于与内源性亲核化合物反应。这种交联试剂的具体实例是均苯三甲酸三（3,5-二溴水杨酸酯）TTDS，其在每个相应的β子单元上影响赖氨酸-82的氨基之间的特异性交联。虽然交联剂TTDS具有三个用于交联反应的可用羧基，但仅有两个反应，留下一个游离羧基用于与外源亲核试剂反应，例如，以使血红蛋白产物通过身体的循环系统用作亲核化合物的载体。

3. 发明申请

WO9924076A9 SALICYLATE DERIVATIZED THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
标题翻译：盐酸衍生的治疗和诊断试剂
公开(公告)号：WO9924076A9
公开(公告)日：2000-06-08
申请号：PCT/US9823706
申请日：1998-11-06
申请人： CONJUCHEM INC , KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QI QI , SETTINERI TINA
发明人： KRANTZ ALEXANDER , SONG YONG HONG , BRIDON DOMINIQUE P , HARDY MARGARET , CHEN QI QI , SETTINERI TINA
IPC分类号： A61K35/16 , A61K38/00 , A61K47/48 , A61K49/00 , A61P7/02 , A61P25/04 , A61P43/00 , C07K7/08 , C07K14/665 , C07K14/75 , C07K14/78
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/6901
摘要： The present invention relates to novel salicylate compounds which comprise a salicylate moiety and a biologically active agent of interest, where the compound binds and bonds specifically through reaction of the salicylate ester to serum albumin at Lys 199. Albumin is a long-lived moiety present in the blood. Novel salicylate compounds of the present invention provide for long-lived maintenance of the biologically active entity in the host. These compounds find broad applications in prophylactic and therapeutic applications, production of antibodies, reduction of the biologically effective concentration or activity of an endogenous or exogenous blood component, and in other situations where long term administration of a physiologically active compound is of interest.
摘要翻译：本发明涉及包含水杨酸酯部分和感兴趣的生物活性剂的新型水杨酸酯化合物，其中该化合物通过水杨酸酯在Lys 199处与血清白蛋白的反应而特异性地结合和键合。白蛋白是存在于血液。本发明的新型水杨酸酯化合物提供宿主中生物活性实体的长期维持。这些化合物在预防和治疗应用中广泛应用，产生抗体，降低内源或外源性血液成分的生物学有效浓度或活性，以及其他感兴趣的生理活性化合物的长期给药的情况。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式