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1. 发明申请

WO2019139977A1 COMBINATION THERAPIES FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA 审中-公开
公开(公告)号：WO2019139977A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/012886
申请日：2019-01-09
申请人： EISAI R&D MANAGEMENT CO., LTD. , SELVARAJ, Anand , SMITH, Peter
发明人： SELVARAJ, Anand , SMITH, Peter
IPC分类号： A61K31/47 , A61K31/496
CPC分类号： A61K31/47 , A61K31/496 , A61K2300/00
摘要： Provided herein is a combination therapy useful for the treatment hepatocellular carcinoma. The combination comprises an FGFR4 inhibitor and lenvatinib.

2. 发明申请

WO2018010763A1 SECURE DEVICE LOCATION DETECTION MECHANISM BY PSEUDO-RANDOM SEQUENCES 审中-公开
标题翻译：伪随机序列的安全装置位置检测机制
公开(公告)号：WO2018010763A1
公开(公告)日：2018-01-18
申请号：PCT/EP2016/066427
申请日：2016-07-11
申请人： HUAWEI TECHNOLOGIES CO., LTD. , LOWE, Christopher , SMITH, Peter
发明人： LOWE, Christopher , SMITH, Peter
IPC分类号： G01S5/00 , G01S5/02 , H04K1/00
CPC分类号： G01S5/0036 , G01S5/0205 , H04K1/00
摘要： A method, network (200) and base station device, the method including receiving a time stamped segment of a randomly generated value sequence from at least one base station (20), the randomly generated value sequence is generated by at least one first random value generator (32) executed on a user equipment device (30), executing at least one random second value generator (14) for generating at least one reference value sequence, identifying a match between the time stamped segment and a time correlated reference segment of the at least one reference value sequence, and determining a location of the user equipment device according to the match and location data received from the at least one base station, wherein the at least one first random value generator and the at least one random second value generator are correlated.
摘要翻译：一种方法，网络（200）和基站设备，所述方法包括：从至少一个基站（20）接收随机生成的值序列的带时间戳的片段，所述随机生成的值序列是由在用户设备装置（30）上执行的至少一个第一随机值生成器（32）生成，执行至少一个随机第二值生成器（14），用于生成至少一个参考值序列，识别所述时间戳片段以及所述至少一个参考值序列的时间相关的参考段，并且根据从所述至少一个基站接收的所述匹配和位置数据来确定所述用户设备的位置，其中，所述至少一个第一随机值生成器和至少一个随机的第二值生成器被关联。

3. 发明申请

WO2017196854A1 DRUG COMBINATIONS FOR REDUCING CELL VIABILITY AND/OR CELL PROLIFERATION 审中-公开
标题翻译：用于降低细胞生存能力和/或细胞增殖的药物组合
公开(公告)号：WO2017196854A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031771
申请日：2017-05-09
申请人： EISAI R&D MANAGEMENT CO., LTD. , SELVARAJ, Anand , SMITH, Peter
发明人： SELVARAJ, Anand , SMITH, Peter
IPC分类号： A61K39/395 , A61K31/4706 , A61K31/506 , A61K31/517 , A61P35/00
CPC分类号： A61K31/4706 , A61K31/506 , A61K31/517 , A61P35/00 , A61K2300/00
摘要： Provided herein is a combination of agents for reducing cell viability and/or cell proliferation. The combination comprises an FGFR4 inhibitor and an EGFR inhibitor.
摘要翻译：本文提供了用于降低细胞存活力和/或细胞增殖的药剂的组合。该组合包含FGFR4抑制剂和EGFR抑制剂。

4. 发明申请

WO2013108004A3 DOMESTIC POWER CONTROLLER 审中-公开
标题翻译：国内功率控制器
公开(公告)号：WO2013108004A3
公开(公告)日：2013-11-28
申请号：PCT/GB2013000018
申请日：2013-01-17
申请人： DUFFETT-SMITH PETER JAMES
发明人： DUFFETT-SMITH PETER JAMES
IPC分类号： H02J3/38
CPC分类号： H02J3/32 , H02J3/383 , H02J3/386 , H02J7/35 , Y02B10/14 , Y02B10/30 , Y02E10/563 , Y02E10/566 , Y02E10/763 , Y02E10/766 , Y02E70/30
摘要： A method and apparatus is presented for using excess electric power generated by a domestic alternative power generation system (101 ) connected to a domestic electricity wiring network. The excess power is consumed within a device whose power consumption may be varied using a control signal. The wiring network is also connected to an external electric power supply system (108). The method operates by measuring the net power flowing between the domestic wiring network and the external electric power supply system (108) together with its direction of flow. A control signal is created to adjust the power consumed by the power-consuming device in such a fashion that (a) the net power flowing from the domestic wiring network to the external electric power supply system (108) is kept near or below a predetermined threshold value (1 14); (b) it varies in response to the difference between the net power flowing and a predetermined threshold value; and (c) it is adjusted to reduce to zero the power consumed by the power-consuming device whenever the direction of net power flow is from the external electric power supply system to the domestic wiring network, or the net power flowing from the wiring network to the external electric power supply system is below the threshold.
摘要翻译：提出了一种用于使用由连接到家用电力布线网络的家用替代发电系统（101）产生的过剩电力的方法和装置。在功耗可以使用控制信号改变的设备内消耗多余的功率。接线网络也连接到外部电力供应系统（108）。该方法通过测量家用布线网络和外部电力供应系统（108）之间流动的净功率及其流向。创建控制信号，以便以下述方式来调节由功耗装置消耗的功率：（a）从家用布线网络流向外部电力供应系统（108）的净功率保持接近或低于预定的阈值（114）; （b）响应于净功率流与预定阈值之间的差异而变化; 以及（c）当净功率方向从外部电力供应系统到家庭布线网络或从布线网络流出的净功率时，调节功率消耗装置消耗的功率为零外部供电系统低于门槛。

5. 发明申请

WO2012166665A3 BROAD SPECTRUM ANTIBIOTICS 审中-公开
标题翻译： BROAD SPECTRUM抗生素
公开(公告)号：WO2012166665A3
公开(公告)日：2013-03-07
申请号：PCT/US2012039727
申请日：2012-05-25
申请人： RQX PHARMACEUTICALS INC , ROBERTS TUCKER CURRAN , SMITH PETER ANDREW , CAMPBELL DAVID , DURON SERGIO G , HIGUCHI ROBERT I
发明人： ROBERTS TUCKER CURRAN , SMITH PETER ANDREW , CAMPBELL DAVID , DURON SERGIO G , HIGUCHI ROBERT I
IPC分类号： C07C271/10 , A61K31/16 , A61P31/00 , C07D207/10
CPC分类号： C07K7/06 , A61K38/00 , A61K45/06 , C07D207/10
摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
摘要翻译：本文提供的是抗菌化合物，其中在一些实施方案中的化合物具有广谱生物活性。本文提供的化合物可以在其它实施方案中克服在细菌信号肽酶（SPase）的限定位置由单个氨基酸突变赋予的抗性，并且在其它实施方案中，与天然产物相比，提供更广谱的抗生素生物活性。还提供了使用本文所述的化合物进行治疗的药物组合物和方法。

6. 发明申请

WO2012142585A1 LIGHT FIXTURE WITH FLAMELESS CANDLE 审中-公开
标题翻译：无光蜡烛灯
公开(公告)号：WO2012142585A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033788
申请日：2012-04-16
申请人： CANDELLA, LLC , LUCAS, Scott , THOMPSON, Jeff , SMITH, Peter , GAST, Bob , YOUNG, Allen , GRAY, Caroline , MCKINNON, Alex
发明人： LUCAS, Scott , THOMPSON, Jeff , SMITH, Peter , GAST, Bob , YOUNG, Allen , GRAY, Caroline , MCKINNON, Alex
IPC分类号： F21S10/04
CPC分类号： H05B37/0218 , F21S9/03 , F21V23/0464 , F21V23/0471 , F21W2111/023 , F21Y2113/20 , F21Y2115/10 , H05B37/0227 , Y02B20/46
摘要： Light fixtures are disclosed having a first light source. The light fixtures can include a second light source, and a flameless candle that includes the first light source. A sensor can also be included that is configured to detect at least one of movement and light, and produces a sensor signal.
摘要翻译：公开了具有第一光源的灯具。灯具可以包括第二光源和包括第一光源的无焰蜡烛。还可以包括被配置为检测运动和光中的至少一个并且产生传感器信号的传感器。

7. 发明申请

WO2012058027A3 METHOD AND SYSTEM FOR FRACTURING A FORMATION 审中-公开
公开(公告)号：WO2012058027A3
公开(公告)日：2012-05-03
申请号：PCT/US2011/056356
申请日：2011-10-14
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , LIANG, Yueming , CHELF, Michael, S. , CRAWFORD, Brian, R. , DALE, Bruce, A. , BARRETT, Elizabeth, L. Templeton , SMITH, Peter, Griffin, Jr. , SEARLES, Kevin, H. , SUNDBERG, Marshall, I. , WU, Xianyun
发明人： LIANG, Yueming , CHELF, Michael, S. , CRAWFORD, Brian, R. , DALE, Bruce, A. , BARRETT, Elizabeth, L. Templeton , SMITH, Peter, Griffin, Jr. , SEARLES, Kevin, H. , SUNDBERG, Marshall, I. , WU, Xianyun
IPC分类号： E21B43/30
摘要： Systems and methods are described for fracturing a hydrocarbon production formation. A method includes the steps of drilling a well into a zone proximate to a hydrocarbon production formation, and increasing a volume of the zone through the well in order to apply a mechanical stress to the hydrocarbon production formation.

8. 发明申请

WO2011154870A1 TEETHER 审中-公开
标题翻译：牙胶
公开(公告)号：WO2011154870A1
公开(公告)日：2011-12-15
申请号：PCT/IB2011/052389
申请日：2011-05-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ENGEN, Marcel, H. , SMITH, Peter, J.
发明人： VAN ENGEN, Marcel, H. , SMITH, Peter, J.
IPC分类号： A61J17/00
CPC分类号： A61J17/001 , A61J17/02 , A61J2200/44
摘要： A teething device comprising a shield connected to a gum soothing portion formed from a frame is disclosed. The frame is configured to locate underneath a lip and against a gum of an infant when in use. Furthermore, the frame is shaped so as to conform to an infant's gumso as to produce a massaging effect on said gum.
摘要翻译：公开了一种出牙装置，其包括连接到由框架形成的口香糖部分的护罩。框架被配置为在使用时定位在唇部和婴儿口香糖之下。此外，框架被成形为符合婴儿的口香糖，以便对所述口香糖产生按摩效果。

9. 发明申请

WO2011150396A1 VIRTUAL LAYER 2 AND MECHANISM TO MAKE IT SCALABLE 审中-公开
标题翻译：虚拟层2和机制使其可扩展
公开(公告)号：WO2011150396A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038443
申请日：2011-05-27
申请人： HUAWEI TECHNOLOGIES CO., LTD. , DUNBAR, Linda , MACK-CRANE, Benjamin, T. , HARES, Susan , SULTAN, Robert , ASHWOOD-SMITH, Peter , YIN, Guoli
发明人： DUNBAR, Linda , MACK-CRANE, Benjamin, T. , HARES, Susan , SULTAN, Robert , ASHWOOD-SMITH, Peter , YIN, Guoli
IPC分类号： H04L29/12 , H04L12/46 , H04L12/56
CPC分类号： H04L12/4633 , H04L12/462 , H04L12/4625 , H04L12/4641 , H04L12/4675 , H04L12/66 , H04L29/12028 , H04L41/12 , H04L45/02 , H04L45/66 , H04L61/103
摘要： An apparatus comprising a service network and a plurality of Layer 2 networks at a plurality of different physical locations coupled to the service network via a plurality of edge nodes at the Layer 2 networks, wherein the edge nodes are configured to maintain a plurality of Internet Protocol (IP) addresses of a plurality of hosts across the Layer 2 networks, and wherein the IP addresses of the hosts in each of the Layer 2 networks are mapped by the other Layer 2 networks to a Media Access Control (MAC) address of each of the edge nodes in the same Layer 2 networks of the hosts.
摘要翻译：一种包括服务网络和多个不同物理位置处的多个第2层网络的装置，其经由第2层网络上的多个边缘节点耦合到服务网络，其中边缘节点被配置为维持多个互联网协议（IP）地址，并且其中每个第2层网络中的主机的IP地址被其他第2层网络映射到每个网络的媒体访问控制（MAC）地址主机的相同二层网络中的边缘节点。

10. 发明申请

WO2011116460A1 DISTRIBUTED FAILURE RECOVERY IN A ROUTED ETHERNET NETWORK 审中-公开
标题翻译：分布式以太网网络中的分布式故障恢复
公开(公告)号：WO2011116460A1
公开(公告)日：2011-09-29
申请号：PCT/CA2011/000288
申请日：2011-03-18
申请人： NORTEL NETWORKS LIMITED , SMITH, Peter Ashwood
发明人： SMITH, Peter Ashwood
IPC分类号： H04L29/14 , H04L12/28
CPC分类号： H04L41/0668 , H04L45/00 , H04L45/02 , H04L45/22 , H04L45/28 , H04L45/66
摘要： Link identifiers such as VIDs, selected from a defined range of values, are locally assigned by each node on a link state protocol controlled Ethernet network to each of its links or adjacencies. The link identifiers are assigned by the nodes such that each link or adjacency at the node is uniquely identified by a different link identifier. A link state protocol adjacency notification mechanism or other flooding mechanism is used to disseminate the locally assigned link identifiers to other nodes on the link state protocol controlled Ethernet network. The link identifiers are added by the nodes to their topology databases to enable detour routes to be locally calculated by the nodes on the network in a distributed manner. Upon occurrence of a failure, the link identifiers are used to source route traffic around the failure so that traffic may continue to traverse the link state protocol controlled Ethernet network.
摘要翻译：从定义的值范围中选择的诸如VID的链路标识符由链路状态协议控制的以太网上的每个节点本地分配给其每个链路或邻接。链路标识符由节点分配，使得节点处的每个链路或邻接被不同的链路标识符唯一地标识。链路状态协议邻接通知机制或其他洪泛机制用于将本地分配的链路标识符传播到链路状态协议控制的以太网上的其他节点。链路标识符被节点添加到它们的拓扑数据库中，以使得绕线路由由网络上的节点以分布式的方式在本地计算。发生故障时，链路标识符用于引发故障周围的路由流量，以便流量可以继续遍历链路状态协议控制的以太网。

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