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1. 发明申请

WO1993003026A1 NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：新型喹啉酮羧酸衍生物
公开(公告)号：WO1993003026A1
公开(公告)日：1993-02-18
申请号：PCT/KR1992000035
申请日：1992-08-01
申请人： DAEWOONG PHARMACEUTICAL CO., LTD. , KIM, Dae, Young , LEE, Jae, Wook , LEE, Kyeu, Sam , SON, Ho, Jung , KANG, Tae, Choong
发明人： DAEWOONG PHARMACEUTICAL CO., LTD.
IPC分类号： C07D401/04
CPC分类号： C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D401/04 , C07D471/04
摘要： The present invention relates to novel quinolone carboxylic acid derivatives of structural formula (I) and pharmaceutically acceptable salts thereof. These compounds also have a potent activity against both Gram-positive bacteria and Gram-negative bacteria, wherein R is hydrogen or alkyl group having one to six carbon atoms, R is alkyl group having one to four carbon atoms, haloalkylgroup having one to four carbon atoms, cycloalkylgroup having three to six carbon atoms, alkenyl group having two to four carbon atoms, or phenyl group which is optionally mono or disubstituted by fluorine atoms, X is hydrogen, halogen, alkyl group having one to four carbon atoms, alkenyl group having two to four carbon atoms, cycloalkyl group having three to six carbon atoms, or amino, A is N or C-Y, Y is hydrogen, halogen, hydroxy, methoxy, or methyl, Z is formula (a), wherein Q, R , m and n are respectively defined as the above.
摘要翻译：本发明涉及结构式（I）的新型喹诺酮羧酸衍生物及其药学上可接受的盐。这些化合物对革兰氏阳性菌和革兰氏阴性细菌都具有有效的活性，其中R 1是氢或具有1至6个碳原子的烷基，R 2是具有1-4个碳原子的烷基，具有1至4个碳原子的卤代烷基，具有3至6个碳原子的环烷基，具有2至4个碳原子的烯基，或任选被氟原子单取代或二取代的苯基，X是氢，卤素，具有1-4个碳原子的烷基碳原子数为2〜4的烯基，碳原子数3〜6的环烷基或氨基，A为N或CY，Y为氢，卤素，羟基，甲氧基或甲基，Z为式（a）其中Q，R 3，m和n分别如上所定义。

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