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1. 发明申请

WO2007036912A3 METHOD AND KIT TO IDENTIFY CORTICAL AXO-AXONIC CELL MODULATORS 审中-公开
标题翻译：方法和套件识别角膜轴向细胞调节剂
公开(公告)号：WO2007036912A3
公开(公告)日：2007-06-21
申请号：PCT/IB2006053557
申请日：2006-09-29
申请人： SOLVO BIOTECHNOLOGY INC , TAMAS GABOR , BARZO PAL
发明人： TAMAS GABOR , BARZO PAL
IPC分类号： G01N33/50
CPC分类号： G01N33/5058
摘要： The present invention provides a method for identifying an agent capable of specifically modulating or eliminating the action of axo-axonic cells, an experimental kit for performing the said method and compounds identifiable by the said method, as well as methods for the treatment or prevention different neurological symptoms by modulating the activity of axo-axonic cells.
摘要翻译：本发明提供了一种用于鉴定能够特异性调节或消除轴突细胞的作用的试剂的方法，用于进行所述方法的实验试剂盒和通过所述方法可鉴定的化合物，以及用于治疗或预防不同的方法神经症状通过调节轴突细胞的活性。

2. 发明申请

WO2007036912A2 METHOD AND TEST KIT FOR THE IDENTIFICATION OF COMPOUNDS SPECIFICALLY MODULATING THE ACTION OF CORTICAL AXO-AXONIC CELLS 审中-公开
标题翻译：用于鉴定化合物的方法和试剂盒特异性调节角膜轴向细胞的作用
公开(公告)号：WO2007036912A2
公开(公告)日：2007-04-05
申请号：PCT/IB2006/053557
申请日：2006-09-29
申请人： SOLVO BIOTECHNOLOGY, INC. , TAMÁS, Gábor , BARZÓ, Pál
发明人： TAMÁS, Gábor , BARZÓ, Pál
IPC分类号： G01N33/50
CPC分类号： G01N33/5058
摘要： The present invention provides a method for identifying an agent capable of specifically modulating or eliminating the action of axo-axonic cells, an experimental kit for performing the said method and compounds identifiable by the said method, as well as methods for the treatment or prevention different neurological symptoms by modulating the activity of axo-axonic cells.
摘要翻译：本发明提供了一种用于鉴定能够特异性调节或消除轴突细胞的作用的试剂的方法，用于进行所述方法的实验试剂盒和通过所述方法可鉴定的化合物，以及用于治疗或预防不同的方法神经症状通过调节轴突细胞的活性。

3. 发明申请

WO2005116648A2 METHOD AND REAGENT KIT FOR EVALUATION OF MULTIDRUG-RESISTANCE ACTIVITY 审中-公开
标题翻译：用于评估多重抗性活性的方法和试剂盒
公开(公告)号：WO2005116648A2
公开(公告)日：2005-12-08
申请号：PCT/IB2005/051707
申请日：2005-05-25
申请人： SOLVO BIOTECHNOLOGY, INC. , SCHWÁB, Richárd , PETÁK, István , SARKADI, Balázs , KOPPER, László , KÉRI, György , PAP, Ákos , SZAKÁCS, Gergely , HOMOLYA, László , JAKAB, Ferenc , MOLDVAY, Judit , FEHÉR, Arnold
发明人： SCHWÁB, Richárd , PETÁK, István , SARKADI, Balázs , KOPPER, László , KÉRI, György , PAP, Ákos , SZAKÁCS, Gergely , HOMOLYA, László , JAKAB, Ferenc , MOLDVAY, Judit , FEHÉR, Arnold
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N2500/10
摘要： The invention provides an in vitro diagnostic method for detecting multi-drug resistance in a biological specimen comprising a heterogeneous population of discrete cells, said method comprising the steps of contacting a first portion of the biological specimen with MDR substrate derivative and a viability reagent; contacting a second portion of the biological specimen with a general inhibitor of transport protein-mediated cell efflux, the MDR substrate derivative, and the viability reagent; measuring the signal generated by the MDR substrate within the viable cells of said second portion; defining an MDR substrate signal intensity range based on data measured above; determining a first rate of MDR substrate accumulation within a population of cells of said first portion of the biological specimen; determining a second rate of MDR substrate accumulation within a population of cells of said second portion of the biological specimen; and calculating the difference in said first and second rates of MDR substrate accumulation, wherein data showing a reduced MDR substrate accumulation in said populations of cells between said first portion and said second portion is indicative of the presence of multi-drug resistance in said biological specimen.
摘要翻译：本发明提供一种体外诊断方法，用于检测包含离散细胞的异质群的生物样本中的多重耐药性，所述方法包括使生物样本的第一部分与MDR底物衍生物和活力试剂接触的步骤; 使生物样品的第二部分与一般的蛋白质介导的细胞外流抑制剂，MDR底物衍生物和活力试剂接触; 测量由所述第二部分的活细胞内的MDR基底产生的信号; 基于上面测量的数据定义MDR衬底信号强度范围; 确定生物样本的所述第一部分的细胞群体内的MDR底物积累的第一速率; 确定生物样本的所述第二部分的细胞群体内的MDR底物积累的第二速率; 并计算所述第一和第二速率的MDR底物积累的差异，其中显示在所述第一部分和所述第二部分之间的所述细胞群体中减少的MDR底物积累的数据指示所述生物样本中存在多重耐药性。

4. 发明申请

WO2004083855A1 METHOD FOR THE IDENTIFICATION OF CELLS SPECIFICALLY MODULATING SLOW INHIBITION IN THE NEOCORTEX 审中-公开
标题翻译：用于鉴定细胞特异性调节慢性阻塞的方法
公开(公告)号：WO2004083855A1
公开(公告)日：2004-09-30
申请号：PCT/IB2004/050289
申请日：2004-03-18
申请人： SOLVO BIOTECHNOLOGY, INC. , TAMÁS, Gábor , SZABADICS, János , LÖRINCZ, Andrea , TÓTH, Éva , SIMON, Anna
发明人： TAMÁS, Gábor , SZABADICS, János , LÖRINCZ, Andrea , TÓTH, Éva , SIMON, Anna
IPC分类号： G01N33/50
CPC分类号： G01N33/5088 , G01N2333/70571
摘要： The present invention relates to a method for identifying neuron types capable of specifically evoking slow IPSP. Thus, the present invention relates to a method for identifying an agent, preferably a compound capable of modulating or eliminating either the activity of or postsynaptic slow inhibition evoked by the identified cells. Moreover, the invention relates to compounds identified by the method of the invention, compositions comprising the said compounds, methods for the treatment or prevention of conditions related to slow inhibition and uses of a cell culture comprising predominantly cells specifically evoking slow IPSP. The cells specifically evoking slow IPSPaccording tothe invention are preferably neurogliaform cells.
摘要翻译：本发明涉及一种识别能够特异性引起慢IPSP的神经元类型的方法。因此，本发明涉及一种用于鉴定试剂的方法，优选地是能够调节或消除由鉴定的细胞诱发的活性或突触后慢抑制的化合物。此外，本发明涉及通过本发明的方法鉴定的化合物，包含所述化合物的组合物，用于治疗或预防与缓慢抑制有关的病症的方法和细胞培养物的用途，所述细胞培养物主要包含特异性诱导慢速IPSP的细胞。专门诱发缓慢IPSP的细胞根据本发明优选是神经胶质细胞。

5. 发明申请

WO2005116648A3 METHOD AND REAGENT KIT FOR EVALUATION OF MULTIDRUG-RESISTANCE ACTIVITY 审中-公开
标题翻译：用于评估多重抗性活性的方法和试剂盒
公开(公告)号：WO2005116648A3
公开(公告)日：2006-03-30
申请号：PCT/IB2005051707
申请日：2005-05-25
申请人： SOLVO BIOTECHNOLOGY INC , SCHWAB RICHARD , PETAK ISTVAN , SARKADI BALAZS , KOPPER LASZLO , KERI GYOERGY , PAP AKOS , SZAKACS GERGELY , HOMOLYA LASZLO , JAKAB FERENC , MOLDVAY JUDIT , FEHER ARNOLD
发明人： SCHWAB RICHARD , PETAK ISTVAN , SARKADI BALAZS , KOPPER LASZLO , KERI GYOERGY , PAP AKOS , SZAKACS GERGELY , HOMOLYA LASZLO , JAKAB FERENC , MOLDVAY JUDIT , FEHER ARNOLD
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/6872 , G01N2500/10
摘要： The invention provides an in vitro diagnostic method for detecting multi-drug resistance in a biological specimen comprising a heterogeneous population of discrete cells, said method comprising the steps of contacting a first portion of the biological specimen with MDR substrate derivative and a viability reagent; contacting a second portion of the biological specimen with a general inhibitor of transport protein-mediated cell efflux, the MDR substrate derivative, and the viability reagent; measuring the signal generated by the MDR substrate within the viable cells of said second portion; defining an MDR substrate signal intensity range based on data measured above; determining a first rate of MDR substrate accumulation within a population of cells of said first portion of the biological specimen; determining a second rate of MDR substrate accumulation within a population of cells of said second portion of the biological specimen; and calculating the difference in said first and second rates of MDR substrate accumulation, wherein data showing a reduced MDR substrate accumulation in said populations of cells between said first portion and said second portion is indicative of the presence of multi-drug resistance in said biological specimen.
摘要翻译：本发明提供一种体外诊断方法，用于检测包含离散细胞的异质群的生物样本中的多重耐药性，所述方法包括使生物样本的第一部分与MDR底物衍生物和活力试剂接触的步骤; 使生物样品的第二部分与一般的蛋白质介导的细胞外流抑制剂，MDR底物衍生物和活力试剂接触; 测量由所述第二部分的活细胞内的MDR基底产生的信号; 基于上面测量的数据定义MDR衬底信号强度范围; 确定生物样本的所述第一部分的细胞群体内的MDR底物积累的第一速率; 确定生物样本的所述第二部分的细胞群体内的MDR底物积累的第二速率; 并计算所述第一和第二速率的MDR底物积累的差异，其中显示在所述第一部分和所述第二部分之间的所述细胞群体中减少的MDR底物积累的数据指示所述生物样本中存在多重耐药性。

6. 发明申请

WO02071073A3 SCREENING SYSTEM BASED ON EXPRESSION OF ABCG2 HALF TRANSPORTER PROTEIN 审中-公开
标题翻译：基于ABCG2 HALF运输蛋白表达的筛选系统
公开(公告)号：WO02071073A3
公开(公告)日：2003-04-03
申请号：PCT/HU0200015
申请日：2002-03-04
申请人： SOLVO BIOTECHNOLOGY INC , OEZVEGY CSILLA , SZAKACS GERGELY , VARADI ANDRAS , NAGY ZOLTAN
发明人： OEZVEGY CSILLA , SZAKACS GERGELY , VARADI ANDRAS , NAGY ZOLTAN
IPC分类号： G01N33/68 , C12N5/00 , G01N33/50 , G01N33/574
CPC分类号： G01N33/6872 , G01N2333/705
摘要： The overexpression of an ABC half-transporter, ABCG2 (MXR/BCRP) transporter causes multidrug resistance in tumors. The present invention is based on the in vitro expression of the ABCG2 protein in insect cells as an expression system free of other, closely related, functional ABC transporters. In particular, the invention is related to a method for testing drugs for their effect on ABCG2 protein, method for the expression of active ABCG2, isolated ABCG2 homooligomers, preferably homodimers and uses thereof for testing drugs. The invention is further related to cell membrane preparations and cells, preferably insect cells comprising active ABCG2 and reagent kits for testing drugs for their effect on an ABCG2 half transporter protein. The invention is also related to a method for identifying ABCG2 activity in a biological sample, utilizing its substrate/inhibitor specificity.
摘要翻译： ABC半转运蛋白ABCG2（MXR / BCRP）转运蛋白的过度表达在肿瘤中引起多药耐药。本发明基于ABCG2蛋白在昆虫细胞中的体外表达，作为不含其他密切相关的功能性ABC转运蛋白的表达系统。特别地，本发明涉及一种用于测试药物对ABCG2蛋白的影响的方法，用于表达活性ABCG2的方法，分离的ABCG2同源二聚体，优选同二聚体及其用于测试药物的用途。本发明还涉及细胞膜制剂和细胞，优选包含活性ABCG2的昆虫细胞和用于测试药物对ABCG2半转运蛋白的影响的试剂盒。本发明还涉及利用其底物/抑制剂特异性鉴定生物样品中ABCG2活性的方法。

7. 发明申请

WO2002071073A2 SCREENING SYSTEM BASED ON EXPRESSION OF ABCG2 HALF TRANSPORTER PROTEIN 审中-公开
标题翻译：基于ABCG2 HALF运输蛋白表达的筛选系统
公开(公告)号：WO2002071073A2
公开(公告)日：2002-09-12
申请号：PCT/HU2002/000015
申请日：2002-03-04
申请人： SOLVO BIOTECHNOLOGY INC. , ÖZVEGY, Csilla , SZAKÁCS, Gergely , VÁRADI, András , NAGY, Zoltán
发明人： ÖZVEGY, Csilla , SZAKÁCS, Gergely , VÁRADI, András , NAGY, Zoltán
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N2333/705
摘要： The overexpression of an ABC half-transporter, ABCG2 (MXR/BCRP) transporter causes multidrug resistance in tumors. The present invention is based on the in vitro expression of the ABCG2 protein in insect cells as an expression system free of other, closely related, functional ABC transporters. In particular, the invention is related to a method for testing drugs for their effect on ABCG2 protein, method for the expression of active ABCG2, isolated ABCG2 homooligomers, preferably homodimers and uses thereof for testing drugs. The invention is further related to cell membrane preparations and cells, preferably insect cells comprising active ABCG2 and reagent kits for testing drugs for their effect on an ABCG2 half transporter protein. The invention is also related to a method for identifying ABCG2 activity in a biological sample, utilizing its substrate/inhibitor specificity.
摘要翻译： ABC半转运蛋白ABCG2（MXR / BCRP）转运蛋白的过度表达在肿瘤中引起多药耐药。本发明基于ABCG2蛋白在昆虫细胞中的体外表达，作为不含其他密切相关的功能性ABC转运蛋白的表达系统。特别地，本发明涉及一种用于测试药物对ABCG2蛋白的影响的方法，用于表达活性ABCG2的方法，分离的ABCG2同源二聚体，优选同二聚体及其用于测试药物的用途。本发明还涉及细胞膜制剂和细胞，优选包含活性ABCG2的昆虫细胞和用于测试药物对ABCG2半转运蛋白的影响的试剂盒。本发明还涉及利用其底物/抑制剂特异性鉴定生物样品中ABCG2活性的方法。

8. 发明申请

WO2003035685A1 USE OF A HALF-TRANSPORTER PROTEIN OF THE ABCG-FAMILY FOR SELECTING CELLS AND IN GENE THERAPY 审中-公开
标题翻译：使用ABCG家族的半转运蛋白选择细胞和基因治疗
公开(公告)号：WO2003035685A1
公开(公告)日：2003-05-01
申请号：PCT/HU2002/000108
申请日：2002-10-24
申请人： SOLVO BIOTECHNOLOGY INC. , NÉMET, Katalin , VÁRADI, György , CERVENAK, Judit , UJHELLY, Olga , SARKADI, Balázs , VÁRADI, András , ÖZVEGY, Csilla
发明人： NÉMET, Katalin , VÁRADI, György , CERVENAK, Judit , UJHELLY, Olga , SARKADI, Balázs , VÁRADI, András , ÖZVEGY, Csilla
IPC分类号： C07K14/47
CPC分类号： C12N5/0647 , A61K48/00 , A61K2035/124 , C07K14/705 , C12N2510/00
摘要： The invention relates to an isolated nucleic acid comprising a sequence encoding a half transporter protein of the ABCG-family for use in gene therapy, to the use of the isolated nucleic acid for selecting somatic mammalian cells against at least one drug transportable by the transporter protein, to vectors, cells, pharmaceutical compositions and kits comprising the nucleic acid and methods for protecting and selecting cells against a cytotoxic drug transportable by said transporter protein and for gene therapy methods.
摘要翻译：使用包含编码ABCG家族的半转运蛋白的序列的分离的核酸，在基因治疗方法中，以及使用至少一种可由转运蛋白转运的药物选择体细胞哺乳动物细胞是新的。还包括以下独立权利要求：（1）用于基因转移到哺乳动物细胞中的载体，其包含核酸; （2）使用至少一种可由转运蛋白转运的药物选择体细胞哺乳动物细胞; （3）由载体转化的体细胞哺乳动物细胞; （4）可从病毒载体获得的感染性病毒粒子; 和（5）包含载体的药物试剂盒。活动：免疫抑制。没有给出生物数据。作用机制：基因治疗; 造血细胞保护。在逆转录病毒转导后，将细胞暴露于5mM Mitoxanthrone（MX）选择3天，并通过G-CSF诱导粒细胞分化，或直接在集落形成测定中进行接种，并通过MX在甲基纤维素中选择。正常或模拟转导的CD34 +细胞没有显示可测量的MX挤出能力，但是在ABCG2-G转导的祖细胞中观察到MX挤出的显着增加，并且通过MX转导的细胞的选择进一步增加了该挤出。当MX用作选择剂时，模拟转导的细胞不形成集落，而MX选择将ABCG2-G转导的细胞中的数量减少约50％。这种减少与消除不表达ABCG2-G的细胞相当。

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