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1. 发明申请

WO2011121276A1 LIPOPHILIC CATIONIC PROBE FOR PET- IMAGING 审中-公开
标题翻译：用于PET成像的LIPOPHILIC阳离子探针
公开(公告)号：WO2011121276A1
公开(公告)日：2011-10-06
申请号：PCT/GB2011/000425
申请日：2011-03-24
申请人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ENTERPRISE LIMITED , UNIVERSITY OF OTAGO , MENON, David Krishna , MURPHY, Michael, P. , AIGBIRHIO, Franklin Imo , SMITH, Robin, A., J.
发明人： MENON, David Krishna , MURPHY, Michael, P. , AIGBIRHIO, Franklin Imo , SMITH, Robin, A., J.
IPC分类号： A61K51/04 , C07B59/00
CPC分类号： A61K51/0404 , C07B59/004
摘要： The present invention provides an imaging probe which comprises a lipophilic cation, a hydrophobic moiety and a PET nucleus. The present invention also provides a precursor molecule for the production of such an imaging probe and methods for using the probe for analysing mitochondrial membrane potential in a subject.
摘要翻译：本发明提供了一种成像探针，其包含亲脂性阳离子，疏水部分和PET核。本发明还提供了用于制备这种成像探针的前体分子和用于分析受试者线粒体膜电位的探针的方法。

2. 发明申请

WO1999026582A2 MITOCHONDRIALLY TARGETED COMPOUNDS 审中-公开
标题翻译： MITOCHENDRIALLY目标化合物
公开(公告)号：WO1999026582A2
公开(公告)日：1999-06-03
申请号：PCT/NZ1998000172
申请日：1998-11-25
申请人： UNIVERSITY OF OTAGO , MURPHY, Michael, Patrick , SMITH, Robin, A., J.
发明人： UNIVERSITY OF OTAGO
IPC分类号： A61K00/00
CPC分类号： C07F9/65522 , A61K47/54 , A61K47/543 , C07F9/54 , C07F9/5722
摘要： The invention provides mitochondrially targeted compounds. A compound of the invention comprises a lipophili cation covalently coupled to a therapeutically or prophylactically useful compound. In preferred embodiments the therapeutically or prophylactically useful compound is an antioxidant moiety. In particularly preferred embodiments, the lipophilic cation is the triphenylphosphonium cation, and the compound is of the formula P(Ph3) XR.Z where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the antioxidant compounds of the invention.
摘要翻译：本发明提供线粒体靶向化合物。本发明的化合物包含与治疗或预防有用的化合物共价偶联的亲脂体。在优选的实施方案中，治疗或预防有用的化合物是抗氧化剂部分。在特别优选的实施方案中，亲脂性阳离子是三苯基鏻阳离子，化合物具有式P（Ph 3）XR.Z-，其中X是连接基团，Z是阴离子，R是抗氧化剂部分。还提供了含有线粒体靶向化合物的药物组合物，以及治疗或预防受益于减少的氧化应激的患者的方法，其包括给予本发明的抗氧化剂化合物的步骤。

3. 发明申请

WO2009145982A1 COMPOSITIONS AND METHODS FOR SKIN CARE 审中-公开
标题翻译：皮肤护理的组合物和方法
公开(公告)号：WO2009145982A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/038123
申请日：2009-03-24
申请人： ANTIPODEAN PHARMACEUTICALS, INC. , MURPHY, Michael, Patrick , SMITH, Robin, A., J. , TAYLOR, Kenneth, Martin , ROSENMAN, Stephen, J.
发明人： MURPHY, Michael, Patrick , SMITH, Robin, A., J. , TAYLOR, Kenneth, Martin
IPC分类号： A61K31/66 , A61K47/40 , A61P17/18 , A61K31/355 , A61K31/385 , A61K31/375 , A01N55/02 , A61P17/02
CPC分类号： A61K31/355 , A61K8/55 , A61K31/203 , A61K31/375 , A61K31/385 , A61K31/66 , A61K45/06 , A61K2800/522 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.
摘要翻译：组合物和方法用于治疗由受试者皮肤中的活性氧产生产生的皮肤状况，包括施用含有亲脂性阳离子 - 线粒体靶向抗氧化剂化合物的局部制剂，并递送治疗有效量的抗氧化剂化合物皮肤成纤维细胞和角质形成细胞。

4. 发明申请

WO2005035546A1 PEPTIDE NUCLEIC ACID CONJUGATES AND USES THEREOF 审中-公开
标题翻译：肽类核酸结合物及其用途
公开(公告)号：WO2005035546A1
公开(公告)日：2005-04-21
申请号：PCT/NZ2004/000255
申请日：2004-10-15
申请人： UNIVERSITY OF OTAGO , ECCLES, Roger, Michael, , MURATOVSKA, Aleksandra , SMITH, Robin, A., J. , MURPHY, Michael, Patrick
发明人： ECCLES, Roger, Michael, , MURATOVSKA, Aleksandra , SMITH, Robin, A., J. , MURPHY, Michael, Patrick
IPC分类号： C07H21/00
CPC分类号： C12N15/113 , A61K38/00 , A61K47/64 , C07F9/5407 , C07F9/5442 , C07K14/003 , C12N15/111 , C12N2310/11 , C12N2310/3181 , C12N2310/351 , C12N2320/32
摘要： The invention provides a triphenylphosphonium peptide nucleic acid conjugate. The conjugate comprises a peptide nucleic acid linked via a disulfide bond, to a triphenylphosphonium group. Conjugates of the invention can be used to deliver PNA oligomers across the plasma membrane into cells.
摘要翻译：本发明提供三苯基鏻肽核酸缀合物。缀合物包含通过二硫键连接的肽核酸与三苯基鏻基团。本发明的缀合物可以用于将PNA寡聚物跨过质膜递送到细胞中。

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