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1. 发明申请

WO2008117943A1 7-(3',4'-DIALKOXYPHENYL)-[1,2,4]-TRIAZOLO[1,5-A]PYRIMIDINE COMPOUNDS, PROCESS FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ARTHRITIS, ATOPIC DERMATITIS, TUMOR AND DEGENERATIVE BRAIN DISEASES COMPRISING THE SAME 审中-公开
标题翻译： 7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-A]吡啶化合物，其制备方法和药物组合物，用于治疗或预防哮喘，慢性阻塞性肺动脉疾病， ARTHRITIS，ATOPIC DERMATITIS，TUMOR AND DEGE
公开(公告)号：WO2008117943A1
公开(公告)日：2008-10-02
申请号：PCT/KR2008/001278
申请日：2008-03-07
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , JEON, Dong Ju , NO, Zaesung , SONG, Jong Hwan , LEE, Gehyeong , KIM, Ikyon , PARK, Chang Min , CHEON, Hyae Gyeong , CHO, Young Sik , SONG, Jin Sook , BAE, Myung Ae , YOO, Sung-eun
发明人： JEON, Dong Ju , NO, Zaesung , SONG, Jong Hwan , LEE, Gehyeong , KIM, Ikyon , PARK, Chang Min , CHEON, Hyae Gyeong , CHO, Young Sik , SONG, Jin Sook , BAE, Myung Ae , YOO, Sung-eun
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel {7-(3',4'-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.
摘要翻译：本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法，以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

2. 发明申请

WO2007139240A1 7-(3,4-DIALKOXYPHENYL)-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS, PROCESS FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ARTHRITIS, ATOPIC DERMATITIS, TUMOR AND DEGENERATIVE BRAIN DISEASES COMPRISING THE SAME 审中-公开
标题翻译： 7-（3,4-二甲氧基苯基） - 吡唑并[1,5-A]吡啶化合物，其制备方法和药物组合物，用于治疗或预防哮喘，慢性阻塞性肺动脉疾病，ARTHRITIS，原发性肿瘤，肿瘤和变性B
公开(公告)号：WO2007139240A1
公开(公告)日：2007-12-06
申请号：PCT/KR2006/002058
申请日：2006-05-29
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , NO, Zae Sung , JEON, Dong Ju , SONG, Jong Hwan , LEE, Gehyeong , PARK, Chang Min , SO, Won Young , KANG, Nam Sook , HONG, Seok Joo , CHEON, Hyae Gyeong , CHO, Young Sik , KIM, Ki Young , BAE, Myung Ae , SONG, Jin Sook , RO, Seonggu , HYUN, Young-Lan , LEE, Woon Young , KIM, Yong Eun , KAANG, Bong-Kiun , LEE, Hye Ryeon , YOO, Sung-Eun
发明人： NO, Zae Sung , JEON, Dong Ju , SONG, Jong Hwan , LEE, Gehyeong , PARK, Chang Min , SO, Won Young , KANG, Nam Sook , HONG, Seok Joo , CHEON, Hyae Gyeong , CHO, Young Sik , KIM, Ki Young , BAE, Myung Ae , SONG, Jin Sook , RO, Seonggu , HYUN, Young-Lan , LEE, Woon Young , KIM, Yong Eun , KAANG, Bong-Kiun , LEE, Hye Ryeon , YOO, Sung-Eun
IPC分类号： C07D231/00 , C07D487/04 , C07D239/00 , A61K31/437 , A61P11/06 , A61P27/14 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention relates to 7- (3,4- dialkoxyphenyl) -pyrazolo [1, 5 -a] pyrimidine compounds, pharmaceutically acceptable salts thereof, preparation thereof and pharmaceutical compositions comprising the same as an active ingredient for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases such as Alzheimer disease, depression or failure of memory.
摘要翻译：本发明涉及7-（3,4-二烷氧基苯基） - 吡唑并[1,5-a]嘧啶化合物，其药学上可接受的盐，其制备方法和药物组合物，其包含与用于治疗或预防炎症性疾病的活性成分哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病和退行性脑疾病如阿尔茨海默病，抑郁症或记忆障碍的癌症。

3. 发明申请

WO2012154009A3 THIENOPYRIMIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING THIENOPYRIMIDINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION CONTAINING THIENOPYRIMIDINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING OR TREATING DIABETES-RELATED DISEASES 审中-公开
标题翻译：三硝基嘧啶衍生物，其药学上可接受的盐，其制备三亚氨基嘧啶衍生物的方法，以及作为用于预防或治疗与糖尿病相关的疾病的活性成分的三硝基嘧啶衍生物的药物组合物
公开(公告)号：WO2012154009A3
公开(公告)日：2013-03-21
申请号：PCT/KR2012003722
申请日：2012-05-11
申请人： KOREA RES INST CHEM TECH , JEON MOON KOOK , AHN JIN HEE , KANG SEUNG KYU , LEE KYU MYUNG , RHEE SANG DAL , KIM HI YOUN , JUNG WON HOON , KIM KWANG ROK , BAE MYUNG-AE , SONG JIN SOOK , SUH JEE HEE , KANG MYOUNG KU , KIM MIN HYE
发明人： JEON MOON KOOK , AHN JIN HEE , KANG SEUNG KYU , LEE KYU MYUNG , RHEE SANG DAL , KIM HI YOUN , JUNG WON HOON , KIM KWANG ROK , BAE MYUNG-AE , SONG JIN SOOK , SUH JEE HEE , KANG MYOUNG KU , KIM MIN HYE
IPC分类号： C07D495/04 , A61K31/519 , A61P3/10 , C07D401/12
CPC分类号： C07D401/12 , C07D495/04
摘要： The present invention relates to novel thienopyrimidine derivatives, and to a pharmaceutical composition containing thienopyrimidine derivatives as active ingredients for preventing or treating diabetes or various diabetes-related diseases. The thienopyrimidine derivatives of the present invention efficiently accelerate the activity of G protein-coupled receptor 119 (GPR119), which has the effects of increasing glucose-dependent insulin secretion and inhibiting increases in appetite and body weight, thus enhancing glucose metabolism and lipid metabolism. Therefore, the thienopyrimidine derivatives of the present invention may be valuably used in a composition for efficiently preventing and treating not only diabetes but also various complications of diabetes such as obesity, hyperlipidemia, and diabetic vascular diseases.
摘要翻译：本发明涉及新颖的噻吩并嘧啶衍生物，以及含有噻吩并嘧啶衍生物作为预防或治疗糖尿病或各种糖尿病相关疾病的有效成分的药物组合物。本发明的噻吩并嘧啶衍生物有效加速G蛋白偶联受体119（GPR119）的活性，其具有增加葡萄糖依赖性胰岛素分泌和抑制食欲和体重增加的作用，从而增强葡萄糖代谢和脂质代谢。因此，本发明的噻吩并嘧啶衍生物可以有价值地用于不仅有效预防和治疗糖尿病的组合物，还包括肥胖症，高脂血症和糖尿病性血管疾病等糖尿病的各种并发症。

4. 发明申请

WO2006004306A1 TRANSGENIC MICE INDUCING ALZHEIMER'S DISEASE EXPRESSING MUTANT BETACTF99 审中-公开
标题翻译：转基因小鼠诱导阿尔茨海默病表达突变型BETACTF99
公开(公告)号：WO2006004306A1
公开(公告)日：2006-01-12
申请号：PCT/KR2005/000969
申请日：2005-04-01
申请人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , HAN, Pyung Lim , LEE, Kang-Woo , YANG, Sung-Don , SONG, Jin-Sook
发明人： HAN, Pyung Lim , LEE, Kang-Woo , YANG, Sung-Don , SONG, Jin-Sook
IPC分类号： C12N15/63
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2267/0312 , C12N15/8509
摘要： The present invention is related to a transgenic animal inducing Alzheimer's disease. More particularly, the present invention is a vector for transformation of animal comprising a carboxyl-terminla fragments of mutant human beta amyloid protein which contains Indiana mutation (βCTF99) and a transgenic mouse inducing Alzheimer's disease prepared by microinjection of the same into a pronuclei of a fertilized oocyte. The transgenic mouse of the present invention exhibited clnicical symptoms of Alzheimer's disease such as decreases of cognitive ability and memory, and increases of anxiety. Therefore, the transgenic mouse of the present invention will be a useful animal model for a research of Alzheimer's disease. Particularly, since the transgenic mouse of the present invention showed more remarkable decreases of cognitive ability than any other transgenic animal model for Alzheimer's disease known in the art, the transgenic mouse of the present invention can be used as an animal model for disease relating anxiety.
摘要翻译：本发明涉及一种诱导阿尔茨海默病的转基因动物。更具体地，本发明是用于转化动物的载体，其包含含有印第安纳突变（ßCTF99）的突变型人β淀粉样蛋白的羧基末端片段和通过将其显微注射到原核中而制备的转基因小鼠诱导的阿尔茨海默氏病受精卵母细胞。本发明的转基因小鼠表现出阿尔茨海默氏病的临床症状，例如认知能力和记忆力的降低以及焦虑的增加。因此，本发明的转基因小鼠将是用于阿尔茨海默病研究的有用的动物模型。特别地，由于本发明的转基因小鼠比本领域已知的阿尔茨海默病的任何其它转基因动物模型显示出更显着的认知能力降低，所以本发明的转基因小鼠可用作与焦虑相关的疾病的动物模型。

5. 发明申请

WO2006004287A1 TRANSGENIC MICE INDUCING ALZHEIMER'S DISEASE EXPRESSING MUTANT APP 审中-公开
标题翻译：转基因小鼠诱导阿尔茨海默病显示突变APP
公开(公告)号：WO2006004287A1
公开(公告)日：2006-01-12
申请号：PCT/KR2005/000923
申请日：2005-03-30
申请人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , HAN, Pyung Lim , LEE, Kang-Woo , YANG, Sung-Don , SONG, Jin-Sook
发明人： HAN, Pyung Lim , LEE, Kang-Woo , YANG, Sung-Don , SONG, Jin-Sook
IPC分类号： C12N15/63
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C07K14/8114 , C12N15/8509
摘要： The present invention is related to a transgenic animal showing Alzheimer's disease pathology. More particularly, the present invention provides a transgenic vector comprising a mutant human beta amyloid precursor protein whith Swedish double mutation and Indiana mutation simultaneously, and a transgenic mouse showing Alzheimer's disease generated by microinjection of the above vector into a pronuclei of a fertilized oocyte followed by generating mice. The transgenic mouse of the present invention exhibited clnicical symptoms of Alzheimer's disease, such as decreases of cognitive ability and memory, and increases of anxiety. Therefore, the transgenic mouse of the present invention will be a useful animal model for a research of Alzheimer's disease. Particularly, because the transgenic mouse of the present invention showed more profound increase of anxiety than any other transgenic animal model for Alzheimer's disease known in the art, the transgenic mouse of the present invention can be used as an animal model for anxiety-related disorders.
摘要翻译：本发明涉及显示阿尔茨海默病病理学的转基因动物。更具体地说，本发明提供了包含同时具有瑞典双重突变和印第安纳突变的突变型人β淀粉样蛋白前体蛋白质的转基因载体，以及通过将上述载体显微注射到受精卵母细胞的原核中而产生的阿尔茨海默氏病的转基因小鼠，产生小鼠。本发明的转基因小鼠表现出阿尔茨海默氏病的临床症状，例如认知能力和记忆力的降低以及焦虑的增加。因此，本发明的转基因小鼠将是用于阿尔茨海默病研究的有用的动物模型。特别地，由于本发明的转基因小鼠比本领域已知的阿尔茨海默病的任何其他转基因动物模型显示更多的焦虑增加，本发明的转基因小鼠可以用作焦虑相关疾病的动物模型。

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