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1. 发明申请

WO2007016366A2 DEFINED CULTURE CONDITIONS OF HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：人类胚胎干细胞的定义文化条件
公开(公告)号：WO2007016366A2
公开(公告)日：2007-02-08
申请号：PCT/US2006029473
申请日：2006-07-28
申请人： UNIV YALE , SNYDER MICHAEL J , LU JOYCE J
发明人： SNYDER MICHAEL J , LU JOYCE J
IPC分类号： A61K35/26
CPC分类号： A61K38/191 , A61K38/1825 , A61K38/28 , A61K38/40
摘要： The present invention relates to compositions and methods for culturing stem cells, particularly embryonic stem cells. Specifically, the invention relates to a culture medium that supports proliferation of substantially undifferentiated stem cells, while maintaining potency of the cells. In an embodiment, the culture medium is defined and supports proliferation of substantially undifferentiated embryonic stem cells in essentially serum free and feeder cell free conditions. Compositions for making the medium and methods using the culture medium are also provided.
摘要翻译：本发明涉及用于培养干细胞，特别是胚胎干细胞的组合物和方法。具体而言，本发明涉及支持基本上未分化的干细胞增殖的培养基，同时保持细胞的效力。在一个实施方案中，限定培养基并且在基本上无血清和无饲养细胞的条件下支持基本上未分化的胚胎干细胞的增殖。还提供了用于制备培养基的组合物和使用培养基的方法。

2. 发明申请

WO2014160986A1 CORE EXERCISING MACHINE 审中-公开
标题翻译：核心练习机
公开(公告)号：WO2014160986A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/032275
申请日：2014-03-28
申请人： SNYDER, Michael, J.
发明人： SNYDER, Michael, J.
IPC分类号： A63B21/008 , A63B23/02
CPC分类号： A63B23/0205 , A63B21/00069 , A63B21/00072 , A63B21/0083 , A63B21/0087 , A63B21/4033 , A63B21/4047 , A63B23/0211 , A63B23/0233 , A63B2208/0233 , A63B2210/50 , A63B2225/09
摘要： A collapsible exercise machine for strengthening the core muscles (transverse abdominal, internal obliques, external obliques, rectus abdominis, and erector spinae) includes a frame mounted on a base on which a user sits and manipulates an upstanding lever arm. A seat is convertible between two differently- angled positions for back extension or abdominal exercises. The lever arm rotates a curved tube having a plurality of force adjustment holes. The tube passes through a frame at the upper end of a gas spring, and engaging an adjustment pin on the frame with different adjustment holes changes the amount of resistance. The entire frame above the base can be vertically adjusted to accommodate different sizes of user without altering the relative position between the seat (and user' s hips) and the axis of rotation of the lever arm thus not affecting/changing the designated resistance between users of different heights (resistance is affected when the lever arm is lengthened). The connection between the frame and the base enables the unit to be collapsed to a profile small enough to fit under a bed.
摘要翻译：用于加强核心肌肉（横腹，内斜角，外斜角，腹直肌和垂直肌）的可折叠锻炼机器包括安装在使用者坐下并操纵直立杆臂的基座上的框架。一个座位可以在两个不同角度的位置之间转换，用于后伸或腹部锻炼。杠杆臂旋转具有多个力调节孔的弯曲管。管通过气弹簧上端的框架，并且与不同调节孔的框架上的调节销接合改变阻力量。基座上方的整个框架可以垂直调整以适应不同尺寸的使用者，而不改变座椅（和使用者的臀部）与杠杆臂的旋转轴线之间的相对位置，从而不影响/改变用户之间的指定阻力不同高度（当杠杆臂加长时，阻力受到影响）。框架和底座之间的连接使得该单元能够折叠成一个小到足以安放在床下的轮廓。

3. 发明申请

WO2007016366A3 DEFINED CULTURE CONDITIONS OF HUMAN EMBRYONIC STEM CELLS 审中-公开
公开(公告)号：WO2007016366A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/029473
申请日：2006-07-28
申请人： YALE UNIVERSITY , SNYDER, Michael, J. , LU, Joyce, J.
发明人： SNYDER, Michael, J. , LU, Joyce, J.
IPC分类号： C12N5/00 , C12N5/02
摘要： The present invention relates to compositions and methods for culturing stem cells, particularly embryonic stem cells. Specifically, the invention relates to a culture medium that supports proliferation of substantially undifferentiated stem cells, while maintaining potency of the cells. In an embodiment, the culture medium is defined and supports proliferation of substantially undifferentiated embryonic stem cells in essentially serum free and feeder cell free conditions. Compositions for making the medium and methods using the culture medium are also provided.

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